CN1255044A - 苦瓜中的口服活性成分,其活性肽,及它们治疗糖尿病的用途 - Google Patents

苦瓜中的口服活性成分,其活性肽,及它们治疗糖尿病的用途 Download PDF

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Publication number
CN1255044A
CN1255044A CN98805001A CN98805001A CN1255044A CN 1255044 A CN1255044 A CN 1255044A CN 98805001 A CN98805001 A CN 98805001A CN 98805001 A CN98805001 A CN 98805001A CN 1255044 A CN1255044 A CN 1255044A
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China
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diabetes
type
peptide
pharmaceutical composition
host
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CN98805001A
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English (en)
Chinese (zh)
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B·纳格
S·麦迪彻拉
S·D·沙玛
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Calyx Therapeutics Inc
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Calyx Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN98805001A 1997-04-01 1998-04-01 苦瓜中的口服活性成分,其活性肽,及它们治疗糖尿病的用途 Pending CN1255044A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83103997A 1997-04-01 1997-04-01
US08/831,039 1997-04-01
US85085597A 1997-05-02 1997-05-02
US08/850,855 1997-05-02

Publications (1)

Publication Number Publication Date
CN1255044A true CN1255044A (zh) 2000-05-31

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CN98805001A Pending CN1255044A (zh) 1997-04-01 1998-04-01 苦瓜中的口服活性成分,其活性肽,及它们治疗糖尿病的用途

Country Status (11)

Country Link
US (3) US6127338A (https=)
EP (1) EP1005274B1 (https=)
JP (1) JP4156038B2 (https=)
KR (1) KR100509438B1 (https=)
CN (1) CN1255044A (https=)
AT (1) ATE403672T1 (https=)
AU (1) AU749792B2 (https=)
CA (1) CA2285452A1 (https=)
DE (1) DE69839842D1 (https=)
ES (1) ES2310006T3 (https=)
WO (1) WO1998043484A1 (https=)

Cited By (17)

* Cited by examiner, † Cited by third party
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CN101824074A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0107多肽类似物及其应用
CN101824075A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0101多肽类似物及其应用
CN101824073A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0103多肽类似物及其应用
CN101824076A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0105多肽类似物及其应用
CN101830969A (zh) * 2010-05-20 2010-09-15 中国药科大学 微波促进固相合成苦瓜降血糖mc-jj0104多肽类似物及其应用
CN101838309A (zh) * 2010-05-20 2010-09-22 中国药科大学 微波促进固相合成苦瓜mc-jj0102多肽类似物及其应用
CN101942010A (zh) * 2010-05-20 2011-01-12 中国药科大学 微波促进固相合成苦瓜mc-jj0106多肽类似物及其应用
WO2011032359A1 (zh) * 2009-09-17 2011-03-24 中国药科大学 苦瓜mc-jj6多肽及其应用与微波促进固相合成方法
WO2011032360A1 (zh) * 2009-09-17 2011-03-24 中国药科大学 苦瓜mc-jj2多肽及其应用与微波促进固相合成方法
CN101691394B (zh) * 2009-09-17 2012-05-09 中国药科大学 微波促进固相合成苦瓜mc-jj6多肽类似物及其应用
CN103421086A (zh) * 2012-05-18 2013-12-04 中国医药大学 多胜肽、编码该多胜肽的核酸分子、以及该多胜肽的应用
CN104650198A (zh) * 2015-02-09 2015-05-27 马海龙 三叉黑顶藻中分离的能治疗糖尿病的活性肽及其用途
CN106729606A (zh) * 2017-01-03 2017-05-31 河北省农林科学院经济作物研究所 苦瓜降糖提取物复合剂及其制备方法
CN107412721A (zh) * 2017-09-15 2017-12-01 李玉保 一种降血糖苦瓜多肽复方胶囊及其制备方法
CN112675292A (zh) * 2021-01-11 2021-04-20 北京欣颂生物科技有限公司 含有益生菌的制剂在治疗疾病中的应用
CN116813700A (zh) * 2022-11-08 2023-09-29 苏秀兰 一种苦瓜生物活性肽、制备方法及其应用
CN117700489A (zh) * 2023-12-19 2024-03-15 深圳泰华赛尔生物科技有限公司 脂肪干细胞在治疗糖尿病的药物中的应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3877530B2 (ja) * 1999-04-13 2007-02-07 プシュパ カハンナ， ツルレイシ（ニガウリ、Ｍｏｍｏｒｄｉｃａｃｈａｒａｎｔｉａ）から取得された蛋白質／ポリペプチド−ｋ
WO2005063156A1 (en) * 2003-12-22 2005-07-14 Shear/Kershman Laboratories, Inc. Oral peptide delivery system with improved bioavailability
EP1563842A1 (en) * 2004-02-03 2005-08-17 Novartis AG Simarouba amara and/or Momordica charantia extracts for the treatment of coccidiosis in poultry
EP1792911A4 (en) * 2004-09-15 2008-09-17 Univ Yokohama City ESSENTIAL AMINO ACID SEQUENCE FOR NEUROSPECIFIC GENE EXPRESSION
WO2008120240A1 (en) * 2007-03-30 2008-10-09 Aparna Dixit Anti diabetic protein
US20100081860A1 (en) * 2008-04-24 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and Method for Memory Modification
TWI342781B (en) 2008-12-01 2011-06-01 Univ China Medical Blood sugar-modulating polypeptides
CN101985644B (zh) * 2010-10-25 2013-06-12 邹远东 一种苦瓜多肽及其制备方法与应用
KR20140038372A (ko) 2011-01-28 2014-03-28 피라말 엔터프라이지즈 리미티드 약초 추출물의 제조방법
CN107412720A (zh) * 2017-09-15 2017-12-01 李玉保 一种治疗糖尿病的苦瓜多肽复方植物药及其制备方法
CN108707181B (zh) * 2018-06-14 2021-03-12 苏秀兰 一种抑制肿瘤细胞增殖的苦瓜多肽及其制备方法和应用
CN110755598A (zh) * 2019-10-25 2020-02-07 李玉保 活化胰岛素及治疗糖尿病的复合苦瓜肽口服药及制备方法
CN119320429B (zh) * 2024-10-15 2025-07-29 天津桂芝堂科技有限公司 包含乳铁蛋白的药物组合物及在降血脂中的应用

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NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3853914A (en) * 1971-01-11 1974-12-10 Syva Co Ligand determination of spin labeled compounds by receptor displacement
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3905654A (en) * 1973-11-14 1975-09-16 Kelsey Hayes Co Skid control system for dual brake
US3945988A (en) * 1974-07-16 1976-03-23 Pushpa Khann Process for isolation of insulin from plant source
US4043989A (en) * 1975-09-11 1977-08-23 Syva Company Oxazepam derivatives for immunoassay reagents
US4069105A (en) * 1977-03-03 1978-01-17 Syva Company Lidocaine antigens and antibodies
US4156081A (en) * 1977-04-15 1979-05-22 Syva Company Theophylline antigens and antibodies
JPS57106626A (en) * 1980-12-22 1982-07-02 Teijin Ltd Cytotoxic protein complex and its preparation
US4985248A (en) * 1987-06-18 1991-01-15 Yaguang Liu Pharmaceutical composition containing a safe extracts of fruits and vegetables for the treating and preventing of diabetes
US5098710A (en) * 1987-06-18 1992-03-24 Yaguang Liu Production of kuguasu
US5086043A (en) * 1987-06-18 1992-02-04 Yaguang Liu Production of Saponins of Lichi
NZ246059A (en) * 1991-12-03 1995-08-28 Proteus Molecular Design Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011032359A1 (zh) * 2009-09-17 2011-03-24 中国药科大学 苦瓜mc-jj6多肽及其应用与微波促进固相合成方法
CN101691394B (zh) * 2009-09-17 2012-05-09 中国药科大学 微波促进固相合成苦瓜mc-jj6多肽类似物及其应用
WO2011032360A1 (zh) * 2009-09-17 2011-03-24 中国药科大学 苦瓜mc-jj2多肽及其应用与微波促进固相合成方法
CN101830969A (zh) * 2010-05-20 2010-09-15 中国药科大学 微波促进固相合成苦瓜降血糖mc-jj0104多肽类似物及其应用
CN101824074A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0107多肽类似物及其应用
CN101838309A (zh) * 2010-05-20 2010-09-22 中国药科大学 微波促进固相合成苦瓜mc-jj0102多肽类似物及其应用
CN101942010A (zh) * 2010-05-20 2011-01-12 中国药科大学 微波促进固相合成苦瓜mc-jj0106多肽类似物及其应用
CN101824076A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0105多肽类似物及其应用
CN101824073A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0103多肽类似物及其应用
CN101824075A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0101多肽类似物及其应用
CN103421086A (zh) * 2012-05-18 2013-12-04 中国医药大学 多胜肽、编码该多胜肽的核酸分子、以及该多胜肽的应用
CN104650198A (zh) * 2015-02-09 2015-05-27 马海龙 三叉黑顶藻中分离的能治疗糖尿病的活性肽及其用途
CN106729606A (zh) * 2017-01-03 2017-05-31 河北省农林科学院经济作物研究所 苦瓜降糖提取物复合剂及其制备方法
CN107412721A (zh) * 2017-09-15 2017-12-01 李玉保 一种降血糖苦瓜多肽复方胶囊及其制备方法
CN112675292A (zh) * 2021-01-11 2021-04-20 北京欣颂生物科技有限公司 含有益生菌的制剂在治疗疾病中的应用
CN112675292B (zh) * 2021-01-11 2021-11-02 中食安泓(广东)健康产业有限公司 含有益生菌的制剂在治疗疾病中的应用
CN116813700A (zh) * 2022-11-08 2023-09-29 苏秀兰 一种苦瓜生物活性肽、制备方法及其应用
CN117700489A (zh) * 2023-12-19 2024-03-15 深圳泰华赛尔生物科技有限公司 脂肪干细胞在治疗糖尿病的药物中的应用

Also Published As

Publication number Publication date
US6391854B1 (en) 2002-05-21
CA2285452A1 (en) 1998-10-08
ES2310006T3 (es) 2008-12-16
JP4156038B2 (ja) 2008-09-24
EP1005274B1 (en) 2008-08-06
ATE403672T1 (de) 2008-08-15
EP1005274A1 (en) 2000-06-07
EP1005274A4 (en) 2004-09-08
US6127338A (en) 2000-10-03
DE69839842D1 (de) 2008-09-18
US6852695B2 (en) 2005-02-08
AU6876598A (en) 1998-10-22
WO1998043484A1 (en) 1998-10-08
KR100509438B1 (ko) 2005-08-23
JP2002516608A (ja) 2002-06-04
KR20010005917A (ko) 2001-01-15
AU749792B2 (en) 2002-07-04
US20020193310A1 (en) 2002-12-19

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