CA2354175A1 - Process for the preparation of pyrazolo¬4,3-d|pyrimidin-7-one compounds and intermediates thereof - Google Patents

Process for the preparation of pyrazolo¬4,3-d|pyrimidin-7-one compounds and intermediates thereof Download PDF

Info

Publication number
CA2354175A1
CA2354175A1 CA002354175A CA2354175A CA2354175A1 CA 2354175 A1 CA2354175 A1 CA 2354175A1 CA 002354175 A CA002354175 A CA 002354175A CA 2354175 A CA2354175 A CA 2354175A CA 2354175 A1 CA2354175 A1 CA 2354175A1
Authority
CA
Canada
Prior art keywords
lower alkyl
halo
groups
optionally substituted
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002354175A
Other languages
English (en)
French (fr)
Inventor
Charlotte Moira Norfor Allerton
Joanna Teresa Negri
Philip Charles Levett
Christopher Gordon Barber
David James Rawson
Keith Micheal Devries
Laurence James Harris
Albert Shaw Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0018660A external-priority patent/GB0018660D0/en
Priority claimed from GB0107526A external-priority patent/GB0107526D0/en
Priority claimed from GB0110251A external-priority patent/GB0110251D0/en
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Publication of CA2354175A1 publication Critical patent/CA2354175A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002354175A 2000-07-28 2001-07-26 Process for the preparation of pyrazolo¬4,3-d|pyrimidin-7-one compounds and intermediates thereof Abandoned CA2354175A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0018660A GB0018660D0 (en) 2000-07-28 2000-07-28 Pharmaceutically active compounds
GB0018660.1 2000-07-28
GB0107526.6 2001-03-26
GB0107526A GB0107526D0 (en) 2001-03-26 2001-03-26 Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-one compounds and intermediates thereof
GB0110251.6 2001-04-26
GB0110251A GB0110251D0 (en) 2001-04-26 2001-04-26 Process for the preparation of pyrazolo[4,4-d]Pyrimidin-7-one compounds and intermediates thereof

Publications (1)

Publication Number Publication Date
CA2354175A1 true CA2354175A1 (en) 2002-01-28

Family

ID=27255823

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002354175A Abandoned CA2354175A1 (en) 2000-07-28 2001-07-26 Process for the preparation of pyrazolo¬4,3-d|pyrimidin-7-one compounds and intermediates thereof

Country Status (17)

Country Link
EP (1) EP1176147A1 (https=)
JP (1) JP2002105076A (https=)
KR (1) KR20020010102A (https=)
CN (1) CN1335317A (https=)
AR (1) AR035650A1 (https=)
AU (1) AU754962B2 (https=)
BR (1) BR0103072A (https=)
CA (1) CA2354175A1 (https=)
CZ (1) CZ20012713A3 (https=)
HK (1) HK1040715A1 (https=)
HU (1) HUP0103075A3 (https=)
IL (1) IL144516A0 (https=)
IN (1) IN191315B (https=)
MX (1) MXPA01007676A (https=)
PL (1) PL348935A1 (https=)
RU (1) RU2224759C2 (https=)
YU (1) YU51701A (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12503439B2 (en) 2022-04-22 2025-12-23 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0106631D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
US6831074B2 (en) 2001-03-16 2004-12-14 Pfizer Inc Pharmaceutically active compounds
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
JP2006219373A (ja) 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
DE602005011784D1 (de) 2004-04-07 2009-01-29 Pfizer Pyrazoloä4,3-düpyrimidine
CA2629077C (en) * 2005-11-16 2014-03-18 F. Hoffmann-La Roche Ag Novel process for the preparation of thoc
GB2450268B (en) * 2006-03-17 2011-01-12 Cipla Ltd Synthesis of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile and 4-[1-(1,2,4-triazol-1-yl)methyl]benzonitrile intermediate
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
AU2008279447A1 (en) * 2007-07-19 2009-01-29 Metabolex, Inc. N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
US8410127B2 (en) 2009-10-01 2013-04-02 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
CN109674753A (zh) 2010-06-23 2019-04-26 希玛贝治疗股份有限公司 固态分散体
AU2017305392A1 (en) 2016-08-03 2019-02-21 Cymabay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2089971A (en) * 1937-08-17 Condensation products of
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9823101D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
AP2002002455A0 (en) * 1999-10-11 2002-06-30 Pfizer 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dIhydropyrazolo[4,3-D] pyrimidin-7-ones as phosphodiesterase inhibitors.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12503439B2 (en) 2022-04-22 2025-12-23 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain

Also Published As

Publication number Publication date
KR20020010102A (ko) 2002-02-02
BR0103072A (pt) 2002-04-09
YU51701A (sh) 2003-12-31
IN191315B (https=) 2003-11-22
AU5767201A (en) 2002-01-31
CN1335317A (zh) 2002-02-13
CZ20012713A3 (cs) 2002-04-17
AU754962B2 (en) 2002-11-28
PL348935A1 (en) 2002-02-11
HU0103075D0 (en) 2001-10-28
HK1040715A1 (zh) 2002-06-21
AR035650A1 (es) 2004-06-23
IL144516A0 (en) 2002-05-23
HUP0103075A3 (en) 2003-04-28
HUP0103075A2 (hu) 2002-07-29
EP1176147A1 (en) 2002-01-30
MXPA01007676A (es) 2002-10-23
RU2224759C2 (ru) 2004-02-27
JP2002105076A (ja) 2002-04-10

Similar Documents

Publication Publication Date Title
EP0526004B1 (en) Pyrazolopyrimidinone antianginal agents
AU754962B2 (en) Process for the preparation of pyrazolo(4,3-d)pyrimidin-7- one compounds and intermediates thereof
RS59100B1 (sr) Antitela usmerena protiv her-3 i njihove upotrebe
OA13050A (en) 5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension.
WO2003076427A1 (en) Quinazoline compounds useful in therapy
JP2000119273A (ja) ピラゾロ［４，３―ｄ］ピリミジン―７―オン類及びそれらの中間体の製造方法
US6667398B2 (en) Process for the preparation of pyrazolopyrimidinones
KR100525698B1 (ko) 피라졸로피리미디논의 제조 방법
US6809200B2 (en) Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof
AU2001262597A1 (en) Process for the preparation of pyrazolopyrimidinones
EP1092720B1 (en) Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof
ES2231498T3 (es) Nuevo procedimiento para la preparacion de pirazolopirimidinonas.
MXPA99009326A (en) Procedure for the preparation of pirazolo [4,3-d] pyrimidin-7-onas and its intermed

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued