CN1196479C - 吸入形式的苯并茚前列腺素制剂的用途 - Google Patents

吸入形式的苯并茚前列腺素制剂的用途 Download PDF

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Publication number
CN1196479C
CN1196479C CNB008051089A CN00805108A CN1196479C CN 1196479 C CN1196479 C CN 1196479C CN B008051089 A CNB008051089 A CN B008051089A CN 00805108 A CN00805108 A CN 00805108A CN 1196479 C CN1196479 C CN 1196479C
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benzindene
pulmonary
aerosolized
dose
use according
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Expired - Lifetime
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CNB008051089A
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English (en)
Chinese (zh)
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CN1379665A (zh
Inventor
G·克卢捷
J·格罗
M·韦德
R·E·帕克
J·E·劳埃德
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United Therapeutics Corp
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United Therapeutics Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB008051089A 1999-03-18 2000-03-17 吸入形式的苯并茚前列腺素制剂的用途 Expired - Lifetime CN1196479C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12499999P 1999-03-18 1999-03-18
US60/124,999 1999-03-18

Publications (2)

Publication Number Publication Date
CN1379665A CN1379665A (zh) 2002-11-13
CN1196479C true CN1196479C (zh) 2005-04-13

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CNB008051089A Expired - Lifetime CN1196479C (zh) 1999-03-18 2000-03-17 吸入形式的苯并茚前列腺素制剂的用途

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US (2) US6521212B1 (enExample)
EP (1) EP1161234B1 (enExample)
JP (2) JP4819224B2 (enExample)
KR (1) KR100750384B1 (enExample)
CN (1) CN1196479C (enExample)
AT (1) ATE245979T1 (enExample)
AU (1) AU4082700A (enExample)
CA (1) CA2365890C (enExample)
DE (1) DE60004181T2 (enExample)
DK (1) DK1161234T3 (enExample)
ES (1) ES2203449T3 (enExample)
PT (1) PT1161234E (enExample)
WO (1) WO2000054758A2 (enExample)

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US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
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US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
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CN101903324B (zh) 2007-12-17 2013-07-03 联合治疗公司 一种制备Remodulin中的活性成分曲前列素的改良方法
US8350079B2 (en) * 2008-05-08 2013-01-08 United Therapeutics Corporation Treprostinil formulation
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KR101544246B1 (ko) * 2009-05-07 2015-08-12 유나이티드 세러퓨틱스 코오포레이션 프로스타시클린 유사체의 고체 제제
KR20160132501A (ko) 2010-03-15 2016-11-18 유나이티드 세러퓨틱스 코오포레이션 폐고혈압의 치료
CN103261142B (zh) 2010-06-03 2014-12-10 联合治疗公司 曲前列环素的制备
US8461393B2 (en) 2011-03-02 2013-06-11 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
CN103193627B (zh) 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193626B (zh) 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
US9387214B2 (en) 2012-01-13 2016-07-12 United Therapeutics Corporation Method of identifying therapies for pulmonary hypertension
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KR102238501B1 (ko) 2013-03-25 2021-04-08 유나이티드 세러퓨틱스 코오포레이션 링커 티올 및 peg화된 형태를 갖는 프로스타시클린 화합물의 제조 방법
EA031604B1 (ru) 2013-10-25 2019-01-31 Инсмед Инкорпорейтед Трепростинильные соединения, композиции и способы их использования
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Also Published As

Publication number Publication date
WO2000054758A2 (en) 2000-09-21
ATE245979T1 (de) 2003-08-15
KR100750384B1 (ko) 2007-08-17
JP4819224B2 (ja) 2011-11-24
EP1161234B1 (en) 2003-07-30
DK1161234T3 (da) 2003-11-24
US6521212B1 (en) 2003-02-18
WO2000054758A3 (en) 2001-02-08
JP2002539154A (ja) 2002-11-19
CN1379665A (zh) 2002-11-13
KR20010108352A (ko) 2001-12-07
US6756033B2 (en) 2004-06-29
US20030053958A1 (en) 2003-03-20
DE60004181D1 (de) 2003-09-04
JP2011201907A (ja) 2011-10-13
ES2203449T3 (es) 2004-04-16
AU4082700A (en) 2000-10-04
EP1161234A2 (en) 2001-12-12
PT1161234E (pt) 2003-12-31
CA2365890A1 (en) 2000-09-21
CA2365890C (en) 2010-09-21
DE60004181T2 (de) 2004-04-15

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