CN1377279A - 可溶性共同刺激分子增强免疫应答的用途 - Google Patents

可溶性共同刺激分子增强免疫应答的用途 Download PDF

Info

Publication number
CN1377279A
CN1377279A CN00810038A CN00810038A CN1377279A CN 1377279 A CN1377279 A CN 1377279A CN 00810038 A CN00810038 A CN 00810038A CN 00810038 A CN00810038 A CN 00810038A CN 1377279 A CN1377279 A CN 1377279A
Authority
CN
China
Prior art keywords
cell
molecule
peptide
antigen
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00810038A
Other languages
English (en)
Chinese (zh)
Inventor
K·斯图尔姆赫菲
S·F·沃尔夫
M·奥托勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of CN1377279A publication Critical patent/CN1377279A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5152Tumor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
CN00810038A 1999-05-06 2000-05-05 可溶性共同刺激分子增强免疫应答的用途 Pending CN1377279A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13294499P 1999-05-06 1999-05-06
US60/132,944 1999-05-06

Publications (1)

Publication Number Publication Date
CN1377279A true CN1377279A (zh) 2002-10-30

Family

ID=22456295

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00810038A Pending CN1377279A (zh) 1999-05-06 2000-05-05 可溶性共同刺激分子增强免疫应答的用途

Country Status (15)

Country Link
EP (1) EP1181053A2 (fr)
JP (1) JP2002544170A (fr)
KR (1) KR20020001865A (fr)
CN (1) CN1377279A (fr)
AU (1) AU4825700A (fr)
BR (1) BR0010711A (fr)
CA (1) CA2373256A1 (fr)
CZ (1) CZ20013964A3 (fr)
HK (1) HK1041810A1 (fr)
HU (1) HUP0201222A3 (fr)
IL (1) IL146106A0 (fr)
NO (1) NO20015396L (fr)
PL (1) PL360915A1 (fr)
WO (1) WO2000067788A2 (fr)
ZA (1) ZA200109376B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012169A (zh) * 2005-06-30 2013-04-03 卫材R&D管理有限公司 用于制备免疫佐剂的化合物
CN103702687A (zh) * 2011-07-29 2014-04-02 西莱克塔生物科技公司 产生体液和细胞毒性t淋巴细胞(ctl)免疫应答的合成纳米载体
CN110743006A (zh) * 2019-11-22 2020-02-04 北京启辰生生物科技有限公司 用于协同解除免疫细胞衰竭的组合物及应用

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
AU2006321888A1 (en) 2005-12-08 2007-06-14 University Of Louisville Research Foundation, Inc. Immunostimulatory compositions and methods
MX2008007287A (es) 2005-12-08 2008-10-27 Univ Louisville Res Found Metodos y composiciones para expandir celulas reguladoras t.
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
EP2834356A4 (fr) * 2012-04-02 2015-09-02 Univ Arizona Bactérie recombinante pour induire une réponse immunitaire cellulaire
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
EP3539564A1 (fr) 2013-11-04 2019-09-18 UTI Limited Partnership Méthodes et compositions d'immunothérapie soutenue
BR112017023853A2 (pt) 2015-05-06 2018-07-17 Uti Limited Partnership composições de nanopartícula para terapia sustentada.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69911793T2 (de) * 1998-07-28 2004-08-12 Micromet Ag Heterominikörper

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012169A (zh) * 2005-06-30 2013-04-03 卫材R&D管理有限公司 用于制备免疫佐剂的化合物
CN103012169B (zh) * 2005-06-30 2016-04-20 卫材R&D管理有限公司 用于制备免疫佐剂的化合物
CN103702687A (zh) * 2011-07-29 2014-04-02 西莱克塔生物科技公司 产生体液和细胞毒性t淋巴细胞(ctl)免疫应答的合成纳米载体
US10933129B2 (en) 2011-07-29 2021-03-02 Selecta Biosciences, Inc. Methods for administering synthetic nanocarriers that generate humoral and cytotoxic T lymphocyte responses
CN110743006A (zh) * 2019-11-22 2020-02-04 北京启辰生生物科技有限公司 用于协同解除免疫细胞衰竭的组合物及应用

Also Published As

Publication number Publication date
WO2000067788A3 (fr) 2001-04-05
NO20015396D0 (no) 2001-11-05
WO2000067788A2 (fr) 2000-11-16
HUP0201222A3 (en) 2004-07-28
HUP0201222A2 (en) 2002-08-28
CZ20013964A3 (cs) 2002-06-12
PL360915A1 (en) 2004-09-20
AU4825700A (en) 2000-11-21
CA2373256A1 (fr) 2000-11-16
HK1041810A1 (zh) 2002-07-26
NO20015396L (no) 2002-01-02
KR20020001865A (ko) 2002-01-09
JP2002544170A (ja) 2002-12-24
ZA200109376B (en) 2003-03-13
IL146106A0 (en) 2002-07-25
EP1181053A2 (fr) 2002-02-27
BR0010711A (pt) 2002-02-13

Similar Documents

Publication Publication Date Title
CN1377279A (zh) 可溶性共同刺激分子增强免疫应答的用途
CN1308037C (zh) 增强蛋白和肽抗原免疫原性的Fc融合蛋白
CN1317301C (zh) Il-2-和il-15-介导的t细胞应答的调节
CN1146442C (zh) 作为抗肿瘤剂的淋巴毒素-α/β复合体和抗淋巴毒素-β受体抗体
CN1184320C (zh) Mhc-ⅱ类配体作为疫苗佐剂以及lag-3用于癌症治疗的应用
CN1805758A (zh) 核酸和细胞疫苗的组分
US20210283242A1 (en) Immune-mediated coronavirus treatments
CN1646153A (zh) 抗血管生成的主动免疫疗法
CN1762490A (zh) 基于癌抑制基因wt1的产物的癌抗原
CN1639323A (zh) T细胞来源囊泡的功能化及其在制备免疫原性药用组合物中的应用
CN1345374A (zh) HER-2/neu融合蛋白
CN1898262A (zh) Il-7融合蛋白
CN1646147A (zh) 用于将系统性免疫应答靶向于特定器官或组织的方法和组合物
CN1194000A (zh) 增强保护性免疫应答的方法
CN101035561A (zh) 作为改善对疫苗的免疫反应的佐剂的组合物和使用方法
CN1871025A (zh) 基于印记位点调节物兄弟(boris)的预防性癌症疫苗
CN1948333A (zh) 一种新的hPEBP4蛋白来源的HLA-A2限制性表位多肽及其应用
CN1181890C (zh) 肠细菌OmpA蛋白在制备特异导向抗原呈递细胞的药物中的应用
CN1191090C (zh) 与抗原相结合的肠细菌OmpA蛋白用于产生抗病毒、抗寄生虫、或抗肿瘤的细胞毒性应答的用途
CN1835769A (zh) Kim-1拮抗剂及其在免疫系统调节中的应用
CN101037475A (zh) 一种嵌合受体及其制备方法和用途
CN1189213C (zh) 免疫抑制
US7011833B1 (en) Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent
CN1192751A (zh) 单核细胞趋化蛋白-4
CN1727362A (zh) 癌胚抗原阳性肿瘤治疗性疫苗的制备及应用

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication