CN1259043C - 鼠尾草酸在制药中的应用 - Google Patents
鼠尾草酸在制药中的应用 Download PDFInfo
- Publication number
- CN1259043C CN1259043C CN03151251.8A CN03151251A CN1259043C CN 1259043 C CN1259043 C CN 1259043C CN 03151251 A CN03151251 A CN 03151251A CN 1259043 C CN1259043 C CN 1259043C
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- Prior art keywords
- carnosic acid
- coxsackie
- virus
- chloroform
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QRYRORQUOLYVBU-VBKZILBWSA-N carnosic acid Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims abstract description 48
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 241000700605 Viruses Species 0.000 description 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- 239000000284 extract Substances 0.000 description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
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- 229910002027 silica gel Inorganic materials 0.000 description 10
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 208000009525 Myocarditis Diseases 0.000 description 3
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 3
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- 229920005654 Sephadex Polymers 0.000 description 2
- 239000012507 Sephadex™ Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000012531 culture fluid Substances 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
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- 241000607626 Vibrio cholerae Species 0.000 description 1
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- 235000015639 rosmarinus officinalis Nutrition 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
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- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
样品编号 | TC50(μg/ml) | 实验初试浓度(μg/ml) | IC50(μg/ml) | SI |
鼠尾草酸 | >500 | 1000 | 12 | 41.66 |
RBV | >1000 | 1000 | 850 | 1.18 |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN03151251.8A CN1259043C (zh) | 2003-09-26 | 2003-09-26 | 鼠尾草酸在制药中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN03151251.8A CN1259043C (zh) | 2003-09-26 | 2003-09-26 | 鼠尾草酸在制药中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1600303A CN1600303A (zh) | 2005-03-30 |
CN1259043C true CN1259043C (zh) | 2006-06-14 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CN03151251.8A Expired - Fee Related CN1259043C (zh) | 2003-09-26 | 2003-09-26 | 鼠尾草酸在制药中的应用 |
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CN (1) | CN1259043C (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108276271B (zh) * | 2018-01-30 | 2021-02-12 | 北京联合大学 | 一种从迷迭香中同时制备高纯度鼠尾草酚和鼠尾草酸的方法 |
CN111440184B (zh) * | 2018-01-30 | 2021-08-27 | 北京联合大学 | 一种制备高纯度鼠尾草酚的方法 |
CN112336708B (zh) * | 2020-11-17 | 2022-03-29 | 北京化工大学 | 替拉曲考在治疗柯萨奇病毒感染中的应用 |
-
2003
- 2003-09-26 CN CN03151251.8A patent/CN1259043C/zh not_active Expired - Fee Related
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Publication number | Publication date |
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CN1600303A (zh) | 2005-03-30 |
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Application publication date: 20050330 Assignee: Shanghai Puchuang Longke Finance Leasing Co.,Ltd. Assignor: SHANGHAI WENDA BIOTECH Inc. Contract record no.: X2020980002915 Denomination of invention: Application of salvia acid in pharmacy Granted publication date: 20060614 License type: Exclusive License Record date: 20200609 |
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Denomination of invention: Application of salvia acid in pharmacy Effective date of registration: 20200609 Granted publication date: 20060614 Pledgee: Shanghai Puchuang Longke Finance Leasing Co.,Ltd. Pledgor: SHANGHAI WENDA BIOTECH Inc. Registration number: Y2020980002917 |
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Assignee: Shanghai Puchuang Longke Finance Leasing Co.,Ltd. Assignor: SHANGHAI WENDA BIOTECH Inc. Contract record no.: X2020980002915 Date of cancellation: 20210809 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210809 Granted publication date: 20060614 Pledgee: Shanghai Puchuang Longke Finance Leasing Co.,Ltd. Pledgor: SHANGHAI WENDA BIOTECH Inc. Registration number: Y2020980002917 |
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Granted publication date: 20060614 Termination date: 20210926 |