CN1268051A - 一种麻醉化合物的清亮的注射用制剂 - Google Patents

一种麻醉化合物的清亮的注射用制剂 Download PDF

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Publication number
CN1268051A
CN1268051A CN98806674A CN98806674A CN1268051A CN 1268051 A CN1268051 A CN 1268051A CN 98806674 A CN98806674 A CN 98806674A CN 98806674 A CN98806674 A CN 98806674A CN 1268051 A CN1268051 A CN 1268051A
Authority
CN
China
Prior art keywords
solution
lecithin
propofol
temperature
bile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98806674A
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English (en)
Chinese (zh)
Inventor
V·德托马索
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WEST Ltd
Original Assignee
WEST Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WEST Ltd filed Critical WEST Ltd
Publication of CN1268051A publication Critical patent/CN1268051A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN98806674A 1997-05-26 1998-05-14 一种麻醉化合物的清亮的注射用制剂 Pending CN1268051A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1224/1997 1997-05-26
CH01224/97A CH692322A5 (it) 1997-05-26 1997-05-26 Formulazione iniettabile limpida di Propofol.

Publications (1)

Publication Number Publication Date
CN1268051A true CN1268051A (zh) 2000-09-27

Family

ID=4205400

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98806674A Pending CN1268051A (zh) 1997-05-26 1998-05-14 一种麻醉化合物的清亮的注射用制剂

Country Status (23)

Country Link
US (1) US6326406B1 (cg-RX-API-DMAC10.html)
EP (1) EP0991405B1 (cg-RX-API-DMAC10.html)
JP (1) JP2001527577A (cg-RX-API-DMAC10.html)
KR (1) KR20010013011A (cg-RX-API-DMAC10.html)
CN (1) CN1268051A (cg-RX-API-DMAC10.html)
AR (1) AR012853A1 (cg-RX-API-DMAC10.html)
AT (1) ATE230984T1 (cg-RX-API-DMAC10.html)
AU (1) AU735020B2 (cg-RX-API-DMAC10.html)
BR (1) BR9809492A (cg-RX-API-DMAC10.html)
CA (1) CA2291261A1 (cg-RX-API-DMAC10.html)
CH (1) CH692322A5 (cg-RX-API-DMAC10.html)
DE (1) DE69810771D1 (cg-RX-API-DMAC10.html)
DZ (1) DZ2503A1 (cg-RX-API-DMAC10.html)
HU (1) HUP0002117A3 (cg-RX-API-DMAC10.html)
IN (1) IN187550B (cg-RX-API-DMAC10.html)
MY (1) MY132911A (cg-RX-API-DMAC10.html)
NO (1) NO995831L (cg-RX-API-DMAC10.html)
PA (1) PA8451701A1 (cg-RX-API-DMAC10.html)
PE (1) PE75299A1 (cg-RX-API-DMAC10.html)
PL (1) PL337026A1 (cg-RX-API-DMAC10.html)
TR (1) TR200000116T2 (cg-RX-API-DMAC10.html)
WO (1) WO1998053805A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA984314B (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100358513C (zh) * 2005-04-07 2008-01-02 常州市第四制药厂有限公司 一种丙泊酚注射液的制备工艺

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
CA2338703C (en) 1998-08-19 2009-03-24 Rtp Pharma Inc. Injectable aqueous dispersions of propofol
DE69922252T2 (de) * 1999-01-28 2005-12-01 Patel, Dinesh Shantilal Parenterale lösungen enthaltend propofol (2,6-diisopropylphenol) und 2.5-di-0-methyl-1.4;3.6-dianhydro-d-glucitol als lösungsmittel
US6177477B1 (en) * 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
US6635456B2 (en) * 2001-02-09 2003-10-21 Fidia Farmaceutici S.P.A. Procedure for the preparation of pure phosphatides with phospholipase D
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
KR100482269B1 (ko) * 2002-10-08 2005-04-14 센츄론(주) 2,6-디이소프로필페놀을 활성성분으로 하는 수용액상의마취용 주사제 및 그 제조방법
EP1585548B1 (en) 2002-12-09 2018-06-27 Abraxis BioScience, LLC Compositions and methods of delivery of pharmacological agents
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US8546453B2 (en) * 2003-08-14 2013-10-01 Rensheng Zhang Propofol compositions and methods for reducing pain associated with propofol injection
JP2005154305A (ja) * 2003-11-21 2005-06-16 Showa Yakuhin Kako Kk ヒアルロン酸含有組成物の製造方法
US8034765B2 (en) 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
ES2784794T3 (es) 2005-08-31 2020-10-01 Abraxis Bioscience Llc Composiciones que comprenden agentes farmacéuticos poco solubles en agua y agentes antimicrobianos
CN102159229A (zh) * 2008-11-20 2011-08-17 帝国制药美国公司 吡唑啉酮衍生物制剂
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations
EP3761961A4 (en) * 2018-03-07 2022-01-05 Andrew Xian Chen AQUEOUS FORMULATIONS FOR INSOLUBLE DRUGS
JP7063217B2 (ja) * 2018-09-27 2022-05-09 住友電気工業株式会社 光ファイバの製造方法
JP7135670B2 (ja) * 2018-09-27 2022-09-13 住友電気工業株式会社 光ファイバ及び紫外線硬化型樹脂組成物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1089510B (de) 1959-03-23 1960-09-22 Rudolf Reiss Dr Verfahren zur Herstellung waessriger, injizierbarer Loesungen von 2-Methoxy-4-allylphenoxyessigsaeure-N, N-Diaethylamid
GB1472793A (en) 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
US4798846A (en) * 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
DE3221579A1 (de) 1982-06-08 1983-12-22 Eckert, Theodor, Prof. Dr., 4400 Münster Solubilisierung von in wasser schwerloeslichen wirkstoffen in waessrige loesung unter verwendung eines gemisches von cholinphosphorsaeureglycerindiester (cholin-lecithin) und natriumdesoxycholat als loesungsvermittler und die therapeutische verwendung der so erhaltenen waessrigen loesungen
CA1319886C (en) 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions
US5085864A (en) * 1989-10-30 1992-02-04 Abbott Laboratories Injectable formulation for lipophilic drugs
DE4039602A1 (de) * 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
GB9405593D0 (en) 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
ZA962214B (en) 1995-04-10 1996-10-07 Farmarc Nederland Bv Pharmaceutical composition
WO1997010814A1 (en) * 1995-09-18 1997-03-27 Vesifact Ag Propofol nanodispersions
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100358513C (zh) * 2005-04-07 2008-01-02 常州市第四制药厂有限公司 一种丙泊酚注射液的制备工艺

Also Published As

Publication number Publication date
AU8209798A (en) 1998-12-30
US6326406B1 (en) 2001-12-04
EP0991405B1 (en) 2003-01-15
HUP0002117A2 (hu) 2000-12-28
KR20010013011A (ko) 2001-02-26
JP2001527577A (ja) 2001-12-25
CH692322A5 (it) 2002-05-15
ZA984314B (en) 1998-12-08
DE69810771D1 (de) 2003-02-20
HUP0002117A3 (en) 2001-04-28
ATE230984T1 (de) 2003-02-15
PE75299A1 (es) 1999-08-26
PL337026A1 (en) 2000-07-31
WO1998053805A1 (en) 1998-12-03
PA8451701A1 (es) 2000-05-24
EP0991405A1 (en) 2000-04-12
CA2291261A1 (en) 1998-12-03
TR200000116T2 (tr) 2000-05-22
NO995831L (no) 2000-01-26
AU735020B2 (en) 2001-06-28
IN187550B (cg-RX-API-DMAC10.html) 2002-05-18
MY132911A (en) 2007-10-31
DZ2503A1 (fr) 2005-01-25
AR012853A1 (es) 2000-11-22
NO995831D0 (no) 1999-11-26
BR9809492A (pt) 2000-06-20

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