CN1447812A - 制造高纯度结晶(r,s)一头孢呋辛酯的方法 - Google Patents

制造高纯度结晶(r,s)一头孢呋辛酯的方法 Download PDF

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Publication number
CN1447812A
CN1447812A CN01814420A CN01814420A CN1447812A CN 1447812 A CN1447812 A CN 1447812A CN 01814420 A CN01814420 A CN 01814420A CN 01814420 A CN01814420 A CN 01814420A CN 1447812 A CN1447812 A CN 1447812A
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CN
China
Prior art keywords
solvent
amine
cefuroxime
axetil
water
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Pending
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CN01814420A
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English (en)
Chinese (zh)
Inventor
O·D·泰亚吉
G·C·亚达
V·K·汉达
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Ranbaxy Laboratories Ltd
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Ranbaxy Laboratories Ltd
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Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of CN1447812A publication Critical patent/CN1447812A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN01814420A 2000-07-17 2001-07-16 制造高纯度结晶(r,s)一头孢呋辛酯的方法 Pending CN1447812A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN653DE2000 IN190849B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2000-07-17 2000-07-17
IN653/DEL/2000 2000-07-17

Publications (1)

Publication Number Publication Date
CN1447812A true CN1447812A (zh) 2003-10-08

Family

ID=11097069

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01814420A Pending CN1447812A (zh) 2000-07-17 2001-07-16 制造高纯度结晶(r,s)一头孢呋辛酯的方法

Country Status (10)

Country Link
US (1) US6833452B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP1303523A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2004504325A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1447812A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2001270928A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR0112598A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2416695A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN190849B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2002006289A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA200300472B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507813B2 (en) 2004-07-22 2009-03-24 Nanomaterials Technology Pte Ltd. Amorphous cefuroxime axetil and preparation process therefore
CN103435632A (zh) * 2013-09-12 2013-12-11 广东立国制药有限公司 一种头孢呋辛酯的制备方法
CN105131016A (zh) * 2015-08-04 2015-12-09 江苏正大清江制药有限公司 一种头孢呋辛酯的制备方法
CN106554361A (zh) * 2016-09-30 2017-04-05 华北制药河北华民药业有限责任公司 一种头孢呋辛酯口服制剂的制备方法
CN108586493A (zh) * 2017-12-18 2018-09-28 蚌埠丰原医药科技发展有限公司 一种结晶型头孢呋辛酯的制备方法
CN109705143A (zh) * 2019-03-05 2019-05-03 安徽丰原利康制药有限公司 一种头孢呋辛酯提纯的方法
CN109705144A (zh) * 2019-03-05 2019-05-03 安徽丰原利康制药有限公司 一种头孢呋辛酯高得率的生产方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
EP1409492B1 (en) * 2001-07-25 2008-10-15 Lupin Limited An improved method for preparation of cefuroxime axetil
US6537985B1 (en) * 2001-11-30 2003-03-25 Phoenix Scientific, Inc. Antibiotic formulation and a method of making this formulation
US20030135041A1 (en) 2002-01-04 2003-07-17 Orchid Chemicals & Pharmaceuticals Limited, India Synthesis of ceftiofur intermediate
DE102005019458A1 (de) 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
ITMI20050871A1 (it) * 2005-05-13 2006-11-14 Acs Dobfar Spa Solvato cristallino di cefuroxima acido
DE102006019619A1 (de) * 2006-04-25 2007-10-31 Grünenthal GmbH Kristalline Modifikation von Cefuroximaxetil

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1094545A (en) 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
YU44680B (en) 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320521D0 (en) 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
JPH02104590A (ja) * 1987-06-15 1990-04-17 Toyohiko Kikuchi 抗生物質の製造方法
US5063224A (en) 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil
JP3121903B2 (ja) * 1992-02-07 2001-01-09 塩野義製薬株式会社 デアセチルセファロスポラン酸のカルバモイル化方法
IT1277426B1 (it) * 1995-08-03 1997-11-10 Acs Dobfar Spa Forma cristallina biodisponibile del cefuroxima axetil
CN1111537C (zh) * 1997-05-15 2003-06-18 第一制糖株式会社 高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
PT937727E (pt) * 1998-02-20 2002-07-31 Fako Ilaclari A S Processo para a producao de cefuroxima azetil cristalina soluvel
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
EP1409492B1 (en) * 2001-07-25 2008-10-15 Lupin Limited An improved method for preparation of cefuroxime axetil

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507813B2 (en) 2004-07-22 2009-03-24 Nanomaterials Technology Pte Ltd. Amorphous cefuroxime axetil and preparation process therefore
CN103435632A (zh) * 2013-09-12 2013-12-11 广东立国制药有限公司 一种头孢呋辛酯的制备方法
CN105131016A (zh) * 2015-08-04 2015-12-09 江苏正大清江制药有限公司 一种头孢呋辛酯的制备方法
CN106554361A (zh) * 2016-09-30 2017-04-05 华北制药河北华民药业有限责任公司 一种头孢呋辛酯口服制剂的制备方法
CN106554361B (zh) * 2016-09-30 2018-10-09 华北制药河北华民药业有限责任公司 一种头孢呋辛酯口服制剂的制备方法
CN108586493A (zh) * 2017-12-18 2018-09-28 蚌埠丰原医药科技发展有限公司 一种结晶型头孢呋辛酯的制备方法
CN109705143A (zh) * 2019-03-05 2019-05-03 安徽丰原利康制药有限公司 一种头孢呋辛酯提纯的方法
CN109705144A (zh) * 2019-03-05 2019-05-03 安徽丰原利康制药有限公司 一种头孢呋辛酯高得率的生产方法

Also Published As

Publication number Publication date
JP2004504325A (ja) 2004-02-12
AU2001270928A1 (en) 2002-01-30
US20020016456A1 (en) 2002-02-07
EP1303523A1 (en) 2003-04-23
WO2002006289A1 (en) 2002-01-24
US6833452B2 (en) 2004-12-21
CA2416695A1 (en) 2002-01-24
BR0112598A (pt) 2003-08-12
ZA200300472B (en) 2003-10-16
IN190849B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2003-08-23

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