CN1395955A - 一种催乳药物、其制备方法及其用途 - Google Patents
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- CN1395955A CN1395955A CN 02129413 CN02129413A CN1395955A CN 1395955 A CN1395955 A CN 1395955A CN 02129413 CN02129413 CN 02129413 CN 02129413 A CN02129413 A CN 02129413A CN 1395955 A CN1395955 A CN 1395955A
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Abstract
Description
2天 | 3天 | 4天 | 5天 | 6天 | 7天 | 8天 | 9天 | 10天 | 11天 | ||
A组 | ∑x1-x2nx(g/只) | 89.94821.0968±0.2569 | 120.12×821.4722*±0.3994 | 121.45821.4811±0.4247 | 121.98821.4876±0.5197 | 130.44×821.5907*±0.4794 | 142.37821.7362±0.4410 | 142.86821.7422±0.4248 | 144.03821.7565±0.3888 | 145.32821.7722±0.3919 | 149.95821.8287±0.4133 |
B组 | ∑x1-x2nx(g/只) | 85.22791.0787±0.1747 | 115.25791.4589±0.4179 | 11 5.68791.4643±0.3753 | 123.57×791.5642*±0.3029 | 124.80791.5797±0.3387 | 139.39△791.7644*±0.2970 | 139.55×791.7665*±0.3294 | 141.26791.7881±0.2851 | 140.45791.7778±0.2262 | 148.27△791.8768*±0.2501 |
C组 | ∑x1-x2nx(g/只) | 62.75820.7652±0.3335 | 105.50821.2866±0.3909 | 120.12821.4649±0.2429 | 118.15821.4409±0.3036 | 120.43821.4687±0.2376 | 141.61821.7270±0.2756 | 137.96821.6824±0.2813 | 155.48△821.8961*±0.3374 | 148.96821.8166±0.2724 | 153.52821.8722±0.2535 |
D组 | ∑x1-x2nx(g/只) | 73.02800.9127±0.2559 | 103.70801.2963±0.3902 | 117.14801.4643±0.4924 | 120.87801.5109±0.4443 | 120.94801.5118±0.4521 | 127.90801.5988±0.4887 | 128.93801.6116±0.5391 | 134.69801.6836±0.5808 | 150.24△801.8780*±0.5046 | 144.08801.8010±0.5426 |
E组 | ∑x1-x2nx(g/只) | 101.24791.2815*±0.2762 | 112.53791.4244±0.2260 | 122.52791.5509*±0.2216 | 123.13791.5586±0.2574 | 124.99791.5822±0.3375 | 125.59791.5898±0.2618 | 133.06791.6843±0.3329 | 130.52791.6522±0.2964 | 134.86791.7071±0.2101 | 133.95791.6956±0.2729 |
1天 | 2天 | 3天 | 4天 | 5天 | 6天 | 7天 | 8天 | 9天 | 10天 | 11天 | ||
A组 | ∑x1-x2nx(g/只) | 1.45820.01768±0.0118 | 1.69820.02061±0.0194 | 4.03820.04915±0.00981 | 3.18△820.03878*±0.007353 | 3.17820.03866±0.00346 | 3.84×820.04682*±0.003357 | 3.59820.04378±0.003056 | 3.82820.04659±0.003544 | 3.93820.04793±0.004718 | 6.73820.08207±0.01588 | 6.67820.08134±0.01643 |
B组 | ∑x1-x2nx(g/只) | 1.44790.01825±0.00610 | 1.67790.02113±0.0052 | 3.87790.04899±0.01241 | 2.68790.03392±0.00539 | 2.95790.03734±0.00189 | 3.65790.04620±0.003499 | 3.67△790.04646*±0.003114 | 4.15△790.05253*±0.00464 | 3.91△790.04949*±0.007184 | 7.62△790.09646*±0.006246 | 6.29790.07962±0.01389 |
C组 | ∑x1-x2nx(g/只) | 1.58820.01927±0.011785 | 1.70820.02073±0.0072 | 2.61820.03183±0.00629 | 2.98820.03634±0.00410 | 3.34△820.04073*±0.00353 | 3.47820.04232±0.003576 | 3.34820.04073±0.002529 | 3.75820.04573±0.003769 | 3.16820.03854±0.002898 | 6.09820.07427±0.0076468 | 7.82820.09537*±0.00766 |
D组 | ∑x1-x2nx(g/只) | 1.07800.01338±0.010966 | 2.20800.02750*±0.00427 | 4.17△800.05213*±0.00881 | 2.15800.02688±0.00344 | 2.17800.03388±0.00308 | 2.92800.03650±0.003013 | 2.70800.03375±0.002401 | 2.88800.03600±0.002858 | 0.98800.01225±0.001492 | 4.97800.06213±0.00632 | 5.33800.06663±0.00651 |
E组 | ∑x1-x2nx(g/只) | 2.54790.03215*±0.032557 | 1.23790.01557±0.00561 | 2.82790.03570±0.00867 | 2.47790.03127±0.00555 | 2.55790.03228±0.00190 | 3.64790.04608±0.003717 | 3.64790.04380±0.004353 | 3.07790.03886±0.003949 | 2.86790.03620±0.002159 | 5.47790.06924±0.007523 | 6.70790.08481±0.00454 |
1天 | 2天 | 3天 | 4天 | 5天 | 6天 | 7天 | 8天 | 9天 | 10天 | 11天 | ||
A组 | ∑x1-x2nx(g/只) | 6.72820.08195±0.01851 | 15.90820.19390±0.011267 | 17.22820.21000±0.05307 | 19.56△820.23854*±0.01804 | 19.24△820.23460*±0.02395 | 12.82820.15634±0.014659 | 11.14820.13585±0.01752 | 13.96820.17024±0.018969 | 15.96820.19463±0.01934 | 17.93820.21866±0.03751 | 4.67820.05695±0.04122 |
B组 | ∑x1-x2nx(g/只) | 6.43790.08139±0.03923 | 15.38790.19468±0.015948 | 16.33790.20671±0.01744 | 18.50790.23418±0.01322 | 14.47790.18316±0.008708 | 14.99△790.18975*±0.019519 | 12.78△790.16177*±0.018525 | 13.55790.17152±0.020801 | 14.31790.18114±0.02459 | 18.06△790.22861*±0.02.76 | 6.77△790.07304*±0.00958 |
C组 | ∑x1-x2nx(g/只) | 4.54820.05537±0.036229 | 10.73820.13085±0.01514 | 12.03820.14671±0.02298 | 13.42820.16366±0.03952 | 15.77820.19232±0.0108136 | 6.47820.07890±0.004713 | 4.15820.05061±0.004039 | 14.69△820.17920*±0.019368 | 15.91820.19402±0.01637 | 17.77820.21671±0.01878 | 2.08820.02537±0.00249 |
D组 | ∑x1-x2nx(g/只) | 6.92800.08650±0.079085 | 11.36800.14200±0.045327 | 15.61800.19513±0.04906 | 11.18800.13975±0.025758 | 13.42820.16775±0.017367 | 10.12800.12650±0.008302 | 3.99800.04988±0.003223 | 8.72800.10900±0.01676 | 17.59△800.21988*±0.01403 | 8.55800.10688±0.011385 | 0.23800.00287±0.00049 |
E组 | ∑x1-x2nx(g/只) | 13.27790.16797*±0.11625 | 15.53790.19658±0.02787 | 17.39790.22013*±0.04290 | 18.20790.23038±0.01370 | 17.25790.21835±0.02072 | 5.61790.07101±0.006272 | 5.45790.06899±0.005112 | 12.86790.16278±0.024589 | 12.81790.16215±0.014215 | 12.53790.15861±0.019849 | 0.92790.01165±0.00151 |
A组 | B组 | C组 | D组 | E组 | |||||
母鼠号 | 泌乳素量 | 母鼠号 | 泌乳素量 | 母鼠号 | 泌乳素量 | 母鼠号 | 泌乳素量 | 母鼠号 | 泌乳素量 |
1 | 4.89 | 11 | 4.72 | 21 | 4.52 | 31 | 3.98 | 41 | 2.85 |
2 | 4.46 | 12 | 6.48 | 22 | 3.51 | 32 | 3.80 | 42 | 3.61 |
3 | 4.61 | 13 | 5.28 | 23 | 3.47 | 33 | 4.31 | 43 | 3.40 |
4 | 3.24 | 14 | 4.74 | 24 | 3.85 | 34 | 3.83 | 44 | 4.01 |
5 | 4.63 | 15 | 4.71 | 25 | 4.61 | 35 | 4.43 | 45 | 4.26 |
6 | 4.47 | 16 | 4.13 | 26 | 4.82 | 36 | 4.75 | 46 | 4.01 |
7 | 5.45 | 17 | 4.38 | 27 | 4.07 | 37 | 4.37 | 47 | 3.47 |
8 | 5.29 | 18 | 4.95 | 28 | 3.80 | 38 | 4.07 | 48 | 4.30 |
9 | 4.54 | 19 | 5.08 | 29 | 4.88 | 39 | 4.49 | 49 | 4.51 |
10 | 4.37 | 20 | 5.16 | 30 | 4.79 | 40 | 4.43 | 50 | 4.08 |
A组 | B组 | C组 | D组 | E组 | |||||
母鼠号 | 雌二醇量 | 母鼠号 | 雌二醇量 | 母鼠号 | 雌二醇量 | 母鼠号 | 雌二醇量 | 母鼠号 | 雌二醇量 |
1 | 10.31 | 11 | 9.81 | 21 | 20.68 | 31 | 14.47 | 41 | 14.61 |
2 | 7.10 | 12 | 11.57 | 22 | 7.52 | 32 | 24.01 | 42 | 35.94 |
3 | 23.17 | 13 | 7.79 | 23 | 14.48 | 33 | 19.85 | 43 | 14.12 |
4 | 10.12 | 14 | 14.34 | 24 | 20.25 | 34 | 10.54 | 44 | 16.51 |
5 | 8.58 | 15 | 18.24 | 25 | 14.24 | 35 | 9.23 | 45 | 23.37 |
6 | 12.75 | 16 | 8.57 | 26 | 13.47 | 36 | 10.06 | 46 | 21.85 |
7 | 9.91 | 17 | 15.69 | 27 | 12.16 | 37 | 15.38 | 47 | 20.59 |
8 | 12.12 | 18 | 14.86 | 28 | 14.98 | 38 | 18.72 | 48 | 12.38 |
9 | 19.29 | 19 | 6.55 | 29 | 9.85 | 39 | 15.01 | 49 | 15.49 |
10 | 14.55 | 20 | 4.50 | 30 | 9.60 | 40 | 9.30 | 50 | 15.02 |
灌胃 | 鼠数 | 中毒症状 | 死亡数 | 备注 |
40ml | ♂ 10 | 第二天8只拉肚子,以后好转 | 0 | 上、下午各灌胃2次,每次1ml |
♀ 10 | 第二天2只拉肚子,以后好转 | 0 | ||
2.8ml | ♂ 10 | 0 | 上午灌2次,每次1ml,下午灌0.8ml | |
♀ 10 | 0 | |||
1.96ml | ♂ 10 | 0 | 上、下午各灌胃1次,每次1ml | |
♀ 10 | 0 | |||
1.37ml | ♂ 10 | 0 | 上、下午各灌胃1次,每次0.7ml | |
♀ 10 | 0 | |||
最大耐受量>4ml×1g/ml×50只/Kg>200g/Kg |
样品号 | 性状 | 鉴别 | 水分(%) | 粒度检查 | 含量测定mg/包 | 卫生学检查 | 检测日期年 月 日 | ||||
吸潮 | 软化 | 细菌 | 霉菌 | 大肠肝菌 | 活螨 | ||||||
930921 | 无 | 无 | 阳性反应 | 2.84 | 合格 | 0.2933 | 0 | 0 | 未检出 | 未检出 | 93 09 28 |
930922 | 无 | 无 | 阳性反应 | 3.63 | 合格 | 0.3866 | 0 | 0 | 未检出 | 未检出 | 93 09 28 |
930923 | 无 | 无 | 阳性反应 | 3.27 | 合格 | 0.4017 | 10 | 0 | 未检出 | 未检出 | 93 09 28 |
930921 | 无 | 无 | 阳性反应 | 3.02 | 合格 | 0.2983 | 0 | 0 | 未检出 | 未检出 | 93 10 28 |
930922 | 无 | 无 | 阳性反应 | 3.48 | 合格 | 0.3645 | 10 | 0 | 未检出 | 未检出 | 93 10 28 |
930923 | 无 | 无 | 阳性反应 | 3.17 | 合格 | 0.2976 | 10 | 0 | 未检出 | 未检出 | 93 10 28 |
930921 | 无 | 无 | 阳性反应 | 2.95 | 合格 | 0.3972 | 10 | 0 | 未检出 | 未检出 | 93 11 26 |
930922 | 无 | 无 | 阳性反应 | 3.34 | 合格 | 0.3628 | 0 | 0 | 未检出 | 未检出 | 93 11 26 |
930923 | 无 | 无 | 阳性反应 | 3.68 | 合格 | 0.3991 | 0 | 0 | 未检出 | 未检出 | 93 11 26 |
930921 | 无 | 无 | 阳性反应 | 3.16 | 合格 | 0.2929 | 0 | 0 | 未检出 | 未检出 | 93 12 28 |
930922 | 无 | 无 | 阳性反应 | 3.55 | 合格 | 0.3684 | 0 | 0 | 未检出 | 未检出 | 93 12 28 |
930923 | 无 | 无 | 阳性反应 | 3.41 | 合格 | 0.3922 | 10 | 0 | 未检出 | 未检出 | 93 12 28 |
Claims (9)
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CN114213516B (zh) * | 2021-12-16 | 2023-07-25 | 吉林国瑞医药有限公司 | 一种轮叶党参来源的催乳及抗乳腺肿瘤的活性肽及其制备方法和用途 |
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