CN1355700A - 皮肤麻醉剂 - Google Patents

皮肤麻醉剂 Download PDF

Info

Publication number
CN1355700A
CN1355700A CN00808753A CN00808753A CN1355700A CN 1355700 A CN1355700 A CN 1355700A CN 00808753 A CN00808753 A CN 00808753A CN 00808753 A CN00808753 A CN 00808753A CN 1355700 A CN1355700 A CN 1355700A
Authority
CN
China
Prior art keywords
hydrogen
anesthesia
group
chemical compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00808753A
Other languages
English (en)
Chinese (zh)
Inventor
A·K·G·阿贝里
G·L·赖特
J·L·陈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bridge Pharma Inc
Original Assignee
Bridge Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bridge Pharma Inc filed Critical Bridge Pharma Inc
Publication of CN1355700A publication Critical patent/CN1355700A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN00808753A 1999-06-10 2000-06-06 皮肤麻醉剂 Pending CN1355700A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13835399P 1999-06-10 1999-06-10
US60/138,353 1999-06-10
US17926700P 2000-01-31 2000-01-31
US60/179,267 2000-01-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 200510128652 Division CN1814589A (zh) 1999-06-10 2000-06-06 皮肤麻醉剂

Publications (1)

Publication Number Publication Date
CN1355700A true CN1355700A (zh) 2002-06-26

Family

ID=26836123

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00808753A Pending CN1355700A (zh) 1999-06-10 2000-06-06 皮肤麻醉剂

Country Status (18)

Country Link
US (1) US6413987B1 (https=)
EP (1) EP1185267B1 (https=)
JP (1) JP2003501469A (https=)
CN (1) CN1355700A (https=)
AT (1) ATE335482T1 (https=)
AU (1) AU777517B2 (https=)
BR (1) BR0011028A (https=)
CA (1) CA2376819C (https=)
CY (1) CY1105721T1 (https=)
DE (1) DE60029954T2 (https=)
DK (1) DK1185267T3 (https=)
ES (1) ES2267546T3 (https=)
IL (2) IL146190A0 (https=)
MX (1) MXPA01012632A (https=)
NO (1) NO323856B1 (https=)
NZ (1) NZ515143A (https=)
PT (1) PT1185267E (https=)
WO (1) WO2000076510A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1321139E (pt) * 2001-12-21 2007-01-31 Chiesi Farma Spa Derivados de 2-indanilamino para a terapêutica da cor crónica
WO2004048332A1 (ja) * 2002-11-26 2004-06-10 Maruishi Pharmaceutical Co., Ltd. イソインドリン誘導体
US7718674B2 (en) * 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
WO2006037047A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
US20090137628A1 (en) * 2005-09-23 2009-05-28 Bridge Pharma, Inc. Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain
US20110218218A1 (en) * 2005-09-23 2011-09-08 Bridge Pharma, Inc. Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain
CA2655809C (en) * 2006-07-21 2013-10-01 Bridge Pharma, Inc. Dermal anesthetic compounds
PL2244737T3 (pl) * 2008-01-22 2020-05-18 The Board Of Regents Of The University Of Texas System Kompozycje lotnego środka znieczulającego zawierające rozpuszczalniki ekstrakcyjne do znieczulania miejscowego i / albo zwalczania bólu
MX386293B (es) * 2011-02-18 2025-03-18 Libertas Bio Inc Compuestos de aminoindano y su uso en el tratamiento del dolor.
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
JP6495654B2 (ja) 2011-10-24 2019-04-03 アサナ バイオサイエンシズ，リミティド ライアビリティ カンパニー シクロヘキシルアミン類
WO2014028675A1 (en) * 2012-08-15 2014-02-20 Endo Pharmaceuticals Inc. Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
KR20180088415A (ko) 2015-11-23 2018-08-03 그레이스 테라퓨틱스 엘엘씨 국소적 막형성 스프레이
EP3897603A4 (en) 2018-12-19 2022-09-14 Grace Therapeutics Inc. THERAPEUTIC COMPOSITION OF INTRANASAL LIDOCAINE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE760018A (fr) * 1969-12-19 1971-06-08 Christiaens Sa A Nouveau derives du 2-amino-indane, leur preparation et leur utilisation
US3923813A (en) 1969-12-19 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindanes
AR206505A1 (es) * 1972-09-18 1976-07-30 Christiaens Sa A Procedimiento para obtener nuevos derivados de n-fenil-n-aminoalquil-2-aminoindano
ZA738419B (en) 1972-11-06 1974-09-25 Christiaens Sa A New derivatives of 2-aminoindane,the preparation and use thereof
GB1462036A (en) * 1973-02-05 1977-01-19 Manuf Prod Pharma Aminoindane derivatives
GB1468347A (en) * 1973-03-02 1977-03-23 Christiaens Sa A Aminoindanes

Also Published As

Publication number Publication date
AU777517B2 (en) 2004-10-21
MXPA01012632A (es) 2004-03-19
CY1105721T1 (el) 2010-12-22
CA2376819A1 (en) 2000-12-21
DE60029954D1 (de) 2006-09-21
EP1185267A4 (en) 2003-09-03
ATE335482T1 (de) 2006-09-15
IL146190A (en) 2008-11-03
NO20016037L (no) 2002-02-11
NO323856B1 (no) 2007-07-16
US6413987B1 (en) 2002-07-02
ES2267546T3 (es) 2007-03-16
DK1185267T3 (da) 2006-12-11
JP2003501469A (ja) 2003-01-14
PT1185267E (pt) 2006-12-29
CA2376819C (en) 2008-09-02
AU5596300A (en) 2001-01-02
WO2000076510A9 (en) 2002-07-04
DE60029954T2 (de) 2007-03-08
WO2000076510A1 (en) 2000-12-21
NO20016037D0 (no) 2001-12-10
NZ515143A (en) 2004-05-28
EP1185267B1 (en) 2006-08-09
IL146190A0 (en) 2002-07-25
EP1185267A1 (en) 2002-03-13
BR0011028A (pt) 2002-02-19

Similar Documents

Publication Publication Date Title
CN110156665B (zh) 一种季铵盐类化合物及其制备方法与用途
US7718674B2 (en) Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
CN1355700A (zh) 皮肤麻醉剂
AU738743B2 (en) Antipruritic
US20060079558A1 (en) R-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics
EP1709957A2 (en) Sustained-release analgesic compounds
EP1009397A2 (en) N,n-bis (phenylcarbamoylmethyl) dimethylammonium chloride and derivatives in the treatment of pain
JP5571072B2 (ja) アルファアドレナリン介在症状の治療方法
EP1097924B1 (en) 4-hydroxy-4-phenylpiperidine derivatives having opioid agonist activity and pharmaceuticals containing the same
WO2020159565A1 (en) Methods of treating post-surgical pain with a thiazoline anti-hyperalgesic agent
US8168632B2 (en) Bicyclic amide derivatives for the treatment of respiratory disorders
CA2655809C (en) Dermal anesthetic compounds
WO2020159588A1 (en) Methods of treating diabetic neuropathy with a thiazoline anti-hyperalgesic agent
EP1658847A2 (en) Indane derivatives as dermal anesthetic agents
CN1107333A (zh) 那布扶林镇痛剂的长效前体药物及其制备方法
US20110124685A1 (en) Anesthetic Compounds
CN113214107B (zh) 一种芳香类化合物、制备方法及在药物中的应用
RU2160267C1 (ru) Дигидрохлорид 1-(2-изопропиламиноэтил)-2-фенилимидазо [1,2-а]-бензимидазола, обладающий местноанестезирующим действием
CN1814589A (zh) 皮肤麻醉剂
WO2010087980A2 (en) Bicyclic amide derivatives for the treatment of respiratory depression
HK1009437B (en) New [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication