CN1195988A - 免疫抑制剂 - Google Patents

免疫抑制剂 Download PDF

Info

Publication number
CN1195988A
CN1195988A CN96196854A CN96196854A CN1195988A CN 1195988 A CN1195988 A CN 1195988A CN 96196854 A CN96196854 A CN 96196854A CN 96196854 A CN96196854 A CN 96196854A CN 1195988 A CN1195988 A CN 1195988A
Authority
CN
China
Prior art keywords
quinoline
methyl
immunosuppressant
dimethoxyphenyl
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96196854A
Other languages
English (en)
Chinese (zh)
Inventor
牧野治彦
左右田隆
大田义一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1195988A publication Critical patent/CN1195988A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN96196854A 1995-09-13 1996-06-19 免疫抑制剂 Pending CN1195988A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23570495 1995-09-13
JP235704/95 1995-09-13

Publications (1)

Publication Number Publication Date
CN1195988A true CN1195988A (zh) 1998-10-14

Family

ID=16990000

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96196854A Pending CN1195988A (zh) 1995-09-13 1996-06-19 免疫抑制剂

Country Status (10)

Country Link
EP (1) EP0850061A1 (pt)
KR (1) KR19990044618A (pt)
CN (1) CN1195988A (pt)
AU (1) AU6137396A (pt)
BR (1) BR9610314A (pt)
CA (1) CA2226915A1 (pt)
HU (1) HUP9900169A2 (pt)
NO (1) NO980788L (pt)
NZ (1) NZ310561A (pt)
WO (1) WO1997009984A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0941987A1 (de) * 1998-03-13 1999-09-15 Lonza A.G. Verfahren zur Herstellung von 2-Amino-4,5,3',4'-tetramethoxybenzophenon
EP1277740A1 (en) * 1998-06-12 2003-01-22 Vertex Pharmaceuticals Incorporated Inhibitors of p38
AU4429799A (en) 1998-06-12 1999-12-30 Vertex Pharmaceuticals Incorporated Inhibitors of p38
DE19853487A1 (de) 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
PL1663197T3 (pl) 2003-09-09 2008-09-30 Biogen Idec Int Gmbh Zastosowanie pochodnych kwasu fumarowego do leczenia niewydolności serca oraz astmy
EP4137819A1 (en) 2007-02-08 2023-02-22 Biogen MA Inc. Compositions and uses for treating multiple sclerosis
CN102050780B (zh) * 2010-11-18 2012-05-02 中国科学院昆明植物研究所 喹啉衍生物,其药物组合物及其用途
WO2017151947A1 (en) * 2016-03-02 2017-09-08 George Robert Pettit 4-azapodophylotoxins compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU633471B2 (en) * 1987-08-26 1993-02-04 Biogen Idec Ma Inc. Biological materials, processes for producing biological materials and for using such materials in therapy
KR0148009B1 (ko) * 1988-05-27 1998-08-01 그래고리 비. 아보트 인터루킨-1 억제제
JP2863265B2 (ja) * 1989-05-19 1999-03-03 ハダサ メディカル オーガニゼーション インターロイキン１インヒビター
US6238875B1 (en) * 1991-03-12 2001-05-29 The Scripps Research Institute Diagnostic methods useful in the characterization of lymphoproliferative disease characterized by increased EPR-1
TW232013B (pt) * 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
EP0664128A4 (en) * 1992-10-07 1997-12-17 Sumitomo Pharma PHARMACEUTICAL AGENT FOR INHIBITING TUMORNESCROSE FACTOR PRODUCTION.
JPH06340658A (ja) * 1993-04-08 1994-12-13 Kyowa Hakko Kogyo Co Ltd ベンゾイミダゾール誘導体
IL111743A0 (en) * 1993-12-08 1995-01-24 Intermune Life Sciences Inc Recombinant genes expressing pp14

Also Published As

Publication number Publication date
NO980788L (no) 1998-03-31
HUP9900169A2 (hu) 2000-03-28
AU6137396A (en) 1997-04-01
BR9610314A (pt) 1999-07-06
KR19990044618A (ko) 1999-06-25
EP0850061A1 (en) 1998-07-01
NZ310561A (en) 1999-07-29
CA2226915A1 (en) 1997-03-20
WO1997009984A1 (en) 1997-03-20
NO980788D0 (no) 1998-02-25

Similar Documents

Publication Publication Date Title
CN1178938C (zh) 1,2-稠合的喹啉衍生物
CN1253449C (zh) 作为蛋白激酶c抑制剂的吲哚基马来酰亚胺衍生物
CN1174980C (zh) 抑制胃酸分泌的咪唑并吡啶衍生物
CN1170538C (zh) 供治疗关节病的法呢基(Farnesyl)蛋白质转移酶抑制剂
CN1104427C (zh) 法呢基蛋白转移酶的三环抑制剂
CN1271070C (zh) 用作腺苷A2α受体的配体的三唑基－咪唑并吡啶和三唑基嘌呤类的衍生物及其作为药物的应用
CN1701074A (zh) 用作依赖细胞周期蛋白激酶抑制剂的吡唑并嘧啶
CN1665811A (zh) 氨基甲酸酯－取代的吡唑并吡啶类化合物
CN1278819A (zh) 作为促肾上腺皮质素释放激素拮抗剂、可用于治疗cns障碍和紧张相关性疾病的杂环基取代的环稠合吡啶和嘧啶
CN1214339A (zh) 吡唑衍生物、其制备方法和在药物中的应用
CN1659145A (zh) 作为egf－r和her2激酶抑制剂的3－氰基喹啉
CN1745077A (zh) 促旋酶抑制剂及其用途
CN1406231A (zh) 嘧啶化合物
CN1820009A (zh) 作为激酶抑制剂的吡咯并[3,4－c]吡唑衍生物
CN1175252A (zh) 作为蛋白激酶特别是egf－r酪氨酸激酶的抑制剂的咪唑衍生物
CN1387517A (zh) 作为环加氧酶－2抑制剂的5－芳基－1h－1,2,4－三唑化合物及含有它们的药物组合物
CN1694705A (zh) 用作依赖细胞周期蛋白激酶抑制剂的吡唑并嘧啶
CN1044464A (zh) 二氮杂双环抗焦虑药
CN1295561A (zh) N－杂环羧酸或羧酸等排物的n－结合氨磺酰
CN1344257A (zh) cGMP磷酸二酯酶的稠合吡啶并哒嗪抑制剂
CN1135754A (zh) 治疗药剂
CN1105363A (zh) 喹啉或喹唑啉衍生物，它们的制法和用途
CN1509291A (zh) 噁唑并嘧啶和呋喃并嘧啶化合物以及它们作为抗肿瘤药物的用途
CN1198158A (zh) 作为酪氨酸激酶抑制剂的双环4－芳烷基氨基嘧啶衍生物
CN1780836A (zh) 作为血管紧张肽原酶抑制剂的新型二氮杂双环壬烯和四氢吡啶衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication