CN1285828A - 被含有一个氮原子的五、六或七元杂环取代的咪唑基烷基 - Google Patents
被含有一个氮原子的五、六或七元杂环取代的咪唑基烷基 Download PDFInfo
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- CN1285828A CN1285828A CN98812984A CN98812984A CN1285828A CN 1285828 A CN1285828 A CN 1285828A CN 98812984 A CN98812984 A CN 98812984A CN 98812984 A CN98812984 A CN 98812984A CN 1285828 A CN1285828 A CN 1285828A
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- compound
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- alkyl
- loratadine
- salt
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- 125000004433 nitrogen atom Chemical group N* 0.000 title claims description 10
- 125000000623 heterocyclic group Chemical group 0.000 title claims description 7
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- 238000006243 chemical reaction Methods 0.000 claims description 42
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- 125000000217 alkyl group Chemical group 0.000 claims description 38
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- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 claims description 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
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- 239000001257 hydrogen Substances 0.000 claims description 20
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- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims description 12
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
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- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96575497A | 1997-11-07 | 1997-11-07 | |
| US08/965,754 | 1997-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1285828A true CN1285828A (zh) | 2001-02-28 |
Family
ID=25510440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98812984A Pending CN1285828A (zh) | 1997-11-07 | 1998-11-05 | 被含有一个氮原子的五、六或七元杂环取代的咪唑基烷基 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1028956A1 (fr) |
| JP (1) | JP2001522845A (fr) |
| KR (1) | KR20010031839A (fr) |
| CN (1) | CN1285828A (fr) |
| AR (1) | AR016671A1 (fr) |
| AU (1) | AU1296799A (fr) |
| CA (1) | CA2309609A1 (fr) |
| HU (1) | HUP0102662A3 (fr) |
| IL (1) | IL135727A0 (fr) |
| PE (1) | PE130699A1 (fr) |
| WO (1) | WO1999024421A1 (fr) |
| ZA (1) | ZA9810186B (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101146786B (zh) * | 2004-12-30 | 2013-03-27 | 詹森药业有限公司 | 作为脂肪酸酰胺水解酶调节剂的哌嗪基脲和哌啶基脲 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6140337A (en) * | 1997-12-23 | 2000-10-31 | Schering Corporation | Methods for the treatment of mental disorders |
| FR2827863A1 (fr) * | 2001-07-27 | 2003-01-31 | Sanofi Synthelabo | Derives d'aminoalkylimidazole, leur preparation et leur utilisation en therapeutique |
| US7183305B2 (en) | 2003-11-11 | 2007-02-27 | Allergan, Inc. | Process for the synthesis of imidazoles |
| US7880017B2 (en) | 2003-11-11 | 2011-02-01 | Allergan, Inc. | Process for the synthesis of imidazoles |
| WO2005058823A1 (fr) * | 2003-12-17 | 2005-06-30 | Takeda Pharmaceutical Company Limited | Derives d'uree, processus de production correspondant et utilisation |
| UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| WO2013151982A1 (fr) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés |
| WO2022175384A1 (fr) * | 2021-02-17 | 2022-08-25 | Fundación Universidad Católica De Valencia San Vicente Mártir | Agents à petites molécules ayant une activité antivirale contre des virus à arn |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW268950B (fr) * | 1991-12-18 | 1996-01-21 | Schering Corp | |
| DK0619818T3 (da) * | 1991-12-18 | 1996-11-25 | Schering Corp | Imidazoylalkyl substitueret med en seks-leddet nitrogenholdig heterocyclisk ring |
| AU7823894A (en) * | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| PE100298A1 (es) * | 1996-08-16 | 1999-01-11 | Schering Corp | Tratamiento de las respuestas alergicas de la vias respiratorias superiores |
-
1998
- 1998-11-05 WO PCT/US1998/023224 patent/WO1999024421A1/fr not_active Application Discontinuation
- 1998-11-05 HU HU0102662A patent/HUP0102662A3/hu unknown
- 1998-11-05 CN CN98812984A patent/CN1285828A/zh active Pending
- 1998-11-05 IL IL13572798A patent/IL135727A0/xx unknown
- 1998-11-05 EP EP98956443A patent/EP1028956A1/fr not_active Withdrawn
- 1998-11-05 CA CA002309609A patent/CA2309609A1/fr not_active Abandoned
- 1998-11-05 JP JP2000520435A patent/JP2001522845A/ja not_active Withdrawn
- 1998-11-05 AU AU12967/99A patent/AU1296799A/en not_active Abandoned
- 1998-11-05 KR KR1020007004911A patent/KR20010031839A/ko not_active Application Discontinuation
- 1998-11-06 PE PE1998001072A patent/PE130699A1/es not_active Application Discontinuation
- 1998-11-06 ZA ZA9810186A patent/ZA9810186B/xx unknown
- 1998-11-06 AR ARP980105620A patent/AR016671A1/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101146786B (zh) * | 2004-12-30 | 2013-03-27 | 詹森药业有限公司 | 作为脂肪酸酰胺水解酶调节剂的哌嗪基脲和哌啶基脲 |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0102662A3 (en) | 2003-01-28 |
| JP2001522845A (ja) | 2001-11-20 |
| WO1999024421A1 (fr) | 1999-05-20 |
| PE130699A1 (es) | 1999-12-16 |
| HUP0102662A2 (hu) | 2001-12-28 |
| AU1296799A (en) | 1999-05-31 |
| EP1028956A1 (fr) | 2000-08-23 |
| ZA9810186B (en) | 1999-05-06 |
| IL135727A0 (en) | 2001-05-20 |
| CA2309609A1 (fr) | 1999-05-20 |
| KR20010031839A (ko) | 2001-04-16 |
| AR016671A1 (es) | 2001-07-25 |
| WO1999024421A8 (fr) | 1999-08-26 |
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