CN120112539A - 用于去除二苯并富烯或二苯并富烯衍生物的方法 - Google Patents
用于去除二苯并富烯或二苯并富烯衍生物的方法 Download PDFInfo
- Publication number
- CN120112539A CN120112539A CN202380075590.1A CN202380075590A CN120112539A CN 120112539 A CN120112539 A CN 120112539A CN 202380075590 A CN202380075590 A CN 202380075590A CN 120112539 A CN120112539 A CN 120112539A
- Authority
- CN
- China
- Prior art keywords
- group
- fmoc
- compound
- dibenzofulvene
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022175592 | 2022-11-01 | ||
| JP2022-175592 | 2022-11-01 | ||
| PCT/JP2023/039324 WO2024096023A1 (ja) | 2022-11-01 | 2023-10-31 | ジベンゾフルベンまたはジベンゾフルベン誘導体の除去方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN120112539A true CN120112539A (zh) | 2025-06-06 |
Family
ID=90930541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202380075590.1A Pending CN120112539A (zh) | 2022-11-01 | 2023-10-31 | 用于去除二苯并富烯或二苯并富烯衍生物的方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4596567A1 (https=) |
| JP (1) | JPWO2024096023A1 (https=) |
| KR (1) | KR20250097854A (https=) |
| CN (1) | CN120112539A (https=) |
| TW (1) | TW202432571A (https=) |
| WO (1) | WO2024096023A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202523345A (zh) | 2023-09-28 | 2025-06-16 | 日商中外製藥股份有限公司 | 使用混合酸酐法的胜肽化合物的製造方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2546808T3 (es) | 2006-03-24 | 2015-09-28 | Jitsubo Co., Ltd. | Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo |
| EP2181983A4 (en) | 2007-07-25 | 2013-01-02 | Ajinomoto Kk | METHOD FOR THE SELECTIVE REMOVAL OF A DIBENZOFULVENE DERIVATIVE |
| JP5445456B2 (ja) | 2008-08-06 | 2014-03-19 | 味の素株式会社 | ジベンゾフルベンの除去方法 |
| US8569453B2 (en) | 2009-03-12 | 2013-10-29 | Ajinomoto Co., Inc. | Fluorene compound |
| WO2010113939A1 (ja) | 2009-03-30 | 2010-10-07 | 味の素株式会社 | ジフェニルメタン化合物 |
| EP2518041A4 (en) | 2009-12-25 | 2013-12-11 | Ajinomoto Kk | benzyl |
| CN106220482B (zh) | 2010-08-30 | 2020-01-07 | 味之素株式会社 | 含有支链的芳香族化合物 |
| JP6136934B2 (ja) | 2011-12-15 | 2017-05-31 | 味の素株式会社 | Ｆｍｏｃ基の除去方法 |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| EP3342777B1 (en) | 2015-08-28 | 2023-01-11 | Sekisui Medical Co., Ltd. | Benzyl compound |
| KR102399022B1 (ko) | 2016-06-20 | 2022-05-17 | 세키스이 메디칼 가부시키가이샤 | 신규 디페닐메탄 보호제 |
| WO2018021233A1 (ja) | 2016-07-25 | 2018-02-01 | 積水メディカル株式会社 | 新規キサンテン保護剤 |
| WO2018088527A1 (ja) | 2016-11-11 | 2018-05-17 | 積水メディカル株式会社 | 新規トリチル保護剤 |
| TW201833127A (zh) | 2017-02-27 | 2018-09-16 | 日商積水醫療股份有限公司 | 新穎四環式保護劑 |
| CN110869544B (zh) | 2017-06-09 | 2024-03-08 | 中外制药株式会社 | 膜透过性高的环状肽化合物及包含其的文库 |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| WO2019117274A1 (ja) | 2017-12-15 | 2019-06-20 | 中外製薬株式会社 | ペプチドの製造方法、及び塩基の処理方法 |
| EP3730497B1 (en) | 2017-12-19 | 2022-11-16 | Sekisui Medical Co., Ltd. | Novel alkyl diphenylmethane protection agent |
| WO2020111238A1 (ja) | 2018-11-30 | 2020-06-04 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
| WO2020122182A1 (ja) | 2018-12-12 | 2020-06-18 | 中外製薬株式会社 | 分子内水素結合可能な官能基を有するアミノ酸とそれらのアミノ酸を含むペプチド化合物、およびそれらの製造方法 |
| EP3916000B1 (en) | 2019-02-28 | 2026-04-08 | FUJIFILM Corporation | Method for producing peptide compound, protecting group-forming reagent, and aromatic heterocyclic compound |
| EP3932899A4 (en) | 2019-02-28 | 2022-04-20 | FUJIFILM Corporation | METHOD FOR PRODUCING A PEPTIDE COMPOUND, PROTECTIVE GROUP-FORMING REAGENT AND FUSED POLYCYCLIC AROMATIC HYDROCARBON COMPOUND |
| CN114585916B (zh) | 2019-10-15 | 2025-03-11 | 中外制药株式会社 | 含有用具有Fmoc骨架的保护基保护的氨基的化合物的定量法 |
| EP4056580A4 (en) | 2019-11-07 | 2023-12-06 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID |
| EP4083051A4 (en) | 2019-12-27 | 2024-01-17 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR SYNTHESIS OF A PEPTIDE COMPOUND |
| JP7766028B2 (ja) | 2020-06-03 | 2025-11-07 | 中外製薬株式会社 | 高難度配列の効率的ペプチド縮合法 |
| KR20230097018A (ko) | 2020-11-05 | 2023-06-30 | 추가이 세이야쿠 가부시키가이샤 | 다이케토피페라진 형성에 의한 결손을 억제하는 펩타이드 합성 방법 |
| WO2022138891A1 (ja) | 2020-12-25 | 2022-06-30 | 中外製薬株式会社 | Ｎ－置換－アミノ酸残基を含むペプチド化合物の製造方法 |
| CN116547295A (zh) | 2020-12-28 | 2023-08-04 | 中外制药株式会社 | 氨基酸向固相合成用树脂的担载方法 |
| US12312379B2 (en) | 2021-05-07 | 2025-05-27 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing cyclic compounds comprising N-substituted amino acid residues |
| JP7716226B2 (ja) | 2021-05-14 | 2025-07-31 | Ｐｈｃ株式会社 | 血液凝固因子活性の測定試薬および測定方法 |
| JP7063409B1 (ja) | 2021-07-02 | 2022-05-09 | ペプチスター株式会社 | Ｆｍоｃ基を除去する方法 |
| TW202342495A (zh) | 2021-12-28 | 2023-11-01 | 日商中外製藥股份有限公司 | N-烷基胺基酸及含有n-烷基胺基酸之胜肽的製造方法 |
-
2023
- 2023-10-31 JP JP2024554537A patent/JPWO2024096023A1/ja active Pending
- 2023-10-31 KR KR1020257016109A patent/KR20250097854A/ko active Pending
- 2023-10-31 EP EP23885777.5A patent/EP4596567A1/en active Pending
- 2023-10-31 TW TW112141748A patent/TW202432571A/zh unknown
- 2023-10-31 WO PCT/JP2023/039324 patent/WO2024096023A1/ja not_active Ceased
- 2023-10-31 CN CN202380075590.1A patent/CN120112539A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024096023A1 (ja) | 2024-05-10 |
| KR20250097854A (ko) | 2025-06-30 |
| JPWO2024096023A1 (https=) | 2024-05-10 |
| TW202432571A (zh) | 2024-08-16 |
| EP4596567A1 (en) | 2025-08-06 |
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