CN1335317A - 制备吡唑并[4,3－d]嘧啶－7－酮化合物的方法及其中间体 - Google Patents

制备吡唑并[4,3－d]嘧啶－7－酮化合物的方法及其中间体 Download PDF

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Publication number
CN1335317A
CN1335317A CN01124351A CN01124351A CN1335317A CN 1335317 A CN1335317 A CN 1335317A CN 01124351 A CN01124351 A CN 01124351A CN 01124351 A CN01124351 A CN 01124351A CN 1335317 A CN1335317 A CN 1335317A
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CN
China
Prior art keywords
group
alkyl group
low alkyl
compound
het
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01124351A
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English (en)
Chinese (zh)
Inventor
C·M·N·艾尔勒顿
C·G·巴伯
K·M·迪福利斯
L·J·哈里斯
P·C·勒维特
J·T·奈格里
D·J·劳森
A·S·伍德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0018660A external-priority patent/GB0018660D0/en
Priority claimed from GB0107526A external-priority patent/GB0107526D0/en
Priority claimed from GB0110251A external-priority patent/GB0110251D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1335317A publication Critical patent/CN1335317A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN01124351A 2000-07-28 2001-07-27 制备吡唑并[4,3－d]嘧啶－7－酮化合物的方法及其中间体 Pending CN1335317A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0018660A GB0018660D0 (en) 2000-07-28 2000-07-28 Pharmaceutically active compounds
GB20000728 2000-07-28
GB0107526.6 2001-03-26
GB0107526A GB0107526D0 (en) 2001-03-26 2001-03-26 Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-one compounds and intermediates thereof
GB0110251.6 2001-04-26
GB0110251A GB0110251D0 (en) 2001-04-26 2001-04-26 Process for the preparation of pyrazolo[4,4-d]Pyrimidin-7-one compounds and intermediates thereof

Publications (1)

Publication Number Publication Date
CN1335317A true CN1335317A (zh) 2002-02-13

Family

ID=27255823

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01124351A Pending CN1335317A (zh) 2000-07-28 2001-07-27 制备吡唑并[4,3－d]嘧啶－7－酮化合物的方法及其中间体

Country Status (17)

Country Link
EP (1) EP1176147A1 (https=)
JP (1) JP2002105076A (https=)
KR (1) KR20020010102A (https=)
CN (1) CN1335317A (https=)
AR (1) AR035650A1 (https=)
AU (1) AU754962B2 (https=)
BR (1) BR0103072A (https=)
CA (1) CA2354175A1 (https=)
CZ (1) CZ20012713A3 (https=)
HK (1) HK1040715A1 (https=)
HU (1) HUP0103075A3 (https=)
IL (1) IL144516A0 (https=)
IN (1) IN191315B (https=)
MX (1) MXPA01007676A (https=)
PL (1) PL348935A1 (https=)
RU (1) RU2224759C2 (https=)
YU (1) YU51701A (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0106631D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
US6831074B2 (en) 2001-03-16 2004-12-14 Pfizer Inc Pharmaceutically active compounds
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
JP2006219373A (ja) 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
DE602005011784D1 (de) 2004-04-07 2009-01-29 Pfizer Pyrazoloä4,3-düpyrimidine
CA2629077C (en) * 2005-11-16 2014-03-18 F. Hoffmann-La Roche Ag Novel process for the preparation of thoc
GB2450268B (en) * 2006-03-17 2011-01-12 Cipla Ltd Synthesis of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile and 4-[1-(1,2,4-triazol-1-yl)methyl]benzonitrile intermediate
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
AU2008279447A1 (en) * 2007-07-19 2009-01-29 Metabolex, Inc. N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
US8410127B2 (en) 2009-10-01 2013-04-02 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
CN109674753A (zh) 2010-06-23 2019-04-26 希玛贝治疗股份有限公司 固态分散体
AU2017305392A1 (en) 2016-08-03 2019-02-21 Cymabay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
UY40234A (es) 2022-04-22 2023-11-15 Vertex Pharma Compuestos heteroarilo para el tratamiento del dolor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2089971A (en) * 1937-08-17 Condensation products of
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9823101D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
AP2002002455A0 (en) * 1999-10-11 2002-06-30 Pfizer 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dIhydropyrazolo[4,3-D] pyrimidin-7-ones as phosphodiesterase inhibitors.

Also Published As

Publication number Publication date
KR20020010102A (ko) 2002-02-02
BR0103072A (pt) 2002-04-09
YU51701A (sh) 2003-12-31
IN191315B (https=) 2003-11-22
AU5767201A (en) 2002-01-31
CZ20012713A3 (cs) 2002-04-17
AU754962B2 (en) 2002-11-28
PL348935A1 (en) 2002-02-11
HU0103075D0 (en) 2001-10-28
HK1040715A1 (zh) 2002-06-21
AR035650A1 (es) 2004-06-23
IL144516A0 (en) 2002-05-23
HUP0103075A3 (en) 2003-04-28
CA2354175A1 (en) 2002-01-28
HUP0103075A2 (hu) 2002-07-29
EP1176147A1 (en) 2002-01-30
MXPA01007676A (es) 2002-10-23
RU2224759C2 (ru) 2004-02-27
JP2002105076A (ja) 2002-04-10

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