CN1422259A - 晶体药物 - Google Patents
晶体药物 Download PDFInfo
- Publication number
- CN1422259A CN1422259A CN01807688A CN01807688A CN1422259A CN 1422259 A CN1422259 A CN 1422259A CN 01807688 A CN01807688 A CN 01807688A CN 01807688 A CN01807688 A CN 01807688A CN 1422259 A CN1422259 A CN 1422259A
- Authority
- CN
- China
- Prior art keywords
- wei
- crystalline form
- luo pin
- solid
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- Granted
Links
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- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 2
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
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- 238000013019 agitation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
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- 239000012298 atmosphere Substances 0.000 description 1
- 229910001632 barium fluoride Inorganic materials 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical group [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
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- 239000002775 capsule Substances 0.000 description 1
- 238000004320 controlled atmosphere Methods 0.000 description 1
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- 238000007405 data analysis Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
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- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
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- 239000000706 filtrate Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
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- 238000004442 gravimetric analysis Methods 0.000 description 1
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- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
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- 238000011081 inoculation Methods 0.000 description 1
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 1
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- 235000013379 molasses Nutrition 0.000 description 1
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- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 1
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- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
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- 125000006850 spacer group Chemical group 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (23)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53825700A | 2000-03-30 | 2000-03-30 | |
US09/538,257 | 2000-03-30 | ||
US09/793,536 | 2001-02-27 | ||
US09/793,536 US6608198B2 (en) | 2000-03-30 | 2001-02-27 | Crystalline pharmaceutical |
PCT/US2001/009112 WO2001074787A2 (en) | 2000-03-30 | 2001-03-21 | Crystalline pharmaceutical |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2007101123988A Division CN101066952A (zh) | 2000-03-30 | 2001-03-21 | 晶体药物 |
Publications (2)
Publication Number | Publication Date |
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CN1422259A true CN1422259A (zh) | 2003-06-04 |
CN1330639C CN1330639C (zh) | 2007-08-08 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CNA2007101123988A Pending CN101066952A (zh) | 2000-03-30 | 2001-03-21 | 晶体药物 |
CNB018076882A Expired - Lifetime CN1330639C (zh) | 2000-03-30 | 2001-03-21 | 晶体药物 |
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Application Number | Title | Priority Date | Filing Date |
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CNA2007101123988A Pending CN101066952A (zh) | 2000-03-30 | 2001-03-21 | 晶体药物 |
Country Status (22)
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EP (1) | EP1268442A2 (zh) |
JP (1) | JP2003529592A (zh) |
KR (1) | KR100773258B1 (zh) |
CN (2) | CN101066952A (zh) |
AR (2) | AR033360A1 (zh) |
AU (3) | AU5092001A (zh) |
BG (1) | BG107165A (zh) |
BR (1) | BR0109433A (zh) |
CA (1) | CA2403635A1 (zh) |
CZ (1) | CZ20023529A3 (zh) |
HU (1) | HUP0302675A3 (zh) |
IL (1) | IL151551A0 (zh) |
MX (1) | MXPA02009559A (zh) |
MY (1) | MY128296A (zh) |
NO (1) | NO325005B1 (zh) |
NZ (1) | NZ521183A (zh) |
PE (1) | PE20011232A1 (zh) |
PL (1) | PL359727A1 (zh) |
SA (2) | SA01220270B1 (zh) |
SK (1) | SK14832002A3 (zh) |
TW (1) | TWI284640B (zh) |
WO (1) | WO2001074787A2 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112830899A (zh) * | 2021-01-18 | 2021-05-25 | 合肥华方医药科技有限公司 | 一种洛匹那韦新晶型及其制备方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US6608198B2 (en) | 2000-03-30 | 2003-08-19 | Abbott Laboratories | Crystalline pharmaceutical |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
ES2459301T3 (es) | 2009-02-06 | 2014-05-08 | Hetero Research Foundation | Nuevos polimorfos de lopinavir |
CA2770338A1 (en) * | 2009-08-27 | 2011-03-03 | Merck Sharp & Dohme Corp. | Processes for preparing protease inhibitors of hepatitis c virus |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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US5914332A (en) * | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
AU8145198A (en) * | 1997-06-16 | 1999-01-04 | Vertex Pharmaceuticals Incorporated | Methods of increasing the bioavailability of stable crystal polymorphs of a compound |
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2001
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- 2001-03-21 WO PCT/US2001/009112 patent/WO2001074787A2/en active IP Right Grant
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- 2001-03-21 AU AU5092001A patent/AU5092001A/xx active Pending
- 2001-03-21 KR KR1020027012849A patent/KR100773258B1/ko active IP Right Grant
- 2001-03-21 HU HU0302675A patent/HUP0302675A3/hu unknown
- 2001-03-21 CN CNA2007101123988A patent/CN101066952A/zh active Pending
- 2001-03-21 AU AU2001250920A patent/AU2001250920B2/en not_active Revoked
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- 2001-03-21 SK SK1483-2002A patent/SK14832002A3/sk not_active Application Discontinuation
- 2001-03-21 CA CA002403635A patent/CA2403635A1/en not_active Abandoned
- 2001-03-21 CN CNB018076882A patent/CN1330639C/zh not_active Expired - Lifetime
- 2001-03-21 PL PL35972701A patent/PL359727A1/xx not_active Application Discontinuation
- 2001-03-29 AR ARP010101522A patent/AR033360A1/es not_active Application Discontinuation
- 2001-03-30 PE PE2001000299A patent/PE20011232A1/es not_active Application Discontinuation
- 2001-05-02 TW TW090107717A patent/TWI284640B/zh active
- 2001-08-07 SA SA01220270A patent/SA01220270B1/ar unknown
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2002
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- 2002-10-03 BG BG107165A patent/BG107165A/bg unknown
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2005
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2006
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112830899A (zh) * | 2021-01-18 | 2021-05-25 | 合肥华方医药科技有限公司 | 一种洛匹那韦新晶型及其制备方法 |
Also Published As
Publication number | Publication date |
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HUP0302675A3 (en) | 2004-03-29 |
WO2001074787A3 (en) | 2002-02-07 |
BG107165A (bg) | 2003-07-31 |
MY128296A (en) | 2007-01-31 |
AR049560A2 (es) | 2006-08-16 |
IL151551A0 (en) | 2003-04-10 |
CA2403635A1 (en) | 2001-10-11 |
PE20011232A1 (es) | 2001-12-08 |
SA06270303B1 (ar) | 2009-08-02 |
AU2001250920B2 (en) | 2006-06-29 |
SA01220270B1 (ar) | 2006-11-14 |
PL359727A1 (en) | 2004-09-06 |
NO325005B1 (no) | 2008-01-14 |
CN101066952A (zh) | 2007-11-07 |
KR100773258B1 (ko) | 2007-11-05 |
MXPA02009559A (es) | 2003-05-21 |
HUP0302675A2 (hu) | 2003-12-29 |
TWI284640B (en) | 2007-08-01 |
AU2006222711A1 (en) | 2006-10-19 |
NZ521183A (en) | 2004-03-26 |
SK14832002A3 (sk) | 2003-02-04 |
BR0109433A (pt) | 2004-08-10 |
JP2003529592A (ja) | 2003-10-07 |
EP1268442A2 (en) | 2003-01-02 |
KR20030011807A (ko) | 2003-02-11 |
CN1330639C (zh) | 2007-08-08 |
NO20024679L (no) | 2002-09-30 |
WO2001074787A2 (en) | 2001-10-11 |
AU5092001A (en) | 2001-10-15 |
CZ20023529A3 (cs) | 2003-02-12 |
AR033360A1 (es) | 2003-12-17 |
NO20024679D0 (no) | 2002-09-30 |
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