CN1203072C - 用于治疗青光眼的吡喃并吲哚 - Google Patents

用于治疗青光眼的吡喃并吲哚 Download PDF

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Publication number
CN1203072C
CN1203072C CNB008193479A CN00819347A CN1203072C CN 1203072 C CN1203072 C CN 1203072C CN B008193479 A CNB008193479 A CN B008193479A CN 00819347 A CN00819347 A CN 00819347A CN 1203072 C CN1203072 C CN 1203072C
Authority
CN
China
Prior art keywords
alkyl
pyrans
compound
indoles
tetrahydrochysene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008193479A
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English (en)
Chinese (zh)
Other versions
CN1451008A (zh
Inventor
J·A·梅
H－H·陈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Alcon Universal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Universal Ltd filed Critical Alcon Universal Ltd
Publication of CN1451008A publication Critical patent/CN1451008A/zh
Application granted granted Critical
Publication of CN1203072C publication Critical patent/CN1203072C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CNB008193479A 2000-03-17 2000-11-14 用于治疗青光眼的吡喃并吲哚 Expired - Fee Related CN1203072C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19028500P 2000-03-17 2000-03-17
US60/190,285 2000-03-17

Publications (2)

Publication Number Publication Date
CN1451008A CN1451008A (zh) 2003-10-22
CN1203072C true CN1203072C (zh) 2005-05-25

Family

ID=22700710

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008193479A Expired - Fee Related CN1203072C (zh) 2000-03-17 2000-11-14 用于治疗青光眼的吡喃并吲哚

Country Status (19)

Country Link
EP (1) EP1268482B1 (pt)
JP (1) JP4088444B2 (pt)
KR (1) KR100577613B1 (pt)
CN (1) CN1203072C (pt)
AR (1) AR034400A1 (pt)
AT (1) ATE250611T1 (pt)
AU (2) AU1603401A (pt)
BR (1) BR0017168A (pt)
CA (1) CA2401952C (pt)
DE (1) DE60005566T2 (pt)
DK (1) DK1268482T3 (pt)
ES (1) ES2206326T3 (pt)
HK (1) HK1050897A1 (pt)
MX (1) MXPA02008294A (pt)
PL (1) PL358480A1 (pt)
PT (1) PT1268482E (pt)
TW (1) TWI229082B (pt)
WO (1) WO2001070745A1 (pt)
ZA (1) ZA200206619B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
CA2488752A1 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. Novel maxi-k channel blockers, methods of use and process for making the same
JP2006511556A (ja) 2002-12-13 2006-04-06 アルコン，インコーポレイテッド 新規のベンゾピラン類似体及び緑内障の治療のためのそれらの使用
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2005058911A2 (en) 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
CN111046497B (zh) * 2019-12-24 2023-04-07 中国航空工业集团公司沈阳飞机设计研究所 一种高空高速飞机突防生存力快速评估装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485539A1 (fr) * 1980-06-26 1981-12-31 Sori Soc Rech Ind Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique
GB9326192D0 (en) * 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
US5750556A (en) * 1996-10-30 1998-05-12 American Home Products Corporation 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives

Also Published As

Publication number Publication date
ZA200206619B (en) 2003-08-19
AR034400A1 (es) 2004-02-25
BR0017168A (pt) 2003-01-14
EP1268482A1 (en) 2003-01-02
DK1268482T3 (da) 2003-12-22
JP4088444B2 (ja) 2008-05-21
AU1603401A (en) 2001-10-03
CA2401952A1 (en) 2001-09-27
DE60005566T2 (de) 2004-07-29
EP1268482B1 (en) 2003-09-24
TWI229082B (en) 2005-03-11
WO2001070745A1 (en) 2001-09-27
ATE250611T1 (de) 2003-10-15
CA2401952C (en) 2008-07-29
ES2206326T3 (es) 2004-05-16
KR20020083163A (ko) 2002-11-01
PL358480A1 (en) 2004-08-09
KR100577613B1 (ko) 2006-05-10
AU2001216034B2 (en) 2004-10-07
PT1268482E (pt) 2004-01-30
DE60005566D1 (de) 2003-10-30
JP2003528103A (ja) 2003-09-24
CN1451008A (zh) 2003-10-22
MXPA02008294A (es) 2002-12-09
HK1050897A1 (en) 2003-07-11

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050525

Termination date: 20091214