HUP0203504A2 - Immunterápiás alkalmazásra szolgáló módosított peptidek és peptid-mimetikumok - Google Patents
Immunterápiás alkalmazásra szolgáló módosított peptidek és peptid-mimetikumokInfo
- Publication number
- HUP0203504A2 HUP0203504A2 HU0203504A HUP0203504A HUP0203504A2 HU P0203504 A2 HUP0203504 A2 HU P0203504A2 HU 0203504 A HU0203504 A HU 0203504A HU P0203504 A HUP0203504 A HU P0203504A HU P0203504 A2 HUP0203504 A2 HU P0203504A2
- Authority
- HU
- Hungary
- Prior art keywords
- amino acids
- ser
- formula
- thr
- substitution
- Prior art date
Links
- 108091005601 modified peptides Proteins 0.000 title abstract 2
- 238000009169 immunotherapy Methods 0.000 title 1
- 239000000816 peptidomimetic Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 238000012986 modification Methods 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 150000001576 beta-amino acids Chemical class 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rehabilitation Therapy (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány (II) általános képletű Q-A1-A2-A3-A4-A5-A6-A7- A8-A9-A10-A11-A12-A13-Z módosított peptid, amely H-Arg-Ser- Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr- Gly-Val-GIy-OH[(I) képlet] eredetű, melyben az A1-A13megfelel az (I) képletben megadott aminosavaknak, Q jelentése H és Zjelentése OH, amelyre jellemző, hogy 1- 6 olyan módosítást tartalmaz,melyet egy vagy több alábbi csoportból választanak ki: a) az A1-A13aminosavak közül 1-6, előnyösen 1-4 aminosavat nem természetes vagybéta-aminosavakkal helyettesítenek; b) egy vagy több amidkötéstredukált amidkötésekkel vagy etilén-izosztérekkel helyettesítenek; c)Q és/vagy Z csoporton helyettesítést végeznek, és adott esetben d)szubsztitúciót végeznek természetes aminosavakkal, legfeljebb 6módosítás erejéig. A találmány szerinti peptidek felhasználhatóktolerancia indukció előidézésére autoimun betegségekben szenvedőszervezetekben. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99203427 | 1999-10-18 | ||
PCT/EP2000/010230 WO2001029081A1 (en) | 1999-10-18 | 2000-10-12 | Modified peptides and peptidomimetics for use in immunotherapy |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203504A2 true HUP0203504A2 (hu) | 2003-04-28 |
HUP0203504A3 HUP0203504A3 (en) | 2005-03-29 |
Family
ID=8240756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203504A HUP0203504A3 (en) | 1999-10-18 | 2000-10-12 | Modified peptides and peptidomimetics for use in immunotherapy |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP1226167A1 (hu) |
JP (1) | JP2003512388A (hu) |
KR (1) | KR20020047245A (hu) |
CN (1) | CN1379786A (hu) |
AR (1) | AR026068A1 (hu) |
AU (1) | AU780238B2 (hu) |
BR (1) | BR0014803A (hu) |
CA (1) | CA2386398A1 (hu) |
CO (1) | CO5271650A1 (hu) |
CZ (1) | CZ20021356A3 (hu) |
HK (1) | HK1046693A1 (hu) |
HU (1) | HUP0203504A3 (hu) |
IL (1) | IL148778A0 (hu) |
MX (1) | MXPA02003520A (hu) |
NO (1) | NO20021763D0 (hu) |
NZ (1) | NZ518256A (hu) |
PE (1) | PE20010692A1 (hu) |
PL (1) | PL354590A1 (hu) |
RU (1) | RU2002113107A (hu) |
SK (1) | SK6842002A3 (hu) |
TR (1) | TR200201036T2 (hu) |
WO (1) | WO2001029081A1 (hu) |
ZA (1) | ZA200202577B (hu) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002951212A0 (en) * | 2002-09-04 | 2002-09-19 | Monash University | A method of modulating cellular activity and molecules for use therein |
EP2016054A2 (en) * | 2006-04-06 | 2009-01-21 | Purdue Research Foundation | Derivatization-enhanced analysis of amino acids and peptides |
EP2114462B1 (en) * | 2006-12-21 | 2013-06-05 | Universite De Geneve | Compounds for fluorescence imaging |
CA2740028A1 (en) | 2008-01-23 | 2009-07-30 | Herlev Hospital | Ykl-40 as a general marker for non-specific disease |
US8580520B2 (en) | 2008-09-15 | 2013-11-12 | Herlev Hospital | YKL-40 as a marker for gastrointestinal cancers |
US11014970B2 (en) | 2014-11-07 | 2021-05-25 | Kineta Chronic Pain, Llc | Modifications and uses of conotoxin peptides |
EP3466963A1 (en) * | 2017-10-05 | 2019-04-10 | Suigeneris Farmacosmetics, S.L. | Anticancer peptides and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL115744A (en) * | 1994-10-27 | 2000-07-16 | Akzo Nobel Nv | Peptides comprising a subsequence of human cartilage glycoprotein - 39 |
IL120561A0 (en) * | 1996-04-24 | 1997-07-13 | Akzo Nobel Nv | Peptides suitable for use in immunosuppressive therapy |
PL330348A1 (en) * | 1996-06-07 | 1999-05-10 | Zeneca Ltd | Peptidic derivatives |
IL122233A (en) * | 1996-12-06 | 2001-04-30 | Akzo Nobel Nv | Method of generating monoclonal antibodies to cell wall and pharmaceutical preparations and diagnostic agents containing them |
-
2000
- 2000-10-12 IL IL14877800A patent/IL148778A0/xx unknown
- 2000-10-12 SK SK684-2002A patent/SK6842002A3/sk not_active Application Discontinuation
- 2000-10-12 AU AU11396/01A patent/AU780238B2/en not_active Ceased
- 2000-10-12 WO PCT/EP2000/010230 patent/WO2001029081A1/en not_active Application Discontinuation
- 2000-10-12 JP JP2001531879A patent/JP2003512388A/ja not_active Withdrawn
- 2000-10-12 HU HU0203504A patent/HUP0203504A3/hu unknown
- 2000-10-12 NZ NZ518256A patent/NZ518256A/en unknown
- 2000-10-12 PL PL00354590A patent/PL354590A1/xx not_active Application Discontinuation
- 2000-10-12 MX MXPA02003520A patent/MXPA02003520A/es unknown
- 2000-10-12 CN CN00814418A patent/CN1379786A/zh active Pending
- 2000-10-12 BR BR0014803-2A patent/BR0014803A/pt not_active IP Right Cessation
- 2000-10-12 TR TR2002/01036T patent/TR200201036T2/xx unknown
- 2000-10-12 EP EP00972790A patent/EP1226167A1/en not_active Withdrawn
- 2000-10-12 RU RU2002113107/15A patent/RU2002113107A/ru not_active Application Discontinuation
- 2000-10-12 CA CA002386398A patent/CA2386398A1/en not_active Abandoned
- 2000-10-12 KR KR1020027004940A patent/KR20020047245A/ko not_active Application Discontinuation
- 2000-10-12 CZ CZ20021356A patent/CZ20021356A3/cs unknown
- 2000-10-17 PE PE2000001107A patent/PE20010692A1/es not_active Application Discontinuation
- 2000-10-18 CO CO00079334A patent/CO5271650A1/es not_active Application Discontinuation
- 2000-10-18 AR ARP000105458A patent/AR026068A1/es unknown
-
2002
- 2002-04-02 ZA ZA200202577A patent/ZA200202577B/en unknown
- 2002-04-15 NO NO20021763A patent/NO20021763D0/no not_active Application Discontinuation
- 2002-11-13 HK HK02108208.9A patent/HK1046693A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2386398A1 (en) | 2001-04-26 |
AU1139601A (en) | 2001-04-30 |
SK6842002A3 (en) | 2002-09-10 |
CZ20021356A3 (cs) | 2002-07-17 |
CN1379786A (zh) | 2002-11-13 |
HUP0203504A3 (en) | 2005-03-29 |
PL354590A1 (en) | 2004-01-26 |
WO2001029081A1 (en) | 2001-04-26 |
MXPA02003520A (es) | 2002-08-20 |
EP1226167A1 (en) | 2002-07-31 |
HK1046693A1 (zh) | 2003-01-24 |
JP2003512388A (ja) | 2003-04-02 |
NZ518256A (en) | 2004-01-30 |
AR026068A1 (es) | 2002-12-26 |
PE20010692A1 (es) | 2001-07-06 |
IL148778A0 (en) | 2002-09-12 |
TR200201036T2 (tr) | 2002-08-21 |
CO5271650A1 (es) | 2003-04-30 |
BR0014803A (pt) | 2002-06-11 |
RU2002113107A (ru) | 2004-01-10 |
KR20020047245A (ko) | 2002-06-21 |
ZA200202577B (en) | 2003-09-23 |
NO20021763L (no) | 2002-04-15 |
NO20021763D0 (no) | 2002-04-15 |
AU780238B2 (en) | 2005-03-10 |
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