CN1053583C - Medicine for diabetes and its prepn - Google Patents
Medicine for diabetes and its prepn Download PDFInfo
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- CN1053583C CN1053583C CN96115929A CN96115929A CN1053583C CN 1053583 C CN1053583 C CN 1053583C CN 96115929 A CN96115929 A CN 96115929A CN 96115929 A CN96115929 A CN 96115929A CN 1053583 C CN1053583 C CN 1053583C
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Abstract
The present invention relates to a medicine for treating diabetes and the complications thereof, and a preparation method thereof. The medicine mainly comprises the following components: ginseng, rehmanniae, common anemarrhena rhizome, pollen, glibenclamide and N-phenethyldiguanide; besides the components, the medicine for treating the complications of diabetes also comprises kudzuvine root, Chinese magnolivine fruit, coptis, hemlock parsley, safflower red sage root, wild castor, red peony root, milkvetch root, aspirin and Tmp. The preparation method of the present invention comprises the mixing, decoction, concentration, drying, pulverization and autoclave sterilization of traditional Chinese medicines, and the mixing of the Western medicines and the traditional Chinese medicines. The present invention can be used for treating diabetes and the complications thereof caused by various causes of disease, the conspicuous effective rate is 95%, and the effective rate is 100%.
Description
The present invention relates to a kind of medicine and its manufacture method for the treatment of diabetes and complication thereof, belong to the medicine class.
The medicine of existing treatment diabetes is a lot, Western medicine such as insulin, and sulphanylureas, biguanides, though effective in cure, to cure the symptoms, not the disease, prolonged application will produce drug resistance and certain toxicity; Chinese patent medicine such as JIANGTANGSHU, glycolipid disappear etc., and be only effective to the diabetes of the specific cause of disease.Because onset diabetes mechanism complexity, type is a lot, and its clinical manifestation differs, and middle and advanced stage can concurrent other disease, and it is all undesirable to be used for clinical multiple Chinese medicine and western medicine, also is so to various complication, part drug price costliness, and general patient also is difficult for accepting.
One of purpose of the present invention is to provide a kind of medicine that can treat Different types of etiopathogenises and type diabetes, and the double medicine of controlling corresponding complication of energy, and two of purpose is to provide the manufacture method of above medicine.
Technical solution of the present invention is as follows: The present invention be directed to Different types of etiopathogenises and the type diabetes are analysed scientifically comprehensively, take into account multiple complications, adopt the compatibility of drugs of science, filter out the cheap effectively Chinese herbal medicine of series and be equipped with corresponding Western medicine and form.
To the treatment of diabetes principle is its lung of profit, and its stomach is grown its kidney clearly, support its moon, so the present invention adopts and have during complement transfers, promote the production of body fluid and allay excitement, the YIN nourishing of astringing the lung, clearing stomach yin nourishing, lung moistening Radix Ginseng, Radix Rehmanniae, the Rhizoma Anemarrhenae, the pollen of effect such as quench the thirst is main medicine, be equipped with the Western medicine glibenclamide, the N-phenformin forms, its parts by weight proportioning is Radix Ginseng 0.5-10 part, Radix Rehmanniae 6-30 part, Rhizoma Anemarrhenae 3-10 part, pollen 5-30 part, glibenclamide 0.6-2.5 part, N-phenformin 7-20 part.Wherein, Radix Ginseng has promoting the production of body fluid to quench thirst, mend strengthening spleen and lung, strengthen Tissue respiration, promote the saccharide zymolysis, have synergism with islets of langerhans, euglycemia and epinephrine induced hyperglycemia there are the reduction effect, can be excited myocardium, improve cardiac function, promote albumen synthetic, strengthen body adaptability and to the disease resistivity to external world.Radix Rehmanniae energy nourishing the blood and yin, vital essence replenishing and marrow benifiting prevents that liver glycogen from reducing, though reduce sugar, glucose in urine improves renal function, heart tonifying, blood pressure lowering, diuresis.Rhizoma Anemarrhenae clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, the blood pressure lowering calmness, its water extract can cause that blood glucose descends, ketoboidies reduces in the urine.The pollen clearing away heat and promoting production of body fluid, the lung moistening stomach reinforcing quenches the thirst, and is used for consumption of body fluid caused by febrile disease, and is thirsty and quench one's thirst.Glibenclamide can stimulate secretion of insulin, promotes myocyte, the adipose cell utilization to glucose, reduces the degraded of liver to insulin.The N-phenformin can promote the adipose cell ingestion of glucose, suppresses the plain release of the high sugar of islets of langerhans, suppresses the generation of insulin antagonist in the body.
The present invention treat the diabetes another kind preferably embodiment be on the said ratio basis, also to include Radix Puerariae, Fructus Schisandrae Chinensis, Rhizoma Coptidis, its parts by weight proportioning is: Radix Puerariae 5-30 part, Fructus Schisandrae Chinensis 3-10 part, Rhizoma Coptidis 1-10 part.Radix Puerariae has analgesic promoting the production of body fluid, and vasospasm is removed in the effect of yang invigorating antidiarrheal, but blood sugar lowering, reduces vascular resistance, and coronary artery dilator increases its blood flow.The Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, restrain astringent or styptic treatment for spontaneous sweating, kidney calming, heart tonifying is regulated cardiovascular function, improves blood circulation.The Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication, blood pressure lowering, calmness, excited heart, coronary blood flow increasing.Microcirculation improvement, the human body immunity improving function.The adding of Radix Puerariae, Fructus Schisandrae Chinensis, Rhizoma Coptidis can make curative effect better.
The present invention also selects for use on above-mentioned two kinds of proportioning bases has blood circulation promoting and blood stasis dispelling, strongly invigorating primordial QI, microcirculation improvement, improve Rhizoma Chuanxiong, Flos Carthami, Radix Salviae Miltiorrhizae, the white wood Chinese tallowtree root bark of immunocompetence, with the multiple complications of treatment diabetes, its parts by weight proportioning is Rhizoma Chuanxiong 3-20 part, Flos Carthami 3-20 part, Radix Salviae Miltiorrhizae 3-30 part, white wood Chinese tallowtree root bark 0.3-3 part.Rhizoma Chuanxiong has blood-activating and qi-promoting, coronary artery dilator, and coronary blood flow increasing promotes microcirculation, suppresses thrombotic effect.Can resist the acute myocardial ischemia that pituitrin causes, reduce the cardiac muscle consumption and support, make vascular resistance reduce blood pressure drops.Radix Salviae Miltiorrhizae has blood circulation promoting and blood stasis dispelling, the relieving restlessness effect that clears away heart-fire, but blood sugar lowering, blood fat, blood pressure, and blood vessel dilating, coronary blood flow increasing strengthens the anti-ability of supporting that lacks of cardiac muscle, and decreasing heart rate improves cardiac function, and anticoagulant prolongs thrombosis.The Flos Carthami promoting blood circulation to remove blood stasis, blood pressure lowering, coronary blood flow increasing and anoxia enduring have preventive effect to myocardial ischemia, prolong clotting time, reduce the total fat of cholesterol in serum, trinitroglycerin and non-esterified fatty acid level, are used for coronary heart disease, angina pectoris.White wood Chinese tallowtree root bark can be removed vasospasm, lowers vascular resistance, increases SBF, and microcirculation improvement is alleviated the optical fundus arteriolospasm, is used for cerebral vasospasm, cerebral embolism, optical fundus arterial thrombus.The adding of Rhizoma Chuanxiong, Flos Carthami, Radix Salviae Miltiorrhizae, white wood Chinese tallowtree root bark can effectively prevent and treat multiple complications in a word.
The present invention to complication another preferably embodiment be on the said ratio basis, to add Radix Paeoniae Rubra 3-15 part, Radix Astragali 6-40 part.Radix Paeoniae Rubra has clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Coronary artery dilator, coronary blood flow increasing reduces vascular resistance, brings high blood pressure down, to resisting myocardial ischemia.Strengthen anoxia tolerance, anticoagulant.The Radix Astragali has tonifying Qi and lifting yang, and inducing diuresis to remove edema quenches the thirst, and blood sugar lowering strengthens heart contraction, and blood vessel dilating increases cardiac output, and decreased heart rate brings high blood pressure down, and enhancing antibody is synthetic, improves the effect of human leukocytes inducement interferon and raise immunity.
The present invention another preferably embodiment be on above-mentioned various proportionings basis, to add aspirin 2-20 part.The effect of aspirin is: 1., suppress hydrogenase, makes that suppository is synthetic with fixed attention reduces, corrects blood platelet disorders, obviously reduce the heart infarction incidence rate, mortality rate is reduced, but the prevention of brain ischemia property crossed outbreak again.2., the prevention cataract forms.The human body crystalline protein accounts for crystal 3 0%, after it once forms, almost completely without metabolism.In case so after the crystalline protein saccharifying,, become the main cause of diabetic cataract promptly with the irreversible reaction accumulation; And aspirin can make the acetylation of crystalline protein free amino group, reduces the nonenzymatic glycosylation level, thereby prevents that cataract from forming.3. but microcirculation improvement reduces retinopathy, prevents that retina from oozing out.4., by pharmacokinetics, the free amount of sulphur urea is increased, thereby increases sulphur urea blood sugar reducing function.
The present invention another preferably embodiment be on above-mentioned various proportionings basis, to add Tmp10-20 part, Tmp has potentiation, pass through pharmacokinetics, in plasma protein joint portion and sulphur urea competition displacement, increase its free amount, thereby heighten the effect of a treatment, Tmp is during from tubular secretion, also can compete, thereby its discharge is slowed down, increasing blood flow concentration with the sulphur urea.
Processing technology of the present invention is as follows:
Chinese medicine mixes, and------------autoclaving---mixes---quantitative package to concentrate drying with the Western medicine after pulverizing in the Chinese medicine pulverizing in decoction.
At first, required Chinese medicine is taken by weighing and mixes by (except Radix Ginseng, the white wood Chinese tallowtree root bark) a certain proportioning, pack into then and decocted 1-2 hour in the decoction pot, so that active ingredient can fully be separated out in the various medicines, pull 3/5 medicinal residues out, remainder sent into together with medicinal liquid carry out concentrate drying in the vacuum concentration drying machine, process conditions are: vacuum 0.1-0.5kg/cm
2, temperature 80-100 ℃, time 1-2 hour.After treating the medicine bone dry, add Radix Ginseng (having the words of white wood Chinese tallowtree root bark also to add) and send in the pulverizer and pulverize, granularity is with can be by 80-120 eye mesh screen degree of being.To pulverize back medicated powder and send into high pressure sterile device sterilization, then with pulverize after the Western medicine mixing and stirring, get final product by quantitative package at last.
The medicine medicine source of the treatment diabetes that the present invention makes does not extensively have special your medicine, and is evident in efficacy, not only can treat the diabetes of Different types of etiopathogenises and type, but also can prevent and treat multiple complications, significantly effective percentage reaches 95%, effective percentage 100%, toxic and side effects is little, can receive the treating both the principal and secondary aspects of a disease effect.
Below take passages the case that several examples adopt the present invention to cure.
Example 1, certain woman, 50 years old, the Pinglidian town office worker of Laizhou City, diabetes 10 years, former blood glucose 16mmol/dl, glucose in urine (++ ++), serious depleted, can't take care of oneself, treat the medicine treatment of diabetes after 2 months through adopting the present invention, blood glucose 7mmol, glucose in urine (-), life can be taken care of oneself, and is engaged in slight work.
Example 2, certain man, 40 years old, glycosuria 5 years once went Jinan, Qingdao, Henan, Beijing treatment, and the state of an illness is not felt any better, and blood glucose is 16.5mmol/l still, glucose in urine ++ ++, behind this medicine treatment first quarter moon, glucose in urine ++, blood glucose 4.5mmol/l.
Example 3, certain man, 46 years old, glucose in urine 4 years, glucose in urine (++ ++), blood glucose 17mmol/dl, treatment back glucose in urine (-), blood glucose 8mmol/dl cures, no complication, check in 8 months after the drug withdrawal, glucose in urine (-) does not have any diabetic symptom.
Provide embodiments of the invention below, be used for further specifying medicine for the treatment of diabetes and preparation method thereof.
One embodiment of the invention is, press 0.5 part of Radix Ginseng, 6 parts of Radix Rehmanniae, 3 parts of the Rhizoma Anemarrhenaes, the weight ratio that pollen is 5 parts accurately takes by weighing medicine, will put into decoction pot decoction 2 hours jointly by other Chinese medicine except that Radix Ginseng, 3/5 the medicinal residues of pulling out from pot abandon, remainder sent into together with medicinal liquid carry out vacuum drying in the vacuum concentration drying machine, its temperature is controlled at 80 ℃, vacuum pressure 0.5kg/cm
2, 2 hours time, adding weighs up Radix Ginseng after the band medicine intensive drying, sends in the pulverizer and pulverizes, and fineness is to be as the criterion by 80 order dusting covers.The medicated powder that makes is carried out autoclaving, then with pulverize after 1 part of Western medicine glibenclamide, 7 parts of N-phenformins, mixing and stirring is packed in the medical capsule by the specification of 0.6g/ ball.
Another embodiment of the present invention is to press 10 parts of Radix Ginsengs, 30 parts of Radix Rehmanniae, 10 parts of the Rhizoma Anemarrhenaes, 30 parts of pollen, 30 parts of Radix Puerariaes, 10 parts of Fructus Schisandrae Chinensis, the ratio that Rhizoma Coptidis is 10 parts takes by weighing medicine, will be except that Radix Ginseng other Chinese medicine put into decoction pot together and decoct 1.5 hours, pull about 3/5 medicinal residues then out and abandon, remainder is sent into together with medicinal liquid and is carried out concentrate drying in the vacuum concentration drying machine, temperature is 100 ℃, vacuum pressure 0.1kg/cm
2, 1 hour time, to treat to add behind the medicine bone dry Radix Ginseng that takes by weighing and pulverize, its fineness is with by 120 order dusting cover degree of being.Medicated powder is carried out autoclaving, then with pulverize after 1.5 parts of Western medicine glibenclamides, 12 parts of N-phenformins, mixing and stirring is packed in the medical capsule by the specification of 0.6g/ ball.
Third embodiment of the invention is: press 5 parts of Radix Ginsengs, 6 parts of Radix Rehmanniae, 3 parts of the Rhizoma Anemarrhenaes, 3 parts of pollen, 5 parts of Radix Puerariaes, 3 parts of Fructus Schisandrae Chinensis, 1 part of Rhizoma Coptidis, 3 parts of Rhizoma Chuanxiongs, 3 parts on Flos Carthami, 3 parts of Radix Salviae Miltiorrhizaes, the ratio that white wood Chinese tallowtree root bark is 0.3 part takes by weighing Chinese medicine, 0.6 part of glibenclamide, it is standby that the ratio that the N-phenformin is 7 parts takes by weighing Western medicine.The Chinese medicine that has taken by weighing is prepared into Chinese medicine powder by the preceding five processes among the embodiment 1, wherein the people participates in white wood Chinese tallowtree root bark and adds when Chinese medicine is pulverized, with take by weighing standby Western medicine pulverize the back with Chinese medicine powder after stirring, packing into by 0.6g/ ball specification promptly becomes the Drug Capsule of treatment diabetes behind the medical capsule.
Four embodiment of the invention is: press 10 parts of Radix Ginsengs, 30 parts of Radix Rehmanniae, 10 parts of the Rhizoma Anemarrhenaes, 30 parts of pollen, 30 parts of Radix Puerariaes, 10 parts of Fructus Schisandrae Chinensis, 10 parts of Rhizoma Coptidis, 15 parts of Radix Paeoniae Rubra, 20 parts of Rhizoma Chuanxiongs, 20 parts on Flos Carthami, 30 parts of Radix Salviae Miltiorrhizaes, 40 parts of the Radixs Astragali, the ratio that white wood Chinese tallowtree root bark is 3 parts takes by weighing Chinese medicine, press 2.5 parts of glibenclamides, it is standby that the ratio that the N-phenformin is 20 parts takes by weighing Western medicine.Preparation method of Chinese medicine is identical with the preceding five processes of embodiment 3, equally the people being participated in white wood Chinese tallowtree root bark adds when Chinese medicine is pulverized, with the Chinese medicine powder that prepared with pulverized standby Western medicine mixing and stirring after, promptly make the Drug Capsule of treatment diabetes after the specification packing by the 0.6g/ ball.
Fifth embodiment of the invention is: take by weighing Chinese medicine in the ratio among the embodiment 4, different is 3 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Chuanxiongs, 10 parts on Flos Carthami, 20 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 1.2 parts of white wood Chinese tallowtree root barks, press 3 parts of aspirin, 2.5 parts of glibenclamides, the ratio that the N-phenformin is 20 parts takes by weighing Western medicine.Its preparation method is identical with embodiment 4, promptly makes the Drug Capsule of treatment diabetes.
Sixth embodiment of the invention is: take by weighing Chinese medicine in the ratio among the embodiment 4, wherein Radix Paeoniae Rubra, Radix Astragali ratio are different with embodiment 4,8 parts of Radix Paeoniae Rubra, 30 parts of the Radixs Astragali are pressed 20 parts of aspirin, 1.8 parts of glibenclamides, 15 parts of N-phenformins, Tmp10 part takes by weighing Western medicine.Manufacture method is identical with embodiment 4.
Embodiment 7, and difference from Example 6 is that Tmp is 20 parts, 10 parts of aspirin.
Above embodiment can adopt 1kg/ part or 100kg/ part, 10kg/ part etc.
Claims (8)
1, a kind of medicine for the treatment of diabetes, it is characterized in that it includes Radix Ginseng, Radix Rehmanniae, the Rhizoma Anemarrhenae, pollen and glibenclamide, N-phenformin, its parts by weight proportioning is Radix Ginseng 0.5-10 part, Radix Rehmanniae 6-30 part, Rhizoma Anemarrhenae 3-10 part, pollen 5-30 part, glibenclamide 0.6-2.5 part, N-phenformin 7-20 part.
2, according to the medicine of the described treatment diabetes of claim 1, it is characterized in that also including Radix Puerariae, Fructus Schisandrae Chinensis, Rhizoma Coptidis, its parts by weight proportioning is Radix Puerariae 5-30 part, Fructus Schisandrae Chinensis 3-10 part, Rhizoma Coptidis 1-10 part.
3,, it is characterized in that also including Rhizoma Chuanxiong 3-20 part, Flos Carthami 3-20 part, Radix Salviae Miltiorrhizae 3-30 part, white wood Chinese tallowtree root bark 0.3-3 part according to the medicine of the described treatment diabetes of claim 1.
4,, it is characterized in that also including Radix Paeoniae Rubra 3-15 part, Radix Astragali 6-40 part according to the medicine of the described treatment diabetes of claim 3.
5, according to claim 1 or 2 or the medicine of 3 or 4 described treatment diabetes, it is characterized in that also being surrounded by aspirin 2-20 part.
6,, it is characterized in that also being surrounded by Tmp10-20 part according to the medicine of the described treatment diabetes of claim 5.
7, a kind of manufacture method for the treatment of the medicine of diabetes, include Chinese medicine mixing, decoction, concentrate drying, Chinese medicine pulverizing, autoclaving, Western medicine pulverizing, the mixing of Chinese and Western medicated powder, packing, it is characterized in that described Chinese medicine mixing does not comprise Radix Ginseng, white wood Chinese tallowtree root bark, these two kinds of Chinese medicines directly add when Chinese medicine is pulverized, described decocting time is 1-2 hour, described concentrate drying is sent into together with medicinal liquid for the remainder of pulling 3/5 medicinal residues after will decocting out and is carried out in the vacuum concentration drying machine, and the granularity of described pulverizing is with can be by 80-120 eye mesh screen degree of being.
8,, it is characterized in that the process conditions of described concentrate drying are: vacuum 0.1-0.5kg/cm according to the medicine manufacture method of the described treatment diabetes of claim 7
2, temperature 80-100 ℃, time 1-2 hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96115929A CN1053583C (en) | 1996-08-15 | 1996-08-15 | Medicine for diabetes and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96115929A CN1053583C (en) | 1996-08-15 | 1996-08-15 | Medicine for diabetes and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1151888A CN1151888A (en) | 1997-06-18 |
| CN1053583C true CN1053583C (en) | 2000-06-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96115929A Expired - Fee Related CN1053583C (en) | 1996-08-15 | 1996-08-15 | Medicine for diabetes and its prepn |
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| Country | Link |
|---|---|
| CN (1) | CN1053583C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318047C (en) * | 2004-09-14 | 2007-05-30 | 李雅谷 | Medicine for preventing and curing cardio cerebral varscular diseases and its preparing method |
| CN101224256B (en) * | 2008-01-11 | 2011-07-20 | 刘振德 | Antidiabetics compounds of Chinese and western materia medica and preparing method thereof |
-
1996
- 1996-08-15 CN CN96115929A patent/CN1053583C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 华西医学，9,4 1919.9.4 王德全，降糖汤治疗53例消渴病效分析 * |
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| Publication number | Publication date |
|---|---|
| CN1151888A (en) | 1997-06-18 |
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