CN1244396A - Preparation of bufonin capsule - Google Patents
Preparation of bufonin capsule Download PDFInfo
- Publication number
- CN1244396A CN1244396A CN98103562A CN98103562A CN1244396A CN 1244396 A CN1244396 A CN 1244396A CN 98103562 A CN98103562 A CN 98103562A CN 98103562 A CN98103562 A CN 98103562A CN 1244396 A CN1244396 A CN 1244396A
- Authority
- CN
- China
- Prior art keywords
- capsule
- cinobufacin
- manufacture method
- decoct
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a Chinese proprietary medicine for treating and hepatitis B. The bufonin capsule is prepared by using a traditional Chinese medicine material of toad skin and is safe, effective and easy to carry about. It is used mainly for treatment of liver cancer, breast cancer, cancer in digestive tract, acute leukamia, malignant lymph tumor, multiple myeloma, chronic hepatitis B, etc.
Description
The present invention relates to a kind of manufacture method that is used for the Chinese patent medicine of anticancer and treatment hepatitis B disease, more particularly the present invention relates to the capsular manufacture method of cinobufacin.
Cancer and hepatitis B are two big diseases of serious harm human life health, it is one of maximum research topic of facing of medical science, still there is not specific medicament at present, preparation of the present invention has anticancer and suppresses the hepatitis B virus proliferation function, it is a kind of Chinese medicine material that its main medicine is supported skin, in Compendium of Material Medica, " Mingyi Bielu ", put down in writing in famous motherland such as the amplification on Canon of Materia Medica medical science ancient books and records: Bufo siccus and goods Venenum Bufonis thereof, Cutis Bufonis etc., " abnormal smells from the patient is hot cool; little poison; have detoxifcation; detumescence; heart tonifying; pain relieving, diuresis " effect, cure mainly " erosion of the vulva cellulitis pestilence malignant boil, the infantile malnutrition worm, crux, toxic swelling, tetanus " etc.Existing domestic is HUACHANSU ZHUSHEYE and the oral liquid that raw material is made with the Cutis Bufonis, have detoxifcation, detumescence, pain relieving, human body immunity improving function, obviously synthesizing of anticancer DNA, RNA reaches the effect that hepatitis B virus is bred, and is mainly used in the treatment of primary hepatocarcinoma, medium and advanced lung cancer, breast carcinoma, alimentary tract cancer acute day disorders of blood, malignant lymphoma, multiple bone marrow cancer, chronic hepatitis B and hepatitis b virus carrier.But injection because of directly with injecting liquid drug in blood vessel, muscle, safety is little, causes side effect such as anaphylaxis, local excitation symptom, phlebitis easily, and uses extremely inconvenient.Because flavour of a drug are very bitter, oral liquid is directly oral also very difficult.This class preparation process thereof complexity in addition, the active ingredient loss is many in leaching process.
Purpose of the present invention: provide a kind of and carry, taking convenience, safe and effective, cancer and hepatitis B disease are had the manufacture method of the cinobufacin pharmaceutical capsules of significant curative effect.
The present invention be realize like this, be raw material with Chinese medicine material Cutis Bufonis, the decoction of employing normal pressure, concentrating under reduced pressure, precipitate with ethanol are made with extra care, the extract that contains a large amount of effective ingredient is filtered, concentrates, makes in cold preservation, add adjuvant more by a certain percentage, make granule, drying incapsulates promptly.Decoct with water under the Cutis Bufonis normal pressure 3 times, add determining alcohol 75～80%, the every capsules of the present invention contains dry maxima skin 5g.
Advantage of the present invention: technological design is reasonable, farthest effective component extracting.Manufactured goods are oral easily, and are evident in efficacy, and toxicity is little than injecting drug use, can avoid injecting the various untoward reaction that cause.Carry, taking convenience, safe in utilization.
Accompanying drawing: be the technological process that proposes according to the present invention.
Embodiment: get dry maxima skin 500g, clean, be soaked in water, put into extraction pot, decoct with water 3 times, be respectively 1 hour to thoroughly, 30 minutes, 30 minutes.Collecting decoction filters, and filtrate decompression is concentrated into 1: 1 weight of raw material, adds ethanol and makes that to contain the alcohol amount be 80%, and cold preservation is placed, and filters, filtrate recycling ethanol is to there not being the alcohol flavor.Obtain cinobufacin extractum, add with supplementary product starch, 10: 1 ratio of dextrin and make granule in right amount, dry, incapsulate and make 100, promptly get the cinobufacin capsule.
Claims (3)
1, the capsular manufacture method of cinobufacin is characterized in that: with Chinese medicine material Cutis Bufonis is primary raw material, adopts normal pressure to decoct, concentrating under reduced pressure, and precipitate with ethanol is refining.The method of filtering and concentrating makes the extract that contains a large amount of effective ingredient, adds the adjuvant of certain formula proportion, and granulation, drying are made the cinobufacin capsule.
2, according to the capsular manufacture method of the described cinobufacin of claim 1, it is characterized in that: decoct with water under the normal pressure 3 times, add determining alcohol 75～80%.
3, according to claim: the manufacture method of cellulose capsule is looked forward or upwards by described China, it is characterized in that: adopt following formula proportion: every of capsule contains dry maxima skin 5g, ratio of adjuvant, and starch is 10: 1 than dextrin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98103562A CN1244396A (en) | 1998-08-12 | 1998-08-12 | Preparation of bufonin capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98103562A CN1244396A (en) | 1998-08-12 | 1998-08-12 | Preparation of bufonin capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1244396A true CN1244396A (en) | 2000-02-16 |
Family
ID=5217990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98103562A Pending CN1244396A (en) | 1998-08-12 | 1998-08-12 | Preparation of bufonin capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1244396A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370974C (en) * | 2005-08-03 | 2008-02-27 | 叶耀良 | Cancer treating |
| CN100441172C (en) * | 2006-01-23 | 2008-12-10 | 北京国药龙立生物医药新技术有限公司 | 'Huachan'essence coated micropills and its preparation process |
| CN101342194B (en) * | 2008-08-29 | 2010-10-20 | 陕西东泰制药有限公司 | Traditional Chinese medicine preparation for treating median or late-stage malignant tumors, chronic hepatitis B, and preparation method thereof |
| CN1846712B (en) * | 2006-01-16 | 2012-01-11 | 西安安健药业有限公司 | Cinobufagin emulsion for injection and its preparation process |
-
1998
- 1998-08-12 CN CN98103562A patent/CN1244396A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370974C (en) * | 2005-08-03 | 2008-02-27 | 叶耀良 | Cancer treating |
| CN1846712B (en) * | 2006-01-16 | 2012-01-11 | 西安安健药业有限公司 | Cinobufagin emulsion for injection and its preparation process |
| CN100441172C (en) * | 2006-01-23 | 2008-12-10 | 北京国药龙立生物医药新技术有限公司 | 'Huachan'essence coated micropills and its preparation process |
| CN101342194B (en) * | 2008-08-29 | 2010-10-20 | 陕西东泰制药有限公司 | Traditional Chinese medicine preparation for treating median or late-stage malignant tumors, chronic hepatitis B, and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101797326B (en) | Chinese materia medica preparation for treating borborygmus diarrhoea and preparation method thereof | |
| CN103099959B (en) | Traditional Chinese medicine preparation for treating ulcerative colitis and preparation method thereof | |
| CN108671002B (en) | Composition containing saussurea involucrate culture extract and application thereof | |
| CN104208581A (en) | Schisandra chinensis health care oral liquid capable of preventing alcoholic liver and preparation method thereof | |
| CN103536826A (en) | Traditional Chinese medicine composition for treating kysthitis and preparation method thereof | |
| CN1190220C (en) | Blood sugar reducing tea and preparation method thereof | |
| CN1244396A (en) | Preparation of bufonin capsule | |
| CN103735663B (en) | Traditional Chinese medicine for reducing blood glucose and preparation method thereof | |
| CN100363046C (en) | Prepn for treating fatty liver and alcoholic liver and its prepn process | |
| CN108077485A (en) | A kind of blue or green money willow herbal tea and preparation method thereof | |
| CN101253991A (en) | Soft capsules health care functional food product and method of preparing the same | |
| CN108260682A (en) | A kind of hypoglycemic, reducing blood lipid and the health protection tea of blood pressure lowering | |
| CN101120977A (en) | Medicine for treating tumor | |
| CN107158299A (en) | It is a kind of that there is composition of enhancing learning memory function and preparation method thereof | |
| CN113476561A (en) | Traditional Chinese medicine formula for treating diabetes | |
| CN104398677B (en) | A kind of tartary buckwheat general flavone and Gynostemma Pentaphyllum compound | |
| CN105435190A (en) | Traditional Chinese medicine composition for treating cold-heat jumble asthma and preparation method of traditional Chinese medicine composition | |
| CN102823867A (en) | Health-care food capable of repairing functions of damaged islet cells | |
| CN108782870A (en) | A kind of anti-tumor healthcare tea and preparation method thereof | |
| CN100375632C (en) | Extractive from combined vegetable drug for treating heart disease of coronary sclerosis, and method of extraction | |
| CN106615362A (en) | Healthcare tea specially used for diabetic patient and preparation method thereof | |
| CN101468060A (en) | Pharmaceutical composition | |
| JP3374341B2 (en) | Red bean cedar extract health food | |
| CN104840746B (en) | A kind of Chinese medicine composition with anti-lung cancer activity and its preparation method and application | |
| CN104840727B (en) | Chinese medicine composition with anti-cancer of the esophagus activity and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |