CN101468144B - Chinese medicine compound preparation for treating ventricular premature beat - Google Patents
Chinese medicine compound preparation for treating ventricular premature beat Download PDFInfo
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- CN101468144B CN101468144B CN2008100021553A CN200810002155A CN101468144B CN 101468144 B CN101468144 B CN 101468144B CN 2008100021553 A CN2008100021553 A CN 2008100021553A CN 200810002155 A CN200810002155 A CN 200810002155A CN 101468144 B CN101468144 B CN 101468144B
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Abstract
The invention relates to a traditional Chinese medicine composite preparation for treating ventricular premature beat, belonging to the traditional Chinese medicine technology field, especially a traditional Chinese medicine composite preparation for treating Yang deficiency type coronary heat disease with ventricular premature beat. The medicine uses cassia twig, lilyturf root, astragalus root, safflower and ass-hide as basic remedy and adjuvant to make into granules, capsules, capsules and pills, extracts, powders or tablets, using yang-activating, migratory arthralgia, qi-supplementing and yin-nourishing, clots-absorbing and channels-activating as curative principles. The clinical trial results show that: the effective rate of the traditional Chinese medicine composite preparation on treating Yang deficiency type coronary heat disease with ventricular premature beat is 88.72% and the traditional Chinese medicine composite preparation obviously improves the clinical symptom without obvious adverse reaction. The single use of the composite preparation or combination of the composite preparation with the other medicine for treating coronary heart disease has high performance price ratio on treating Yang deficiency type coronary heat disease with ventricular premature beat.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to the compound Chinese medicinal preparation of a kind of therapeutic room premature beat, especially treat the compound Chinese medicinal preparation that deficiency of yang type coronary heart disease merges ventricular premature contraction.
Background technology
Ventricular premature contraction is more common in the complication of organic heart diseasies such as coronary heart disease, myocarditis, myocardial infarction.Clinical manifestation is: the patient except that the symptom that protopathy is arranged, also with paroxysmal cardiopalmus, uncomfortable in chest, breathe hard, symptom such as weak, dizzy.The treatment measure of clinical common employing is: slight or general ventricular premature contraction does not need Drug therapy usually, only needs to adopt corresponding treatment to get final product to protopathy, and the above person side of moderate considers to adopt Drug therapy.At present, the western medicine of ventricular premature contraction adopts medicines such as metoprolol, propafenone, mexiletine, amiodaronum or lignocaine more.Clinical practice shows: lignocaine to ventricular premature contraction effectively but can not reduce the mortality rate that causes therefrom; Above-mentioned other anti-arrhythmic manifests effectively ventricular premature contraction; But following situation occurs now and then: medicine itself causes new arrhythmia, and toxic and side effects is bigger.It is reported; Domestic tcm field is followed these illness of principle treatment such as QI invigorating warming YANG, promoting blood circulation to remove obstruction in the collateral, clearing away phlegm and removing blood stasis more; As adopt therapeutic room's premature beats such as Radix Glycyrrhizae Preparata granule, stem and leaf of Radix Ginseng saponin, berberine, the quiet capsule of coronary disease, heartbeat health or WENXIN KELI; Display effect differs as a result, and curative effect is generally 50%-80%.
Summary of the invention:
The compound Chinese medicinal preparation that the purpose of this invention is to provide a kind of therapeutic room premature beat relates in particular to a kind of compound Chinese medicinal preparation that deficiency of yang type coronary heart disease merges ventricular premature contraction of treating.
The present invention follows the Therapeutic Principle of the migratory arthralgia of activating yang, supplementing QI and nourishing YIN, disperse blood stasis and dredge collateral; Adopting Chinese crude drug Ramulus Cinnamomi, Radix Ophiopogonis, the Radix Astragali, Flos Carthami, Colla Corii Asini is principal agent; Be equipped with excipient substance, process the present invention and treat the compound Chinese medicinal preparation that deficiency of yang type coronary heart disease merges ventricular premature contraction.
Chinese crude drug involved in the present invention, wherein:
Ramulus Cinnamomi: the dry twig for the green arbor Cortex Cinnamomi of Lauraceae Cinnamomum cassia Presl is wind-cold-dispersing medicinal;
The Radix Astragali: the dry root for pulse family perennial herb Radix Astragali (Radix Astragali) Astragalus membranaceus (Fisch.) Bunge or Radix Astagali A.membranaceus (Fisch.) Bunge varmongholicus (Bunge) Hsiao is Qi-tonifying drug;
Radix Ophiopogonis: the dried root for Liliaceae perennial herb Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl. is yin-nourishing drug;
Flos Carthami: the dried floral for 2 years draft Flos Carthamis of Compositae Carthamus tinctorius L. is promoting blood flow and remove blood stasis drug;
Colla Corii Asini: be the skin of equine species donkey Equus asinus Linnaeus,, be hematonic through decocting, concentrating the solid gum of processing.
Chinese crude drug involved in the present invention is recorded Chinese medicine by Chinese Pharmacopoeia one one of version in 2000, and meets the pharmacopeia prescription.
The weight proportion of said each crude drug of compound preparation of the present invention such as following, (every 1000ml contains the crude drug amount, gram):
Ramulus Cinnamomi 333～825, the Radix Astragali 333～825, Radix Ophiopogonis 333～825, Flos Carthami 165～333, Colla Corii Asini 165～333.
The preferred weight ratio range of above-mentioned raw materials medicine is:
Ramulus Cinnamomi 500～600, the Radix Astragali 500～750, Radix Ophiopogonis 500～700, Flos Carthami 200～300, Colla Corii Asini 200～300.
The most preferably weight proportion of above-mentioned raw materials medicine is:
Ramulus Cinnamomi 825, the Radix Astragali 990, Radix Ophiopogonis 990, Flos Carthami 330, Colla Corii Asini 330.
Compound preparation of the present invention prepares through following method and step:
By the above-mentioned crude drug of respectively distinguishing the flavor of of described weight proportion weighing, decocte with water secondary, 2 hours for the first time, 1 hour for the second time; Merge the secondary medicinal liquid, left standstill 24 hours, draw supernatant, be evaporated to relative density 1.10 (20 ℃); Add the ethanol of qdx, stir, left standstill 48 hours, draw supernatant; Reclaim ethanol, and continue to be concentrated into relative density 1.08 (20 ℃), add benzoic acid 1g, ethyl hydroxybenzoate 0.1g; Boiled 30 minutes, adding distil water stirs to 1000ml, and filtration, embedding get extracting solution.
The above-mentioned extracting solution that makes is equipped with excipient substance, processes said electuary, capsule, soft gelatin capsule, extractum, dry powder doses or tablet on the pharmaceutics by conventional method.
Adopt compound preparation of the present invention that 65 routine clinical diagnosises are treated research for the patient that deficiency of yang type coronary heart disease merges ventricular premature contraction; The result shows: compound preparation of the present invention can significantly improve the clinical symptoms that coronary heart disease merges the ventricular premature contraction patient; The Treatment of Ventricular Extrasystole effective percentage is reached 88.72%, do not see obvious adverse reaction.Compound preparation list of the present invention with or unite other treatment medicaments for coronary disease treatment deficiency of yang type coronary heart disease and merge ventricular premature contraction, curative effect is better, and method for preparing is easy, low price has high cost performance.
The specific embodiment:
Embodiment 1 (every 1000ml contains the crude drug amount, gram):
Ramulus Cinnamomi 100 Radixs Astragali 100 Flos Carthamis, 50 Colla Corii Asini 50,150 Radix Ophiopogonis
By the above-mentioned weight proportion weighing Chinese medicine of respectively distinguishing the flavor of, decocte with water secondary, 2 hours for the first time, 1 hour for the second time; Merge the secondary medicinal liquid, left standstill 24 hours, draw supernatant, be evaporated to relative density 1.10 (20 ℃); Add the ethanol of qdx, stir, left standstill 48 hours, draw supernatant; Reclaim ethanol, and continue to be concentrated into relative density 1.08 (20 ℃), add benzoic acid 1g, ethyl hydroxybenzoate 0.1g; Boiled 30 minutes, adding distil water stirs to 1000ml, and filtration, embedding embedding get extracting solution.
The above-mentioned extracting solution that makes is equipped with excipient substance, processes said electuary or capsule on the pharmaceutics by conventional method.
Embodiment 2 (every 1000ml contains the crude drug amount, gram):
Ramulus Cinnamomi 150 Radixs Astragali 150 Flos Carthamis, 100 Colla Corii Asini 100,200 Radix Ophiopogonis
By the above-mentioned weight proportion weighing Chinese medicine of respectively distinguishing the flavor of, the decocte with water secondary 2 hours for the first time, 1 hour for the second time, merges the secondary medicinal liquid; Left standstill 24 hours, and drew supernatant, be evaporated to relative density 1.10 (20 ℃), add the ethanol of qdx, stir; Left standstill 48 hours, and drew supernatant, reclaim ethanol, and continue to be concentrated into relative density 1.08 (20 ℃), add benzoic acid 1g; Ethyl hydroxybenzoate 0.1g boiled 30 minutes, and adding distil water stirs to 1000ml, and filtration, embedding promptly get.
The above-mentioned extracting solution that makes is equipped with excipient substance, processes said capsule or soft gelatin capsule on the pharmaceutics by conventional method.
Embodiment 3 (every 1000ml contains the crude drug amount, gram):
Ramulus Cinnamomi 300 Radixs Astragali 300 Flos Carthamis, 50 Colla Corii Asini 100,200 Radix Ophiopogonis
By the above-mentioned weight proportion weighing Chinese medicine of respectively distinguishing the flavor of, the decocte with water secondary 2 hours for the first time, 1 hour for the second time, merges the secondary medicinal liquid; Left standstill 24 hours, and drew supernatant, be evaporated to relative density 1.10 (20 ℃), add the ethanol of qdx, stir; Left standstill 48 hours, and drew supernatant, reclaim ethanol, and continue to be concentrated into relative density 1.08 (20 ℃), add benzoic acid 1g; Ethyl hydroxybenzoate 0.1g boiled 30 minutes, and adding distil water stirs to 1000ml, and filtration, embedding promptly get.
The above-mentioned extracting solution that makes is equipped with excipient substance, processes said extractum or dry powder doses or tablet on the pharmaceutics by conventional method.
Embodiment 4 (every 1000ml contains the crude drug amount, gram):
Ramulus Cinnamomi 250 Radixs Astragali 300 Flos Carthamis, 100 Colla Corii Asini 100,300 Radix Ophiopogonis
By the above-mentioned weight proportion weighing Chinese medicine of respectively distinguishing the flavor of, the decocte with water secondary 2 hours for the first time, 1 hour for the second time, merges the secondary medicinal liquid; Left standstill 24 hours, and drew supernatant, be evaporated to relative density 1.10 (20 ℃), add the ethanol of qdx, stir; Left standstill 48 hours, and drew supernatant, reclaim ethanol, and continue to be concentrated into relative density 1.08 (20 ℃), add benzoic acid 1g; Ethyl hydroxybenzoate 0.1g boiled 30 minutes, and adding distil water stirs to 1000ml, and filtration, embedding promptly get.
The above-mentioned extracting solution that makes is equipped with excipient substance, by conventional method process on the pharmaceutics said electuary or extractum.
Embodiment 5 (every 1000ml contains the crude drug amount, gram):
Ramulus Cinnamomi 825 Radixs Astragali 990 Flos Carthamis, 330 Colla Corii Asini 330,990 Radix Ophiopogonis
By the above-mentioned weight proportion weighing Chinese medicine of respectively distinguishing the flavor of, the decocte with water secondary 2 hours for the first time, 1 hour for the second time, merges the secondary medicinal liquid; Left standstill 24 hours, and drew supernatant, be evaporated to relative density 1.10 (20 ℃), add the ethanol of qdx, stir; Left standstill 48 hours, and drew supernatant, reclaim ethanol, and continue to be concentrated into relative density 1.08 (20 ℃), add benzoic acid 1g; Ethyl hydroxybenzoate 0.1g boiled 30 minutes, and adding distil water stirs to 1000ml, and filtration, embedding promptly get.
The above-mentioned extracting solution that makes is equipped with excipient substance, processes said dry powder doses or tablet on the pharmaceutics by conventional method.
Embodiment 6
Observe list and close propafenone treatment coronary heart disease merging ventricular premature contraction totally 60 examples surely with compound preparation of the present invention and different pleasure, wherein 30 examples are organized in treatment, matched group 30 examples.
The result shows: single to use compound preparation of the present invention be 88.72% to the effective percentage of ventricular premature contraction, and it is 90.15% to the effective percentage of ventricular premature contraction that different pleasure is closed propafenone surely, and both compare no significant difference, P＞0.05.The result shows: single have obvious curative effects with compound preparation of the present invention to ventricular premature contraction, and to close the propafenone effect surely similar with different pleasure.Discovery is observed in improvement to patient's clinical symptoms; Single with compound preparation of the present invention to cardiopalmus, uncomfortable in chest, breathe hard, the effective percentage of dizzy symptom is respectively 92.51%, 87.32%, 96.24%, 91.47%; The effective percentage that different pleasure is closed propafenone surely is respectively 84.36%, 82.13%, 70.26%, 73.38%; The effective percentage of pointing out compound preparation of the present invention that coronary heart disease merging ventricular premature contraction clinical symptoms is improved is significantly higher than different pleasure and closes the propafenone group surely; Relatively there were significant differences between two groups of effective percentage property, P＞0.05.Confirm that compound preparation of the present invention has remarkable improvement effect to the clinical symptoms that deficiency of yang type coronary heart disease merges the ventricular premature contraction patient, and obviously be superior to different pleasure and close the propafenone group surely.
The foregoing description Chinese medicine dosage, through clinical observation, its pharmacological action is identical, and is wherein best with the curative effect of embodiment 4, and side effect is minimum.
Claims (3)
1. the compound Chinese medicinal preparation of therapeutic room's premature beat is characterized in that being processed by following raw materials by weight proportions, and every 1000ml contains the crude drug amount:
Ramulus Cinnamomi 333～825 grams, the Radix Astragali 333～825 grams, restrain Radix Ophiopogonis 333～825, Flos Carthami 165～333 grams, Colla Corii Asini 165～333 grams;
Described compound preparation prepares through following method and step:
By the above-mentioned crude drug of respectively distinguishing the flavor of of described weight proportion weighing, the decocte with water secondary 2 hours for the first time, 1 hour for the second time, merges the secondary medicinal liquid; Left standstill 24 hours, and drew supernatant, be evaporated to 1.10,20 ℃ of relative densities, add the ethanol of qdx; Stir, left standstill 48 hours, draw supernatant, reclaim ethanol; And continue to be concentrated into 1.08,20 ℃ of relative densities, add benzoic acid 1g, ethyl hydroxybenzoate 0.1g; Boiled 30 minutes, adding distil water stirs to 1000ml, and filtration, embedding get extracting solution; Extracting solution is equipped with excipient substance and makes compound preparation.
2. by the compound Chinese medicinal preparation of the described therapeutic room of claim 1 premature beat, it is characterized in that described crude drug, every 1000ml contains the crude drug amount:
Ramulus Cinnamomi 500～600 grams, the Radix Astragali 500～750 grams, restrain Radix Ophiopogonis 500～700, Flos Carthami 200～300 grams, Colla Corii Asini 200～300 grams.
3. by the compound Chinese medicinal preparation of the described therapeutic room of claim 1 premature beat, it is characterized in that described preparation is electuary, capsule, soft gelatin capsule, extractum, dry powder doses or tablet.
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| CN2008100021553A CN101468144B (en) | 2007-12-29 | 2008-01-12 | Chinese medicine compound preparation for treating ventricular premature beat |
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| CN200710173879.X | 2007-12-29 | ||
| CN200710173879 | 2007-12-29 | ||
| CN2008100021553A CN101468144B (en) | 2007-12-29 | 2008-01-12 | Chinese medicine compound preparation for treating ventricular premature beat |
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| CN101468144A CN101468144A (en) | 2009-07-01 |
| CN101468144B true CN101468144B (en) | 2012-01-11 |
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| CN103720859B (en) * | 2013-12-31 | 2015-11-04 | 齐洪涛 | A kind of manufacture method for the treatment of the Chinese herbal medicine of frequent premature ventricular beats |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686510A (en) * | 2005-04-14 | 2005-10-26 | 赵宏伟 | Ready prepared Chinese medicine for preventing and treating brain apoplexia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686510A (en) * | 2005-04-14 | 2005-10-26 | 赵宏伟 | Ready prepared Chinese medicine for preventing and treating brain apoplexia |
Non-Patent Citations (1)
| Title |
|---|
| 张清.炙甘草汤加减治疗早搏60例.《浙江中西医结合杂志》.2000,第10卷(第12期),743. * |
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Granted publication date: 20120111 Termination date: 20160112 |