AU2017311664C1 - Regimens and methods of treating multiple sclerosis using ofatumumab - Google Patents

Regimens and methods of treating multiple sclerosis using ofatumumab Download PDF

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Publication number
AU2017311664C1
AU2017311664C1 AU2017311664A AU2017311664A AU2017311664C1 AU 2017311664 C1 AU2017311664 C1 AU 2017311664C1 AU 2017311664 A AU2017311664 A AU 2017311664A AU 2017311664 A AU2017311664 A AU 2017311664A AU 2017311664 C1 AU2017311664 C1 AU 2017311664C1
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ofatumumab
regimen
multiple sclerosis
during
day
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AU2017311664B2 (en
AU2017311664A1 (en
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Joseph Michael KAHN
Algirdas Jonas KAKARIEKA WEISSKOPF
Marina SAVELIEVA PRAZ
Erik WALLSTRÖM
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Pressure Welding/Diffusion-Bonding (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
AU2017311664A 2016-08-15 2017-08-11 Regimens and methods of treating multiple sclerosis using ofatumumab Active AU2017311664C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020201112A AU2020201112C1 (en) 2016-08-15 2020-02-17 Regimens and methods of treating multiple sclerosis using ofatumumab

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662374986P 2016-08-15 2016-08-15
US62/374,986 2016-08-15
PCT/IB2017/054909 WO2018033841A1 (en) 2016-08-15 2017-08-11 Regimens and methods of treating multiple sclerosis using ofatumumab

Related Child Applications (1)

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AU2020201112A Division AU2020201112C1 (en) 2016-08-15 2020-02-17 Regimens and methods of treating multiple sclerosis using ofatumumab

Publications (3)

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AU2017311664A1 AU2017311664A1 (en) 2019-01-31
AU2017311664B2 AU2017311664B2 (en) 2020-01-02
AU2017311664C1 true AU2017311664C1 (en) 2025-05-22

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AU2020201112A Active AU2020201112C1 (en) 2016-08-15 2020-02-17 Regimens and methods of treating multiple sclerosis using ofatumumab

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US (5) US11161909B2 (https=)
EP (5) EP3497132B1 (https=)
JP (2) JP6851391B2 (https=)
KR (2) KR20190038914A (https=)
CN (5) CN120053638A (https=)
AU (2) AU2017311664C1 (https=)
CA (2) CA3030530C (https=)
CY (1) CY1123350T1 (https=)
DE (1) DE202017007542U1 (https=)
DK (2) DK3497132T3 (https=)
ES (2) ES2954259T3 (https=)
FI (1) FI3733712T3 (https=)
HR (2) HRP20230894T1 (https=)
HU (2) HUE051948T2 (https=)
IL (4) IL302488B2 (https=)
LT (2) LT3497132T (https=)
MX (1) MX388593B (https=)
PL (2) PL3497132T3 (https=)
PT (2) PT3497132T (https=)
RS (2) RS64541B1 (https=)
RU (1) RU2749951C2 (https=)
SI (2) SI3497132T1 (https=)
TW (1) TWI752995B (https=)
WO (1) WO2018033841A1 (https=)

Families Citing this family (5)

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CN120053638A (zh) * 2016-08-15 2025-05-30 诺华股份有限公司 使用奥法木单抗治疗多发性硬化的方案和方法
ES2957112T3 (es) 2019-09-11 2024-01-11 Novartis Ag Tratamiento del RMS mediante cambio de terapia
MX2022003030A (es) 2019-09-11 2022-04-07 Novartis Ag Tratamiento de afecciones distintas de la esclerosis multiple en pacientes tratados con ofatumumab.
US20230151106A1 (en) * 2020-04-09 2023-05-18 Novartis Ag OFATUMUMAB FOR TREATING MS WHILE MAINTAINING SERUM IgG
US20240228647A1 (en) * 2021-04-14 2024-07-11 Novartis Ag Ofatumumab for treating multiple sclerosis in asian patients

Citations (1)

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WO2012096924A1 (en) * 2011-01-10 2012-07-19 Glaxo Group Limited Novel uses

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PL3497132T3 (pl) 2020-11-30
SI3733712T1 (sl) 2023-12-29
US20240150485A1 (en) 2024-05-09
IL313932A (en) 2024-08-01
US11161909B2 (en) 2021-11-02
EP3497132B1 (en) 2020-06-24
IL264804B (en) 2020-09-30
RU2021105514A (ru) 2021-04-19
JP6851391B2 (ja) 2021-03-31
WO2018033841A1 (en) 2018-02-22
US12338290B2 (en) 2025-06-24
CA3030530C (en) 2021-02-23
JP2020100630A (ja) 2020-07-02
CN120037367A (zh) 2025-05-27
JP2019511506A (ja) 2019-04-25
HUE051948T2 (hu) 2021-03-29
SI3497132T1 (sl) 2020-10-30
MX388593B (es) 2025-03-20
EP3497132A1 (en) 2019-06-19
CA3030530A1 (en) 2018-02-22
EP4252847A2 (en) 2023-10-04
AU2020201112C1 (en) 2025-05-22
RS60807B1 (sr) 2020-10-30
EP4371611A3 (en) 2024-07-24
US20240317878A1 (en) 2024-09-26
JP7198786B2 (ja) 2023-01-04
AU2017311664B2 (en) 2020-01-02
HUE063625T2 (hu) 2024-01-28
EP4371611A2 (en) 2024-05-22
CY1123350T1 (el) 2021-12-31
EP4252847A3 (en) 2023-11-15
TWI752995B (zh) 2022-01-21
US20220081488A1 (en) 2022-03-17
CN120000782A (zh) 2025-05-16
IL302488A (en) 2023-06-01
RU2021105514A3 (https=) 2022-02-08
RU2749951C2 (ru) 2021-06-21
IL302488B1 (en) 2024-08-01
PT3497132T (pt) 2020-09-25
HRP20230894T1 (hr) 2023-11-24
IL276890B2 (en) 2023-10-01
US12570754B2 (en) 2026-03-10
EP4711008A2 (en) 2026-03-18
AU2020201112A1 (en) 2020-03-05
CN109641965A (zh) 2019-04-16
EP3733712A1 (en) 2020-11-04
AU2020201112B2 (en) 2021-07-22
MX2019001860A (es) 2019-07-08
LT3497132T (lt) 2020-10-12
US20190177424A1 (en) 2019-06-13
PL3733712T3 (pl) 2023-10-16
IL276890B1 (en) 2023-06-01
IL302488B2 (en) 2024-12-01
KR20200136503A (ko) 2020-12-07
RS64541B1 (sr) 2023-09-29
KR20190038914A (ko) 2019-04-09
AU2017311664A1 (en) 2019-01-31
LT3733712T (lt) 2023-09-11
DE202017007542U1 (de) 2022-07-19
IL276890A (en) 2020-10-29
ES2954259T3 (es) 2023-11-21
EP3733712B1 (en) 2023-05-24
CA3101514A1 (en) 2018-02-22
PT3733712T (pt) 2023-08-31
RU2019107146A (ru) 2020-09-15
ES2821924T3 (es) 2021-04-28
HRP20201388T1 (hr) 2020-11-27
DK3497132T3 (da) 2020-09-07
FI3733712T3 (fi) 2023-08-22
US20250289902A1 (en) 2025-09-18
RU2019107146A3 (https=) 2020-09-15
TW201808333A (zh) 2018-03-16
CN120053639A (zh) 2025-05-30
DK3733712T3 (da) 2023-08-21
CN120053638A (zh) 2025-05-30

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