CN1420924B - 重组α-L-艾杜糖苷酶,其生产和纯化的方法以及治疗其缺陷导致的疾病的方法 - Google Patents

重组α-L-艾杜糖苷酶,其生产和纯化的方法以及治疗其缺陷导致的疾病的方法 Download PDF

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CN1420924B
CN1420924B CN008181705A CN00818170A CN1420924B CN 1420924 B CN1420924 B CN 1420924B CN 008181705 A CN008181705 A CN 008181705A CN 00818170 A CN00818170 A CN 00818170A CN 1420924 B CN1420924 B CN 1420924B
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iduronidase
enzyme
leu
recombinant alpha
ala
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CN1420924A (zh
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J·M·亨德斯特兰德
秦民民
陈炜鹏
陈临
P·A·菲茨帕特里克
D·J·文特
G·N·泽切尔勒
C·M·斯塔尔
E·D·卡基斯
B·塔纳马奇
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HARBOR-UCLA
Biomarin Pharmaceutical Inc
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CN008181705A 1999-11-12 2000-11-09 重组α-L-艾杜糖苷酶,其生产和纯化的方法以及治疗其缺陷导致的疾病的方法 Expired - Lifetime CN1420924B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/439,923 US6426208B1 (en) 1999-11-12 1999-11-12 Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US09/439,923 1999-11-12
PCT/US2000/031293 WO2002004616A1 (en) 1999-11-12 2000-11-09 RECOMBINANT α-L-IDURONIDASE, METHODS FOR PRODUCING AND PURIFYING THE SAME AND METHODS FOR TREATING DISEASES CAUSED BY DEFICIENCIES THEREOF

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CNA2008101440588A Division CN101407796A (zh) 1999-11-12 2000-11-09 重组α-L-艾杜糖苷酶,其生产和纯化的方法以及治疗其缺陷导致的疾病的方法

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CN1420924A CN1420924A (zh) 2003-05-28
CN1420924B true CN1420924B (zh) 2010-05-05

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CN008181705A Expired - Lifetime CN1420924B (zh) 1999-11-12 2000-11-09 重组α-L-艾杜糖苷酶,其生产和纯化的方法以及治疗其缺陷导致的疾病的方法

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EP (2) EP1792983B1 (OSRAM)
JP (3) JP2004502456A (OSRAM)
CN (2) CN101407796A (OSRAM)
AT (2) ATE430193T1 (OSRAM)
AU (2) AU773663B2 (OSRAM)
BR (1) BRPI0015533B8 (OSRAM)
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EP3411488A1 (en) 2016-02-03 2018-12-12 The Trustees Of The University Of Pennsylvania Gene therapy for treating mucopolysaccharidosis type i
KR20250022877A (ko) * 2017-01-31 2025-02-17 리젠엑스바이오 인크. 완전히-인간 글리코실화된 인간 알파-l-이두로니다아제(idua)를 이용한 뮤코다당증 1형의 치료
AU2018298133A1 (en) 2017-07-06 2020-01-23 The Trustees Of The University Of Pennsylvania AAV9-mediated gene therapy for treating mucopolysaccharidosis type I
SG11202002457RA (en) 2017-09-22 2020-04-29 Univ Pennsylvania Gene therapy for treating mucopolysaccharidosis type ii
CN107699590A (zh) * 2017-10-13 2018-02-16 成都中医药大学 一种制备重组人α‑L‑艾杜糖醛酸酶的方法
CN113301925A (zh) 2018-12-19 2021-08-24 小利兰·斯坦福大学理事会 用于溶酶体靶向的双官能分子以及相关的组合物和方法
CN110577559B (zh) * 2019-08-19 2023-02-17 江西科技师范大学 α-L-艾杜糖醛酸酶测定用荧光糖苷酶底物的合成方法
WO2022145449A1 (ja) * 2021-01-04 2022-07-07 国立大学法人徳島大学 ライソゾームを標的とした新規ｄｄｓの開発
CN115109790A (zh) * 2021-03-23 2022-09-27 北京据德医药科技有限公司 一种重组a-L-艾杜糖醛酸普酶及其制备方法
JP2024524614A (ja) 2021-07-14 2024-07-05 ライシア セラピューティクス， インコーポレイテッド Ａｓｇｐｒ細胞表面受容体結合化合物及びコンジュゲート
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US20060286087A1 (en) 2006-12-21
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DE60042137D1 (de) 2009-06-10
CA2391098A1 (en) 2002-01-17
EP1332206B1 (en) 2006-10-18
ZA200203619B (en) 2003-07-30
AU8463501A (en) 2002-01-21
DE60031456D1 (de) 2006-11-30
HK1104836A1 (en) 2008-01-25
HK1057059A1 (en) 2004-03-12
CN101407796A (zh) 2009-04-15
AU2004208651A1 (en) 2004-09-30
MXPA02004742A (es) 2005-09-08
US6426208B1 (en) 2002-07-30
BRPI0015533B8 (pt) 2021-05-25
AU773663B2 (en) 2004-06-03
IL192078A0 (en) 2008-12-29
ES2273748T3 (es) 2007-05-16
EP1792983B1 (en) 2009-04-29
EP1792983A1 (en) 2007-06-06
JP2006312648A (ja) 2006-11-16
US20030013179A1 (en) 2003-01-16
CA2391098C (en) 2007-10-23
ATE342964T1 (de) 2006-11-15
IL192078A (en) 2011-06-30
BRPI0015533B1 (pt) 2020-12-08
IL149568A0 (en) 2002-11-10
JP2005046154A (ja) 2005-02-24
JP2004502456A (ja) 2004-01-29
DE60031456T2 (de) 2007-08-23
CN1420924A (zh) 2003-05-28
US7041487B2 (en) 2006-05-09
BR0015533A (pt) 2002-06-25
JP3857705B2 (ja) 2006-12-13
IL149568A (en) 2010-04-29
ATE430193T1 (de) 2009-05-15
WO2002004616A1 (en) 2002-01-17

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