CN120053638A - 使用奥法木单抗治疗多发性硬化的方案和方法 - Google Patents

使用奥法木单抗治疗多发性硬化的方案和方法 Download PDF

Info

Publication number
CN120053638A
CN120053638A CN202510270941.5A CN202510270941A CN120053638A CN 120053638 A CN120053638 A CN 120053638A CN 202510270941 A CN202510270941 A CN 202510270941A CN 120053638 A CN120053638 A CN 120053638A
Authority
CN
China
Prior art keywords
ofatuzumab
regimen
dose
during
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510270941.5A
Other languages
English (en)
Chinese (zh)
Inventor
E·华尔斯特罗姆
M·萨夫列瓦普拉兹
A·J·卡卡列卡威斯柯夫
J·M·卡恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN120053638A publication Critical patent/CN120053638A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Pressure Welding/Diffusion-Bonding (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN202510270941.5A 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法 Pending CN120053638A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662374986P 2016-08-15 2016-08-15
US62/374,986 2016-08-15
CN201780049932.7A CN109641965A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法
PCT/IB2017/054909 WO2018033841A1 (en) 2016-08-15 2017-08-11 Regimens and methods of treating multiple sclerosis using ofatumumab

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780049932.7A Division CN109641965A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法

Publications (1)

Publication Number Publication Date
CN120053638A true CN120053638A (zh) 2025-05-30

Family

ID=59901554

Family Applications (5)

Application Number Title Priority Date Filing Date
CN202510270941.5A Pending CN120053638A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法
CN202510270903.XA Pending CN120037367A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法
CN202510270924.1A Pending CN120000782A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法
CN201780049932.7A Pending CN109641965A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法
CN202510270961.2A Pending CN120053639A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN202510270903.XA Pending CN120037367A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法
CN202510270924.1A Pending CN120000782A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法
CN201780049932.7A Pending CN109641965A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法
CN202510270961.2A Pending CN120053639A (zh) 2016-08-15 2017-08-11 使用奥法木单抗治疗多发性硬化的方案和方法

Country Status (24)

Country Link
US (5) US11161909B2 (https=)
EP (5) EP3497132B1 (https=)
JP (2) JP6851391B2 (https=)
KR (2) KR20190038914A (https=)
CN (5) CN120053638A (https=)
AU (2) AU2017311664C1 (https=)
CA (2) CA3030530C (https=)
CY (1) CY1123350T1 (https=)
DE (1) DE202017007542U1 (https=)
DK (2) DK3497132T3 (https=)
ES (2) ES2954259T3 (https=)
FI (1) FI3733712T3 (https=)
HR (2) HRP20230894T1 (https=)
HU (2) HUE051948T2 (https=)
IL (4) IL302488B2 (https=)
LT (2) LT3497132T (https=)
MX (1) MX388593B (https=)
PL (2) PL3497132T3 (https=)
PT (2) PT3497132T (https=)
RS (2) RS64541B1 (https=)
RU (1) RU2749951C2 (https=)
SI (2) SI3497132T1 (https=)
TW (1) TWI752995B (https=)
WO (1) WO2018033841A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120053638A (zh) * 2016-08-15 2025-05-30 诺华股份有限公司 使用奥法木单抗治疗多发性硬化的方案和方法
ES2957112T3 (es) 2019-09-11 2024-01-11 Novartis Ag Tratamiento del RMS mediante cambio de terapia
MX2022003030A (es) 2019-09-11 2022-04-07 Novartis Ag Tratamiento de afecciones distintas de la esclerosis multiple en pacientes tratados con ofatumumab.
US20230151106A1 (en) * 2020-04-09 2023-05-18 Novartis Ag OFATUMUMAB FOR TREATING MS WHILE MAINTAINING SERUM IgG
US20240228647A1 (en) * 2021-04-14 2024-07-11 Novartis Ag Ofatumumab for treating multiple sclerosis in asian patients

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US4816401A (en) 1985-09-09 1989-03-28 University Of Rochester Serum free cell culture medium
JPS63501765A (ja) 1985-11-01 1988-07-21 インタ−ナショナル、ジェネティック、エンジニアリング　インコ−ポレ−テッド 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
DE69232137T2 (de) 1991-11-25 2002-05-29 Enzon Inc Multivalente antigen-bindende proteine
JP2003529361A (ja) 2000-03-30 2003-10-07 アムジェン インコーポレイテッド ＣＤ２０／ＩｇＥレセプター様分子およびその使用
EA013564B1 (ru) 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
CN101928344B (zh) 2002-10-17 2014-08-13 根马布股份公司 抗cd20的人单克隆抗体
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
DOP2006000029A (es) 2005-02-07 2006-08-15 Genentech Inc Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas)
US10155816B2 (en) 2005-11-28 2018-12-18 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
UA107557C2 (xx) 2007-07-06 2015-01-26 Композиція антитіла офатумумабу
TW201014605A (en) 2008-09-16 2010-04-16 Genentech Inc Methods for treating progressive multiple sclerosis
WO2012018704A1 (en) 2010-08-02 2012-02-09 Sanofi-Aventis U.S. Llc Use of teriflunomide for treating multiple sclerosis
EP2663331A4 (en) 2011-01-10 2015-07-15 Glaxosmithkline Intellectual Property Man Ltd NEW USES
TWI606064B (zh) * 2012-02-08 2017-11-21 Ｉｇｍ生物科技公司 細胞死亡誘導分子（ｃｄｉｍ）結合蛋白類及彼等之用途
EP2692343A1 (en) 2012-08-03 2014-02-05 Forward Pharma A/S Combination therapy for treatment of multiple sclerosis
SG11201500499TA (en) 2012-08-10 2015-03-30 Boehringer Ingelheim Int Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
WO2015162504A1 (en) 2014-04-23 2015-10-29 Novartis Ag Novel dosing and uses of ofatumumab
EA201692180A1 (ru) 2014-04-29 2017-08-31 Тева Фармасьютикал Индастриз Лтд. Лахинимод для лечения пациентов с рецидивирующе-ремиттирующим рассеянным склерозом (рррс) с высоким статусом инвалидизации
WO2016123329A2 (en) * 2015-01-28 2016-08-04 Genentech, Inc. Gene expression markers and treatment of multiple sclerosis
CN106699886A (zh) 2015-07-13 2017-05-24 西藏海思科药业集团股份有限公司 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体
CN120053638A (zh) 2016-08-15 2025-05-30 诺华股份有限公司 使用奥法木单抗治疗多发性硬化的方案和方法
ES2957112T3 (es) 2019-09-11 2024-01-11 Novartis Ag Tratamiento del RMS mediante cambio de terapia
MX2022003030A (es) 2019-09-11 2022-04-07 Novartis Ag Tratamiento de afecciones distintas de la esclerosis multiple en pacientes tratados con ofatumumab.
US20230151106A1 (en) 2020-04-09 2023-05-18 Novartis Ag OFATUMUMAB FOR TREATING MS WHILE MAINTAINING SERUM IgG
US20240228647A1 (en) 2021-04-14 2024-07-11 Novartis Ag Ofatumumab for treating multiple sclerosis in asian patients
IL310813A (en) 2021-08-16 2024-04-01 Novartis Ag OFATUMUMAB for the treatment of multiple sclerosis in children

Also Published As

Publication number Publication date
PL3497132T3 (pl) 2020-11-30
SI3733712T1 (sl) 2023-12-29
US20240150485A1 (en) 2024-05-09
IL313932A (en) 2024-08-01
US11161909B2 (en) 2021-11-02
EP3497132B1 (en) 2020-06-24
IL264804B (en) 2020-09-30
RU2021105514A (ru) 2021-04-19
JP6851391B2 (ja) 2021-03-31
WO2018033841A1 (en) 2018-02-22
US12338290B2 (en) 2025-06-24
CA3030530C (en) 2021-02-23
JP2020100630A (ja) 2020-07-02
CN120037367A (zh) 2025-05-27
JP2019511506A (ja) 2019-04-25
HUE051948T2 (hu) 2021-03-29
SI3497132T1 (sl) 2020-10-30
MX388593B (es) 2025-03-20
EP3497132A1 (en) 2019-06-19
CA3030530A1 (en) 2018-02-22
EP4252847A2 (en) 2023-10-04
AU2020201112C1 (en) 2025-05-22
RS60807B1 (sr) 2020-10-30
EP4371611A3 (en) 2024-07-24
US20240317878A1 (en) 2024-09-26
JP7198786B2 (ja) 2023-01-04
AU2017311664B2 (en) 2020-01-02
HUE063625T2 (hu) 2024-01-28
EP4371611A2 (en) 2024-05-22
CY1123350T1 (el) 2021-12-31
EP4252847A3 (en) 2023-11-15
TWI752995B (zh) 2022-01-21
US20220081488A1 (en) 2022-03-17
CN120000782A (zh) 2025-05-16
AU2017311664C1 (en) 2025-05-22
IL302488A (en) 2023-06-01
RU2021105514A3 (https=) 2022-02-08
RU2749951C2 (ru) 2021-06-21
IL302488B1 (en) 2024-08-01
PT3497132T (pt) 2020-09-25
HRP20230894T1 (hr) 2023-11-24
IL276890B2 (en) 2023-10-01
US12570754B2 (en) 2026-03-10
EP4711008A2 (en) 2026-03-18
AU2020201112A1 (en) 2020-03-05
CN109641965A (zh) 2019-04-16
EP3733712A1 (en) 2020-11-04
AU2020201112B2 (en) 2021-07-22
MX2019001860A (es) 2019-07-08
LT3497132T (lt) 2020-10-12
US20190177424A1 (en) 2019-06-13
PL3733712T3 (pl) 2023-10-16
IL276890B1 (en) 2023-06-01
IL302488B2 (en) 2024-12-01
KR20200136503A (ko) 2020-12-07
RS64541B1 (sr) 2023-09-29
KR20190038914A (ko) 2019-04-09
AU2017311664A1 (en) 2019-01-31
LT3733712T (lt) 2023-09-11
DE202017007542U1 (de) 2022-07-19
IL276890A (en) 2020-10-29
ES2954259T3 (es) 2023-11-21
EP3733712B1 (en) 2023-05-24
CA3101514A1 (en) 2018-02-22
PT3733712T (pt) 2023-08-31
RU2019107146A (ru) 2020-09-15
ES2821924T3 (es) 2021-04-28
HRP20201388T1 (hr) 2020-11-27
DK3497132T3 (da) 2020-09-07
FI3733712T3 (fi) 2023-08-22
US20250289902A1 (en) 2025-09-18
RU2019107146A3 (https=) 2020-09-15
TW201808333A (zh) 2018-03-16
CN120053639A (zh) 2025-05-30
DK3733712T3 (da) 2023-08-21

Similar Documents

Publication Publication Date Title
US12338290B2 (en) Regimens and methods of treating multiple sclerosis using ofatumumab
RU2782069C2 (ru) Схемы и способы лечения рассеянного склероза с применением офатумумаба
HK40101642A (en) Regimens and methods of treating multiple sclerosis using ofatumumab
HK40111448A (en) Regimens and methods of treating multiple sclerosis using ofatumumab
HK40032047A (en) Regimens and methods of treating multiple sclerosis using ofatumumab
HK40005527A (en) Regimens and methods of treating multiple sclerosis using ofatumumab
HK40005527B (en) Regimens and methods of treating multiple sclerosis using ofatumumab
HK40032047B (en) Regimens and methods of treating multiple sclerosis using ofatumumab

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination