CN1290530C - Fumaiding Chinese medicinal preparation for treating arrhythmia and its preparation method - Google Patents

Abstract

The present invention relates to a 'Fumaiding' traditional Chinese medicine preparation for treating arrhythmia and a preparation method for preparing capsules of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from pilose asiabell root, astragalus root, polygala, mulberry fruit and hemlock parsley in certain weight proportions, which are extracted with ethanol, concentrated, dried, pulverized, etc. The traditional Chinese medicine preparation has the efficacy of activating blood circulation, removing blood stasis, relieving mental stress, supplementing qi and nourishing yin, and can treat arrhythmia caused by various factors. The present invention has the advantages of small toxic and side effects, convenient and safe taking, and reliable clinical effect.

Description

Treat ARR Fumaiding Chinese medicine preparation and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, particularly treat ARR Fumaiding capsule, the invention still further relates to the preparation method of this medicine.

Technical background

Arrhythmia is a kind of common symptoms that is caused by multiple disease, as artrial premature beat, ventricular premature contraction etc.Domestic have a data report, and patients with arrhythmia is occupied 15.84% of institute's number, accounts for 25% of Electrocardioscopy, and old people's sickness rate is higher.If untimely treatment makes not only that sb.'s illness took a turn for the worse, influence labour force and health, and the danger of sudden death is arranged.At present, treatment clinically is based on Western medicine, the good effect that has, but side effect is big, takes the patient for a long time and is difficult for accepting.Find that through clinical observation some treats ARR medicine also can cause ARR generation simultaneously, so the patient must tight monitoring at period in a medicine.In recent years, engendered that some treat ARR Chinese patent medicine, as the Fumaiding electuary, curative effect is more definite, and no obvious toxic-side effects is subjected to the welcome of extensive patients deeply, distinguish the flavor of and contain sugar, dextrin in Chinese crude drug and the preparation but contain fiber crops such as Radix Polygalae in the prescription, should not take for a long time by cardiovascular patient.Under the patient is occurred together the situation of diabetes, more can not take.

Summary of the invention

The object of the present invention is to provide that a kind of toxicity is little, taking convenience safety, curative effect treats ARR Fumaiding Chinese medicine preparation reliably.

Another object of the present invention provides the preparation method of this Fumaiding Chinese medicine preparation.

Technical scheme provided by the invention is as described below: this Chinese medicine preparation is made by following weight (part) proportion raw material, Radix Codonopsis 725～1506 Radixs Astragali 714～1071 Radix Polygalaes 595～892 Fructus Moris 610～878 Rhizoma Chuanxiongs 305～439.

Formula optimization weight (part) ratio range of preparation medicament of the present invention is: Radix Codonopsis 856～1235 Radixs Astragali 780～890 Radix Polygalaes 623～761 Fructus Moris 697～854 Rhizoma Chuanxiongs 352～411.

The medicament made from above-mentioned various raw materials is the dosage form of saying on any pharmaceutics.Capsule preferably.

The capsular preparation method of the ARR Fumaiding of treatment of the present invention is carried out according to the following steps successively:

(1) get above-mentioned Chinese medicine of the five flavours by weight ratio, the alcohol reflux of usefulness 60%-90% 2-5 time filters merging filtrate;

(2) decompression recycling ethanol and be concentrated in right amount is dissolved in water, and boils 5-10 minute, and room temperature was placed 38-55 hour, made it precipitation;

(3) get the supernatant of post precipitation, pass through D ₁₀₁The type macroporous adsorptive resins with the ethanol elution of 80%-95%, is collected eluent and is reclaimed ethanol again and be concentrated in right amount adding appropriate amount of starch mixing;

(4) precipitate with (2) gained adds the appropriate amount of starch mixing;

(5) with the material of (3), (4) gained respectively at 60-85 ℃ of dry 2-4 days, natural cooling, the 20-100 order of pulverizing after the taking-up, sieve merges at last, and is evenly mixed;

(6) powder after will mixing incapsulates.

Five kinds of raw materials that the present invention chooses are Chinese medicine, can buy from the market.After (part) was taken a sample by weight with above-mentioned five kinds of Chinese medicines, the ethanol that adds 60%-90% refluxed, and extracts 2-5 time, filters out medicinal residues, and each filtrate is merged.Concentrating under reduced pressure or thin film concentration or vacuum film concentrate the ethanol that reclaims in the filtrate then, make it to be concentrated in right amount, add water again concentrate is dissolved, and boiled 5-10 minute, leave standstill 38-55 hour under room temperature (about 20 ℃), make it precipitation.Get the supernatant of post precipitation, make it to pass through D ₁₀₁The type macroporous adsorptive resins, with the ethanol elution of 80%-95%, but the repeated multiple times eluting collects each eluent and reclaims ethanol again and be concentrated in right amount, add an amount of abundant stirring and evenly mixing of starch.In taking the remaining precipitate of supernatant away, add the abundant mixing of appropriate amount of starch.The effect that adds appropriate amount of starch is to absorb moisture, forms pasty state.With the material of twice gained respectively at 60 ℃ of-80 ℃ of dryings, available constant pressure and dry also can be used the vacuum decompression drying, 2-4 days drying time, from drying baker, take out after cooling, pulverize separately is powdered, and it is back evenly mixed to sieve with the 20-100 order, make and be yellowish-brown or auburn powder, can incapsulate, or compacting in flakes, or make micropill, every net weight 0.35 restrains.

It is raw material that the present invention selects the botanical herbs of natural edible for use, utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of, blood circulation promoting and blood stasis dispelling, mind tranquilizing and the heart calming, supplementing QI and nourishing YIN.Can treat the arrhythmia that a variety of causes causes, not have chemical sweeting agent, nontoxic to human body.The present invention makes Chinese patent medicine, need not decoct, and does not have the fiber crops flavor and the dextrin of electuary again, and patient's taking convenience is convenient to take for a long time.This product can increase the myocardial nutrition blood flow, and calmness and analgesic effect are arranged again, and the pharmacological action gentleness is taken safety, and is reliable through the clinical trial curative effect.Can be used for palpitation with a distress feeling, cardiopalmus, irregularly intermittent and regularly intermittent pulse, or light moderate artrial premature beat, ventricular premature contraction has above-mentioned disease person.The capsular usage of the made Fumaiding of the present invention: oral, 1 time 3,3 times on the 1st, specification: every adorn 0.35 the gram, contain the Radix Astragali with astragaloside (C ₁₄H ₆₈O ₁₄) meter be no less than 0.30 milligram.

Clinical trial situation following (adopt capsule preparations and Fumaiding electuary compare): no matter allly meet the Chinese and western medicine diagnostic criteria and differential diagnosis in tcm person age-sex all can include the clinical trial case in.Treatment group (100 example): each 3 of oral capsule (1.05 gram), every day 3 times.Matched group (60 example): each 1 bag of oral Fumaiding electuary (15 gram), every day 3 times, be 21 days two groups of courses of treatment, and experimental session must not add the Chinese and western medicine medicine relevant with treating primary disease.Two groups of treatment back effect contrasts are as shown in the table:

The clinical general curative effect comparison sheet of table 1 Ridit check: R=0.35 U=3.26 P=0.0011

Group	n	Clinical recovery		Produce effects		Effectively		Invalid		Total obvious effective rate %	Total effective rate %
												n	％	n	％	n	％	n	％
		The treatment group	100	19	19	39	39	35	35											7	7	58	93
Matched group	60									3	5	19	31.67	24	40	14	23	36.67	76.67

Table 2 traditional Chinese medical science disease curative effect comparison sheet Ridit check: R=0.39 U=2.42 P=0.015

Group	n	Clinical recovery		Produce effects		Effectively		Invalid		Total obvious effective rate %	Total effective rate %
												n	％	n	％	n	％	n	％
		The treatment group	100	29	29	38	38	27	27											6	6	67	94
Matched group	60									9	15	21	35	22	36.7	8	13	50	86.67

Ambulatory electrocardiogram curative effect comparison sheet before and after table 3 treatment

Index	Treatment group (n=38)			Matched group (n=18)			X 2	p
									Before the treatment	After the treatment	Disappearance rate %	Before the treatment	After the treatment	Disappearance rate %
	The room early	16	7	56.25	12	11									8.33	4.93	0.026
The chamber early							22	13	40.91	6	4	33.33	0.018	0.89

Can reach a conclusion by above data: curative effect all is better than Fumaiding electuary group to the made capsule of the present invention aspect the artrial premature beat at clinical efficacy, traditional Chinese medical science disease curative effect and reducing.

The specific embodiment

Embodiment 1

Take by weighing raw material (gram) by following weight proportion: Radix Codonopsis 1105 Radixs Astragali 813 Radix Polygalaes 725 Fructus Moris 713 Rhizoma Chuanxiongs 380.

Production method is as follows: the ethanol of adding 80% refluxes, and extracts 3 times, filters out medicinal residues, and each filtrate is merged.Concentrating under reduced pressure reclaims the ethanol in the filtrate then, makes it to be concentrated in right amount, adds water again concentrate is dissolved, and boiled 7 minutes, leaves standstill 40 hours under room temperature (20 ℃), makes it precipitation.Get the supernatant of post precipitation, make it to pass through D ₁₀₁The type macroporous adsorptive resins, the ethanol elution with 90%, the repeated multiple times eluting is collected each eluent and is reclaimed ethanol again and be concentrated in right amount, adds an amount of abundant stirring and evenly mixing of starch.In taking the remaining precipitate of supernatant away, add the abundant mixing of appropriate amount of starch.The soft material material of gained respectively at 80 ℃ of constant pressure and dries, is taken out from drying baker 3 days drying times after cooling, be ground into Powderedly, and sieve with 40 orders, remerge this moment, is yellowish-brown or dark brown powder after evenly mixed, just can incapsulate.With every net weight 0.35 gram is standard.

Embodiment 2

Take by weighing raw material (gram) by following weight proportion: Radix Codonopsis 995 Radixs Astragali 1023 Radix Polygalaes 823 Fructus Moris 523 Rhizoma Chuanxiongs 412

Production method is as follows: add 70% and reflux, extract 4 times, filter medicinal residues, each filtrate is merged.The thin film concentration that reduces pressure then reclaims the ethanol in the filtrate, makes it to be concentrated in right amount, adds water again concentrate is dissolved, and boiled 10 minutes, leaves standstill 55 hours under the room temperature (20 ℃), makes it precipitation.Get the supernatant of post precipitation, make it to pass through D ₁₀₁The type macroporous adsorptive resins, the ethanol elution with 90%, the repeated multiple times eluting is collected each eluent and is reclaimed ethanol again and be concentrated in right amount, adds an amount of abundant stirring and evenly mixing of starch.In taking the remaining precipitate of supernatant away, add the abundant mixing of appropriate amount of starch.The soft material thing of gained respectively at 80 ℃ of vacuum decompression dryings, is taken out from drying baker 2 days drying times after cooling, be ground into Powderedly, and sieve with 60 orders, remerge this moment, is yellowish-brown or dark brown powder after evenly mixed, just can incapsulate.With every net weight 0.35 gram is standard.

Claims (7)

1. the ARR Fumaiding Chinese medicine preparation of treatment is characterized in that it is made by the following weight proportion raw material: Radix Codonopsis 725～1506 Radixs Astragali 714～1071 Radix Polygalaes 595～892 Fructus Mori 610～878 Rhizoma Chuanxiongs 305～439.

2. the ARR Fumaiding Chinese medicine preparation of treatment according to claim 1, wherein the weight proportion of each raw material is: Radix Codonopsis 856～1235 Radixs Astragali 780～890 Radix Polygalaes 623～761 Fructus Mori 697～854 Rhizoma Chuanxiongs 352～411.

3. the ARR Fumaiding Chinese medicine preparation of treatment according to claim 2, wherein the weight proportion of each raw material is: Radix Codonopsis 1105 Radixs Astragali 813 Radix Polygalaes 725 Fructus Mori 713 Rhizoma Chuanxiongs 380.

4. the ARR Fumaiding Chinese medicine preparation of treatment according to claim 1, wherein said Chinese medicine preparation is the dosage form of saying on any pharmaceutics.

5. the ARR Fumaiding Chinese medicine preparation of treatment according to claim 4 is characterized in that said dosage form is a capsule.

6. the ARR Fumaiding capsule of treatment according to claim 5, its preparation method carries out according to the following steps successively: (1) gets above-mentioned Chinese medicine of the five flavours by weight ratio, and the alcohol reflux of usefulness 60%-90% 2-5 time filters merging filtrate;

(2) decompression recycling ethanol and be concentrated in right amount is dissolved in water, and boils 5-10 minute, and room temperature was placed 38-55 hour, made it precipitation;

(3) get the supernatant of post precipitation, pass through D ₁₀₁The type macroporous adsorptive resins with the ethanol elution of 80%-95%, is collected eluent and is reclaimed ethanol again and be concentrated in right amount adding appropriate amount of starch mixing;

(4) precipitate with (2) gained adds the appropriate amount of starch mixing;

(5) with the material of (3), (4) gained respectively at 60-85 ℃ of dry 2-4 days, natural cooling, the 20-100 order of pulverizing after the taking-up, sieve merges at last, and is evenly mixed;

(6): the powder after will mixing incapsulates.

7. the ARR Fumaiding capsule of treatment according to claim 6, the used ethanol of step in its preparation method (3) is 90%.