CN1262668C - 转移核酸通过核被膜的细胞转运系统的用途 - Google Patents

转移核酸通过核被膜的细胞转运系统的用途 Download PDF

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Publication number
CN1262668C
CN1262668C CNB008034478A CN00803447A CN1262668C CN 1262668 C CN1262668 C CN 1262668C CN B008034478 A CNB008034478 A CN B008034478A CN 00803447 A CN00803447 A CN 00803447A CN 1262668 C CN1262668 C CN 1262668C
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dna
nuclear
localization signal
sequence
peptide
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Expired - Fee Related
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CNB008034478A
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English (en)
Chinese (zh)
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CN1339068A (zh
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G·希本科顿
R·克里斯汀
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Amaxa AG
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Amaxa AG
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Priority claimed from DE19933939A external-priority patent/DE19933939A1/de
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CNB008034478A 1999-01-08 2000-01-03 转移核酸通过核被膜的细胞转运系统的用途 Expired - Fee Related CN1262668C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19900513.3 1999-01-08
DE19900513 1999-01-08
DE19933939A DE19933939A1 (de) 1999-01-08 1999-07-20 Ausnutzung zelleigener Transportsysteme zum Transfer von Nukleinsäuren durch die Kernhülle
DE19933939.2 1999-07-20

Publications (2)

Publication Number Publication Date
CN1339068A CN1339068A (zh) 2002-03-06
CN1262668C true CN1262668C (zh) 2006-07-05

Family

ID=26051245

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008034478A Expired - Fee Related CN1262668C (zh) 1999-01-08 2000-01-03 转移核酸通过核被膜的细胞转运系统的用途

Country Status (8)

Country Link
US (1) US6521456B1 (https=)
EP (1) EP1141364A1 (https=)
JP (2) JP3997056B2 (https=)
CN (1) CN1262668C (https=)
AU (1) AU764660B2 (https=)
CA (1) CA2358040C (https=)
IL (1) IL143983A0 (https=)
WO (1) WO2000040742A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069173A1 (en) * 1998-03-16 2003-04-10 Life Technologies, Inc. Peptide-enhanced transfections
EP1141364A1 (de) * 1999-01-08 2001-10-10 Amaxa GmbH Ausnutzung zelleigener transportsysteme zum transfer von nukleinsäuren durch die kernhülle
EP1235914A2 (en) * 1999-11-24 2002-09-04 Joseph Rosenecker Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
US20040063906A1 (en) * 2000-11-24 2004-04-01 Nielsen Peter E. Pna analogues
WO2002053574A2 (en) * 2001-01-05 2002-07-11 Pantheco A/S Modified pna molecules
KR100912741B1 (ko) 2001-01-10 2009-08-18 아막사 아게 모듈식 트랜스펙션 시스템
WO2003092735A2 (en) * 2002-05-01 2003-11-13 Pantheco A/S Peptide nucleic acid conjugates with beta-amino acid polymers or reptoids
US8324365B2 (en) * 2003-04-03 2012-12-04 Korea Advanced Institute Of Science And Technology Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
US8969543B2 (en) * 2003-04-03 2015-03-03 Bioneer Corporation SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
US20070149496A1 (en) * 2003-10-31 2007-06-28 Jack Tuszynski Water-soluble compound
CA2619533C (en) * 2005-08-17 2014-02-04 Bioneer Corporation Sirna-hydrophilic polymer conjugates for intracellular delivery of sirna and method thereof
EP1900820A1 (en) * 2006-09-13 2008-03-19 Amaxa AG Nuclear transport agent and method for producing said agent
AU2019269066B2 (en) 2018-05-18 2022-10-06 F. Hoffmann-La Roche Ag Targeted intracellular delivery of large nucleic acids

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
WO1993019768A1 (en) * 1992-04-03 1993-10-14 The Regents Of The University Of California Self-assembling polynucleotide delivery system
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
US5631237A (en) 1992-12-22 1997-05-20 Dzau; Victor J. Method for producing in vivo delivery of therapeutic agents via liposomes
EP0745134A1 (en) * 1994-02-22 1996-12-04 Danafarber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof
EP0753069A1 (en) * 1994-04-15 1997-01-15 Targeted Genetics Corporation Gene delivery fusion proteins
US5670347A (en) * 1994-05-11 1997-09-23 Amba Biosciences Llc Peptide-mediated gene transfer
EP0874910A4 (en) 1995-06-07 1999-04-21 Life Technologies Inc ENHANCED CATIONIC LIPID TRANSFECTION BY PEPTIDES
DE19541679A1 (de) 1995-11-08 1997-05-15 Gerhard Dr Friedrich Nicht virale Gentransfersysteme mit NLS (nuclear localization sequences) und/oder magnetisierbaren Mikropartikeln und das damit verbundene Herstellungsverfahren
AUPN741696A0 (en) * 1996-01-05 1996-01-25 Commonwealth Scientific And Industrial Research Organisation Delivery of nucleic acids ii
EP0946718A1 (en) * 1996-12-23 1999-10-06 Gene-Cell Nucleic acid constructs and uses thereof for direct nucleic acid incorporation into cells
JP2002514078A (ja) * 1997-04-18 2002-05-14 ミレニアム ファーマシューティカルズ インク． Ｆｔｈｍａ−０７０関連蛋白質ファミリーおよびｔ８５関連蛋白質ファミリーの新規分子ならびにそれらの使用
EP1141364A1 (de) * 1999-01-08 2001-10-10 Amaxa GmbH Ausnutzung zelleigener transportsysteme zum transfer von nukleinsäuren durch die kernhülle
US6312956B1 (en) * 1999-10-01 2001-11-06 Vanderbilt University Nuclear targeted peptide nucleic acid oligomer

Also Published As

Publication number Publication date
AU764660B2 (en) 2003-08-28
IL143983A0 (en) 2002-04-21
EP1141364A1 (de) 2001-10-10
CN1339068A (zh) 2002-03-06
AU2533700A (en) 2000-07-24
JP2006345867A (ja) 2006-12-28
US6521456B1 (en) 2003-02-18
JP3997056B2 (ja) 2007-10-24
CA2358040A1 (en) 2000-07-13
JP2002534437A (ja) 2002-10-15
WO2000040742A1 (de) 2000-07-13
CA2358040C (en) 2008-06-10

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