CN1286468C - 含藻酸或藻酸盐的药物组合物 - Google Patents
含藻酸或藻酸盐的药物组合物 Download PDFInfo
- Publication number
- CN1286468C CN1286468C CNB2004100461678A CN200410046167A CN1286468C CN 1286468 C CN1286468 C CN 1286468C CN B2004100461678 A CNB2004100461678 A CN B2004100461678A CN 200410046167 A CN200410046167 A CN 200410046167A CN 1286468 C CN1286468 C CN 1286468C
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- Prior art keywords
- alginate
- compositions
- acid residue
- ratio
- total amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940072056 alginate Drugs 0.000 claims abstract description 123
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical group OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 claims abstract description 41
- 125000005613 guluronic acid group Chemical group 0.000 claims abstract description 37
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- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 229960001407 sodium bicarbonate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9708773.8 | 1997-04-30 | ||
| GBGB9708772.0A GB9708772D0 (en) | 1997-04-30 | 1997-04-30 | Organic compositions |
| GBGB9708773.8A GB9708773D0 (en) | 1997-04-30 | 1997-04-30 | Organic compositions |
| GB9708772.0 | 1997-04-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB98804594XA Division CN1197584C (zh) | 1997-04-30 | 1998-04-23 | 可倾倒的藻酸盐组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1552344A CN1552344A (zh) | 2004-12-08 |
| CN1286468C true CN1286468C (zh) | 2006-11-29 |
Family
ID=26311463
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100461678A Expired - Fee Related CN1286468C (zh) | 1997-04-30 | 1998-04-23 | 含藻酸或藻酸盐的药物组合物 |
| CNB98804594XA Expired - Lifetime CN1197584C (zh) | 1997-04-30 | 1998-04-23 | 可倾倒的藻酸盐组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB98804594XA Expired - Lifetime CN1197584C (zh) | 1997-04-30 | 1998-04-23 | 可倾倒的藻酸盐组合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6395307B1 (https=) |
| EP (2) | EP1842544A3 (https=) |
| JP (1) | JP2001522368A (https=) |
| KR (1) | KR20010020438A (https=) |
| CN (2) | CN1286468C (https=) |
| AR (1) | AR012621A1 (https=) |
| AU (1) | AU740972B2 (https=) |
| BR (1) | BR9809310A (https=) |
| CA (1) | CA2288743C (https=) |
| ID (1) | ID23809A (https=) |
| PL (3) | PL195410B1 (https=) |
| WO (1) | WO1998048814A1 (https=) |
| ZA (1) | ZA983707B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0005743D0 (en) * | 2000-03-10 | 2000-05-03 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions including alginates |
| KR100620404B1 (ko) * | 2000-08-09 | 2006-09-13 | 파나세아 바이오테크 리미티드 | 항결핵 약물의 신규 약제학적 조성물 및 그의 제조방법 |
| GB0107651D0 (en) * | 2001-03-27 | 2001-05-16 | Syngenta Ltd | Composition |
| AU2002327007B2 (en) * | 2001-09-21 | 2005-10-20 | Stryker Corporation | Pore-forming agents for orthopedic cements |
| GB2384986B (en) * | 2002-02-12 | 2004-01-07 | Reckitt Benckiser Healthcare | Compositions for the treatment of disorders of the upper gastrointestinal tract |
| US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
| JP4873877B2 (ja) * | 2005-03-30 | 2012-02-08 | 小林製薬株式会社 | アルギン酸ナトリウム含有錠剤の製造方法及び該製造方法により得られる錠剤 |
| KR101690631B1 (ko) | 2007-11-27 | 2017-01-09 | 알지파마 아이피알 에이에스 | 바이오필름 퇴치에 있어서의 알기네이트 올리고머의 용도 |
| WO2010092468A1 (en) * | 2009-02-13 | 2010-08-19 | Carlo Ghisalberti | Composition comprising alginates and d-limonene to treat gerd and dyspepsia |
| BRPI1011248A2 (pt) | 2009-06-03 | 2016-03-22 | Algipharma As | métodos in vitro ou ex vivo de superação de resitência a pelo menos um antibiótico, para combate de contaminação de um sítio e melhora da eficácia de um antibiótico de macrolídeo para inibir o crescimento de bactéria mdr gram negativa, uso de um oligômero de alginato e produto |
| CN101933894B (zh) * | 2009-07-03 | 2012-07-11 | 张清 | 胃肠粘膜保护胶 |
| EA024050B1 (ru) | 2010-04-23 | 2016-08-31 | С-БИОТЕК ХОЛДИНГ АпС | Твердая фармацевтическая композиция для нейтрализации желудочной кислоты |
| EA015747B1 (ru) | 2010-07-08 | 2011-10-31 | Общество С Ограниченной Ответственностью "Вдс" | Состав для профилактики кандидозов |
| DK177435B1 (en) | 2011-06-03 | 2013-05-21 | Biotek Holding Aps S | An aqueous diet product, a unit dosage and a kit comprising at least one alginate, and a method for the preparation of said diet product |
| US9636360B2 (en) * | 2012-09-18 | 2017-05-02 | pH Science Holdings, Inc | Method and composition for treating gastro-esophageal disorders |
| US9993497B2 (en) | 2012-12-30 | 2018-06-12 | Hadasit Medical Research Services And Development Ltd. | Use of alginate compositions in preventing or reducing liver damage caused by a hepatotoxic agent |
| US11931227B2 (en) | 2013-03-15 | 2024-03-19 | Cook Medical Technologies Llc | Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding |
| ITUB20150279A1 (it) * | 2015-03-09 | 2016-09-09 | S I I T S R L Servizio Int Imballaggi Termosaldanti | Sistema flottante per la cura dei sintomi delle affezioni gastriche |
| WO2019067680A1 (en) | 2017-09-27 | 2019-04-04 | Cook Medical Technologies Llc | CROSSLINKING SUBMUCOSAL INJECTION SYSTEM |
| WO2019092608A1 (en) | 2017-11-08 | 2019-05-16 | Materias S.R.L. | In situ gelifying powder |
| CN108451973A (zh) * | 2018-01-30 | 2018-08-28 | 无锡福尔顺科技有限公司 | 一种消化道凝胶保护剂及其使用方法和应用 |
| IT202100000059A1 (it) * | 2021-01-04 | 2022-07-04 | Nyuma Pharma Srl | Nuove composizioni di sucralfato in alginato e loro utilizzo in terapia |
| WO2023018649A1 (en) * | 2021-08-10 | 2023-02-16 | Bayer Healthcare Llc | Liquid formulations comprising alginic acid, pectin, and carrageenan and methods of using thereof for gastric and gastroesophageal disorders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1524740A (en) * | 1976-11-09 | 1978-09-13 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions for use in the suppression of gastric reflux |
| GB1566609A (en) * | 1977-03-10 | 1980-05-08 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions containing cholestyramine and alginic acid |
| DE3152319C2 (de) * | 1980-09-03 | 1986-05-07 | Kyosei Pharmaceutical Co., Ltd., Hokkaido | Verwendung einer Lösung eines Salzes der Alginsäure zur Behandlung von Strahlenschäden und Ulcera |
| JPS5746920A (en) | 1980-09-03 | 1982-03-17 | Kyosei Seiyaku Kk | Drug for digestive tract |
| JPH0764737B2 (ja) * | 1984-04-19 | 1995-07-12 | ローヌ−プーラン ローラー インターナショナル （ホウルディングス） インコーポレイテッド | 制酸組成物 |
| US4869902A (en) * | 1984-04-19 | 1989-09-26 | Rorer Pharmaceutical Corporation | Antacid composition |
| US4744986A (en) * | 1986-03-07 | 1988-05-17 | Rorer Pharmaceutical Corporation | Process for the preparation of a viscosity-stable antacid composition |
| GB8618847D0 (en) * | 1986-08-01 | 1986-09-10 | Smith Kline French Lab | Pharmaceutical formulations |
| DK179687D0 (da) * | 1987-04-08 | 1987-04-08 | Farma Food As | Praeparat |
| GB9010039D0 (en) * | 1990-05-03 | 1990-06-27 | Reckitt & Colmann Prod Ltd | Medicament preparation |
| GB9218749D0 (en) * | 1992-09-04 | 1992-10-21 | Courtaulds Plc | Alginate gels |
| US5888540A (en) * | 1993-10-29 | 1999-03-30 | Sugden; Keith | Pharmaceutical products |
| GB2298365B (en) | 1995-03-03 | 1997-05-07 | Reckitt & Colmann Prod Ltd | A liquid pharmaceutical composition alginate and potassium bicarbonate |
| GB9504599D0 (en) * | 1995-03-03 | 1995-04-26 | Reckitt & Colmann Prod Ltd | Improvements in or relating to organic compositions |
-
1998
- 1998-04-23 US US09/403,217 patent/US6395307B1/en not_active Expired - Fee Related
- 1998-04-23 PL PL98378778A patent/PL195410B1/pl not_active IP Right Cessation
- 1998-04-23 AU AU70680/98A patent/AU740972B2/en not_active Expired
- 1998-04-23 CA CA002288743A patent/CA2288743C/en not_active Expired - Fee Related
- 1998-04-23 BR BR9809310-0A patent/BR9809310A/pt not_active Application Discontinuation
- 1998-04-23 JP JP54671798A patent/JP2001522368A/ja not_active Ceased
- 1998-04-23 EP EP06024990A patent/EP1842544A3/en not_active Withdrawn
- 1998-04-23 PL PL98378779A patent/PL194696B1/pl not_active IP Right Cessation
- 1998-04-23 ID IDW991279A patent/ID23809A/id unknown
- 1998-04-23 CN CNB2004100461678A patent/CN1286468C/zh not_active Expired - Fee Related
- 1998-04-23 WO PCT/GB1998/001188 patent/WO1998048814A1/en not_active Ceased
- 1998-04-23 CN CNB98804594XA patent/CN1197584C/zh not_active Expired - Lifetime
- 1998-04-23 EP EP98917452A patent/EP0979091A1/en not_active Ceased
- 1998-04-23 PL PL98336724A patent/PL195031B1/pl not_active IP Right Cessation
- 1998-04-23 KR KR1019997010069A patent/KR20010020438A/ko not_active Withdrawn
- 1998-04-28 ZA ZA983707A patent/ZA983707B/xx unknown
- 1998-04-29 AR ARP980101993A patent/AR012621A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2288743C (en) | 2008-04-22 |
| CN1552344A (zh) | 2004-12-08 |
| US6395307B1 (en) | 2002-05-28 |
| KR20010020438A (ko) | 2001-03-15 |
| JP2001522368A (ja) | 2001-11-13 |
| CA2288743A1 (en) | 1998-11-05 |
| PL195031B1 (pl) | 2007-08-31 |
| PL336724A1 (en) | 2000-07-03 |
| EP0979091A1 (en) | 2000-02-16 |
| EP1842544A2 (en) | 2007-10-10 |
| PL194696B1 (pl) | 2007-06-29 |
| AU7068098A (en) | 1998-11-24 |
| CN1253505A (zh) | 2000-05-17 |
| EP1842544A3 (en) | 2007-10-17 |
| AR012621A1 (es) | 2000-11-08 |
| ZA983707B (en) | 1999-02-26 |
| CN1197584C (zh) | 2005-04-20 |
| WO1998048814A1 (en) | 1998-11-05 |
| BR9809310A (pt) | 2000-07-04 |
| AU740972B2 (en) | 2001-11-15 |
| ID23809A (id) | 2000-05-11 |
| PL195410B1 (pl) | 2007-09-28 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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Granted publication date: 20061129 Termination date: 20100423 |