CN1318047C - Medicine for preventing and curing cardio cerebral varscular diseases and its preparing method - Google Patents
Medicine for preventing and curing cardio cerebral varscular diseases and its preparing method Download PDFInfo
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- CN1318047C CN1318047C CNB2004100514410A CN200410051441A CN1318047C CN 1318047 C CN1318047 C CN 1318047C CN B2004100514410 A CNB2004100514410 A CN B2004100514410A CN 200410051441 A CN200410051441 A CN 200410051441A CN 1318047 C CN1318047 C CN 1318047C
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Abstract
The present invention relates to a medicine for preventing and treating cardiovascular/cerebrovascular diseases and a preparation method thereof. The crude drugs of the medicine for preventing and treating cardiovascular/cerebrovascular diseases mainly comprise acetylsalicylic acid and red sage roots, wherein the weight ratio of the acetylsalicylic acid and the red sage root is 1: (2 to 100), and the preparation type adopts oral preparation. The preparation method of the medicine for preventing and treating cardiovascular/cerebrovascular diseases comprises: after red sage root extract, the acetylsalicylic acid and dispersants are mixed, the mixture is manufactured into granules, and the granules are further processed into various preparations. The medicine for preventing and treating cardiovascular/cerebrovascular diseases of the present invention is characterized in that the acetylsalicylic acid is a western medicine, which can treat manifestations of diseases, and the acetylsalicylic acid is used for reducing blood viscosity and preventing thrombosis; the red sage root is a traditional Chinese medicine, which can treat root causes of diseases, and the red sage roots are used for protecting myocardium, dilating coronary vessels, preventing myocardial ischemia, improving microcirculation and reducing blood lipid; the acetylsalicylic acid and the red sage roots are combined to realize the synergy of Chinese and western medicines for treating both manifestations and root causes of diseases, the curative effect is improved, and the toxic side effects on human bodies are reduced.
Description
Technical field
The present invention relates to a kind of medicine of preventing and treating cardiovascular and cerebrovascular disease, relate in particular to the aspirin compound preparation, the invention still further relates to this medicine production method.
Background technology
Aspirin is as antipyretic analgesic, because determined curative effect, applied widely, safe in utilization and cheap becomes one of whole world medicine that generally acknowledge, most widely used.From the seventies find this medical instrument have suppress the prostaglandin anabolic effect since, novel clinical use is on the increase, particularly at treating cardiac and cerebral vascular diseases, low-dosage aspirin has blood viscosity, dilute blood, the anticoagulant of reduction, prevents thrombotic effect.Radix Salviae Miltiorrhizae has protection cardiac muscle, improves cardiac function, coronary artery dilator, increase coronary flow, resists myocardial ischemia, improves myocardial infarction, expansion peripheral vessels, blood pressure lowering, anticoagulant and coagulation function, microcirculation improvement and hemorheology status, antithrombotic form, protection erythrocyte membrane and effects such as anti-hypoxia, blood fat reducing and atherosclerosis.
Chinese patent 46115929.4 relates to a kind of medicine for the treatment of diabetes and complication thereof and preparation method thereof, its Main Ingredients and Appearance has Radix Ginseng, Radix Rehmanniae, the Rhizoma Anemarrhenae etc., also need add Chinese medicines such as Rhizoma Chuanxiong, Flos Carthami, Radix Salviae Miltiorrhizae and Western medicine aspirin, TMP for complication, be Radix Salviae Miltiorrhizae, aspirin and other drug compound recipe, be used for the treatment of diabetic complication.
Up to now, do not see the report of two medicines as compound preparation treatment cardiovascular and cerebrovascular disease.
Summary of the invention
Purpose of the present invention is exactly in order to overcome single effect that can not play treating both the principal and secondary aspects of a disease with aspirin or Radix Salviae Miltiorrhizae, the shortcoming of and poor effect big to the using dosage of control cardiovascular and cerebrovascular disease provides the good aspirin of a kind for the treatment of both the principal and secondary aspects of a disease, synergistic action effect and the compound preparation of Radix Salviae Miltiorrhizae.The present invention also provides the production method of this preparation.
The compound preparation that the present invention also further provides the little cardiovascular and cerebrovascular diseases medicament of aspirin, Radix Salviae Miltiorrhizae and other toxic and side effects such as Radix Angelicae Sinensis, Flos Carthami to make.
The present invention realizes like this.
The drug main of control cardiovascular and cerebrovascular disease of the present invention will be the compound preparation that aspirin and Radix Salviae Miltiorrhizae are formed by crude drug, Radix Salviae Miltiorrhizae is processed into extractum earlier and is used as medicine, wherein aspirin [chemical name: 2-acetoxy-benzoic acid] can be 1: 21.5 with the weight ratio of Radix Salviae Miltiorrhizae extractum, 1: 2,1: 100, add filler, diluent, disintegrating agent, binding agent, food coloring, sweeting agent of acceptable routine pharmaceutically etc., make pharmaceutically conventional peroral dosage form, comprise tablet, capsule, soft capsule, granule, pill.In order to alleviate the stimulation of aspirin to stomach, these tablets, capsule, granular preparation can be after granulation enteric coated material, make enteric coated preparation.
Its production method is that Radix Salviae Miltiorrhizae of the present invention is made Radix Salviae Miltiorrhizae extractum earlier.Radix Salviae Miltiorrhizae extractum adopts the common process in present technique field to make, and can adopt following prepared:
Radix Salviae Miltiorrhizae adds the ethanol submergence, refluxes 1～2 hour, filters, and filtrate recycling ethanol concentrates; Adding 40～70% ethanol (percent by volume, promptly alcoholic acid volume account for and mix the percent by volume that solvent is extracted in the back, down together) second time refluxed 1～2 hour, filter, also can add water more for the third time and reflux 1～2 hour, filter, merge two, three times filtrate, reclaim ethanol, concentrate; Merge with primary concentrated solution, mixing is concentrated into the extractum that proportion is 1.35～1.39 (55～60 ℃) (grams per milliliters).Wherein every gram Radix Salviae Miltiorrhizae is made the Radix Salviae Miltiorrhizae extractum of 0.1～0.3 gram.
Get above-mentioned Radix Salviae Miltiorrhizae extractum, mix, add dispersants such as amount of starch, add an amount of wetting agent such as ethanol with the aspirin fine powder, the granulation of sieving, granule is made in oven dry; Or further encapsulated, make capsule.
Get above-mentioned Radix Salviae Miltiorrhizae extractum, mix, add an amount of wetting agent such as starch slurry with aspirin fine powder, amount of starch, the granulation of sieving, oven dry, granulate sieves; Adding fluidizer magnesium stearate, Pulvis Talci lubricate, and tabletting is made tablet.
Make the sheet heart with above-mentioned conventional tablet, copolymer L type (German Romo Co.,Ltd produces) with methacrylic acid-methyl methacrylate is made coating material, uses dissolve with ethanol, makes 10～15% solution, the enteric coated enteric coatel tablets of making, these enteric coatel tablets are solvable more than pH6.The enteric-coating material that the present invention also can adopt other present technique field those of ordinary skill to know.
Compound preparation of the present invention also can add 1/5～5 times Radix Angelicae Sinensis of Radix Salviae Miltiorrhizae weight and/or 1/3～3 times crude drug such as Flos Carthami except that Radix Salviae Miltiorrhizae and aspirin, show also possess similar curative effect through clinical trial.
The medicine of control cardiovascular and cerebrovascular disease of the present invention as weighing foundation, is grown up to 27mg～30mg measures at every turn every day 1～3 time with the dose of aspirin.
The medicine of control cardiovascular and cerebrovascular disease of the present invention, the Western medicine aspirin takes stopgap measures, and blood viscosity lowering, prevents thrombosis; salviamiltiorrhizabung effects a permanent cure; protection cardiac muscle, resists myocardial ischemia microcirculation improvement at dilating coronary blood vessel; blood fat reducing; two medicines share, and reach the Chinese medicine and western medicine synergism, the effect for the treatment of both the principal and secondary aspects of a disease; have both effects but improved curative effect simultaneously, reduced toxic and side effects human body.
The specific embodiment
The invention will be further described below in conjunction with embodiment, but not therefore, limit the present invention in the scope of described embodiment.
Embodiment 1:
The compound tablet of aspirin and Radix Salviae Miltiorrhizae
Prescription: aspirin 10g
Radix Salviae Miltiorrhizae extractum 215g
Starch 15g
Magnesium stearate 5g
Pulvis Talci 5g
Production method:
Get the aspirin fine powder and mix,,, make soft material, cross 80 orders [order, i.e. every square centimeter hole count] nylon mesh and granulate, dried 30 minutes for 60～70 ℃, with 80 order ferrum sieve granulate with the moistening of 70% (percent by volume) ethanol with the Radix Salviae Miltiorrhizae extractum mixing with starch; Add magnesium stearate, Pulvis Talci mixing, tabletting.Make 1000.
Embodiment 2:
The compound capsule agent of aspirin and Radix Salviae Miltiorrhizae
Prescription: aspirin 10g
Radix Salviae Miltiorrhizae extractum 20g
Starch 8g
Magnesium stearate 2g
Production method:
Get the aspirin fine powder and mix with starch, with the Radix Salviae Miltiorrhizae extractum mixing, with the moistening of 30% (percent by volume) ethanol, make soft material, cross 100 order nylon mesh and granulate, 60～70 ℃ of oven dry with 100 order ferrum sieve granulate, add the magnesium stearate mixing, make 1000 of capsules.
Embodiment 3:
Aspirin and red sage compound granule
Prescription: aspirin 10g
Radix Salviae Miltiorrhizae extractum 1000g
Starch 220g
Production method:
Get the aspirin fine powder with dilution method and the starch mixing of progressively increasing, with the Radix Salviae Miltiorrhizae extractum mixing, with 70% ethanol moistening, make soft material, cross 80 mesh sieves and granulate, dried 1 hour for 60～70 ℃, the granulate that sieves is made granule, is distributed into 1000 bags.
Embodiment 4:
Increasing Flos Carthami 50g among the embodiment 1 is principal agent, and Flos Carthami is made extractum with conventional method, further is processed into tablet.
Embodiment 5:
After embodiment 1 makes tablet, as the sheet heart, make coating material with the copolymer L type of methacrylic acid-methyl methacrylate, make 1.5% solution with dissolve with ethanol, coating is made enteric coatel tablets according to a conventional method.
Embodiment 6:
The clinical statistics data:
Embodiments of the invention 1 are through treating between 35～65 years old stable angina pectoris patient 30 examples the age, and total effective rate reaches 90%, compares with aspirin with single, improves about 20%.To the treatment of unstable angina pectoris patient 20 example, total effective rate reaches 85%, compares with aspirin with single, improves approximately 20%, to acute myocardial infarction patients, effect is arranged also, but because the state of an illness is urgent, medication separately.
Embodiments of the invention 1 are wherein cured 17 examples, total effective 29 examples through to atherosclerotic cerebral infarction, the heart source property cerebral embolism patient 32 example treatments of age between 42～67 years old; Improve about 10% than single total effective rate with aspirin, Radix Salviae Miltiorrhizae Tabellae.
Comparatively severe complications, toxic and side effects are not found in above-mentioned clinical trial.
Embodiments of the invention 2～5 through clinical trial, also have the 1 akin curative effect with embodiment, no longer enumerate in an embodiment one by one.
Claims (4)
1, a kind of medicine of preventing and treating cardiovascular and cerebrovascular disease, the crude drug that it is characterized in that it is made up of aspirin and Radix Salviae Miltiorrhizae, and Radix Salviae Miltiorrhizae is prepared into Radix Salviae Miltiorrhizae extractum earlier, again with aspirin, further be processed into peroral dosage form, the weight ratio of aspirin and Radix Salviae Miltiorrhizae extractum is 1: 21.5.
2, the medicine of control cardiovascular and cerebrovascular disease according to claim 1 is characterized in that it makes the enteric dosage form.
3, the medicine of control cardiovascular and cerebrovascular disease according to claim 1, the crude drug that it is characterized in that it has 1/3～3 times Flos Carthami of Radix Salviae Miltiorrhizae weight, and Flos Carthami is made extractum earlier.
4, a kind of medicine production method of control cardiovascular and cerebrovascular disease as claimed in claim 1 has following steps:
1) Radix Salviae Miltiorrhizae is prepared into Radix Salviae Miltiorrhizae extractum;
2) after aspirin fine powder and the dispersant, with the Radix Salviae Miltiorrhizae extractum mixing;
3) add a spot of wetting agent moistening, the granulation of sieving, oven dry;
4) granulate that sieves is made granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100514410A CN1318047C (en) | 2004-09-14 | 2004-09-14 | Medicine for preventing and curing cardio cerebral varscular diseases and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100514410A CN1318047C (en) | 2004-09-14 | 2004-09-14 | Medicine for preventing and curing cardio cerebral varscular diseases and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1615977A CN1615977A (en) | 2005-05-18 |
| CN1318047C true CN1318047C (en) | 2007-05-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100514410A Expired - Fee Related CN1318047C (en) | 2004-09-14 | 2004-09-14 | Medicine for preventing and curing cardio cerebral varscular diseases and its preparing method |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129587A (en) * | 1995-12-22 | 1996-08-28 | 王介明 | Naofusu capsule for encephalopathy and preparation thereof |
| CN1151888A (en) * | 1996-08-15 | 1997-06-18 | 林华 | Medicine for diabetes and its prepn |
-
2004
- 2004-09-14 CN CNB2004100514410A patent/CN1318047C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129587A (en) * | 1995-12-22 | 1996-08-28 | 王介明 | Naofusu capsule for encephalopathy and preparation thereof |
| CN1151888A (en) * | 1996-08-15 | 1997-06-18 | 林华 | Medicine for diabetes and its prepn |
Non-Patent Citations (3)
| Title |
|---|
| 中西医结合治疗缺血性脑血管病临床疗效观察 陈石，中华神经医学杂志，第3卷第4期 2004 * |
| 复方降糖灵治疗糖尿病64例 王松茂等，山西中医，第9卷第2期 1993 * |
| 复方降糖灵治疗糖尿病64例 王松茂等，山西中医，第9卷第2期 1993;中西医结合治疗缺血性脑血管病临床疗效观察 陈石，中华神经医学杂志，第3卷第4期 2004 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1615977A (en) | 2005-05-18 |
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