CN1390218A - 新的活性海洋生物碱类物质 - Google Patents

新的活性海洋生物碱类物质 Download PDF

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Publication number
CN1390218A
CN1390218A CN00815559A CN00815559A CN1390218A CN 1390218 A CN1390218 A CN 1390218A CN 00815559 A CN00815559 A CN 00815559A CN 00815559 A CN00815559 A CN 00815559A CN 1390218 A CN1390218 A CN 1390218A
Authority
CN
China
Prior art keywords
compound
formula
jorumycine
hydrogen
new active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00815559A
Other languages
English (en)
Chinese (zh)
Inventor
G·西米诺
A·方塔纳
D·加西亚格拉瓦洛斯
S·瓦希杜拉
C·G·奈克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto Biomar SA
Original Assignee
Instituto Biomar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto Biomar SA filed Critical Instituto Biomar SA
Publication of CN1390218A publication Critical patent/CN1390218A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN00815559A 1999-09-10 2000-09-11 新的活性海洋生物碱类物质 Pending CN1390218A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9921477.7 1999-09-10
GBGB9921477.7A GB9921477D0 (en) 1999-09-10 1999-09-10 New active marine alkaloids

Publications (1)

Publication Number Publication Date
CN1390218A true CN1390218A (zh) 2003-01-08

Family

ID=10860734

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00815559A Pending CN1390218A (zh) 1999-09-10 2000-09-11 新的活性海洋生物碱类物质

Country Status (15)

Country Link
EP (1) EP1210346B1 (fr)
JP (1) JP2003509424A (fr)
CN (1) CN1390218A (fr)
AT (1) ATE244242T1 (fr)
AU (1) AU7028500A (fr)
BR (1) BR0014176A (fr)
CA (1) CA2384656A1 (fr)
DE (1) DE60003697T2 (fr)
DK (1) DK1210346T3 (fr)
ES (1) ES2200922T3 (fr)
GB (1) GB9921477D0 (fr)
IL (1) IL148590A0 (fr)
MX (1) MXPA02002615A (fr)
PT (1) PT1210346E (fr)
WO (1) WO2001019824A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100358516C (zh) * 2004-12-07 2008-01-02 中国科学院大连化学物理研究所 一种多皱软磺酸在抗hiv-1病毒的药物中的应用
CN104755084A (zh) * 2012-08-29 2015-07-01 南加州大学 抑制缺氧诱导型转录因子复合体的活性的组合物和方法及其治疗肿瘤的用途

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6809099B2 (en) 2000-11-03 2004-10-26 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0262085A1 (fr) * 1986-08-15 1988-03-30 Gesellschaft für Biotechnologische Forschung mbH (GBF) Antibiotiques à partir de myxococcus

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100358516C (zh) * 2004-12-07 2008-01-02 中国科学院大连化学物理研究所 一种多皱软磺酸在抗hiv-1病毒的药物中的应用
CN104755084A (zh) * 2012-08-29 2015-07-01 南加州大学 抑制缺氧诱导型转录因子复合体的活性的组合物和方法及其治疗肿瘤的用途
CN104755084B (zh) * 2012-08-29 2018-04-03 南加州大学 抑制缺氧诱导型转录因子复合体的活性的组合物和方法及其治疗肿瘤的用途

Also Published As

Publication number Publication date
MXPA02002615A (es) 2002-10-23
DE60003697T2 (de) 2004-06-17
EP1210346A2 (fr) 2002-06-05
EP1210346B1 (fr) 2003-07-02
WO2001019824A3 (fr) 2001-09-27
AU7028500A (en) 2001-04-17
BR0014176A (pt) 2002-05-07
CA2384656A1 (fr) 2001-03-22
ATE244242T1 (de) 2003-07-15
WO2001019824A2 (fr) 2001-03-22
ES2200922T3 (es) 2004-03-16
PT1210346E (pt) 2003-09-30
GB9921477D0 (en) 1999-11-17
DE60003697D1 (de) 2003-08-07
IL148590A0 (en) 2002-09-12
DK1210346T3 (da) 2003-10-06
JP2003509424A (ja) 2003-03-11

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication