CN1332975C - 甾族化合物、该化合物在制备减数分裂调节药物中的应用以及制备这些化合物的方法 - Google Patents

甾族化合物、该化合物在制备减数分裂调节药物中的应用以及制备这些化合物的方法 Download PDF

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Publication number
CN1332975C
CN1332975C CNB028073673A CN02807367A CN1332975C CN 1332975 C CN1332975 C CN 1332975C CN B028073673 A CNB028073673 A CN B028073673A CN 02807367 A CN02807367 A CN 02807367A CN 1332975 C CN1332975 C CN 1332975C
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CN
China
Prior art keywords
pregna
methyl
dimethyl
dien
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028073673A
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English (en)
Chinese (zh)
Other versions
CN1543473A (zh
Inventor
托尔斯滕·布卢默
彼得·埃斯珀林
克里斯塔·黑格勒－哈通
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Novo Nordisk AS
Original Assignee
Schering AG
Novo Nordisk AS
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Publication date
Application filed by Schering AG, Novo Nordisk AS filed Critical Schering AG
Publication of CN1543473A publication Critical patent/CN1543473A/zh
Application granted granted Critical
Publication of CN1332975C publication Critical patent/CN1332975C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028073673A 2001-03-26 2002-03-20 甾族化合物、该化合物在制备减数分裂调节药物中的应用以及制备这些化合物的方法 Expired - Fee Related CN1332975C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01250108A EP1245572A1 (en) 2001-03-26 2001-03-26 Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation
EP01250108.6 2001-03-26

Publications (2)

Publication Number Publication Date
CN1543473A CN1543473A (zh) 2004-11-03
CN1332975C true CN1332975C (zh) 2007-08-22

Family

ID=8181575

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028073673A Expired - Fee Related CN1332975C (zh) 2001-03-26 2002-03-20 甾族化合物、该化合物在制备减数分裂调节药物中的应用以及制备这些化合物的方法

Country Status (18)

Country Link
US (1) US6916921B2 (cg-RX-API-DMAC10.html)
EP (2) EP1245572A1 (cg-RX-API-DMAC10.html)
JP (1) JP2004534011A (cg-RX-API-DMAC10.html)
KR (1) KR20030088043A (cg-RX-API-DMAC10.html)
CN (1) CN1332975C (cg-RX-API-DMAC10.html)
AU (1) AU2002315260B2 (cg-RX-API-DMAC10.html)
BR (1) BR0208381A (cg-RX-API-DMAC10.html)
CA (1) CA2438210A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ20032578A3 (cg-RX-API-DMAC10.html)
HU (1) HUP0303643A2 (cg-RX-API-DMAC10.html)
IL (1) IL157272A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA03008199A (cg-RX-API-DMAC10.html)
NO (1) NO20034273L (cg-RX-API-DMAC10.html)
PL (1) PL369576A1 (cg-RX-API-DMAC10.html)
RU (1) RU2289587C2 (cg-RX-API-DMAC10.html)
UA (1) UA75130C2 (cg-RX-API-DMAC10.html)
WO (1) WO2002079220A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200308271B (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1514874A1 (en) * 2003-07-28 2005-03-16 Schering Aktiengesellschaft Thiomorpholino steroid compounds, the use thereof for the preparation of meiosis regulating medicaments and method for the preparation thereof
KR100689260B1 (ko) * 2005-05-24 2007-03-02 삼원산업주식회사 항산화성 스틸벤계 형광증백제 및 이의 합성방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1930473A1 (de) * 1969-06-14 1970-12-17 Schering Ag 22-N-substituierte (20R)-23,24-dinor-cholanderivate
WO1999058549A1 (en) * 1998-05-13 1999-11-18 Novo Nordisk A/S Meiosis regulating compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1095167A (en) * 1963-12-05 1967-12-13 Shalom Sarel Amino-steroids
US3419661A (en) * 1964-01-13 1968-12-31 Univ Missouri Oral contraceptive for birds
DE1643004A1 (de) * 1967-02-07 1971-04-08 Schering Ag Bisnorcholenderivate und Verfahren zu ihrer Herstellung
US5716777A (en) 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols
EP0813595A1 (en) * 1995-03-06 1997-12-29 Novo Nordisk A/S Stimulation of meiosis
ATE254628T1 (de) 1995-06-23 2003-12-15 Novo Nordisk As Meiose regulierende verbindungen.
EP0946584B1 (en) 1996-12-20 2003-04-23 Novo Nordisk A/S Meiosis regulating compounds
KR20010043828A (ko) 1998-05-26 2001-05-25 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 ｃＡＭＰ-증강 화합물 단독 또는 감수분열-자극 화합물하나 이상과의 조합에 의한 불임 치료 방법
EP1156821B1 (en) 1999-02-24 2007-05-02 Novo Nordisk A/S Treatment of infertility
AU2794100A (en) 1999-02-24 2000-09-14 Novo Nordisk A/S Treatment of infertility
CN1341147A (zh) 1999-02-26 2002-03-20 诺沃挪第克公司 减数分裂活化甾醇增大着床率
JP2003509365A (ja) 1999-09-16 2003-03-11 ノボ ノルディスク アクティーゼルスカブ Ｉｖｆ用の組成物
AU3376501A (en) 2000-02-25 2001-09-03 Novo Nordisk A/S Improvement of implantation rate
US6988613B2 (en) * 2001-02-06 2006-01-24 Novo Nordisk A/S Composition for IVF
ATE386495T1 (de) * 2001-02-06 2008-03-15 Novo Nordisk As Behältnis mit niedrigem sauerstoffgehalt, das ff- mas enthält

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1930473A1 (de) * 1969-06-14 1970-12-17 Schering Ag 22-N-substituierte (20R)-23,24-dinor-cholanderivate
WO1999058549A1 (en) * 1998-05-13 1999-11-18 Novo Nordisk A/S Meiosis regulating compounds

Also Published As

Publication number Publication date
US6916921B2 (en) 2005-07-12
NO20034273L (no) 2003-11-25
CN1543473A (zh) 2004-11-03
BR0208381A (pt) 2004-06-15
IL157272A0 (en) 2004-02-19
JP2004534011A (ja) 2004-11-11
WO2002079220A2 (en) 2002-10-10
US20020188143A1 (en) 2002-12-12
ZA200308271B (en) 2005-01-24
UA75130C2 (en) 2006-03-15
MXPA03008199A (es) 2004-01-29
KR20030088043A (ko) 2003-11-15
HUP0303643A2 (hu) 2004-03-01
RU2289587C2 (ru) 2006-12-20
RU2003130228A (ru) 2005-04-10
WO2002079220A3 (en) 2003-10-16
AU2002315260B2 (en) 2008-04-03
CZ20032578A3 (cs) 2003-12-17
PL369576A1 (en) 2005-05-02
NO20034273D0 (no) 2003-09-25
EP1401856A2 (en) 2004-03-31
CA2438210A1 (en) 2002-10-10
EP1245572A1 (en) 2002-10-02
HK1070900A1 (en) 2005-06-30

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