CN1280128A - 顺式－1－{2－[4－(6－甲氧基－2－苯基－1,2,3,4－四氢化萘－1－基)苯氧基]乙基}吡咯烷的制备方法 - Google Patents

顺式－1－{2－[4－(6－甲氧基－2－苯基－1,2,3,4－四氢化萘－1－基)苯氧基]乙基}吡咯烷的制备方法 Download PDF

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Publication number
CN1280128A
CN1280128A CN00108576A CN00108576A CN1280128A CN 1280128 A CN1280128 A CN 1280128A CN 00108576 A CN00108576 A CN 00108576A CN 00108576 A CN00108576 A CN 00108576A CN 1280128 A CN1280128 A CN 1280128A
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CN
China
Prior art keywords
phenyl
methoxyl group
ethyl
benzyloxy
bromo
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00108576A
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English (en)
Chinese (zh)
Inventor
赵国锋
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Pfizer Products Inc
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Pfizer Products Inc
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Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1280128A publication Critical patent/CN1280128A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/48—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN00108576A 1999-05-24 2000-05-18 顺式－1－{2－[4－(6－甲氧基－2－苯基－1,2,3,4－四氢化萘－1－基)苯氧基]乙基}吡咯烷的制备方法 Pending CN1280128A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13557899P 1999-05-24 1999-05-24
US60/135,578 1999-05-24

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CNB2003101196675A Division CN1226265C (zh) 1999-05-24 2000-05-18 用于制备顺式－1－{2－[4－（6－甲氧基－2－苯基－1，2，3，4－四氢化萘－1－基）苯氧基]乙基}吡咯烷的中间体
CNB200310119668XA Division CN1271030C (zh) 1999-05-24 2000-05-18 用于制备顺式－1－{2－[4－（6－甲氧基－2－苯基－1，2，3，4－四氢化萘－1－基）苯氧基]乙基}吡咯烷的中间体

Publications (1)

Publication Number Publication Date
CN1280128A true CN1280128A (zh) 2001-01-17

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ID=22468706

Family Applications (3)

Application Number Title Priority Date Filing Date
CN00108576A Pending CN1280128A (zh) 1999-05-24 2000-05-18 顺式－1－{2－[4－(6－甲氧基－2－苯基－1,2,3,4－四氢化萘－1－基)苯氧基]乙基}吡咯烷的制备方法
CNB200310119668XA Expired - Fee Related CN1271030C (zh) 1999-05-24 2000-05-18 用于制备顺式－1－{2－[4－（6－甲氧基－2－苯基－1，2，3，4－四氢化萘－1－基）苯氧基]乙基}吡咯烷的中间体
CNB2003101196675A Expired - Fee Related CN1226265C (zh) 1999-05-24 2000-05-18 用于制备顺式－1－{2－[4－（6－甲氧基－2－苯基－1，2，3，4－四氢化萘－1－基）苯氧基]乙基}吡咯烷的中间体

Family Applications After (2)

Application Number Title Priority Date Filing Date
CNB200310119668XA Expired - Fee Related CN1271030C (zh) 1999-05-24 2000-05-18 用于制备顺式－1－{2－[4－（6－甲氧基－2－苯基－1，2，3，4－四氢化萘－1－基）苯氧基]乙基}吡咯烷的中间体
CNB2003101196675A Expired - Fee Related CN1226265C (zh) 1999-05-24 2000-05-18 用于制备顺式－1－{2－[4－（6－甲氧基－2－苯基－1，2，3，4－四氢化萘－1－基）苯氧基]乙基}吡咯烷的中间体

Country Status (24)

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US (3) US6232476B1 (enExample)
EP (1) EP1055658B1 (enExample)
JP (2) JP3296809B2 (enExample)
KR (1) KR100388176B1 (enExample)
CN (3) CN1280128A (enExample)
AR (1) AR035990A1 (enExample)
AT (1) ATE234269T1 (enExample)
AU (1) AU769690B2 (enExample)
BR (1) BR0001813B1 (enExample)
CA (1) CA2308922C (enExample)
DE (1) DE60001599T2 (enExample)
DK (1) DK1055658T3 (enExample)
ES (1) ES2191597T3 (enExample)
HU (1) HUP0001988A3 (enExample)
ID (1) ID26146A (enExample)
IL (1) IL136231A (enExample)
IN (1) IN188849B (enExample)
PL (1) PL340237A1 (enExample)
PT (1) PT1055658E (enExample)
RU (1) RU2195445C2 (enExample)
TR (1) TR200001476A2 (enExample)
TW (1) TWI231295B (enExample)
YU (1) YU26700A (enExample)
ZA (1) ZA200002514B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU26700A (sh) * 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
BR0308758A (pt) * 2002-03-28 2004-12-28 Pfizer Prod Inc Lasofoxifeno purificado e método para purificação de lasofoxifeno racêmico por recristalização
PA8576201A1 (es) * 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco
JP5212931B2 (ja) * 2006-01-26 2013-06-19 学校法人東京理科大学 ラソフォキシフェン及びその類縁体の製造方法
CZ2007373A3 (cs) * 2007-05-29 2008-12-10 Zentiva, A. S Zpusob prípravy lasofoxifenu
CN102424661A (zh) * 2011-10-21 2012-04-25 南开大学 一种偶氮类色素半抗原与人工抗原的合成方法
CN103113323B (zh) * 2013-02-05 2015-11-11 南京华威医药科技开发有限公司 酒石酸拉索昔芬中间体的制备方法
BR112019007254A2 (pt) 2016-10-11 2019-07-02 Duke University tratamento lasofoxifeno de câncer de mama er+
WO2019199891A1 (en) 2018-04-10 2019-10-17 Duke University Lasofoxifene treatment of breast cancer
GB202116903D0 (en) 2021-11-18 2022-01-05 Sermonix Pharmaceuticals Inc Lasofoxifene treatment of aromatase-resistant er+ cancer
WO2025043004A1 (en) 2023-08-21 2025-02-27 Duke University Treatment of solid cancer with lasofoxifene

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US3274213A (en) * 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
US3234090A (en) 1962-09-10 1966-02-08 Ciba Geigy Corp Pharmaceutical compositions comprising saturated basic ethers
US3522319A (en) 1964-01-23 1970-07-28 Ciba Geigy Corp Phenol substituted tetrahydronaphthalenes useful as estrogenics
FR2678938B1 (fr) * 1991-07-10 1993-10-08 Rhone Poulenc Rorer Sa Derives de pyrrolidine, leur preparation et les medicaments les contenant.
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US5552241A (en) * 1995-05-10 1996-09-03 Electrochemical Systems, Inc. Low temperature molten salt compositions containing fluoropyrazolium salts
UA51676C2 (uk) * 1995-11-02 2002-12-16 Пфайзер Інк. (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція
WO1997019059A1 (en) * 1995-11-17 1997-05-29 Sibia Neurosciences, Inc. Novel substituted aryl compounds useful as modulators of acetylcholine receptors
JP2001513501A (ja) * 1997-08-07 2001-09-04 イーライ・リリー・アンド・カンパニー エストロゲン阻害活性を有する１−［４−（置換アルコキシ）ベンジル］ナフタレン化合物
YU26700A (sh) * 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin

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JP3296809B2 (ja) 2002-07-02
DK1055658T3 (da) 2003-04-22
PL340237A1 (en) 2000-12-04
CN1502598A (zh) 2004-06-09
HK1061843A1 (en) 2004-10-08
ES2191597T3 (es) 2003-09-16
KR100388176B1 (ko) 2003-06-19
CA2308922C (en) 2007-05-01
YU26700A (sh) 2002-06-19
BR0001813A (pt) 2001-01-02
CN1502597A (zh) 2004-06-09
ATE234269T1 (de) 2003-03-15
DE60001599T2 (de) 2003-11-13
TWI231295B (en) 2005-04-21
HUP0001988A2 (en) 2001-03-28
JP3600206B2 (ja) 2004-12-15
KR20010029733A (ko) 2001-04-16
JP2000327670A (ja) 2000-11-28
CN1271030C (zh) 2006-08-23
IL136231A (en) 2005-06-19
PT1055658E (pt) 2003-07-31
JP2002205990A (ja) 2002-07-23
EP1055658A3 (en) 2000-12-13
CA2308922A1 (en) 2000-11-24
EP1055658B1 (en) 2003-03-12
HU0001988D0 (en) 2000-08-28
US20020042524A1 (en) 2002-04-11
DE60001599D1 (de) 2003-04-17
AU769690B2 (en) 2004-01-29
US6395911B1 (en) 2002-05-28
AU3636200A (en) 2000-11-30
ZA200002514B (en) 2002-02-22
IN188849B (enExample) 2002-11-09
RU2195445C2 (ru) 2002-12-27
US6323345B1 (en) 2001-11-27
TR200001476A2 (tr) 2001-02-21
CN1226265C (zh) 2005-11-09
US6232476B1 (en) 2001-05-15
HUP0001988A3 (en) 2002-04-29
BR0001813B1 (pt) 2011-03-22
ID26146A (id) 2000-11-30
EP1055658A2 (en) 2000-11-29
AR035990A1 (es) 2004-08-04
IL136231A0 (en) 2001-05-20

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