CN1056980C - Compound balsom pear capsules for curing diabetes and prepn. method thereof - Google Patents
Compound balsom pear capsules for curing diabetes and prepn. method thereof Download PDFInfo
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- CN1056980C CN1056980C CN94111598A CN94111598A CN1056980C CN 1056980 C CN1056980 C CN 1056980C CN 94111598 A CN94111598 A CN 94111598A CN 94111598 A CN94111598 A CN 94111598A CN 1056980 C CN1056980 C CN 1056980C
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Abstract
The present invention discloses a compound traditional Chinese medicine preparation for treating diabetes, which is prepared from bitter melon, calabash husk, angelica, madagascar periwinkle herb, bitter cotoneaster root, wolfberry bark, white mulberry root bark, etc. The preparation of the present invention has obvious curative effect especially for treating noninsulin-dependent diabetes mellitus. Through 1000 cases of clinical verification, the total effective rate reaches 92.5%, and the present invention also has conspicuous hypoglycemic functions for diabetes type I.
Description
The present invention relates to a kind of Chinese medicine preparation, especially for the Chinese traditional compound medicine of treatment diabetes.
This is according to the diabetes principle of classification suggestion that WHO " diabetologist committee " announced in 1980, and it is insulin-dependent that diabetes mainly are divided into type i diabetes; Type ii diabetes is a non-insulin-depending type; All the other types claimed stable diabetes in the past.At present common clinically and sickness rate is the highest is noninsulindependent diabetes.Interrelated data shows that there are about 1.2 hundred million people of diabetics in the whole world, and China has 2,100 ten thousand people approximately.Shanghai City citizen sickness rate 1% for example, it is many to send out the patient between 40-60 year, and the men and women remains basically stable, and this age bracket patient mostly is the II diabetes.
Each medical institutions measure of being used for treating diabetes at present mainly contains three kinds: the one, and the oral medication medicine, sulphanylureas, thus mainly stimulate the B emiocytosis insulin blood sugar lowering concentration of islets of langerhans, commercially available this quasi drugs such as tolbutamide (D 860, tolbutamide); Chlorpropamide (Mellinese); Glyburide (HB419), but this class medicine has only 70% patient that hypoglycemic reaction effectively and easily takes place, however it is more undesirable to have the percentage ratio of significant curative effect.The actual efficacy clinical expert of biguanides is difficult to final conclusion, and loss of appetite arranged, feel sick, side effect such as epigastric discomfort, the case report that erythra and lactic acidosis take place is still arranged; The 2nd, insulinize is mainly supplementation with insulin insufficiency of function alternative medicine; The 3rd, the style of work of one inner disease outer treat was risen in China in recent years, occurred diabetes control body-building generation on the market, it is said certain effect, but the clinical practice curative effect waits just can reach a conclusion after the long-term checking of extensive patients.
Medicine typing is adopted in the Chinese traditional treatment of diabetes more, and the principle with the disease plus-minus relates to over one hundred kind of medicine for treatment, the prescription dozens of, but curative effect is all undesirable.Continuous progress along with medical research, the pharmacology of Chinese herbal medicine, toxicity, especially chemical composition analysis research, in medicines and health protection system and chemical industry, each professional system of making up, especially Hundreds of flowers are in full bloom like rain the back spring bamboo, and Chinese herbal medicine dialectical the executing of the change old model prescription for a medical decoction song prescription of part is controlled, and trend is according to the pharmacological action of its chemical constituent and this composition thereof, in conjunction with the doctor trained in Western medicine theory, form new pharmacology dosage form.
The present invention tries hard to break away from differential diagnosis in tcm to execute the principles of formulating prescriptions of controlling, employing contains the Chinese herbal medicine that diabetes is had the effective ingredient of certain curative effect, pouring scorching to the diabetes theory of Chinese medical science deficiency of YIN is main levying, and with nourishing YIN and clearing away heat medicine Cheng Fang, develops compound preparation of the present invention.
An object of the present invention is to provide a kind of to diabetes particularly noninsulindependent diabetes tall and erect Chinese traditional compound medicine of imitating is arranged.
Another object of the present invention provides a kind of preparing such formulations.
The parts by weight prescription of preparation of the present invention is:
20 parts of Radix Angelicae Sinensis 9.5-10.5 of Fructus Momordicae charantiae part
Herba Catharanthi Rosei 7.5-8.5 part Pericarpium Lagenariae sicerariae 19.5-20.5 part
Coolie's bud 11.5-12.5 part Cortex Lycii 8.5-11.5 part
Cortex Mori 8.5-11.5 part Cortex Phellodendri 9.5-10.5 part.
A kind of preferred manufacturing procedure of medicament of the present invention is as follows:
Fructus Momordicae charantiae, Herba Catharanthi Rosei, coolie's bud, Radix Angelicae Sinensis, Cortex Phellodendri are made powder; After Pericarpium Lagenariae sicerariae was carried with decocting in water, concentrated leach cooking liquid got clear paste; After Cortex Lycii and Cortex Mori were carried with decocting in water, concentrated leach cooking liquid got clear paste; Described powder mixes with clear paste, drying, makes granule.
Preferably include described granule is incapsulated.
The pharmacology that main medicine in the medicament of the present invention is formed is according to being: kind of alkaloid surplus Herba Catharanthi Rosei-basis " Chinese medicine voluminous dictionary " record contains 70, and as vinblastine, vincristine etc.External among the people with Changchun floral leaf and whole plant treatment sucrose solution disease, compositions such as isolated Vindoline, Lourosine, Lochnerine, Catharanthine, Tetrahydroa, Lslonine, Vindinine all have blood sugar reducing function in various degree from Herba Catharanthi Rosei, beginning is slow, but effect is lasting.Cortex Lycii-basis " Chinese medicine voluminous dictionary " record: its decoct clothes back elder generation short time blood sugar increasing, persistent decline then appears, and animal experiment confirms that also senior animals such as hairy rat are had significant blood sugar reducing function.Its blood sugar reducing function is main because it contains the derivant of " guanidine ", and " clinical practice Chinese materia medica " claims to control to quench one's thirst, and " Treatise on Dietetic Therapy " claims " heat of boning is quenched one's thirst ", and the extract (RE) of its decoct of modern study and root has remarkable and persistent blood sugar lowering effect.Fructus Momordicae charantiae-basis " Chinese medicine voluminous dictionary " record: hypoglycemic activity is arranged, rabbit normal and the trouble alloxan diabetes is gavaged the Fructus Momordicae charantiae juice can make blood glucose obviously reduce, the rat that subcutaneous injection anterior pituitary extractum causes hyperglycemia, gavaging Fructus Momordicae charantiae slurry sweat extract has the effect of blood sugar lowering, rabbit is irritated Charantin blood sugar reducing function, and the cat of extracing pancreas is also had blood sugar reducing function.
Each composition complements each other in the preparation of the present invention, and synergism makes this medicament to treatment noninsulindependent diabetes (NIDDM) example checking surplus 1000, and total effective rate reaches 92.5%, and curative effect is very remarkable.This medicine also can obviously reduce the oral glucose tolerance test blood sugar level, the effect of the patient's NIDDM carbohydrate tolerance that is significantly improved.In treatment and with this agent auxiliary treatment, find that this agent has the effect that reduces insulin dosage for insulin-dependent diabetes, can make the state of an illness steady, illustrate that this medicament also has curative effect preferably to type i diabetes.The effect of this medicament is lasting, effect stability.
Further specify the present invention below by embodiment:
Embodiment: get 7.2732kg Fructus Momordicae charantiae, 2.9093kg Herba Catharanthi Rosei, 4.3884kg coolie's bud, 3.6366kg Radix Angelicae Sinensis, 3.6366kg Cortex Phellodendri and make powder; 7.3140kg Pericarpium Lagenariae sicerariae after decocting in water is carried, filter leach cooking liquid, concentrated leach cooking liquid gets clear paste; After 3.2119kg Cortex Lycii and 3.2119kg Cortex Mori are carried with decocting in water together, filter leach cooking liquid, concentrated leach cooking liquid gets clear paste; Described powder is become bulky grain with clear paste mixing after drying, pulverizes guiding humid medium (as water) and become wet grain, dry positive grain finished particle, filled capsules makes finished product.Every capsules contains granule 0.25 gram.This capsule oral, every day three times, each 2-3 grain.
The quality standard of finished product is as follows:
1. microscopical identification: get one of capsule, check at microscopically in accordance with the law: be multiaspect shape, square, class biconial (r=11-32 μ m) under the calcium oxalate crystal, the visual field, the person is more for Cortex Mori class biconial.Cortex Phellodendri is less, and it is diffusing from the person that stone cell has in groups the person also have, and similar round, class are square, the class polygon all has, and bright-coloured yellow person is a Cortex Phellodendri, and yellowish-brown burgundy person is a Cortex Mori.
2. content uniformity: appoint and get that 10 of finished capsule products are accurate respectively to claim to decide content, every loading amount is compared with labelled amount should be between 0.225-0.275, and defective work must not be more than 2, and one times of an overrun must not be arranged.
3. disintegration: appoint and get 6 of finished capsule products, put in the disintegration of tablet instrument, operated 30 minutes in accordance with the law, all screen cloth is passed through in disintegrate.
4. moisture: press 30 pages of moisture analysis of 90 editions appendix of Chinese Pharmacopoeia, must not＞9%.
5. hygiology is tested: test method according to the medicine health, the every gram of assorted bacterium sum must not surpass 10000, and escherichia coli, the demodicid mite that lives must not detect, and the every gram of mycete must not be above 500.
Use example surplus this pharmaceutical treatment noninsulindependent diabetes 1000, the patient who 120 examples is taken this medicament carries out Prospective Study, and with 30 surplus example use diabetes pill the same period patient relatively.Criterion of therapeutical effect is: treatment back symptom obviously disappears, and fasting glucose is reduced to＜130mg/dl, the 24h glucose in urine quantitatively＜10g or blood glucose and the more preceding decline 30% above person of 24h glucose in urine are produce effects; Treatment back symptom is obviously improved, and fasting glucose is reduced to＜150mg/dl, and quantitative 10-25g of 24h glucose in urine or blood glucose and the more preceding decline of 24h glucose in urine 10-20% person are effective; Treatment back blood glucose and glucose in urine do not reach above-mentioned standard person for invalid.The result shows, the clinical treatment group of taking this medicament, and blood glucose and twenty-four-hour urine sugar obviously reduce, total effective rate 92.5%, and take the diabetes pill matched group, effective percentage only is 80.0% (P＜0.05).This medicament still can obviously reduce the oral glucose tolerance test blood sugar level in addition, the effect of the patient's NIDDM carbohydrate tolerance that is significantly improved, and the treatment to type ii diabetes has obvious curative effects.Type i diabetes is also used this medicament in treatment, find that this medicament has the effect that reduces insulin dosage, can make the state of an illness steady.
Claims (3)
1. Chinese traditional compound medicine for the treatment of diabetes is characterized in that being made by following materials based on weight:
20 parts of Radix Angelicae Sinensis 9.5-10.5 of Fructus Momordicae charantiae part
Herba Catharanthi Rosei 7.5-8.5 part Pericarpium Lagenariae sicerariae 19.5-20.5 part
Coolie's bud 11.5-12.5 part Cortex Lycii 8.5-11.5 part
Cortex Mori 8.5-11.5 part Cortex Phellodendri 9.5-10.5 part.
2. the preparation method of a preparation as claimed in claim 1 is characterized in that Fructus Momordicae charantiae, Herba Catharanthi Rosei, coolie's bud, Radix Angelicae Sinensis, Cortex Phellodendri make powder; After Pericarpium Lagenariae sicerariae was carried with decocting in water, concentrated leach cooking liquid got clear paste; After Cortex Lycii and Cortex Mori were carried with decocting in water, concentrated leach cooking liquid got clear paste; Described powder mixes with clear paste, drying, makes granule.
3. method as claimed in claim 2 is characterized in that described granule is incapsulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94111598A CN1056980C (en) | 1994-11-08 | 1994-11-08 | Compound balsom pear capsules for curing diabetes and prepn. method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94111598A CN1056980C (en) | 1994-11-08 | 1994-11-08 | Compound balsom pear capsules for curing diabetes and prepn. method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1122699A CN1122699A (en) | 1996-05-22 |
| CN1056980C true CN1056980C (en) | 2000-10-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94111598A Expired - Fee Related CN1056980C (en) | 1994-11-08 | 1994-11-08 | Compound balsom pear capsules for curing diabetes and prepn. method thereof |
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| Country | Link |
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| CN (1) | CN1056980C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057225C (en) * | 1997-04-17 | 2000-10-11 | 胡荣龙 | Process for preparing charantin |
| CN102048132B (en) * | 2009-10-27 | 2013-06-19 | 上海黄金搭档生物科技有限公司 | Health-care food for reducing blood sugar |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066602A (en) * | 1992-05-08 | 1992-12-02 | 王德修 | The compound method of hypoglycemic compound capsule |
| CN1082844A (en) * | 1992-08-21 | 1994-03-02 | 刘春天 | Process for producing health beverage specially for diabetics |
-
1994
- 1994-11-08 CN CN94111598A patent/CN1056980C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066602A (en) * | 1992-05-08 | 1992-12-02 | 王德修 | The compound method of hypoglycemic compound capsule |
| CN1082844A (en) * | 1992-08-21 | 1994-03-02 | 刘春天 | Process for producing health beverage specially for diabetics |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1122699A (en) | 1996-05-22 |
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