KR20200136503A - 오파투무맙을 사용한 다발성 경화증의 치료 요법 및 방법 - Google Patents

오파투무맙을 사용한 다발성 경화증의 치료 요법 및 방법 Download PDF

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KR20200136503A
KR20200136503A KR1020207034140A KR20207034140A KR20200136503A KR 20200136503 A KR20200136503 A KR 20200136503A KR 1020207034140 A KR1020207034140 A KR 1020207034140A KR 20207034140 A KR20207034140 A KR 20207034140A KR 20200136503 A KR20200136503 A KR 20200136503A
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Prior art keywords
ofatumumab
antibody
dose
cell
multiple sclerosis
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KR1020207034140A
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Korean (ko)
Inventor
에리크 발스트룀
마리나 자펠리바 프라츠
알기르다스 요나스 카카리카 바이스코프
조셉 마이클 칸
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노파르티스 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pressure Welding/Diffusion-Bonding (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
KR1020207034140A 2016-08-15 2017-08-11 오파투무맙을 사용한 다발성 경화증의 치료 요법 및 방법 Ceased KR20200136503A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662374986P 2016-08-15 2016-08-15
US62/374,986 2016-08-15
PCT/IB2017/054909 WO2018033841A1 (en) 2016-08-15 2017-08-11 Regimens and methods of treating multiple sclerosis using ofatumumab

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197007454A Division KR20190038914A (ko) 2016-08-15 2017-08-11 오파투무맙을 사용한 다발성 경화증의 치료 요법 및 방법

Publications (1)

Publication Number Publication Date
KR20200136503A true KR20200136503A (ko) 2020-12-07

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ID=59901554

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KR1020207034140A Ceased KR20200136503A (ko) 2016-08-15 2017-08-11 오파투무맙을 사용한 다발성 경화증의 치료 요법 및 방법
KR1020197007454A Ceased KR20190038914A (ko) 2016-08-15 2017-08-11 오파투무맙을 사용한 다발성 경화증의 치료 요법 및 방법

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KR1020197007454A Ceased KR20190038914A (ko) 2016-08-15 2017-08-11 오파투무맙을 사용한 다발성 경화증의 치료 요법 및 방법

Country Status (24)

Country Link
US (5) US11161909B2 (https=)
EP (5) EP3497132B1 (https=)
JP (2) JP6851391B2 (https=)
KR (2) KR20200136503A (https=)
CN (5) CN120000782A (https=)
AU (2) AU2017311664C1 (https=)
CA (2) CA3030530C (https=)
CY (1) CY1123350T1 (https=)
DE (1) DE202017007542U1 (https=)
DK (2) DK3733712T3 (https=)
ES (2) ES2954259T3 (https=)
FI (1) FI3733712T3 (https=)
HR (2) HRP20230894T1 (https=)
HU (2) HUE063625T2 (https=)
IL (4) IL302488B2 (https=)
LT (2) LT3733712T (https=)
MX (1) MX388593B (https=)
PL (2) PL3497132T3 (https=)
PT (2) PT3733712T (https=)
RS (2) RS60807B1 (https=)
RU (1) RU2749951C2 (https=)
SI (2) SI3497132T1 (https=)
TW (1) TWI752995B (https=)
WO (1) WO2018033841A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3733712T (lt) 2016-08-15 2023-09-11 Novartis Ag Išsėtinės sklerozės gydymo schemos ir būdai, panaudojant ofatumumabą
MX2022003010A (es) * 2019-09-11 2022-06-02 Novartis Ag Tratamiento de la emr mediante cambio de terapia.
US20220389109A1 (en) * 2019-09-11 2022-12-08 Novartis Ag Management of conditions other than multiple sclerosis in ofatumumab-treated patients
EP4707302A2 (en) * 2020-04-09 2026-03-11 Novartis AG Ofatumumab for treating ms while maintaining serum igg
WO2022219057A1 (en) * 2021-04-14 2022-10-20 Novartis Ag Ofatumumab for treating multiple sclerosis in asian patients

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LT3733712T (lt) 2016-08-15 2023-09-11 Novartis Ag Išsėtinės sklerozės gydymo schemos ir būdai, panaudojant ofatumumabą
US20220389109A1 (en) 2019-09-11 2022-12-08 Novartis Ag Management of conditions other than multiple sclerosis in ofatumumab-treated patients
MX2022003010A (es) 2019-09-11 2022-06-02 Novartis Ag Tratamiento de la emr mediante cambio de terapia.
EP4707302A2 (en) 2020-04-09 2026-03-11 Novartis AG Ofatumumab for treating ms while maintaining serum igg
WO2022219057A1 (en) 2021-04-14 2022-10-20 Novartis Ag Ofatumumab for treating multiple sclerosis in asian patients
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IL302488B1 (en) 2024-08-01
PT3497132T (pt) 2020-09-25
US12570754B2 (en) 2026-03-10
US20220081488A1 (en) 2022-03-17
RS60807B1 (sr) 2020-10-30
CN120053639A (zh) 2025-05-30
US20240150485A1 (en) 2024-05-09
MX388593B (es) 2025-03-20
US20240317878A1 (en) 2024-09-26
JP2020100630A (ja) 2020-07-02
IL264804B (en) 2020-09-30
CN120037367A (zh) 2025-05-27
MX2019001860A (es) 2019-07-08
AU2017311664A1 (en) 2019-01-31
IL276890A (en) 2020-10-29
PT3733712T (pt) 2023-08-31
AU2020201112B2 (en) 2021-07-22
EP4252847A3 (en) 2023-11-15
DK3733712T3 (da) 2023-08-21
DK3497132T3 (da) 2020-09-07
AU2017311664B2 (en) 2020-01-02
HUE051948T2 (hu) 2021-03-29
EP4711008A2 (en) 2026-03-18
AU2020201112C1 (en) 2025-05-22
HRP20201388T1 (hr) 2020-11-27
ES2954259T3 (es) 2023-11-21
EP3733712A1 (en) 2020-11-04
PL3497132T3 (pl) 2020-11-30
CN109641965A (zh) 2019-04-16
AU2020201112A1 (en) 2020-03-05
JP2019511506A (ja) 2019-04-25
HRP20230894T1 (hr) 2023-11-24
SI3497132T1 (sl) 2020-10-30
WO2018033841A1 (en) 2018-02-22
AU2017311664C1 (en) 2025-05-22
TWI752995B (zh) 2022-01-21
CA3101514A1 (en) 2018-02-22
IL276890B2 (en) 2023-10-01
IL302488A (en) 2023-06-01
EP4371611A2 (en) 2024-05-22
EP3733712B1 (en) 2023-05-24
IL302488B2 (en) 2024-12-01
CN120000782A (zh) 2025-05-16
ES2821924T3 (es) 2021-04-28
HUE063625T2 (hu) 2024-01-28
IL276890B1 (en) 2023-06-01
RS64541B1 (sr) 2023-09-29
CY1123350T1 (el) 2021-12-31
FI3733712T3 (fi) 2023-08-22
CN120053638A (zh) 2025-05-30
TW201808333A (zh) 2018-03-16
RU2019107146A (ru) 2020-09-15
LT3497132T (lt) 2020-10-12
US20190177424A1 (en) 2019-06-13
PL3733712T3 (pl) 2023-10-16
RU2019107146A3 (https=) 2020-09-15
LT3733712T (lt) 2023-09-11
RU2021105514A (ru) 2021-04-19
DE202017007542U1 (de) 2022-07-19
US12338290B2 (en) 2025-06-24
SI3733712T1 (sl) 2023-12-29
EP4252847A2 (en) 2023-10-04
CA3030530C (en) 2021-02-23
EP4371611A3 (en) 2024-07-24
IL313932A (en) 2024-08-01
US11161909B2 (en) 2021-11-02
JP7198786B2 (ja) 2023-01-04
EP3497132A1 (en) 2019-06-19
CA3030530A1 (en) 2018-02-22
EP3497132B1 (en) 2020-06-24
RU2749951C2 (ru) 2021-06-21
US20250289902A1 (en) 2025-09-18
RU2021105514A3 (https=) 2022-02-08
KR20190038914A (ko) 2019-04-09

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