CN1379786A - 用于免疫治疗的修饰肽和肽类似物 - Google Patents
用于免疫治疗的修饰肽和肽类似物 Download PDFInfo
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- YRCHYHRCBXNYNU-UHFFFAOYSA-N n-[[3-fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]carbamothioyl]-2-(4-fluorophenyl)acetamide Chemical compound N1=CC(CNCCOC)=CC=C1C1=CC2=NC=CC(OC=3C(=CC(NC(=S)NC(=O)CC=4C=CC(F)=CC=4)=CC=3)F)=C2S1 YRCHYHRCBXNYNU-UHFFFAOYSA-N 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- MOOYVEVEDVVKGD-UHFFFAOYSA-N oxaldehydic acid;hydrate Chemical compound O.OC(=O)C=O MOOYVEVEDVVKGD-UHFFFAOYSA-N 0.000 description 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 150000002993 phenylalanine derivatives Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- RKSOPLXZQNSWAS-UHFFFAOYSA-N tert-butyl bromide Chemical compound CC(C)(C)Br RKSOPLXZQNSWAS-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99203427.2 | 1999-10-18 | ||
| EP99203427 | 1999-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1379786A true CN1379786A (zh) | 2002-11-13 |
Family
ID=8240756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00814418A Pending CN1379786A (zh) | 1999-10-18 | 2000-10-12 | 用于免疫治疗的修饰肽和肽类似物 |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1226167A1 (pt) |
| JP (1) | JP2003512388A (pt) |
| KR (1) | KR20020047245A (pt) |
| CN (1) | CN1379786A (pt) |
| AR (1) | AR026068A1 (pt) |
| AU (1) | AU780238B2 (pt) |
| BR (1) | BR0014803A (pt) |
| CA (1) | CA2386398A1 (pt) |
| CO (1) | CO5271650A1 (pt) |
| CZ (1) | CZ20021356A3 (pt) |
| HK (1) | HK1046693A1 (pt) |
| HU (1) | HUP0203504A3 (pt) |
| IL (1) | IL148778A0 (pt) |
| MX (1) | MXPA02003520A (pt) |
| NO (1) | NO20021763D0 (pt) |
| NZ (1) | NZ518256A (pt) |
| PE (1) | PE20010692A1 (pt) |
| PL (1) | PL354590A1 (pt) |
| RU (1) | RU2002113107A (pt) |
| SK (1) | SK6842002A3 (pt) |
| TR (1) | TR200201036T2 (pt) |
| WO (1) | WO2001029081A1 (pt) |
| ZA (1) | ZA200202577B (pt) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107249616A (zh) * | 2014-11-07 | 2017-10-13 | 奇尼塔慢性疼痛有限责任公司 | 芋螺毒素(conotoxin)肽的修饰和用途 |
| CN111164094A (zh) * | 2017-10-05 | 2020-05-15 | 独特药妆公司 | 抗癌肽及其用途 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002951212A0 (en) * | 2002-09-04 | 2002-09-19 | Monash University | A method of modulating cellular activity and molecules for use therein |
| US20100240137A1 (en) * | 2006-04-06 | 2010-09-23 | Purdue Research Foundation | Derivatization-enhanced analysis of amino acids and peptides |
| EP2114462B1 (en) * | 2006-12-21 | 2013-06-05 | Universite De Geneve | Compounds for fluorescence imaging |
| AU2009207922B2 (en) | 2008-01-23 | 2015-05-14 | Herlev Hospital | YKL-40 as a general marker for non-specific disease |
| NZ592241A (en) | 2008-09-15 | 2012-11-30 | Herlev Hospital | Ykl-40 as a marker for gastrointestinal cancers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115744A (en) * | 1994-10-27 | 2000-07-16 | Akzo Nobel Nv | Peptides comprising a subsequence of human cartilage glycoprotein - 39 |
| IL120561A0 (en) * | 1996-04-24 | 1997-07-13 | Akzo Nobel Nv | Peptides suitable for use in immunosuppressive therapy |
| WO1997046578A1 (en) * | 1996-06-07 | 1997-12-11 | Zeneca Limited | Peptide derivatives |
| IL122233A (en) * | 1996-12-06 | 2001-04-30 | Akzo Nobel Nv | Method of generating monoclonal antibodies to cell wall and pharmaceutical preparations and diagnostic agents containing them |
-
2000
- 2000-10-12 TR TR2002/01036T patent/TR200201036T2/xx unknown
- 2000-10-12 WO PCT/EP2000/010230 patent/WO2001029081A1/en not_active Application Discontinuation
- 2000-10-12 KR KR1020027004940A patent/KR20020047245A/ko not_active Application Discontinuation
- 2000-10-12 IL IL14877800A patent/IL148778A0/xx unknown
- 2000-10-12 CZ CZ20021356A patent/CZ20021356A3/cs unknown
- 2000-10-12 EP EP00972790A patent/EP1226167A1/en not_active Withdrawn
- 2000-10-12 JP JP2001531879A patent/JP2003512388A/ja not_active Withdrawn
- 2000-10-12 SK SK684-2002A patent/SK6842002A3/sk not_active Application Discontinuation
- 2000-10-12 PL PL00354590A patent/PL354590A1/xx not_active Application Discontinuation
- 2000-10-12 MX MXPA02003520A patent/MXPA02003520A/es unknown
- 2000-10-12 CA CA002386398A patent/CA2386398A1/en not_active Abandoned
- 2000-10-12 HU HU0203504A patent/HUP0203504A3/hu unknown
- 2000-10-12 BR BR0014803-2A patent/BR0014803A/pt not_active IP Right Cessation
- 2000-10-12 CN CN00814418A patent/CN1379786A/zh active Pending
- 2000-10-12 AU AU11396/01A patent/AU780238B2/en not_active Ceased
- 2000-10-12 NZ NZ518256A patent/NZ518256A/en unknown
- 2000-10-12 RU RU2002113107/15A patent/RU2002113107A/ru not_active Application Discontinuation
- 2000-10-17 PE PE2000001107A patent/PE20010692A1/es not_active Application Discontinuation
- 2000-10-18 CO CO00079334A patent/CO5271650A1/es not_active Application Discontinuation
- 2000-10-18 AR ARP000105458A patent/AR026068A1/es unknown
-
2002
- 2002-04-02 ZA ZA200202577A patent/ZA200202577B/en unknown
- 2002-04-15 NO NO20021763A patent/NO20021763D0/no not_active Application Discontinuation
- 2002-11-13 HK HK02108208.9A patent/HK1046693A1/zh unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107249616A (zh) * | 2014-11-07 | 2017-10-13 | 奇尼塔慢性疼痛有限责任公司 | 芋螺毒素(conotoxin)肽的修饰和用途 |
| US11014970B2 (en) | 2014-11-07 | 2021-05-25 | Kineta Chronic Pain, Llc | Modifications and uses of conotoxin peptides |
| US11618772B2 (en) | 2014-11-07 | 2023-04-04 | Kineta Chronic Pain, Llc | Modifications and uses of conotoxin peptides |
| CN111164094A (zh) * | 2017-10-05 | 2020-05-15 | 独特药妆公司 | 抗癌肽及其用途 |
| CN111164094B (zh) * | 2017-10-05 | 2023-07-07 | 独特药妆公司 | 抗癌肽及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2002113107A (ru) | 2004-01-10 |
| EP1226167A1 (en) | 2002-07-31 |
| WO2001029081A1 (en) | 2001-04-26 |
| CO5271650A1 (es) | 2003-04-30 |
| HUP0203504A2 (hu) | 2003-04-28 |
| ZA200202577B (en) | 2003-09-23 |
| HK1046693A1 (zh) | 2003-01-24 |
| NZ518256A (en) | 2004-01-30 |
| CA2386398A1 (en) | 2001-04-26 |
| NO20021763L (no) | 2002-04-15 |
| AR026068A1 (es) | 2002-12-26 |
| IL148778A0 (en) | 2002-09-12 |
| SK6842002A3 (en) | 2002-09-10 |
| MXPA02003520A (es) | 2002-08-20 |
| HUP0203504A3 (en) | 2005-03-29 |
| CZ20021356A3 (cs) | 2002-07-17 |
| JP2003512388A (ja) | 2003-04-02 |
| PE20010692A1 (es) | 2001-07-06 |
| TR200201036T2 (tr) | 2002-08-21 |
| BR0014803A (pt) | 2002-06-11 |
| AU780238B2 (en) | 2005-03-10 |
| NO20021763D0 (no) | 2002-04-15 |
| KR20020047245A (ko) | 2002-06-21 |
| AU1139601A (en) | 2001-04-30 |
| PL354590A1 (en) | 2004-01-26 |
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| C20 | Patent right or utility model deemed to be abandoned or is abandoned |