CN1380883A - 雪花胺的新衍生物和类似物 - Google Patents

雪花胺的新衍生物和类似物 Download PDF

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Publication number
CN1380883A
CN1380883A CN01801342A CN01801342A CN1380883A CN 1380883 A CN1380883 A CN 1380883A CN 01801342 A CN01801342 A CN 01801342A CN 01801342 A CN01801342 A CN 01801342A CN 1380883 A CN1380883 A CN 1380883A
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China
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compound
nmr
cdcl
group
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Pending
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CN01801342A
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English (en)
Chinese (zh)
Inventor
U·乔迪斯
J·福罗里克
M·特鲁
M·赫恩夏尔
L·斯佐尔纳
B·卡尔兹
S·维尔兹格
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Sanochemia Pharmazeutika AG
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Sanochemia Pharmazeutika AG
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Publication of CN1380883A publication Critical patent/CN1380883A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
CN01801342A 2000-03-31 2001-03-22 雪花胺的新衍生物和类似物 Pending CN1380883A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT5462000 2000-03-31
ATA546/2000 2000-03-31
AT2382001 2001-02-15
ATA238/2001 2001-02-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 200610054791 Division CN1827621A (zh) 2000-03-31 2001-03-22 雪花胺的新衍生物和类似物

Publications (1)

Publication Number Publication Date
CN1380883A true CN1380883A (zh) 2002-11-20

Family

ID=25608130

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01801342A Pending CN1380883A (zh) 2000-03-31 2001-03-22 雪花胺的新衍生物和类似物

Country Status (26)

Country Link
US (2) US7166588B2 (https=)
EP (1) EP1181294B1 (https=)
JP (1) JP2003529602A (https=)
CN (1) CN1380883A (https=)
AT (1) ATE263171T1 (https=)
AU (1) AU785385B2 (https=)
BG (1) BG65134B1 (https=)
BR (1) BR0105563A (https=)
CA (1) CA2368966A1 (https=)
CZ (1) CZ300160B6 (https=)
DE (1) DE50101827D1 (https=)
DK (1) DK1181294T3 (https=)
ES (1) ES2215885T3 (https=)
HK (1) HK1049832A1 (https=)
HU (1) HUP0202233A3 (https=)
IS (1) IS2287B (https=)
MX (1) MXPA01012275A (https=)
NO (1) NO326458B1 (https=)
NZ (1) NZ516302A (https=)
PL (1) PL202463B1 (https=)
PT (1) PT1181294E (https=)
RU (1) RU2241001C2 (https=)
SI (1) SI1181294T1 (https=)
SK (1) SK285909B6 (https=)
TR (1) TR200400857T4 (https=)
WO (1) WO2001074820A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116082352A (zh) * 2023-02-16 2023-05-09 西南交通大学 一种加兰他敏衍生物及其制备方法和用途
CN118908968A (zh) * 2024-10-09 2024-11-08 威胜生物医药(苏州)股份有限公司 一种加兰他敏中间体衍生物及其催化氧化制备方法
CN119528922A (zh) * 2024-11-22 2025-02-28 泰安汉威集团有限公司 一种氢溴酸加兰他敏关键杂质-氢溴酸表加兰他敏的手性合成方法

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JP4721386B2 (ja) * 2001-07-10 2011-07-13 第一三共株式会社 新規ガランタミン類縁体
CN1646536A (zh) * 2002-03-25 2005-07-27 萨诺化学萨物股份公司 制备降雪花胺以及其异构体、盐和水合物的方法
AT414125B (de) * 2003-09-29 2006-09-15 Sanochemia Pharmazeutika Ag Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln
AT500143A1 (de) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
US7877350B2 (en) * 2005-06-27 2011-01-25 Ab Initio Technology Llc Managing metadata for graph-based computations
JP2009508903A (ja) * 2005-09-22 2009-03-05 ガラントス ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング 認知障害を伴う疾患の治療に用いるための脳血液関門透過性が改善されたコリン作用増強剤
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2008022365A2 (de) * 2006-08-24 2008-02-28 Sanochemia Ltd. Mittel zum beeinflussen der wirkungen von organophosphorverbindungen und verwendung von galanthamin, dessen derivaten und analoga zum herstellen solcher mittel
CA2721007C (en) 2008-04-14 2014-04-29 Galantos Pharma Gmbh Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
BG110141A (en) * 2008-05-23 2009-12-31 "Софарма" Ад GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE
KR101687213B1 (ko) 2010-06-15 2016-12-16 아브 이니티오 테크놀로지 엘엘시 동적으로 로딩하는 그래프 기반 계산
WO2013160728A1 (en) 2012-04-26 2013-10-31 Alma Mater Studiorum - Universita' Di Bologna Dual targeting compounds for the treatment of alzheimer's disease
US10108521B2 (en) * 2012-11-16 2018-10-23 Ab Initio Technology Llc Dynamic component performance monitoring
CA3114544C (en) 2013-12-05 2025-09-02 Ab Initio Technology Llc Interface management for data flow graphs composed of subgraphs
SG11201701584SA (en) 2014-09-02 2017-03-30 Ab Initio Technology Llc Compiling graph-based program specifications
CN107145344B (zh) 2014-09-02 2020-12-04 起元科技有限公司 在基于图的程序中指定组件
US10657134B2 (en) 2015-08-05 2020-05-19 Ab Initio Technology Llc Selecting queries for execution on a stream of real-time data
US12006301B1 (en) 2021-05-13 2024-06-11 Florida A&M University And synthesis of dual 5-HT1A and 5-HT7 receptor ligands

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US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
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US4954502A (en) 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
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US5153193A (en) * 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
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WO1996012692A1 (de) * 1994-10-21 1996-05-02 Waldheim Pharmazeutika Gesellschaft M.B.H. VERFAHREN ZUM HERSTELLEN VON DERIVATEN DES 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINS
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AT414125B (de) 2003-09-29 2006-09-15 Sanochemia Pharmazeutika Ag Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116082352A (zh) * 2023-02-16 2023-05-09 西南交通大学 一种加兰他敏衍生物及其制备方法和用途
CN118908968A (zh) * 2024-10-09 2024-11-08 威胜生物医药(苏州)股份有限公司 一种加兰他敏中间体衍生物及其催化氧化制备方法
CN118908968B (zh) * 2024-10-09 2025-03-04 威胜生物医药(苏州)股份有限公司 一种加兰他敏中间体衍生物及其催化氧化制备方法
CN119528922A (zh) * 2024-11-22 2025-02-28 泰安汉威集团有限公司 一种氢溴酸加兰他敏关键杂质-氢溴酸表加兰他敏的手性合成方法
CN119528922B (zh) * 2024-11-22 2025-12-09 泰安汉威集团有限公司 一种氢溴酸加兰他敏关键杂质-氢溴酸表加兰他敏的手性合成方法

Also Published As

Publication number Publication date
NZ516302A (en) 2004-02-27
IS2287B (is) 2007-10-15
CZ300160B6 (cs) 2009-02-25
US20070027138A1 (en) 2007-02-01
HK1049832A1 (zh) 2003-05-30
CA2368966A1 (en) 2001-10-11
DE50101827D1 (de) 2004-05-06
AU4208501A (en) 2001-10-15
CZ20014178A3 (cs) 2002-11-13
RU2241001C2 (ru) 2004-11-27
SI1181294T1 (en) 2004-08-31
EP1181294A1 (de) 2002-02-27
BG106155A (en) 2002-08-30
AU785385B2 (en) 2007-03-29
ATE263171T1 (de) 2004-04-15
HK1045990A1 (en) 2002-12-20
NO20015857L (no) 2002-01-29
HUP0202233A2 (hu) 2002-11-28
SK285909B6 (sk) 2007-10-04
IS6174A (is) 2001-11-23
US7166588B2 (en) 2007-01-23
JP2003529602A (ja) 2003-10-07
MXPA01012275A (es) 2003-06-24
NO326458B1 (no) 2008-12-08
NO20015857D0 (no) 2001-11-30
BG65134B1 (bg) 2007-03-30
ES2215885T3 (es) 2004-10-16
PL202463B1 (pl) 2009-06-30
DK1181294T3 (da) 2004-08-02
TR200400857T4 (tr) 2004-06-21
EP1181294B1 (de) 2004-03-31
US20030199493A1 (en) 2003-10-23
PT1181294E (pt) 2004-07-30
PL352638A1 (en) 2003-09-08
SK17022001A3 (sk) 2003-02-04
BR0105563A (pt) 2002-04-02
WO2001074820A1 (de) 2001-10-11
HUP0202233A3 (en) 2004-12-28

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