CN100441172C - 'Huachan'essence coated micropills and its preparation process - Google Patents
'Huachan'essence coated micropills and its preparation process Download PDFInfo
- Publication number
- CN100441172C CN100441172C CNB2006100018227A CN200610001822A CN100441172C CN 100441172 C CN100441172 C CN 100441172C CN B2006100018227 A CNB2006100018227 A CN B2006100018227A CN 200610001822 A CN200610001822 A CN 200610001822A CN 100441172 C CN100441172 C CN 100441172C
- Authority
- CN
- China
- Prior art keywords
- micropill
- coated micropill
- coated
- cinobufacin
- acrylic resin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to cinobufotoxin coated micro-pills for treating tumours and hepatitis B, which comprises cinobufotoxin powdered extract, a diluting agent, a bonding agent and a coating liquid, wherein the coating liquid is an alcoholic solution of the mixture of a coating material, a plasticizer and an opacifier or an antisticking agent. The preparation method of the cinobufotoxin coated micro-pills for treating tumours and hepatitis B comprises the following steps: after the cinobufotoxin powdered extract and the diluting agent are mixed in uniformity, the bonding agent is added, and the mixture is put into an extruder; the extruded objects are put into a spheronizator and then are put into a fluidized bed after being rolled into pills; the pills are dried at the temperature of 40 to 60 DEG C for 0.5 to 4 hours; then, the coating liquid is sprayed onto the pills, and the coated micro-pills are obtained. The coated micro-pills provided by the present invention have the advantages of beautiful appearance, simple preparation process, low production cost and small bioavailability difference between individuals.
Description
Technical field
The present invention relates to a kind of coated micropill, specifically relate to a kind of 'Huachan ' essence coated micropills that is used for the treatment of tumor, hepatitis B and preparation method thereof.
Background technology
Bufo siccus is China's Chinese medicine material, Compendium of Material Medica record, the Bufo siccus abnormal smells from the patient is hot cool, little poison, have bring down a fever, the effect of damp eliminating, parasite killing, be the key medicine of treatment infantile malnutrition disease, carbuncle, all skin ulcers.Cinobufacin is the dry in the shade extract of whole bark of Bufo siccus, mainly contains indoles alkaloid, has the effects such as heavily fortified point of bursting of heat-clearing and toxic substances removing, pain relieving, inducing diuresis to remove edema, blood stasis dispelling.Modern pharmacological research confirms that cinobufacin has multiple pharmacological effect such as antitumor, immunological enhancement and antivirus action.
Malignant tumor and hepatitis B are the height morbidities of current society, are seriously threatening human beings'health.Treating above-mentioned disease does not still have specific medicament at present, and clinical application mostly is chemical synthetic drug, has more serious toxic and side effects.The domestic cinobufacin preparation variety that has gone on the market has tablet, oral liquid and injection, but all there is shortcoming and defect in various degree in above-mentioned preparation.The cinobufacin enteric coatel tablets are subject to the influence of food, gastrointestinal transit speed, and disintegration time is long, and it is slow to absorb onset, and bioavailability is low.HUACHANSU ZHUSHEYE belongs to the intrusive mood administration, and patient uses inconvenience, and blood vessel irritation is produced anaphylaxis greatly and easily; Be difficult for again storing, transporting.Cinobufacin oral liquid bitter in the mouth, mouthfeel is poor, and patient is difficult to take, and the production cost height, poor stability, storage period is short, the inconvenience of transportation storage.
Summary of the invention
The purpose of this invention is to provide a kind of 'Huachan ' essence coated micropills that overcomes the shortcoming and defect of existing cinobufacin sheet, oral liquid and injection.
For achieving the above object, the invention provides a kind of coated micropill that is used for the treatment of tumor, hepatitis B, it is characterized in that being prepared from by following components by part by weight:
Cinobufacin extract powder 40-50, diluent 30-40, binding agent 0.5-5, coating material, plasticizer, opacifier or antiplastering aid total amount 1-10.
The particle diameter of described coated micropill is 0.5-2.5mm, and the particle diameter of micropill is followed successively by 05.-1mm, and 0.5-0.7mm, 0.5-0.6mm are good.
Described diluent is at least a among lactose, mannitol, starch, dextrin, Icing Sugar, the microcrystalline Cellulose MCC.
Described binding agent is wherein at least a of water, alcoholic acid aqueous solution, starch slurry, methylcellulose MC, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose CMC-Na, polyvinylpyrrolidone PVP.
Described coating solution is formed the alcoholic solution of the mixture that comprises coating material, plasticizer, opacifier or antiplastering aid, and wherein coating material, plasticizer, opacifier or antiplastering aid weight part ratio are:
Coating material 0.9-8, plasticizer＞0-5, opacifier or antiplastering aid＞0-3 get coating material, plasticizer, opacifier or antiplastering aid and add the ethanol of 60-100% percetage by weight to 80-120ml.
Wherein at least a of described enteric-coating material cellulose acetate-phthalate CAP, phthalic acid hydroxypropyl methylcellulose HPMCP, hydroxypropyl methylcellulose acetic acid succinate HPMCAS, acrylic resin.
Described acrylic resin is number wherein at least a of acrylic resin L30D-55, acrylic resin S100, acrylic resin L100, acrylic resin II number, acrylic resin III.
Described gastric solubleness coating material is ethyl cellulose EC, cellulose acetate CA a kind of 2-5 weight portion and Polyethylene Glycol PEG, the hydroxypropyl methylcellulose HPMC formed coating material of a kind of 0.2-5 weight portion wherein wherein.
Described plasticizer is wherein at least a of glycerol, propylene glycol, Polyethylene Glycol PEG, Oleum Ricini, triethyl citrate, triglycerin acetate, diethyl phthalate.
Described opacifier is a titanium dioxide.
Described antiplastering aid is Pulvis Talci or magnesium stearate.
A kind of method for preparing coated micropill comprises the steps:
With cinobufacin extract powder, mixing diluents evenly after, add binding agent and place in the extruder, extrudate places spheronizator, behind the round as a ball one-tenth micropill, place fluid bed, temperature 40-60 ℃ condition following drying time of 0.5-4 hour, spray again with coating solution, make coated micropill.
The another kind of method for preparing coated micropill comprises the steps:
With cinobufacin extract powder, mixing diluents evenly after, add binding agent system soft material, cross the 15-20 mesh sieve and granulate, place coating pan, behind the round as a ball one-tenth micropill, the blowing hot-air drying is 0.5-4 hour under temperature 40-60 ℃ condition, sprays with coating solution again, makes coated micropill.
The method that another prepares coated micropill comprises the steps:
Cinobufacin extract powder, diluent are placed centrifugal-fluid bed, with 0.5-2.5m
3/ min blasts air-flow, and mix homogeneously sprays into the solution of binding agent then, makes the micropill of particle size range at 0.5-2.5mm, and gained micropill in ebullated bed under 40-60 ℃ of condition hot air drying 0.5-4 hour sprays into coating solution again, makes coated micropill.
Described binding agent is the aqueous solution or the alcoholic solution of the aqueous solution of the aqueous solution of water, ethanol water, starch slurry, methylcellulose or alcoholic solution, sodium carboxymethyl cellulose or alcoholic solution, polyvinylpyrrolidone.
The described alcoholic solution concentration that is weight percentage is the 60-90% alcoholic solution.
Preparation cinobufacin extract powder is the method preparation of all knowing with those skilled in the art, for example:
Dry maxima skin is cleaned, decocted with water secondary, 45 minutes for the first time, 30 minutes for the second time, collecting decoction filtered, it is 1.1～1.2 that filtrate is concentrated into relative density, and the temperature that relative density is measured is 80 ℃, is cooled to 40 ℃, adding ethanol makes and contains alcohol amount and reach 60%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to there not being the alcohol flavor, adding ethanol makes and contains alcohol amount and reach 85%, stir evenly, left standstill 48 hours, filter, reclaim ethanol to there not being the alcohol flavor, under 80 ℃ of conditions, be condensed into the thick paste that relative density is 1.3-1.6,, pulverize again through the low-temperature reduced-pressure drying, cross 100 mesh sieves, promptly get (Chinese medicine ministry standard WS 3-B-2687-97 the 14th).
Coated micropill of the present invention is the spherical shape solid dosage forms of particle diameter between 0.5-2.5mm, divides gastric solubleness coated micropill and enteric coated-pellet, has good fluidity, and medicine stability is good, and can cover the cinobufacin disagreeable taste, promotes the preparation exterior quality; Utilize the coated micropill size of preparation method preparation provided by the invention even, stripping absorbs fast, bioavailability height, instant effect, good looking appearance, preparation technology is simple, and production cost is low, can be loaded on hard capsule or packed, be convenient to store, transport, be convenient to patient again and take, carry.
The only disintegrate in intestinal of enteric-coating material that the inventor filters out from numerous coating materials through a large amount of tests, can avoid the zest of medicine to gastric mucosa, wherein preferred acrylic resin L30D-55, acrylic resin S100, acrylic resin L100, acrylic resin II number, acrylic resin III number, can be in intestinal disintegrate fast, and unexpectedly, the curative effect of cinobufacin also is greatly improved; The gastric solubleness coated micropill extensively distributes equably at gastric, and is wide with the contact area of gastric mucosa, overcome the local irritation of tablet to stomach.The influence of unable to take food things such as the transhipment in gastrointestinal tract, absorption and gastric emptying absorbs rapid-actionly, and infiltration rate is even, and bioavailability among individuals difference is little.
Clinical research confirmation, coated micropill of the present invention, this medicine in the treatment, diseases such as late tumor, chronic hepatitis B have significant curative effect.
The specific embodiment
Other has except the explanation, and the preparation method of cinobufacin extract powder is as follows among the embodiment:
Dry maxima skin is cleaned, decocted with water secondary, 45 minutes for the first time, 30 minutes for the second time, collecting decoction filtered, it is 1.1～1.2 that filtrate is concentrated into relative density, and the temperature that relative density is measured is 80 ℃, is cooled to 40 ℃, adding ethanol makes and contains alcohol amount and reach 60%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to there not being the alcohol flavor, adding ethanol makes and contains alcohol amount and reach 85%, stir evenly, left standstill 48 hours, filter, reclaim ethanol to there not being the alcohol flavor, under 80 ℃ of conditions, be condensed into the thick paste that relative density is 1.3-1.6,, pulverize again through the low-temperature reduced-pressure drying, cross 100 mesh sieves, promptly get (Chinese medicine ministry standard WS3-B-2687-97 the 14th).
Embodiment 1
Enteric coated micropill prescription (inventorys of 200 capsules):
Cinobufacin extract powder 45g
Dextrin 40g
Water 5g
Coating solution: following each component is prepared into the 100ml alcoholic solution
Phthalic acid hydroxypropyl methylcellulose HPMCP 6g triethyl citrate 0.6g
Titanium dioxide 0.49g
Behind above-mentioned 3 kinds of component mix homogeneously, adding weight percent concentration is 70% ethanol, makes the 100ml coating solution.
Preparation technology: with cinobufacin extract powder, diluent dextrin mix homogeneously; Mixture system soft material with binding agent water and cinobufacin extract powder, dextrin, place in the extruder, be squeezed into cylindrical strip extrudate, place spheronizator then, behind the round as a ball one-tenth micropill, place fluid bed, in 0.5 hour following drying time of condition of 50 ℃ of temperature, spray again with coating solution, make coated micropill, be loaded in the capsulae vacuus after the drying.The particle diameter of coated micropill is 0.5-2.5mm.
Embodiment 2
Enteric coated micropill prescription (inventorys of 200 capsules):
Cinobufacin 40g
Mannitol: lactose (1: 1 weight ratio) mixture 40g
Hydroxypropyl methylcellulose 0.6g
Coating solution: following each component is prepared into the 100ml alcoholic solution
Hydroxypropyl methylcellulose acetic acid succinate HPMCAS 4g
Triethyl citrate 0.4g
Pulvis Talci 3g
Behind above-mentioned 3 kinds of component mix homogeneously, adding weight percent concentration is 65% ethanol, makes the 100ml coating solution.
Preparation technology: after will getting cinobufacin extract powder, mannitol and lactose mix homogeneously, it is 10% the aqueous solution and the mixture system soft material of cinobufacin extract powder, mannitol and lactose that the binding agent hydroxypropyl methylcellulose is prepared into percentage by weight, cross 18 sieve series grains, place coating pan, behind the round as a ball one-tenth micropill, 4 hours drying times of blowing hot-air under 40 ℃ of conditions of temperature, spray again with coating solution, make coated micropill, be loaded in the capsulae vacuus.The particle diameter of coated micropill is 0.5-1.0mm.
Embodiment 3
Enteric coated micropill prescription (inventorys of 200 capsules):
Cinobufacin 42g
Icing Sugar: starch (1: 2 weight ratio) mixture 32g
Methylcellulose 0.8g
Coating solution: following each component is prepared into the 100ml alcoholic solution
Acrylic resin L100 5g
Triglycerin acetate 0.5g
Magnesium stearate 2g
Behind above-mentioned 3 kinds of component mix homogeneously, adding weight percent concentration is 85% ethanol, makes the 100ml coating solution.
Preparation technology: after will getting cinobufacin extract powder, Icing Sugar and starch mix homogeneously, it is 10% the aqueous solution and the mixture system soft material of cinobufacin extract powder, Icing Sugar and starch that the binding agent methylcellulose is prepared into percentage by weight, crossing 15 mesh sieves granulates, place coating pan, behind the round as a ball one-tenth micropill, 0.5 hour drying time of blowing hot-air under 60 ℃ of conditions of temperature, spray again with coating solution, make coated micropill, be loaded in the capsulae vacuus.The particle diameter of coated micropill is 0.5-0.7mm.
Embodiment 4
Enteric coated micropill prescription (inventorys of 200 capsules):
Cinobufacin 48g
Microcrystalline Cellulose: lactose (4: 1 weight ratios) mixture 38g
Starch slurry starch 0.5g adds water 10g
Coating solution: following each component is prepared into the 100ml alcoholic solution
Acrylic resin L30D-55 2g
Glycerol 0.2g
Pulvis Talci 2g
Behind above-mentioned 3 kinds of component mix homogeneously, adding weight percent concentration is 90% ethanol, makes the 100ml coating solution.
Preparation technology: after will getting cinobufacin extract powder, microcrystalline Cellulose and lactose mix homogeneously, with starch slurry system soft material, crossing 20 mesh sieves granulates, put in the hands coating pan, behind the round as a ball one-tenth micropill, 2 hours drying times of blowing hot-air under 50 ℃ of conditions of temperature, spray again with coating solution, make coated micropill, be loaded in the capsulae vacuus.The particle diameter of coated micropill is 0.5-0.6mm; The weight percent concentration of starch slurry is 10%.
Embodiment 5
Enteric coated micropill prescription (inventorys of 200 capsules)
Cinobufacin 50g Icing Sugar 40g ethanol 60% percetage by weight solution 5ml
Coating solution: following each component is prepared into the 100ml alcoholic solution
Acrylic resin S100 5g
Diethyl phthalate 0.5g
Magnesium stearate 2g
Behind above-mentioned 3 kinds of component mix homogeneously, adding weight percent concentration is 60% ethanol, makes the 100ml coating solution.
Preparation technology: cinobufacin extract powder, diluent Icing Sugar are placed centrifugal-fluid bed, with 2.5m
3/ min blasts air-flow, mix homogeneously, spray into the binding agent alcoholic solution then, the percent by volume of alcoholic solution is 70%, make the micropill of particle size range at 0.5-2.5mm, the gained micropill in ebullated bed under 60 ℃ of conditions of temperature 0.5 hour hot air drying time, spray into coating solution again, make coated micropill.The particle diameter of coated micropill is 0.5-2.5mm.
Embodiment 6
Enteric coated micropill prescription (inventorys of 200 capsules)
Cinobufacin extract powder 40g
Mannitol 35g
Sodium carboxymethyl cellulose 0.5g
Coating solution: following each component is prepared into the 100ml alcoholic solution
Cellulose acetate-phthalate CAP 5g
Polyethylene glycol 6000 2.7g
Diethyl phthalate 0.3g
Pulvis Talci 2g
Behind above-mentioned 4 kinds of component mix homogeneously, add dehydrated alcohol, make the 100ml coating solution.
Preparation technology: cinobufacin extract powder, diluent Icing Sugar are placed centrifugal-fluid bed, with 2.5m
3/ min blasts air-flow, mix homogeneously, spray into the percentage by weight that is prepared into by the binding agent sodium carboxymethyl cellulose then and be 5% aqueous solution, make the micropill of particle size range at 0.5-0.6mm, the gained micropill in ebullated bed under 50 ℃ of conditions of temperature 2.5 hours hot air drying time, spray into coating solution again, make coated micropill.The particle diameter of coated micropill is 0.5-2.5mm.
Embodiment 7
Gastric solubleness micropill prescription (inventorys of 200 capsules):
Cinobufacin extract powder 50g
Microcrystalline Cellulose 30g
Polyvinylpyrrolidone 0.5g
Coating solution: following each component is prepared into the 100ml alcoholic solution
Ethyl cellulose EC 3g
Polyethylene Glycol PEG4000 3g
Diethyl phthalate 0.2g
Titanium dioxide 3g
Behind above-mentioned 4 kinds of component mix homogeneously, adding weight percent concentration is 80% ethanol, makes the 100ml coating solution.
Preparation technology: with cinobufacin extract powder, diluents microcrystalline cellulose mix homogeneously; Polyvinyl pyrrolidone is prepared into the mixture system soft material that percentage by weight is 10% alcoholic solution and cinobufacin extract powder, microcrystalline Cellulose, place in the extruder, be squeezed into cylindrical strip extrudate, place spheronizator then, behind the round as a ball one-tenth ball, place fluid bed, in 3 hours following drying times of condition of 60 ℃ of temperature, spray again with coating solution, make coated micropill, be loaded in the capsulae vacuus after the drying.The particle diameter of coated micropill is 0.5-2.5mm.
Embodiment 8
Gastric solubleness micropill prescription (inventorys of 200 capsules)
Cinobufacin 48g dextrin 35g 70% percetage by weight ethanol 7ml
Coating solution: following each component is prepared into the 100ml alcoholic solution
Cellulose acetate CA 3g
Polyethylene Glycol PEG 5g
Propylene glycol 0.5g
Magnesium stearate 0.4g
Behind above-mentioned 4 kinds of component mix homogeneously, add dehydrated alcohol, make the 100ml coating solution.
Preparation technology: cinobufacin extract powder, diluent Icing Sugar are placed centrifugal-fluid bed, with 0.5m
3/ min blasts air-flow, and mix homogeneously sprays into binding agent then, the ethanol water of percetage by weight 70% makes the micropill of particle size range at 0.5-2.5mm, the gained micropill in ebullated bed under 40 ℃ of conditions of temperature 4 hours hot air drying time, spray into coating solution again, make coated micropill.The particle diameter of coated micropill is 0.5-2.5mm.
Embodiment 9
Gastric solubleness micropill prescription (inventorys of 200 capsules):
Cinobufacin extract powder 40g
Mannitol 35g
Hydroxypropyl methylcellulose HPMC 0.5g
Coating solution: following each component is prepared into the 100ml alcoholic solution
Hydroxypropyl methylcellulose HPMC 5g
Ethyl cellulose EC 4g
Titanium dioxide 0.5g
Behind above-mentioned 3 kinds of component mix homogeneously, being dissolved in weight percent concentration is in 70% ethanol, makes the 100ml coating solution.
Preparation technology: with cinobufacin extract powder, diluent mannitol mix homogeneously; The binding agent hydroxypropyl methylcellulose is prepared into the mixture system soft material that percentage by weight is 5% alcoholic solution and cinobufacin extract powder, mannitol, place in the extruder, be squeezed into cylindrical strip extrudate, place spheronizator then, behind the round as a ball one-tenth ball, place fluid bed, in 4 hours following drying times of condition of 60 ℃ of temperature, spray again with coating solution, make coated micropill, be loaded in the capsulae vacuus after the drying.The particle diameter of coated micropill is 0.5-2.5mm.
Embodiment 10
Micropill prescription (inventorys of 200 capsules):
Cinobufacin extract powder 40g
Mannitol 35g
Sodium carboxymethyl cellulose 0.5g
Coating solution: following each component is prepared into the 100ml alcoholic solution
Hydroxypropyl methylcellulose HPMC 5g
Cellulose acetate CA 3.7g
Titanium dioxide 1g
Behind above-mentioned 3 kinds of component mix homogeneously, being dissolved in weight percent concentration is in 70% ethanol, makes the 20ml coating solution.
Preparation technology: with cinobufacin extract powder, diluent mannitol mix homogeneously; The binding agent sodium carboxymethyl cellulose is prepared into the mixture system soft material that percentage by weight is 10% alcoholic solution and cinobufacin extract powder, mannitol, place in the extruder, be squeezed into cylindrical strip extrudate, place spheronizator then, behind the round as a ball one-tenth ball, place fluid bed, in 4 hours following drying times of condition of 50 ℃ of temperature, spray again with coating solution, make coated micropill, be loaded in the capsulae vacuus after the drying.The particle diameter of coated micropill is 0.5-2.5mm.
Table 1 pellet capsule provided by the invention and the external disintegrate of commercially available cinobufacin sheet, stripping measurement result relatively see the following form
As shown in Table 1, coated micropill provided by the invention is compared with commercially available cinobufacin sheet, and disintegration time on average has only 10 minutes, and dissolution time on average has only 18 minutes fully, has shortened disintegration time and complete dissolution time greatly, and drug effect is improved.
Coated micropill prescription provided by the invention is reasonable, production technology is simple, quality standard improves comprehensively.Particularly adopted film-coated technique, made micropill weightening finish few, supplementary product consumption is little, and the film-coat layer has protection against the tide, shading, effect such as heat insulation, has improved the stability of micropill, has prolonged the storage period of medicine.Prepared 'Huachan ' essence coated micropills both can be distributed into capsule and use, and can be distributed into pouch again or be pressed into tablet for clinical practice.
Micropill has that to absorb onset rapid among the present invention, bioavilability height, determined curative effect, bad reaction Few, good looking appearance is stored the characteristics such as easy to use, has overcome the many of the existing preparation of cinobufagin fully and has lacked Put and deficiency, enriched the clinical application kind of this medicine, can satisfy better the needs of medical treatment.
Claims (13)
1, a kind of coated micropill that is used for the treatment of tumor, hepatitis B is characterized in that being prepared from by following components by part by weight:
Cinobufacin extract powder 40-50, diluent 30-40, binding agent 0.5-5, coating material, plasticizer, opacifier or antiplastering aid total amount 1-10.
2, according to the coated micropill of claim 1, the particle diameter that it is characterized in that described coated micropill is 0.5-2.5mm.
3. according to the coated micropill of claim 2, the particle diameter that it is characterized in that described coated micropill is 0.5-1mm.
4. according to the coated micropill of claim 3, the particle diameter that it is characterized in that described coated micropill is 0.5-0.7mm.
5. according to the coated micropill of claim 4, the particle diameter that it is characterized in that described coated micropill is 0.5-0.6mm.
6,, it is characterized in that described diluent is wherein at least a of lactose, mannitol, starch, dextrin, Icing Sugar, microcrystalline Cellulose MCC according to the coated micropill of claim 1.
7,, it is characterized in that described binding agent is wherein at least a of water, alcoholic acid aqueous solution, starch slurry, methylcellulose MC, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose CMC-Na, polyvinylpyrrolidone PVP according to the coated micropill of claim 1.
8,, it is characterized in that described coating solution composition comprises according to the coated micropill of claim 1: the alcoholic solution of the mixture of coating material, plasticizer, opacifier or antiplastering aid, wherein coating material, plasticizer, opacifier or antiplastering aid weight part ratio are:
Coating material 0.9-8, plasticizer＞0-5, opacifier or antiplastering aid＞0-3 get coating material, plasticizer, opacifier or antiplastering aid and add the ethanol of 60-100% percetage by weight to 80-120ml.
9, coated micropill according to Claim 8 is characterized in that described coating material is wherein at least a of cellulose acetate-phthalate CAP, phthalic acid hydroxypropyl methylcellulose HPMCP, hydroxypropyl methylcellulose acetic acid succinate HPMCAS, acrylic resin.
10,, it is characterized in that described acrylic resin is wherein at least a in acrylic resin L30D-55, acrylic resin S100, acrylic resin L100, acrylic resin II number, acrylic resin III number according to the coated micropill of claim 9.
0.5-0.7mm。
10. according to the coated micropill of claim 9, the particle diameter that it is characterized in that described coated micropill is 0.5-0.6mm.
11, a kind of 'Huachan ' essence coated micropills as claimed in claim 1 is characterized in that preparing in order to the below method:
With cinobufacin extract powder, mixing diluents evenly after, add binding agent and place in the extruder, extrudate places spheronizator, behind the round as a ball one-tenth micropill, place fluid bed, temperature 40-60 ℃ condition following drying time of 0.5-4 hour, spray again with coating solution, make coated micropill.
12, a kind of 'Huachan ' essence coated micropills as claimed in claim 1 is characterized in that preparing in order to the below method:
With cinobufacin extract powder, mixing diluents evenly after, add binding agent system soft material, cross the granulation of 15-20 mesh sieve, place coating pan, behind the round as a ball one-tenth micropill, blowing hot-air is 0.5-4 drying time hour under temperature 40-60 ℃ condition, spray again with coating solution, make coated micropill.
13, a kind of 'Huachan ' essence coated micropills as claimed in claim 1 is characterized in that preparing in order to the below method:
Cinobufacin extract powder, diluent are placed centrifugal-fluid bed, with 0.5-2.5m
3/ min blasts air-flow, and mix homogeneously sprays into the solution of binding agent then, makes the micropill of particle size range at 0.5-2.5mm, the gained micropill in ebullated bed under temperature 40-60 ℃ condition 0.5-4 hour hot air drying time, spray into coating solution again, make coated micropill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100018227A CN100441172C (en) | 2006-01-23 | 2006-01-23 | 'Huachan'essence coated micropills and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100018227A CN100441172C (en) | 2006-01-23 | 2006-01-23 | 'Huachan'essence coated micropills and its preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1839885A CN1839885A (en) | 2006-10-04 |
| CN100441172C true CN100441172C (en) | 2008-12-10 |
Family
ID=37029187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100018227A Active CN100441172C (en) | 2006-01-23 | 2006-01-23 | 'Huachan'essence coated micropills and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100441172C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499891B (en) * | 2011-09-30 | 2014-12-17 | 沈阳药科大学 | Moisture-proof preparation method for solvent-free solid preparation |
| CN102626426B (en) * | 2012-04-17 | 2013-09-11 | 吉林大学 | Anti-tumor compound poria cocos preparation and preparation method thereof |
| CN105582023B (en) * | 2015-05-25 | 2019-10-25 | 浙江中医药大学 | A kind of preparation method of toad cake extract and its sustained release pellet |
| CN107873932A (en) * | 2017-11-30 | 2018-04-06 | 胡江宇 | Crisp sugar of gingko and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244396A (en) * | 1998-08-12 | 2000-02-16 | 袁敬 | Preparation of bufonin capsule |
| CN1634577A (en) * | 2004-10-15 | 2005-07-06 | 张平 | Cinobufotalin lyophilized powder for injection and its preparation method |
| CN1729998A (en) * | 2005-08-03 | 2006-02-08 | 叶耀良 | Cancer treating |
-
2006
- 2006-01-23 CN CNB2006100018227A patent/CN100441172C/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244396A (en) * | 1998-08-12 | 2000-02-16 | 袁敬 | Preparation of bufonin capsule |
| CN1634577A (en) * | 2004-10-15 | 2005-07-06 | 张平 | Cinobufotalin lyophilized powder for injection and its preparation method |
| CN1729998A (en) * | 2005-08-03 | 2006-02-08 | 叶耀良 | Cancer treating |
Non-Patent Citations (8)
| Title |
|---|
| 中华人民共和国卫生部药品标准中药成方制剂（第十四册）. 中华人民共和国卫生部药典委员会，第42页，中华人民共和国卫生部. 1997 |
| 中华人民共和国卫生部药品标准中药成方制剂(第十四册). 中华人民共和国卫生部药典委员会，第42页，中华人民共和国卫生部.1997 * |
| 华蟾素口服液治疗慢性乙型肝炎疗效观察. 董晋瑛，董晋钢.临床医药实践杂志，第12卷第12期. 2003 |
| 华蟾素口服液治疗慢性乙型肝炎疗效观察. 董晋瑛，董晋钢. 临床医药实践杂志，第12卷第12期. 2003 * |
| 华蟾素抗肿瘤作用及其机制的研究进展. 韩鸿彬，陈嘉勇.中国肿瘤生物治疗杂志，第12卷第2期. 2005 |
| 华蟾素抗肿瘤作用及其机制的研究进展. 韩鸿彬，陈嘉勇. 中国肿瘤生物治疗杂志，第12卷第2期. 2005 * |
| 流化床制粒法制备中药纯浸膏包衣微丸的工艺研究. 黄坤，张陈炎，袁彦洁，程一帆，古碧秀，吴苏.中国药业，第14卷第7期. 2005 |
| 流化床制粒法制备中药纯浸膏包衣微丸的工艺研究. 黄坤，张陈炎，袁彦洁，程一帆，古碧秀，吴苏. 中国药业，第14卷第7期. 2005 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1839885A (en) | 2006-10-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5989615A (en) | Mopidamol medicine | |
| CN100441172C (en) | 'Huachan'essence coated micropills and its preparation process | |
| CN104997735A (en) | Berberine hydrochloride taste-masked pellet, and preparation thereof | |
| JP2016539955A (en) | Drug composition, method for producing the same, and use | |
| CN102626428B (en) | Ginkgo leaf extract osmotic pump controlled-release preparation and preparation method thereof | |
| CN101007071A (en) | Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology | |
| CN103735525A (en) | Dapoxetine tablets and preparation method thereof | |
| CN106822907B (en) | Two-phase release preparation containing racecadotril and preparation method thereof | |
| CN102048836A (en) | Chinese medicinal composition for treating acute gastroenteritis | |
| CN102058878B (en) | Prosoma pellet tablet for generating allicin in stomach and preparation method thereof | |
| CN101444567A (en) | Double-layer traditional Chinese medicine patch for treating oral ulcer and preparation method thereof | |
| CN101120931A (en) | Bezafibrate sustained-release composition | |
| CN103222964B (en) | Orlistat oral preparation and preparation method thereof | |
| CN103845323B (en) | Mycophenolic Acid and its salt enteric coated preparations and preparation method | |
| CN104906160A (en) | Enteric preparation of erigeron breviscapus extractive | |
| CN105617391B (en) | A kind of scutelloside colon specific drug preparation and preparation method thereof | |
| CN100482220C (en) | Oral preparation of bilobalide with high bioavailability and preparation method thereof | |
| CN103040835B (en) | A kind of Pharmaceutical composition containing sildenafil citrate and preparation method thereof | |
| CN102657615A (en) | Vincamine sustained-release pellet preparation and preparation method thereof | |
| CN101491677A (en) | Method for preparing medicine composite with reduced bitter | |
| CN1970071A (en) | Preparation method of minipills of 'Xiao Chai Hu' | |
| CN102048677B (en) | Valganciclovir Hydrochloride solid preparation and preparation method thereof | |
| CN101991528A (en) | Diclofenac potassium dry suspension and preparation method thereof | |
| JP4864024B2 (en) | Timed release formulation | |
| CN101450199A (en) | Medicine composition for treating acute gastroenteritis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: GUANGDONG TONGDE PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: BEIJING TRADITIONAL CHINESE MEDICINE LONGLI BIOLOGICAL MEDICINE NEW TECHNOLOGY CO., LTD. Effective date: 20100304 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100036 ROOM 2105, BUILDING 19, NO.4, CUIWEI ROAD, HAIDIAN DISTRICT, BEIJINGCITY TO: 524018 NO.4, WEST 5TH ROAD, ZHENCHUAN AVENUE, ZHANJIANG CITY, GUANGDONG PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20100304 Address after: 524018 Guangdong city of Zhanjiang province Shen Chuan Road West five road No. 4 Patentee after: Guangdong Tongde Pharmaceutical Co., Ltd. Address before: 100036 Beijing city Haidian District Cuiwei Road No. 4 Building 19 room 2105 Patentee before: Beijing Gylongly Biomedtech Ltd. |