CN1272011C - 植物甾醇和/或植物甾烷醇衍生物 - Google Patents
植物甾醇和/或植物甾烷醇衍生物 Download PDFInfo
- Publication number
- CN1272011C CN1272011C CNB2003101154954A CN200310115495A CN1272011C CN 1272011 C CN1272011 C CN 1272011C CN B2003101154954 A CNB2003101154954 A CN B2003101154954A CN 200310115495 A CN200310115495 A CN 200310115495A CN 1272011 C CN1272011 C CN 1272011C
- Authority
- CN
- China
- Prior art keywords
- ester
- mixture
- plant sterol
- acid
- food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
- A23D9/013—Other fatty acid esters, e.g. phosphatides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Polymers & Plastics (AREA)
- Hematology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Child & Adolescent Psychology (AREA)
- Wood Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Edible Oils And Fats (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
成分 | g/100g无水混合物 |
蛋白质 | 18.7 |
纤维 | 6.6 |
脂肪 | 18.3 |
糖类 | 39.2 |
食物能量(MJ/Kg) | 16 |
脂肪中的代谢能量(%) | 42 |
脂肪酸 | 1组对比组 | 2组2%(谷甾醇混合物+Trisun) | 3组2%谷甾烷醇-DHA酯 | 4组2%豆甾醇-EPA酯 | 5组2%谷甾醇混合物-EPA/DHA酯 |
饱和的 | 57.73 | 56.57 | 57.62 | 56.41 | 56.86 |
单烯 | 18.84 | 25.35 | 15.59 | 15.62 | 16.34 |
PUFAs | 23.43 | 18.08 | 26.79 | 27.98 | 26.81 |
总和n-6 | 22.08 | 16.76 | 16.85 | 16.92 | 17.47 |
总和n-3 | 1.21 | 1.15 | 9.91 | 10.89 | 9.20 |
C14 | 33.91 | 33.63 | 34.99 | 34.05 | 34.04 |
C16 | 17.84 | 16.64 | 16.76 | 16.58 | 16.66 |
C18 | 5.38 | 5.64 | 5.33 | 5.26 | 5.42 |
C18:1-9 | 17.99 | 24.39 | 15.08 | 15.02 | 15.16 |
C 18:1-7 | 0.55 | 0.67 | 0.41 | 0.42 | 0.56 |
C18:2-6 | 21.91 | 16.54 | 16.31 | 16.56 | 16.74 |
C18:3-3 | 1.21 | 1.15 | 1.17 | 1.21 | 1.25 |
C20:5-3 | 0.00 | 0.00 | 0.11 | 9.52 | 4.56 |
C22:6-3 | 0.00 | 0.00 | 8.58 | 0.13 | 2.76 |
0周 | 第2周 | 第4周 | |||
试验组 | 平均值±SD | 平均值±SD | %变化a | 平均值±SD | %变化a |
1组 | 2.69±0.42 | 2.48±0.44 | -8 | 2.24±0.47c | -17 |
2组 | 3.25±0.80 | 2.10±0.31 | -35 | 1.23±0.20b | -62 |
3组 | 2.90±0.58 | 1.79±0.37b | -38 | 1.23±0.26b | -58 |
4组 | 2.97±0.49 | 1.94±0.12b | -35 | 1.61±0.25b | -46 |
5组 | 3.58±0.52 | 1.73±0.26b | -52 | 1.22±0.21b | -66 |
HDL胆甾醇 | 非HDL胆甾醇 | |
平均值 | 平均值 | |
1组 | 0.60±0.09 | 1.64±0.47b |
2组 | 0.71±0.08 | 0.52±0.14a |
3组 | 0.49±0.10b | 0.75±0.21a |
4组 | 0.53±0.08 | 1.07±0.26a,b |
5组 | 0.68±0.19 | 0.54±0.10a |
0周 | 第2周 | 第4周 | |||
平均值±SD | 平均值±SD | %变化a | 平均值±SD | %变化a | |
1组 | 1.08±0.23 | 1.09±0.21 | 1 | 1.22±0.13 | 13 |
2组 | 1.00±0.17 | 1.04±0.17 | 4 | 1.08±0.15 | 7 |
3组 | 1.25±0.26 | 0.83±0.13b | -34 | 0.74±0.15b,c | -41 |
4组 | 0.98±0.15 | 0.81±0.19b | -17 | 0.83±0.13b,c | -15 |
5组 | 1.59±0.51 | 0.94±0.16 | -41 | 1.00±0.13b | -37 |
Claims (7)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98122412 | 1998-11-26 | ||
EP98122412.4 | 1998-11-26 | ||
EP99119337.6 | 1999-09-29 | ||
EP99119337 | 1999-09-29 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB99124382XA Division CN1135234C (zh) | 1998-11-26 | 1999-11-26 | 植物甾醇和/或植物甾烷醇衍生物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1494909A CN1494909A (zh) | 2004-05-12 |
CN1272011C true CN1272011C (zh) | 2006-08-30 |
Family
ID=26149828
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2003101154954A Expired - Fee Related CN1272011C (zh) | 1998-11-26 | 1999-11-26 | 植物甾醇和/或植物甾烷醇衍生物 |
CNB99124382XA Expired - Fee Related CN1135234C (zh) | 1998-11-26 | 1999-11-26 | 植物甾醇和/或植物甾烷醇衍生物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB99124382XA Expired - Fee Related CN1135234C (zh) | 1998-11-26 | 1999-11-26 | 植物甾醇和/或植物甾烷醇衍生物 |
Country Status (17)
Country | Link |
---|---|
US (4) | US20020160990A1 (zh) |
EP (1) | EP1004594B1 (zh) |
JP (1) | JP2000159792A (zh) |
KR (1) | KR100678831B1 (zh) |
CN (2) | CN1272011C (zh) |
AR (1) | AR025141A1 (zh) |
AT (1) | ATE246704T1 (zh) |
AU (1) | AU762539B2 (zh) |
BR (1) | BR9905398A (zh) |
CA (1) | CA2290331C (zh) |
DE (1) | DE69910152T2 (zh) |
DK (1) | DK1004594T3 (zh) |
ES (1) | ES2204052T3 (zh) |
ID (1) | ID24148A (zh) |
MX (1) | MX215122B (zh) |
NO (1) | NO314357B1 (zh) |
NZ (1) | NZ501169A (zh) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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US6586212B1 (en) * | 1999-02-10 | 2003-07-01 | Eastman Chemical Company | Corn fiber for the production of advanced chemicals and materials: derivatizable cellulose and cellulose derivatives made therefrom |
EP1211955A1 (en) * | 1999-08-30 | 2002-06-12 | Ocean Nutrition Canada Ltd. | A nutritional supplement for lowering serum triglyceride and cholesterol levels |
US6998501B1 (en) * | 1999-08-30 | 2006-02-14 | Ocean Nutrition Canada Limited | Nutritional supplement for lowering serum triglyceride and cholesterol levels |
US6838098B2 (en) | 2000-09-07 | 2005-01-04 | Cadbury Adams Usa, Llc | Continuous formation of center filled gum |
SE523094C2 (sv) * | 2001-01-11 | 2004-03-30 | Karlshamns Ab | Förfarande för framställning av en fettkomposition som innehåller sterolestrar, fria steroler och glycerider, fettkomposition framställd genom förfarandet samt fettkompositionens användning |
US6623266B2 (en) | 2001-01-19 | 2003-09-23 | Cadbury Adams Usa Llc | Apparatus for making a center-filled gum lollipop with hard candy shell |
KR100440613B1 (ko) * | 2001-04-20 | 2004-08-16 | 주식회사 유엘바이오텍 | 식물성스테롤과 생 플라보노이드의 결합체를 이용한 혈중콜레스테롤 저하제의 제조방법과 이에 의해 제조한 혈중콜레스테롤 저하제 |
KR20020081834A (ko) * | 2001-04-20 | 2002-10-30 | 주식회사 유엘바이오텍 | 식물성 스테롤의 유도체를 이용한 혈중 콜레스테롤저하제의 제조방법 및 이에 의해 제조된 혈중 콜레스테롤저하제 |
EP1275309A1 (en) * | 2001-07-13 | 2003-01-15 | Ikeda Food Research Co. Ltd. | Sterol fatty acid ester composition and foods containing the same |
WO2003009854A1 (en) * | 2001-07-20 | 2003-02-06 | Lonza Ag | Lipid lowering composition comprising carnitine and phytosterol |
FI20012553A0 (fi) * | 2001-12-21 | 2001-12-21 | Raisio Benecol Oy | Syötävät koostumukset |
WO2003086468A1 (en) * | 2002-04-10 | 2003-10-23 | Cargill, Incorporated | Aqueous dispersible steryl ester compositions |
US20040081678A1 (en) | 2002-08-09 | 2004-04-29 | Anthony Cincotta | Therapeutic process for the treatment of obesity and associated metabolic disorders |
US8821915B2 (en) | 2002-08-09 | 2014-09-02 | Veroscience, Llc | Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders |
WO2004091603A1 (fr) * | 2003-04-07 | 2004-10-28 | Clinigenetics | Utilisation d’un ester de dha pour le traitement des malades cardiovasculaires |
EP1466597A1 (en) * | 2003-04-07 | 2004-10-13 | Clinigenetics | Use of dha esters to control or prevent cardiovascular diseases |
KR101054913B1 (ko) * | 2003-12-31 | 2011-08-05 | 주식회사 삼양제넥스 | 식물스테롤, 헤스페리딘 및 루틴을 포함하는 고지혈증,동맥경화증 및 간질환 예방 및 치료용 조성물 |
US8158184B2 (en) * | 2004-03-08 | 2012-04-17 | Bunge Oils, Inc. | Structured lipid containing compositions and methods with health and nutrition promoting characteristics |
US7727565B2 (en) | 2004-08-25 | 2010-06-01 | Cadbury Adams Usa Llc | Liquid-filled chewing gum composition |
US7678399B2 (en) | 2005-12-05 | 2010-03-16 | Bunge Oils, Inc. | Phytosterol containing deep-fried foods and methods with health promoting characteristics |
WO2007117627A2 (en) | 2006-04-05 | 2007-10-18 | Cadbury Adams Usa Llc | Calcium phosphate complex and salts in oral delivery systems |
CN101415393B (zh) | 2006-04-05 | 2013-07-24 | 卡夫食品环球品牌有限责任公司 | 含酸糖食中的磷酸钙复合物 |
US20070298079A1 (en) * | 2006-06-26 | 2007-12-27 | Tropicana Products, Inc. | Food fortified with omega-3 fatty acids |
US8683899B2 (en) | 2006-06-29 | 2014-04-01 | Intercontinental Great Brands, LLC | Chain cutter for continuously forming center-filled gum pieces |
GB0905367D0 (en) * | 2009-03-27 | 2009-05-13 | Danisco | Method |
US9352025B2 (en) | 2009-06-05 | 2016-05-31 | Veroscience Llc | Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders |
CN101919537B (zh) * | 2010-09-09 | 2012-08-08 | 浙江大学 | 植物甾烷醇酯和共轭亚油酸酯在功能性肉制品中的应用 |
FI123374B (fi) * | 2011-03-25 | 2013-03-15 | Ravintoraisio Oy | Uusi syötävä koostumus |
CN102318686B (zh) * | 2011-06-01 | 2012-12-19 | 黑龙江省大豆技术开发研究中心 | 一种制备含有植物甾醇酯的功能性保健油脂的方法 |
CN102603846A (zh) * | 2012-02-03 | 2012-07-25 | 江南大学 | 一种离子液体中植物甾醇酯的制备方法 |
CN103242407A (zh) * | 2013-05-15 | 2013-08-14 | 张雅茹 | 含多不饱和脂肪酰基的磷脂酰甾醇和/或磷脂酰甾烷醇及制备方法和应用 |
IL237290A0 (en) * | 2015-02-17 | 2015-06-30 | Enzymotec Ltd | Oil mixtures for use in formulas |
BR112017022523B1 (pt) * | 2015-04-23 | 2023-12-19 | Basf Se | Formulação para cápsulas de gel, cápsula de gel, e, processo para produção de uma formulação |
CN109200061A (zh) * | 2017-06-29 | 2019-01-15 | 四川国为制药有限公司 | 一种高纯度鱼油与植物甾醇酯的降血脂组合物 |
WO2020259493A1 (en) * | 2019-06-24 | 2020-12-30 | Basf Se | Compositions and methods for the prevention or treatment, or dietary management of nafld |
CN113197310A (zh) * | 2021-05-21 | 2021-08-03 | 江苏越红生物科技有限公司 | 一种富含油酸的植物甾醇酯的制备方法 |
Family Cites Families (7)
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USRE30910E (en) * | 1971-03-19 | 1982-04-20 | Intellectual Property Development Corporation | Reducing cholesterol levels |
US4588717A (en) * | 1984-06-13 | 1986-05-13 | David C. Mitchell Medical Research Institute | Compounds and vitamin supplements and methods for making same |
CA2102112C (en) * | 1991-05-03 | 2010-04-13 | Tatu Miettinen | A substance for lowering high cholesterol level in serum and a method for preparing the same |
US5593691A (en) * | 1993-06-03 | 1997-01-14 | Marigen S.A. | Biotenside solvents for pharmaceuticals and cosmetics |
FI107015B (fi) * | 1996-08-09 | 2001-05-31 | Raisio Benecol Oy | Kasvistanolirasvahappoestereiden seos ja sen käyttö sekä elintarvike |
AU4891699A (en) * | 1998-07-20 | 2000-02-14 | Forbes Medi-Tech Inc. | Compositions comprising phytosterol, phytostanol or mixtures of both and omega-3fatty acids or derivatives thereof and use of the composition in treating or preventing cardiovascular disease and other disorders |
US5892068A (en) * | 1998-08-25 | 1999-04-06 | Mcneil-Ppc, Inc. | Preparation of sterol and stanol-esters |
-
1999
- 1999-11-18 NZ NZ501169A patent/NZ501169A/en not_active IP Right Cessation
- 1999-11-18 ID IDP991068A patent/ID24148A/id unknown
- 1999-11-19 CA CA002290331A patent/CA2290331C/en not_active Expired - Fee Related
- 1999-11-19 AT AT99122978T patent/ATE246704T1/de not_active IP Right Cessation
- 1999-11-19 ES ES99122978T patent/ES2204052T3/es not_active Expired - Lifetime
- 1999-11-19 DE DE69910152T patent/DE69910152T2/de not_active Revoked
- 1999-11-19 DK DK99122978T patent/DK1004594T3/da active
- 1999-11-19 MX MX9910678A patent/MX215122B/es not_active IP Right Cessation
- 1999-11-19 EP EP99122978A patent/EP1004594B1/en not_active Revoked
- 1999-11-22 JP JP11330770A patent/JP2000159792A/ja not_active Withdrawn
- 1999-11-23 KR KR1019990052052A patent/KR100678831B1/ko not_active IP Right Cessation
- 1999-11-23 US US09/448,356 patent/US20020160990A1/en not_active Abandoned
- 1999-11-24 AR ARP990105983A patent/AR025141A1/es unknown
- 1999-11-25 AU AU60655/99A patent/AU762539B2/en not_active Ceased
- 1999-11-25 BR BR9905398-5A patent/BR9905398A/pt not_active Application Discontinuation
- 1999-11-25 NO NO19995784A patent/NO314357B1/no not_active IP Right Cessation
- 1999-11-26 CN CNB2003101154954A patent/CN1272011C/zh not_active Expired - Fee Related
- 1999-11-26 CN CNB99124382XA patent/CN1135234C/zh not_active Expired - Fee Related
-
2001
- 2001-11-20 US US09/989,554 patent/US20020055493A1/en not_active Abandoned
-
2005
- 2005-07-25 US US11/189,667 patent/US20050261259A1/en not_active Abandoned
-
2006
- 2006-12-04 US US11/634,032 patent/US20070078115A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1135234C (zh) | 2004-01-21 |
US20050261259A1 (en) | 2005-11-24 |
NO995784D0 (no) | 1999-11-25 |
US20020055493A1 (en) | 2002-05-09 |
BR9905398A (pt) | 2000-08-08 |
JP2000159792A (ja) | 2000-06-13 |
ATE246704T1 (de) | 2003-08-15 |
CA2290331C (en) | 2008-01-15 |
MX9910678A (en) | 2000-04-30 |
NO995784L (no) | 2000-05-29 |
ID24148A (id) | 2000-07-13 |
DE69910152D1 (de) | 2003-09-11 |
DE69910152T2 (de) | 2004-06-09 |
ES2204052T3 (es) | 2004-04-16 |
KR20000035619A (ko) | 2000-06-26 |
AU6065599A (en) | 2000-06-01 |
CN1256277A (zh) | 2000-06-14 |
AU762539B2 (en) | 2003-06-26 |
NZ501169A (en) | 2001-05-25 |
US20070078115A1 (en) | 2007-04-05 |
NO314357B1 (no) | 2003-03-10 |
DK1004594T3 (da) | 2003-11-17 |
CA2290331A1 (en) | 2000-05-26 |
US20020160990A1 (en) | 2002-10-31 |
MX215122B (en) | 2003-07-08 |
CN1494909A (zh) | 2004-05-12 |
KR100678831B1 (ko) | 2007-02-05 |
EP1004594A1 (en) | 2000-05-31 |
EP1004594B1 (en) | 2003-08-06 |
AR025141A1 (es) | 2002-11-13 |
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