CN1275994C - 液体分散体聚合物组合物及其制备和用途 - Google Patents
液体分散体聚合物组合物及其制备和用途 Download PDFInfo
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- CN1275994C CN1275994C CNB018198813A CN01819881A CN1275994C CN 1275994 C CN1275994 C CN 1275994C CN B018198813 A CNB018198813 A CN B018198813A CN 01819881 A CN01819881 A CN 01819881A CN 1275994 C CN1275994 C CN 1275994C
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- C—CHEMISTRY; METALLURGY
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
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Abstract
包含分散在硅氧烷聚合物流体中的亲水、水溶性或水溶胀性聚合物,优选为丙烯酸基聚合物和水包油表面活性剂的液体分散体聚合物组合物可以用来制备微粒稠化体系,以稠化水性或水性/有机组合物,特别用于个人护理和药物制剂中。
Description
发明领域
本发明涉及包含分散的聚合物相、连续的载体相和表面活性剂的液体分散体聚合物组合物,及其制备和使用这些液体分散体聚合物组合物制备微粒稠化体系,该体系能够稠化水性或水性/有机组合物。更具体地,本发明涉及液体分散体聚合物组合物,其包含亲水的、水溶性或水溶胀性聚合物微粒,优选的是丙烯酸基聚合物,所述聚合物分散在在硅氧烷聚合物流体载体相中,该组合物还包含水包油型表面活性剂,本发明还涉及该组合物的制备以及使用这些液体分散体聚合物组合物制备微粒稠化系统,以稠化水性或水性/有机组合物,特别是用在个人护理和药物制剂中。
稠化剂广泛用在个人护理制剂如化妆品和药物制剂中,以影响美观性、产品的涂抹和活性原料的悬浮与分送。聚合物稠化剂已经用于该目的许多年了。已经使用的聚合物稠化剂种类范围为从天然树胶如瓜耳树胶、改性的天然物质如羟乙基纤维素、到合成稠化剂如基于聚丙烯酸类的Carbomers。
通过Ciba Specialty Chemicals可以获得的液体分散体聚合物的Salcare类是一类在疏水载体介质中的微粒丙烯酸基聚合物稠化剂。SalcareSC91是基于丙烯酸钠聚合物和矿物油载体的阴离子稠化剂,用PPG-1 trideceth-6作为活性剂表面活性剂。SalcareSC92是包含polyquaternium 32和矿物油的阳离子共聚物稠化剂和调理剂。SalcareSC95和SalcareSC96是阳离子均聚物稠化剂和调理剂。SalcareSC95包含在含有PPG-1 trideceth-6的矿物油中的polyquaternium 37。SalcareSC96包含在含有PPG-1 trideceth-6的丙二醇二辛酸酯二癸酸酯中的Polyquaternium37。SalcareAST是在含有PPG-1 trideceth-6的豆油中的基于丙烯酸钠聚合物的阴离子稠化剂。
上述亲水丙烯酸聚合物的微小球形微粒,无论在荷电方面是阴离子还是阳离子的,其典型颗粒尺寸为0.1-2微米,平均颗粒尺寸为0.5-1.0微米。聚合物微粒优选通过其中利用油包水聚合法聚合水溶性乙烯基加成单体的方法制备。
在把以上液体分散体聚合物搅拌到含水体系中时,活化剂表面活性剂把疏水载体转变成水包油型乳液。术语“活化剂表面活性剂”是指激活疏水载体变为水包油型乳液这种转变的表面活性剂。同时,亲水聚合物在与水接触时膨胀但不溶解,导致平稳迅速的粘度增大。典型地,聚合物颗粒溶胀,获得包含典型颗粒尺寸在直径为2.5-5微米范围内的聚合物颗粒的微粒稠化体系。由于水分子通过渗透移动到聚合物小颗粒中,聚合物颗粒所经过的渗透作用是体系中存在的水和任何电解质之间的平衡。因此,高电解质含量减小聚合物颗粒的溶胀。
微粒稠化体系具有假塑性流变特性,其给出低剪切速率下的良好稳定性和悬浮特性(如产品在静置时的情况),和高剪切速率下的低表观粘度,这对应于优异的擦入(rub-in)特性。
如前所述,以上的Salcare液体分散体聚合物的连续有机载体相至少部分地由硅氧烷聚合物流体提供。
发明概述
在一个方面,本发明提供一种液体分散体聚合物组合物,其包含亲水的、水溶性或水溶胀性聚合物作为分散的聚合物相,硅氧烷聚合物流体作为连续的载体相,并含有水包油型表面活性剂,其中,所述聚合物是平均颗粒尺寸为0.1-2微米的微粒形式。
典型地,该液体分散体聚合物组合物包含:
a)35-65重量%的聚合物,
b)20-50重量%的硅氧烷聚合物流体,和
c)5-25重量%的表面活性剂或表面活性剂混合物,
各自基于组合物的总重量计。
有利地,所述亲水聚合物a)是水溶胀性的,即其足够交联,以便溶胀但不溶于水。优选其是丙烯酸基的。其还优选为阴离子或阳离子的。
硅氧烷聚合物流体b)对于化妆品工业是熟知的,并且已经在头发和皮肤制剂中使用了许多年。由于它们改善了皮肤和头发美感并且在用于头发护理用途时赋予光泽,所以相对于矿物油,它们是特别受喜爱的。本发明的产品提供在不同离子体系中的相容性并且给出由任何其它液体分散体聚合物不能提供的使用硅氧烷技术的配方的通用性水平。
优选地,表面活性剂混合物c)包含可以用在可溶胀聚合物微粒a)制造中的两种表面活性剂,和用作后续水包油微粒稠化乳液的活化剂的至少一种表面活性剂。用于水包油稠化乳液的这种活化剂表面活性剂占组合物的1.0-10.0重量%,优选占组合物的2.0-8.0重量%。优选该活化剂表面活性剂是HLB一般大于7的非离子水包油乳化剂。这种类型的合适的乳化剂是本领域技术人员熟知的。乙氧基化的醇是优选的。
此外,该组合物可以含有少量不影响其主要特性的其它组分。典型地,这些其它组分可以包含最多约3重量%的水和挥发性有机溶剂以及制备水溶性或水溶胀性聚合物残留的少量其它组分中的每一种。
有利地,该组合物包含
a)40-60重量%的聚合物,其中,该聚合物是阴离子或阳离子的并且是水溶胀性的,
b)25-45重量%的硅氧烷聚合物流体,和
c)8-20重量%的表面活性剂或表面活性剂混合物,
其中每一种均基于该组合物的总重量计。
特别优选的组合物包含:
a)45-58重量%的聚合物,其中,该聚合物是阴离子或阳离子的并且是水溶胀性的,
b)30-40重量%的硅氧烷聚合物流体,和
c)10-18重量%的表面活性剂混合物,
其中每一种均基于该组合物的总重量计。
非常特别优选的组合物包含:
a)45-58重量%的水溶胀性聚合物,其中,该聚合物是阳离子的,
b)32-38重量%的硅氧烷聚合物流体,和
c)12-18重量%的表面活性剂混合物,
其中每一种均基于该组合物的总重量计。
本发明的仍然另一个方面提供稠化的水性或含水组合物,特别是个人护理制剂,其包含:
a)0.1-8重量%,优选1-6重量%的如上所述的液体分散体聚合物组合物,
b)0.1-70重量%,优选2-35重量%的附加成分,例如,个人护理成分,如化妆品或药物赋形剂和/或活性成分和
c)45-99重量%水或水与水混溶性有机溶剂如低级醇的混合物。
这样的低级醇包括乙醇、异丙醇、丙二醇、二异丙醇和其它已知的低级醇。
这些组合物可以是洗剂、霜剂、油膏剂、凝胶、乳剂、喷雾剂、泡沫或软膏形式的
其它成分可以是可以形成水包油型稠化水乳液的一部分的任何成分。化妆成分的非限制性实例包括:杀菌剂(如三氯生“RTM”、法呢醇“RTM”);皮肤调理剂和润肤剂如羊毛脂及其衍生物;酯如丙酸异丙酯、油酸癸酯、异硬脂酸异丙酯、三辛酸甘油酯、三硬脂酸甘油酯、丙酸肉豆蔻酯;脂肪醇;角鲨烯;硅氧烷如环甲基硅氧烷、二甲基硅氧烷、二甲基硅氧烷共聚醇;乙酰胺单乙醇胺;二甲基聚硅氧烷;湿润剂如真芦荟、护肤脂、润肤剂、α和β羟基酸如乳酸和乙醇酸;消炎活性成分如尿囊素和红没药醇;紫外光防晒剂如对氨基苯甲酸、水杨酸辛酯和甲氧基肉桂酸辛酯、“晒不到太阳的”皮肤晒黑剂、增白剂、驱虫剂、香精油如广藿香、薄荷油、迷迭香油、香茅油、茶树油、橙油或柠檬油、柏木油和檀香油、维生素、着色剂和颜料;头发调理剂如氨基二甲基硅氧烷(amodimethicone)、环甲基硅氧烷、泛醇、月桂酰胺二乙醇胺、月桂胺氧化物和丝蛋白;香料组分;染发剂和漂白剂及防腐剂如甲基-、乙基-、丙基-对羟基苯甲酸酯和咪唑烷基脲。
药物活性成分可以广泛变化并且包括所有的意欲用于皮肤或头发局部敷用的所有治疗药剂,特别是治疗瘙痒、刺痛感、皮屑、炎症或皮肤感染、烧伤和人类或其他哺乳动物的头皮脱发的物质。
本发明的另一个方面是提供一种制备治疗用的洗液、霜剂、油膏剂、凝胶或软膏的方法,其包括把0.1-8重量%,优选1-6重量%的如上所述液体分散体聚合物混入含有0.1-70重量%的至少一种治疗药剂和/或赋形剂的水性或水性/有机组合物中。
本发明的还有另一个方面是提供一种皮肤的局部治疗方法,其包括把如上所述的组合物涂敷到需要这样的治疗的人类或其它哺乳动物的皮肤、脸或头皮上。治疗的类型取决于在该组合物中溶解或悬浮的活性成分。例如,该组合物可以包含面霜如护肤脂;润湿霜、洗液或乳液;清洁剂或有机调色剂;手和身体乳液或洗液;含有抵抗UV-A和UV-B辐射的防晒剂的身体喷雾剂、霜剂、洗液或乳液;“晒不到太阳的”皮肤晒黑剂、洗液或喷雾液;皮肤漂白霜剂、洗液或喷雾剂;脱毛霜;头发调理霜、洗液或香波;染发霜或洗液;前用或后用剃须霜、洗液、凝胶或香膏、消毒剂霜、洗液、软膏或凝胶;在为晒黑晒太阳后涂敷的润肤霜、洗液或喷雾剂,等等。
从以下的讨论和实施例,本发明的其它方面将变得显而易见。这些实施例仅说明本发明的某些方面并且不作为其限制。
发明详述
用在本发明中的亲水、水溶胀性丙烯酸基液体分散体聚合物组合物可以是阴离子或阳离子的。所述聚合物可以是均聚物或共聚物。它们用一种或多种单烯键式不饱和单体形成,这些单体是水溶性的阴离子或阳离子单体,或者用主要为单体的阴离子或阳离子共混物形成,这些单体可以由阴离子和阳离子单体组成或者可以由阴离子和/或阳离子单体与少量非离子单体的混合物组成。
该聚合物可以方便地以平均颗粒尺寸为0.1-2微米的微粒形式获得,其方法为在疏水液体中合适的单体的反相乳液聚合过程,所述疏水液体即与水有足够低混溶性的液体,它可以用作反相聚合中的非水相。在可能合成聚合物的温度范围(例如15-100℃)内,该液体必须对聚合物或者对形成聚合物的单体基本没有溶剂化作用,因为溶剂化的介质对于反相乳液聚合是不能令人满意的。同样,单体或单体共混物必须是水溶性的,以便能使反相聚合进行。
合适的阴离子单体包括丙烯酸、甲基丙烯酸以及它们的碱金属盐和铵盐、2-丙烯酰胺基-2-甲基-丙磺酸及其盐、苯乙烯磺酸钠等。丙烯酸是最优选的阴离子单体。优选的是羧酸基至少50%,有利的是65-85%为碱金属盐或铵盐形式的,特别是钠盐形式的。
合适的阴离子单体包括二烯丙基二烷基单体如二烯丙基二甲基氯化铵,但是优选阳离子单体为二烷基氨基烷基(甲基)丙烯酸酯或-丙烯酰胺。虽然聚合物可以为游离碱形式的,特别是当其为阳离子丙烯酰胺或甲基丙烯酰胺时,优选的是酸加成物或季铵盐形式,如甲基丙烯酰胺基丙基三甲基氯化铵。
当单体是阳离子丙烯酰胺或甲基丙烯酰胺时,二烷基氨基烷基基团一般是二烷基氨基丙基或二烷基氨基异丙基基团。当单体是阴离子丙烯酸酯或甲基丙烯酸酯时,二烷基氨基烷基基团一般是二烷基氨基乙基基团。
阳离子单体是二烷基氨基烷基(甲基)丙烯酸酯的酸式盐或季铵盐通常是优选的,最优选的是甲基丙烯酸二甲基氨基乙酯。其通常以甲基氯季铵盐形式存在。
合适的非离子单体包括丙烯酰胺、甲基丙烯酰胺、N-二烷基丙烯酰胺、N,N-二烷基丙烯酰胺、N-乙烯基吡咯烷酮和水溶性羟基取代的丙烯酸或甲基丙烯酸酯。
如果使用阳离子共混物,阳离子单体的量优选大于共混物重量的50%,通常其至少为共混物重量的70%,或至少80%。优选的阳离子聚合物完全由阳离子单体形成。
如果使用阴离子共混物,则阴离子单体的量优选大于共混物重量的60%,并且通常其为共混物重量的至少80%。优选的阴离子聚合物完全由阴离子单体形成。
有利的是,所述液体分散体聚合物组合物通过向聚合混合物中引入少量合适的交联剂进行交联,所述交联剂例如多官能乙烯基加成单体。优选使用水溶性交联剂。
可以使用可溶于单体或单体共混物中的任何传统烯键式不饱和交联剂或多烯键式不饱和交联剂,包括作为二-、三-或四烯键式不饱和的物质。优选的是二烯键式不饱和化合物,如亚甲基双丙烯酰胺、二(甲基)丙烯酸乙二醇酯、二(甲基)丙烯酰胺、三烯丙基铵盐、乙烯氧基乙基丙烯酸酯或-甲基丙烯酸酯等。亚甲基双丙烯酰胺是最优选的交联剂。
交联剂的用量一般为100-10,000重量份交联剂/百万份(按干重计)单体。对于阳离子或阴离子单体,最优选的是约500-2000ppm,特别是500-900ppm。最佳用量可以通过常规试验确定。
用于本发明的特别优选的聚合物是分散在SalcareSC91和SalcareAST中的阴离子聚合物和分散在SalcareSC92、SalcareSC95和SalcareSC96液体分散体聚合物中的阳离子聚合物。
通过亲水单体,优选为一种或多种丙烯酸酯/或甲基丙烯酸酯单体在疏水液相中的反相乳液聚合来制备亲水聚合物。反相乳液聚合是众所周知的技术,其描述在例如美国专利4,628,078中,该专利的公开内容整体并入本文作为参考。
制备本液体分散体聚合物组合物所用的连续相至少部分由硅氧烷聚合物流体提供。由于液体分散体聚合物组合物主要用于化妆品或药物用途,硅氧烷聚合物流体是化妆品和/或药物可接受的并且其用作反相聚合中的连续相是足够疏水的,故其优选用作所述连续相。许多这样的材料是已知的并且可以购得。这样的硅氧烷流体包括环甲基硅氧烷、二甲基硅氧烷、苯基二甲基硅氧烷、苯基三甲基硅氧烷等,包括其混合物。苯基三甲基硅氧烷是优选的。
在聚合中所用的疏水液相量主要由提供满意的反相乳液介质的要求决定。这一般是至少约0.5重量份硅氧烷聚合物流体/重量份亲水聚合物(干重)。为了获得在硅氧烷聚合物流体中具有较高微粒量的液体分散体聚合物组合物,例如在硅氧烷聚合物流体中1.2-约1.7重量份亲水聚合物(干重),以及促进加工,便利的是使用挥发性惰性疏水溶剂。合适的惰性疏水溶剂包括烃和卤代烃。一种特别优选的烃混合物是得自Exxon的Isopar G“RTM”。方便地,使用1-2份,优选1.3-1.9份挥发性惰性疏水溶剂/份亲水聚合物,按干重计。
通过传统的反相乳液过程制备该聚合物,即向约1-3重量份至少部分包含液体疏水硅氧烷聚合物流体并含有约0.1-0.2份的至少一种HLB值小于9.0传统的油包水乳化剂及任选的0.5-10.0份的聚合物稳定剂表面活性剂的疏水液体中,加入1重量份(干重)的至少一种水性烯键式不饱和单体,任选包含多价螯合剂(sequesterant)和交联性烯键式不饱和单体,并剧烈搅拌,以便形成所要求细颗粒尺寸的基本稳定的乳液。稳定的油包水乳化剂是本领域技术人员熟知的。山梨聚糖酯是优选的。二亚乙基三胺五乙酸钠盐是合适的螯合剂。烯键式不饱和单体可以是二烯键式或多烯键式不饱和的。
用氮气吹扫反应混合物并加入传统的自由基源来引发聚合。合适的聚合引发剂是本领域技术人员熟知的。典型的形成自由基的催化剂包括过氧化合物如过硫酸钠、过硫酸钾和过硫酸铵、过氧化辛酰、过氧化苯甲酰、过氧化氢、过氧化壬酰、氢过氧化枯烯、二过邻苯二甲酸叔丁酯、过苯甲酸叔丁酯、过乙酸钠、过氧化二碳酸二(2-乙基己基)酯等,以及偶氮催化剂如偶氮二异丁腈。其它有用的催化剂是重金属活化催化剂体系。优选的聚合引发剂类型是氧化还原引发剂对。在引发后,保持合适的温度和搅拌条件直至单体到聚合物的转变基本完成。合适的条件对于本领域技术人员是熟知的。
然后从反相乳液中去除水和任何挥发性溶剂,例如通过减压蒸馏,以产生在硅氧烷聚合物流体中分散的尺寸小于2微米的聚合物颗粒的基本无水的稳定分散体。
在蒸馏完成后,以组合物的重量为基准,加入约1.0-10.0重量%,优选2-8重量%的HLB一般大于7的非离子水包油乳化剂。合适的该类乳化剂是本领域技术人员熟知的。乙氧基化的醇是优选的。
本发明的另一个特征是使用合适的聚合物稳定化剂表面活性剂作为加工助剂以保持在蒸馏过程中的乳液完整性,并且即使其含有高含量的水溶性或水溶胀性分散聚合物微粒,也可以提供成为自由流动液体的最终液体聚合物分散体。
有利地,使用0.5-10.0份,优选1.0-6.0份该表面活性剂/重量份(干重)烯键式不饱和单体。
优选的聚合物表面活性剂是(甲基)丙烯酸烷基酯和氨基官能单体的共聚物,其可以按如下制备:
把(甲基)丙烯酸烷基酯、氨基官能单体和合适的油溶性热引发剂,例如2,2’-偶氮双(2-甲基丁腈),溶解在惰性溶剂中,例如脂肪族或芳香族烃溶剂如Isopar G“RTM”。在80-90℃的反应温度下,在2-6小时期间,把该混合物送入含有其它溶剂和热引发剂的容器中。把反应物在该温度下再保持两个小时,然后冷却并放出。
(甲基)丙烯酸烷基酯的烷基可以是任何合适的烷基,但是,C8-C22的基团是优选的。
氨基官能单体具有通式(1):
(1)CH2=CRC(=O)-R1R2NR3R4
R是氢或C1-C4烷基
R1是氧或氮
R2是C1-C4烷基
R3是氢或C1-C10烷基
R4是C1-C10烷基
(甲基)丙烯酸烷基酯与氨基官能单体的比例可以为0.5-8.0∶1,按摩尔计。优选为0.75-6.0∶1,最优选为1.0-4.0∶1,按摩尔计。
通过本领域技术人员熟知的常规色谱技术确定分子量。典型的分子量为10,000-60,000,最常见为15,000-40,000。
在把液体分散体搅拌到水性体系中时,非离子表面活性剂使疏水载体转变成水包油乳液。同时,亲水聚合物在与水接触时膨胀,导致平稳迅速的粘度增大。典型地,所述聚合物颗粒溶胀,得到包含典型颗粒尺寸为2.5-5.0微米的聚合物颗粒的微粒稠化系统。
本发明的液体分散组合物提供微粒稠化体系,其在0.1-8.0%的浓度下对水性或水性/有机制剂产生有效的稠化。优选所述浓度为1-6重量%。但是,另外它们将液体分散体聚合物的稠化作用和硅氧烷聚合物流体的优点相结合。
所述液体分散体聚合物组合物与许多个人护理成分和助剂相容。可以使用该聚合物的典型制剂实例包括:
皮肤护理制剂,包括所有种类的面部和身体乳液,如霜剂、洗液、乳液和喷雾剂,用于护理、清洁、除臭和脱毛,彩色化妆品如液体粉底、液体眼影、液体胭脂、口红和水性染眉毛油;美容面具、唇膏、皮肤护理制剂如身体洗涤剂,所有种类的剃须制品;香皂、皂条和皂液。
头发护理制剂,包括护发素、染发剂(永久、半永久和暂时的)、定型胶、洗液和霜剂、香波、头发膨松剂(hair relaxers)、烫发剂(hain perms)和假发(hair mask)。
日晒制剂,如日晒霜、洗液和喷雾剂、防晒乳、晒黑促进剂、日晒后的霜剂、洗液和喷雾剂以及晒不到太阳的晒黑洗液或霜剂。
以下的配制实施例仅说明配制可能性的少数典型方面,不以任何方式限制本发明。最特别优选的组合物是在液体分散体聚合物中的聚合物包含水溶胀性阳离子聚合物微粒的情况,并且,其中硅氧烷聚合物流体是苯基三甲基硅氧烷。
所有的百分比是配方的重量百分比。粘度用Brookfield粘度计测定。
实施例1
日用护发增湿洗液/霜剂
商品名 | 供应商 | INCI名称 | % | |
1 | 液体 | 到100 | ||
2 | SalcareSilicone | Ciba SpecialtyChemicals | 待确定 | 2.75 |
3 | 山梨糖醇 | UPI | 山梨糖醇 | 1.50 |
4 | Eldew CL 301 | Ajinomoto | 谷氨酸胆甾醇酯/山嵛酯/十八烷基酯/月桂酰酯 | 0.50 |
5 | Cup1 PIC | Bernel | PPG-2 Isocetech-20乙酸酯 | 0.25 |
6 | 泛醇-液体 | Roche | 泛醇(Pro-Vitamin B5) | 0.25 |
7 | NipaguardBPX | Nipa | 对羟基苯甲酸苯氧基乙醇酯和对羟基苯甲酸甲酯和对羟基苯甲酸丙酯和2-溴-2-硝基丙烷1,3-二醇 | 0.15 |
8 | 香料 | 如果需要 |
方法:
1)向烧杯中加入1,开始搅拌,然后加入3、4和5,良好混合约5-10分钟。然后,加入6、7和8,并继续搅拌。
2)在提高搅拌器速度后,缓慢加入2,继续缓慢搅拌约5-10分钟,直至粘稠并均匀。
典型的性质:
外观:光滑的低粘度霜剂
粘度:10,000-20,000cPs
pH:3.5-4.25。
实施例2
通用日用手和身体洗液
商品名 | 供应商 | INCI名称 | % | |
1 | 液体 | 到100 | ||
2 | 甘油 | Procter & Gamble | 甘油 | 3.0 |
3 | Kessco | Stepan Company | 异壬酸辛酯 | 5.5 |
4 | 真芦荟 | Active Organics | 巴巴多斯芦荟 | 0.5 |
5 | SalcareSilicone | Ciba SpecialtyChemicals | 待确定 | 2.5 |
6 | Crodamol OPG | Croda | 壬酸辛酯 | 2.25 |
7 | Germaben ii | Sutton | 丙二醇和二重氮利定脲和对羟基苯甲酸甲酯和对羟基苯甲酸丙酯,根据要求 | 0.75 |
8 | 香料 | 如果需要 |
方法:
1)向烧杯中加入1,开始搅拌,然后加入2、3和4,良好混合约5-10分钟。然后,加入6、7和8,并继续搅拌。
2)在提高搅拌器速度后,缓慢加入5,继续缓慢搅拌约5-10分钟,直至粘稠并均匀。
典型的性质:
外观::“浓的”洗液
粘度:7,500-10,500cPs
pH:5.5-7.0。
实施例3
日晒后的洗液/霜剂
商品名 | 供应商 | INCI名称 | % | |
1 | 液体 | 到100 | ||
2 | 甜杏仁油 | AE Connock | Prunus Dulcis | 4.50 |
3 | ActiphyteKola Nut | Active Organics | 可乐果提取物 | 5.00 |
4 | 真芦荟 | Active Organics | 巴巴多芦荟 | 2.00 |
5 | SalcareSilicone | Ciba SpecialtyChemicals | 待确定 | 3.25 |
6 | Tinoderm P | Ciba SpecialtyChemicals | 液体和泛醇和辛酸/癸酸三甘油酯和聚山梨醇酯80和卵磷脂 | 1.25 |
7 | Nipaguard BPX | NipaLaboratories | 苯氧基乙醇和对羟基苯甲酸甲酯和对羟基苯甲酸丙酯和2-溴-2-硝基丙烷1,3-二醇 | 0.20 |
方法:
1)向烧杯中加入1,开始搅拌,然后加入2、3、4、6和7,良好混合约5-10分钟。
2)在提高搅拌器速度后,缓慢加入5,继续缓慢搅拌约5-10分钟,直至粘稠并均匀。
典型的性质:
外观:可流动的洗液
粘度:5,000-8,000cPs
pH:5.0-6.5。
Claims (13)
1.一种液体分散体聚合物组合物,其包含分散在硅氧烷聚合物流体b)中的亲水、水溶性或溶胀性聚合物a)和水包油表面活性剂c),其中,该聚合物是平均颗粒尺寸为0.1-2微米的微粒形式,其包含:
a)35-65重量%的聚合物,
b)20-50重量%的硅氧烷聚合物流体,和
c)5-25重量%的表面活性剂或表面活性剂混合物,
各自均以该组合物的总重量为基准计。
2.根据权利要求1的液体分散体聚合物组合物,其包含:
a)40-60重量%的聚合物,其中,该聚合物是阴离子或阳离子的并且是水溶胀性的,
b)25-45重量%的硅氧烷聚合物流体,和
c)8-20重量%的表面活性剂或表面活性剂混合物,
各自均以该组合物的总重量为基准计。
3.根据权利要求1-2的任一项的液体分散体聚合物组合物,其中,所述聚合物a)是用500-2000ppm交联剂交联的polyquaternium 37。
4.根据权利要求1-2的任一项的液体分散体聚合物组合物,其中,所述亲水聚合物a)通过一种或多种丙烯酸酯和/或甲基丙烯酸酯单体在包含至少一种硅氧烷聚合物流体的疏水液相中的反相乳液聚合制备。
5.根据权利要求1-2的任一项的液体分散体聚合物组合物,其中,所述硅氧烷聚合物流体b)是化妆品和/或药品可接受的。
6.一种稠化的水性或含水组合物,其包含:
a)0.1-8重量%的根据权利要求1-5的任一项的液体分散体聚合物组合物,
b)2-35重量%的个人护理成分,和
c)45-99%的水或水与水混溶性有机溶剂混合物,
并且上述各组分含量之和为100%。
7.根据权利要求6的稠化的水性或含水组合物,其中个人护理成分为化妆品或药物赋形剂和/或活性成分。
8.根据权利要求6的稠化的水性或含水组合物,其是洗液、霜剂、油膏剂、凝胶、软膏、乳剂、喷雾剂或泡沫形式的。
9.一种制备治疗洗液、霜剂、油膏剂、凝胶、软膏、乳剂、喷雾剂或泡沫的方法,其包括把0.1-8重量%的根据权利要求1-5的任一项的液体分散体聚合物混入含有0.1-70重量%的至少一种治疗药剂和/或赋型剂的水性或水性/有机组合物中。
10.一种制备根据权利要求1-5的任一项的液体分散体聚合物组合物的方法,其包括在包含至少一种硅氧烷聚合物流体的疏水液相中进行亲水单体的反相乳液聚合。
11.根据权利要求10的方法,其包括:
a)向1-3重量份包含液体疏水硅氧烷和任选的挥发性惰性疏水溶剂并含有至少一种HLB值小于9.0的油包水乳化剂及任选的聚合物稳定剂表面活性剂的疏水液体中,加入干重1重量份的亲水烯键式不饱和单体,后者任选包含螯合剂和交联性烯键式不饱和单体,并剧烈搅拌,以便形成细颗粒尺寸的基本稳定的乳液,
b)提供惰性气氛,
c)加入自由基引发剂,
d)保持合适的温度和搅拌条件直至单体到聚合物的转变基本完成,
e)在减压条件下从反相乳液中去除水和任选的挥发性溶剂,以便产生在硅氧烷中分散的尺寸小于2微米的聚合物颗粒的基本无水的稳定分散体,和
f)按组合物的重量计,向聚合物颗粒在硅氧烷的分散体中加入0.5-8重量%的HLB大于7的非离子水包油乳化剂。
12.根据权利要求10或11的方法,其中,亲水烯键式不饱和单体是用氯甲烷季化的甲基丙烯酸二甲基氨基乙酯,交联性烯键式不饱和单体是亚甲基双丙烯酰胺,硅氧烷聚合物流体是苯基三甲基硅氧烷,且存在聚合物稳定剂表面活性剂。
13.根据权利要求10或11的方法,其中,聚合物稳定剂表面活性剂是甲基丙烯酸烷基酯或丙烯酸烷基酯和氨基官能单体的反应产物。
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GBGB0029198.9A GB0029198D0 (en) | 2000-11-30 | 2000-11-30 | Liquid dispersion polymer compositions their preparation and their use |
GB0029198.9 | 2000-11-30 |
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EP (1) | EP1358236A2 (zh) |
JP (3) | JP2004524384A (zh) |
KR (1) | KR100884223B1 (zh) |
CN (1) | CN1275994C (zh) |
AU (1) | AU2002235735A1 (zh) |
BR (1) | BR0115751A (zh) |
CA (1) | CA2429464A1 (zh) |
GB (1) | GB0029198D0 (zh) |
MX (1) | MXPA03004828A (zh) |
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WO2004013209A1 (en) * | 2002-08-02 | 2004-02-12 | Ionic Solutions Limited | Polymeric compositions and their production and uses |
FR2866245B1 (fr) * | 2004-02-17 | 2006-03-31 | Snf Sas | Nouveaux agents epaississants et leur procede de preparation |
CN101671407B (zh) * | 2004-04-06 | 2014-04-30 | 西巴特殊化学制品控股公司 | 液体分散聚合物组合物、其制备及其应用 |
GB2422605A (en) * | 2005-01-29 | 2006-08-02 | Dow Corning | Ionic thickening agent for compositions |
FR2887450B1 (fr) * | 2005-06-23 | 2007-08-24 | Rhodia Chimie Sa | Ingredient concentre pour le traitement et/ou la modification de surfaces, et son utilisation dans des compositions cosmetiques |
EP1779893B1 (en) * | 2005-10-26 | 2011-06-15 | KPSS-Kao Professional Salon Services GmbH | Process for producing an aqueous composition |
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WO2014075964A1 (en) | 2012-11-14 | 2014-05-22 | Basf Se | Process for tertiary mineral oil production |
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BR112019011745B1 (pt) | 2016-12-07 | 2023-05-09 | Chevron U.S.A. Inc | Métodos para preparar uma solução polimérica aquosa e método para recuperar hidrocarboneto |
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WO2021175757A1 (en) | 2020-03-06 | 2021-09-10 | Basf Se | Method of manufacturing an aqueous polyacrylamide premix |
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-
2000
- 2000-11-30 GB GBGB0029198.9A patent/GB0029198D0/en not_active Ceased
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2001
- 2001-11-19 RU RU2003117706/04A patent/RU2003117706A/ru not_active Application Discontinuation
- 2001-11-19 BR BR0115751-5A patent/BR0115751A/pt not_active IP Right Cessation
- 2001-11-19 CN CNB018198813A patent/CN1275994C/zh not_active Expired - Fee Related
- 2001-11-19 MX MXPA03004828A patent/MXPA03004828A/es unknown
- 2001-11-19 AU AU2002235735A patent/AU2002235735A1/en not_active Abandoned
- 2001-11-19 CA CA002429464A patent/CA2429464A1/en not_active Abandoned
- 2001-11-19 KR KR1020037007218A patent/KR100884223B1/ko not_active IP Right Cessation
- 2001-11-19 EP EP01985816A patent/EP1358236A2/en not_active Withdrawn
- 2001-11-19 US US10/432,761 patent/US6833406B1/en not_active Expired - Lifetime
- 2001-11-19 WO PCT/EP2001/013348 patent/WO2002044228A2/en active Application Filing
- 2001-11-19 JP JP2002546594A patent/JP2004524384A/ja active Pending
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2009
- 2009-10-02 JP JP2009230439A patent/JP2010043275A/ja active Pending
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Also Published As
Publication number | Publication date |
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AU2002235735A1 (en) | 2002-06-11 |
MXPA03004828A (es) | 2003-08-19 |
WO2002044228A2 (en) | 2002-06-06 |
WO2002044228A3 (en) | 2003-09-04 |
BR0115751A (pt) | 2003-12-30 |
JP2014193905A (ja) | 2014-10-09 |
RU2003117706A (ru) | 2004-10-27 |
KR20030065530A (ko) | 2003-08-06 |
CA2429464A1 (en) | 2002-06-06 |
KR100884223B1 (ko) | 2009-02-17 |
JP2004524384A (ja) | 2004-08-12 |
JP2010043275A (ja) | 2010-02-25 |
GB0029198D0 (en) | 2001-01-17 |
US6833406B1 (en) | 2004-12-21 |
EP1358236A2 (en) | 2003-11-05 |
CN1553926A (zh) | 2004-12-08 |
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