CN1363288A - Nano medicine for eliminating thrombus and its preparing process - Google Patents
Nano medicine for eliminating thrombus and its preparing process Download PDFInfo
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- CN1363288A CN1363288A CN 01100211 CN01100211A CN1363288A CN 1363288 A CN1363288 A CN 1363288A CN 01100211 CN01100211 CN 01100211 CN 01100211 A CN01100211 A CN 01100211A CN 1363288 A CN1363288 A CN 1363288A
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Abstract
A nano medicine "Xiaoshuan Zaizao" is prepared from the nano powders of 38 Chinese-medicinal materials including Dragon's blood, red peony root, myrrh, Chinese angelica root, etc through proportioning, microwave extracting, vacuum concentrating and supersonic-jet spray drying. Its advantages include high biologic utilization rate and high curative effect.
Description
The present invention relates to that a kind of eliminating embolism and invigorating blood circulation, blood circulation promoting and blood stasis dispelling, endogenous wind stopping are had one's ideas straightened out, invigorating QI and blood, cure mainly the nano medicine for eliminating thrombus of heart brain embulus disease, the invention still further relates to the method for this medication preparation.
XIAOSHUAN ZAIZAO WAN is a kind of classical Chinese patent medicine, mainly contain and promote cholesterol and lipid metabolism, blood fat reducing, minimizing platelet, prolong effects such as clotting time and antithrombotic, be used for apoplexy sequela, hemiplegia of limb, hemiplegia, facial hemiparalysis, speech disorder, depressed and oppressed sensation in the chest that blood stagnancy due to deficiency of QI, obstruction of collateral caused by windphlegm cause.But traditional XIAOSHUAN ZAIZAO WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine for eliminating thrombus of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine for eliminating thrombus.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Sanguis Draxonis 5-50 part nanometer Radix Paeoniae Rubra 8-50 part nanometer Myrrha 8-50 part
Nano Chinese angelica 10-50 part nanometer Radix Achyranthis Bidentatae 10-50 part nano red sage 10-50 part
Nanometer Rhizoma Chuanxiong 5-40 part nanometer Ramulus Cinnamomi 5-50 part nanometer Radix Notoginseng 5-50 part
Nanometer Fructus Amomi Rotundus 10-50 part nanometer Radix Curcumae 10-50 part nanometer Fructus Aurantii 10-50 part
Nanometer Rhizoma Atractylodis Macrocephalae 5-50 part nano ginseng 5-40 part nanometer Lignum Aquilariae Resinatum 5-40 part
Nanometer Bungarus Parvus 5-40 part nanometer Bombyx Batryticatus 5-40 part nanometer Rhizoma Typhonii 10-50 part
Nano gastrodia 10-50 part nanometer Radix Stephaniae Tetrandrae 5-50 part nanometer Fructus Chaenomelis 10-50 part
Nanometer Scorpio 10-50 part nanometer Radix Clematidis 10-50 part nano astragalus 10-50 part
Nanometer Rhizoma Alismatis 5-40 part nano Poria 5-40 part nanometer Cortex Eucommiae 5-40 part
Nanometer Flos Sophorae Immaturus 10-50 part nanometer 5-50 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 10-50 part
Nanometer Rhizoma Drynariae 10-50 part nanometer Colophonium 5-40 part nanometer Fructus Crataegi 10-50 part
Nanometer Cortex Cinnamomi 5-40 part nanometer Borneolum Syntheticum 0.1-3 part nano storax 0.1-3 part
Nanometer Benzoinum 1-10 part nanometer Cinnabaris 3-15 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Sanguis Draxonis 10-30 part nanometer Radix Paeoniae Rubra 15-40 part nanometer Myrrha 15-40 part
Nano Chinese angelica 20-40 part nanometer Radix Achyranthis Bidentatae 15-40 part nano red sage 15-40 part
Nanometer Rhizoma Chuanxiong 10-30 part nanometer Ramulus Cinnamomi 10-30 part nanometer Radix Notoginseng 15-40 part
Nanometer Fructus Amomi Rotundus 15-40 part nanometer Radix Curcumae 15-40 part nanometer Fructus Aurantii 15-40 part
Nanometer Rhizoma Atractylodis Macrocephalae 10-40 part nano ginseng 10-30 part nanometer Lignum Aquilariae Resinatum 10-30 part
Nanometer Bungarus Parvus 10-30 part nanometer Bombyx Batryticatus 10-30 part nanometer Rhizoma Typhonii 15-40 part
Nano gastrodia 20-40 part nanometer Radix Stephaniae Tetrandrae 15-40 part nanometer Fructus Chaenomelis 20-40 part
Nanometer Scorpio 15-30 part nanometer Radix Clematidis 15-40 part nano astragalus 15-40 part
Nanometer Rhizoma Alismatis 10-30 part nano Poria 10-30 part nanometer Cortex Eucommiae 10-30 part
Nanometer Flos Sophorae Immaturus 15-40 part nanometer 10-30 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 15-40 part
Nanometer Rhizoma Drynariae 15-40 part nanometer Colophonium 10-30 part nanometer Fructus Crataegi 20-40 part
Nanometer Cortex Cinnamomi 10-30 part nanometer Borneolum Syntheticum 0.5-2 part nano storax 0.5-2 part
Nanometer Benzoinum 3-8 part nanometer Cinnabaris 5-10 part
The optimum weight proportioning of medicine of the present invention is:
26 parts of 25 parts of nanometer Myrrhas of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Sanguis Draxonis
25 parts of 23 parts of nano red sages of 28 parts of nanometer Radix Achyranthis Bidentataes of nano Chinese angelica
25 parts of 20 parts of nanometer Radix Notoginseng of 18 parts of nanometer Ramulus Cinnamomi of nanometer Rhizoma Chuanxiong
26 parts of 25 parts of nanometer Fructus Aurantiis of 26 parts of nanometer Radix Curcumaes of nanometer Fructus Amomi Rotundus
18 parts of 20 parts of nanometer Lignum Aquilariae Resinatum of 24 parts of nano ginsengs of the nanometer Rhizoma Atractylodis Macrocephalae
23 parts of 20 parts of nanometer Rhizoma Typhoniis of 18 parts of nanometer Bombyx Batryticatus of nanometer Bungarus Parvus
30 parts of 25 parts of nanometer Fructus Chaenomeliss of 30 parts of nanometer Radixs Stephaniae Tetrandrae of nano gastrodia
28 parts of 25 parts of nano astragalus of 18 parts of nanometer Radix Clematidiss of nanometer Scorpio
20 parts of 20 parts of nanometer Cortexs Eucommiae of 20 parts of nano Porias of nanometer Rhizoma Alismatis
25 parts of 26 parts of nanometers of the nanometer Flos Sophorae Immaturus, 20 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
28 parts of 20 parts of nanometer Fructus Crataegis of 23 parts of nanometer Colophonium of nanometer Rhizoma Drynariae
1 part of 1 part of nano storax of 20 parts of nanometer Borneolum Syntheticums of nanometer Cortex Cinnamomi
10 parts in 5 parts of nanometer Cinnabaris of nanometer Benzoinum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get eliminating thrombus preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine for eliminating thrombus is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common XIAOSHUAN ZAIZAO WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine for eliminating thrombus etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as blood fat reducing, prevention and treatment heart brain embulus disease, and clinical efficacy significantly is better than traditional XIAOSHUAN ZAIZAO WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
26 parts of 25 parts of nanometer Myrrhas of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Sanguis Draxonis
25 parts of 23 parts of nano red sages of 28 parts of nanometer Radix Achyranthis Bidentataes of nano Chinese angelica
25 parts of 20 parts of nanometer Radix Notoginseng of 18 parts of nanometer Ramulus Cinnamomi of nanometer Rhizoma Chuanxiong
26 parts of 25 parts of nanometer Fructus Aurantiis of 26 parts of nanometer Radix Curcumaes of nanometer Fructus Amomi Rotundus
18 parts of 20 parts of nanometer Lignum Aquilariae Resinatum of 24 parts of nano ginsengs of the nanometer Rhizoma Atractylodis Macrocephalae
23 parts of 20 parts of nanometer Rhizoma Typhoniis of 18 parts of nanometer Bombyx Batryticatus of nanometer Bungarus Parvus
30 parts of 25 parts of nanometer Fructus Chaenomeliss of 30 parts of nanometer Radixs Stephaniae Tetrandrae of nano gastrodia
28 parts of 25 parts of nano astragalus of 18 parts of nanometer Radix Clematidiss of nanometer Scorpio
20 parts of 20 parts of nanometer Cortexs Eucommiae of 20 parts of nano Porias of nanometer Rhizoma Alismatis
25 parts of 26 parts of nanometers of the nanometer Flos Sophorae Immaturus, 20 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
28 parts of 20 parts of nanometer Fructus Crataegis of 23 parts of nanometer Colophonium of nanometer Rhizoma Drynariae
1 part of 1 part of nano storax of 20 parts of nanometer Borneolum Syntheticums of nanometer Cortex Cinnamomi
10 parts in 5 parts of nanometer Cinnabaris of nanometer Benzoinum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
26 parts of 25 parts of nanometer Myrrhas of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Sanguis Draxonis
25 parts of 23 parts of nano red sages of 28 parts of nanometer Radix Achyranthis Bidentataes of nano Chinese angelica
25 parts of 20 parts of nanometer Radix Notoginseng of 18 parts of nanometer Ramulus Cinnamomi of nanometer Rhizoma Chuanxiong
26 parts of 25 parts of nanometer Fructus Aurantiis of 26 parts of nanometer Radix Curcumaes of nanometer Fructus Amomi Rotundus
18 parts of 20 parts of nanometer Lignum Aquilariae Resinatum of 24 parts of nano ginsengs of the nanometer Rhizoma Atractylodis Macrocephalae
23 parts of 20 parts of nanometer Rhizoma Typhoniis of 18 parts of nanometer Bombyx Batryticatus of nanometer Bungarus Parvus
30 parts of 25 parts of nanometer Fructus Chaenomeliss of 30 parts of nanometer Radixs Stephaniae Tetrandrae of nano gastrodia
28 parts of 25 parts of nano astragalus of 18 parts of nanometer Radix Clematidiss of nanometer Scorpio
20 parts of 20 parts of nanometer Cortexs Eucommiae of 20 parts of nano Porias of nanometer Rhizoma Alismatis
25 parts of 26 parts of nanometers of the nanometer Flos Sophorae Immaturus, 20 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
28 parts of 20 parts of nanometer Fructus Crataegis of 23 parts of nanometer Colophonium of nanometer Rhizoma Drynariae
1 part of 1 part of nano storax of 20 parts of nanometer Borneolum Syntheticums of nanometer Cortex Cinnamomi
10 parts in 5 parts of nanometer Cinnabaris of nanometer Benzoinum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer eliminating thrombus powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
26 parts of 25 parts of nanometer Myrrhas of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Sanguis Draxonis
25 parts of 23 parts of nano red sages of 28 parts of nanometer Radix Achyranthis Bidentataes of nano Chinese angelica
25 parts of 20 parts of nanometer Radix Notoginseng of 18 parts of nanometer Ramulus Cinnamomi of nanometer Rhizoma Chuanxiong
26 parts of 25 parts of nanometer Fructus Aurantiis of 26 parts of nanometer Radix Curcumaes of nanometer Fructus Amomi Rotundus
18 parts of 20 parts of nanometer Lignum Aquilariae Resinatum of 24 parts of nano ginsengs of the nanometer Rhizoma Atractylodis Macrocephalae
23 parts of 20 parts of nanometer Rhizoma Typhoniis of 18 parts of nanometer Bombyx Batryticatus of nanometer Bungarus Parvus
30 parts of 25 parts of nanometer Fructus Chaenomeliss of 30 parts of nanometer Radixs Stephaniae Tetrandrae of nano gastrodia
28 parts of 25 parts of nano astragalus of 18 parts of nanometer Radix Clematidiss of nanometer Scorpio
20 parts of 20 parts of nanometer Cortexs Eucommiae of 20 parts of nano Porias of nanometer Rhizoma Alismatis
25 parts of 26 parts of nanometers of the nanometer Flos Sophorae Immaturus, 20 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
28 parts of 20 parts of nanometer Fructus Crataegis of 23 parts of nanometer Colophonium of nanometer Rhizoma Drynariae
1 part of 1 part of nano storax of 20 parts of nanometer Borneolum Syntheticums of nanometer Cortex Cinnamomi
10 parts in 5 parts of nanometer Cinnabaris of nanometer Benzoinum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer eliminating thrombus membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine for eliminating thrombus is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Sanguis Draxonis 5-50 part nanometer Radix Paeoniae Rubra 8-50 part nanometer Myrrha 8-50 part
Nano Chinese angelica 10-50 part nanometer Radix Achyranthis Bidentatae 10-50 part nano red sage 10-50 part
Nanometer Rhizoma Chuanxiong 5-40 part nanometer Ramulus Cinnamomi 5-50 part nanometer Radix Notoginseng 5-50 part
Nanometer Fructus Amomi Rotundus 10-50 part nanometer Radix Curcumae 10-50 part nanometer Fructus Aurantii 10-50 part
Nanometer Rhizoma Atractylodis Macrocephalae 5-50 part nano ginseng 5-40 part nanometer Lignum Aquilariae Resinatum 5-40 part
Nanometer Bungarus Parvus 5-40 part nanometer Bombyx Batryticatus 5-40 part nanometer Rhizoma Typhonii 10-50 part
Nano gastrodia 10-50 part nanometer Radix Stephaniae Tetrandrae 5-50 part nanometer Fructus Chaenomelis 10-50 part
Nanometer Scorpio 10-50 part nanometer Radix Clematidis 10-50 part nano astragalus 10-50 part
Nanometer Rhizoma Alismatis 5-40 part nano Poria 5-40 part nanometer Cortex Eucommiae 5-40 part
Nanometer Flos Sophorae Immaturus 10-50 part nanometer 5-50 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 10-50 part
Nanometer Rhizoma Drynariae 10-50 part nanometer Colophonium 5-40 part nanometer Fructus Crataegi 10-50 part
Nanometer Cortex Cinnamomi 5-40 part nanometer Borneolum Syntheticum 0.1-3 part nano storax 0.1-3 part
Nanometer Benzoinum 1-10 part nanometer Cinnabaris 3-15 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine for eliminating thrombus according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Sanguis Draxonis 10-30 part nanometer Radix Paeoniae Rubra 15-40 part nanometer Myrrha 15-40 part
Nano Chinese angelica 20-40 part nanometer Radix Achyranthis Bidentatae 15-40 part nano red sage 15-40 part
Nanometer Rhizoma Chuanxiong 10-30 part nanometer Ramulus Cinnamomi 10-30 part nanometer Radix Notoginseng 15-40 part
Nanometer Fructus Amomi Rotundus 15-40 part nanometer Radix Curcumae 15-40 part nanometer Fructus Aurantii 15-40 part
Nanometer Rhizoma Atractylodis Macrocephalae 10-40 part nano ginseng 10-30 part nanometer Lignum Aquilariae Resinatum 10-30 part
Nanometer Bungarus Parvus 10-30 part nanometer Bombyx Batryticatus 10-30 part nanometer Rhizoma Typhonii 15-40 part
Nano gastrodia 20-40 part nanometer Radix Stephaniae Tetrandrae 15-40 part nanometer Fructus Chaenomelis 20-40 part
Nanometer Scorpio 15-30 part nanometer Radix Clematidis 15-40 part nano astragalus 15-40 part
Nanometer Rhizoma Alismatis 10-30 part nano Poria 10-30 part nanometer Cortex Eucommiae 10-30 part
Nanometer Flos Sophorae Immaturus 15-40 part nanometer 10-30 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 15-40 part
Nanometer Rhizoma Drynariae 15-40 part nanometer Colophonium 10-30 part nanometer Fructus Crataegi 20-40 part
Nanometer Cortex Cinnamomi 10-30 part nanometer Borneolum Syntheticum 0.5-2 part nano storax 0.5-2 part
Nanometer Benzoinum 3-8 part nanometer Cinnabaris 5-10 part
3, nano medicine for eliminating thrombus according to claim 1, wherein the weight proportion of each nano raw material is:
26 parts of 25 parts of nanometer Myrrhas of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Sanguis Draxonis
25 parts of 23 parts of nano red sages of 28 parts of nanometer Radix Achyranthis Bidentataes of nano Chinese angelica
25 parts of 20 parts of nanometer Radix Notoginseng of 18 parts of nanometer Ramulus Cinnamomi of nanometer Rhizoma Chuanxiong
26 parts of 25 parts of nanometer Fructus Aurantiis of 26 parts of nanometer Radix Curcumaes of nanometer Fructus Amomi Rotundus
18 parts of 20 parts of nanometer Lignum Aquilariae Resinatum of 24 parts of nano ginsengs of the nanometer Rhizoma Atractylodis Macrocephalae
23 parts of 20 parts of nanometer Rhizoma Typhoniis of 18 parts of nanometer Bombyx Batryticatus of nanometer Bungarus Parvus
30 parts of 25 parts of nanometer Fructus Chaenomeliss of 30 parts of nanometer Radixs Stephaniae Tetrandrae of nano gastrodia
28 parts of 25 parts of nano astragalus of 18 parts of nanometer Radix Clematidiss of nanometer Scorpio
20 parts of 20 parts of nanometer Cortexs Eucommiae of 20 parts of nano Porias of nanometer Rhizoma Alismatis
25 parts of 26 parts of nanometers of the nanometer Flos Sophorae Immaturus, 20 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
28 parts of 20 parts of nanometer Fructus Crataegis of 23 parts of nanometer Colophonium of nanometer Rhizoma Drynariae
1 part of 1 part of nano storax of 20 parts of nanometer Borneolum Syntheticums of nanometer Cortex Cinnamomi
10 parts in 5 parts of nanometer Cinnabaris of nanometer Benzoinum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine for eliminating thrombus.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine for eliminating thrombus; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100211 CN1363288A (en) | 2001-01-10 | 2001-01-10 | Nano medicine for eliminating thrombus and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100211 CN1363288A (en) | 2001-01-10 | 2001-01-10 | Nano medicine for eliminating thrombus and its preparing process |
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| CN1363288A true CN1363288A (en) | 2002-08-14 |
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| CN 01100211 Pending CN1363288A (en) | 2001-01-10 | 2001-01-10 | Nano medicine for eliminating thrombus and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007505936A (en) * | 2003-09-23 | 2007-03-15 | ティアンジン タスリー ファーマシューティカル カンパニー リミテッド | Pharmaceutical compositions for the treatment of cardiovascular and cerebrovascular diseases |
| CN100341547C (en) * | 2003-11-21 | 2007-10-10 | 成都地奥制药集团有限公司 | Medicinal composition for regulating blood fat, prepn. method and use thereof |
| CN104497652A (en) * | 2014-12-25 | 2015-04-08 | 中国工程物理研究院材料研究所 | Gold-nano-encapsulated aroma type leather coating agent and preparation method thereof |
-
2001
- 2001-01-10 CN CN 01100211 patent/CN1363288A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007505936A (en) * | 2003-09-23 | 2007-03-15 | ティアンジン タスリー ファーマシューティカル カンパニー リミテッド | Pharmaceutical compositions for the treatment of cardiovascular and cerebrovascular diseases |
| JP4943846B2 (en) * | 2003-09-23 | 2012-05-30 | ティアンジン タスリー ファーマシューティカル カンパニー リミテッド | Pharmaceutical compositions for the treatment of cardiovascular and cerebrovascular diseases |
| CN100341547C (en) * | 2003-11-21 | 2007-10-10 | 成都地奥制药集团有限公司 | Medicinal composition for regulating blood fat, prepn. method and use thereof |
| CN104497652A (en) * | 2014-12-25 | 2015-04-08 | 中国工程物理研究院材料研究所 | Gold-nano-encapsulated aroma type leather coating agent and preparation method thereof |
| CN104497652B (en) * | 2014-12-25 | 2016-09-21 | 中国工程物理研究院材料研究所 | A kind of aroma type leather finishing agent of gold nanoencapsulation and preparation method thereof |
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