CN1195058C - 草酰乙酸水解酶缺陷型真菌宿主细胞 - Google Patents

草酰乙酸水解酶缺陷型真菌宿主细胞 Download PDF

Info

Publication number
CN1195058C
CN1195058C CNB008041679A CN00804167A CN1195058C CN 1195058 C CN1195058 C CN 1195058C CN B008041679 A CNB008041679 A CN B008041679A CN 00804167 A CN00804167 A CN 00804167A CN 1195058 C CN1195058 C CN 1195058C
Authority
CN
China
Prior art keywords
nucleic acid
acid sequence
polypeptide
filamentous fungal
mutant cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008041679A
Other languages
English (en)
Chinese (zh)
Other versions
CN1341149A (zh
Inventor
卡斯滕·M·约尔特
亨里克·佩德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Original Assignee
Novozymes AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8091215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1195058(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novozymes AS filed Critical Novozymes AS
Publication of CN1341149A publication Critical patent/CN1341149A/zh
Application granted granted Critical
Publication of CN1195058C publication Critical patent/CN1195058C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB008041679A 1999-02-22 2000-02-18 草酰乙酸水解酶缺陷型真菌宿主细胞 Expired - Fee Related CN1195058C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900231 1999-02-22
DKPA199900231 1999-02-22

Publications (2)

Publication Number Publication Date
CN1341149A CN1341149A (zh) 2002-03-20
CN1195058C true CN1195058C (zh) 2005-03-30

Family

ID=8091215

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008041679A Expired - Fee Related CN1195058C (zh) 1999-02-22 2000-02-18 草酰乙酸水解酶缺陷型真菌宿主细胞

Country Status (8)

Country Link
EP (1) EP1157100B1 (enExample)
JP (2) JP4741082B2 (enExample)
CN (1) CN1195058C (enExample)
AT (1) ATE315638T1 (enExample)
AU (1) AU2658200A (enExample)
DE (1) DE60025467T2 (enExample)
DK (1) DK1157100T3 (enExample)
WO (1) WO2000050576A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1195058C (zh) * 1999-02-22 2005-03-30 诺维信公司 草酰乙酸水解酶缺陷型真菌宿主细胞
US6544765B1 (en) 1999-02-22 2003-04-08 Novozymes, A/S Oxaloacetate hydrolase deficient fungal host cells
US20060127976A1 (en) * 2003-02-05 2006-06-15 Wenzel Thibaut J Use of oxalate deficient aspergillus niger strains for producing a polypeptide
EP1613761B1 (en) 2003-03-31 2009-09-02 Novozymes Inc. Methods for producing biological substances in enzyme-deficient mutants of aspergillus niger
DK1786908T3 (da) * 2004-08-18 2010-06-07 Bayer Cropscience Ag Planter med forøget plastidisk aktivitet af stivelsesphosphorylerende R3-enzym
EP2423315B1 (en) 2006-06-29 2015-01-07 DSM IP Assets B.V. A method for achieving improved polypeptide expression
MX346700B (es) 2009-03-10 2017-03-28 Dsm Ip Assets Bv Metodo para mejorar el rendimiento de un polipeptido.
DK2406372T3 (da) 2009-03-10 2017-11-27 Dsm Ip Assets Bv Prægastrisk esterase og derivater deraf
CN102414323B (zh) 2009-04-22 2015-07-08 帝斯曼知识产权资产管理有限公司 用于生产感兴趣的重组多肽的方法
CA2768608A1 (en) 2009-07-22 2011-01-27 Dsm Ip Assets B.V. Improved host cell for the production of a compound of interest
BR112014016587A2 (pt) * 2012-01-05 2020-10-27 Novartis Ag células fúngicas filamentosas deficientes de protease e métodos de uso das mesmas
JP6468561B2 (ja) 2012-07-19 2019-02-13 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ＡｇｓＥ欠損株
US11396665B2 (en) 2015-01-06 2022-07-26 Dsm Ip Assets B.V. CRISPR-CAS system for a filamentous fungal host cell
ES2815628T3 (es) 2015-02-20 2021-03-30 Roal Oy Métodos para controlar la producción de proteasas
EP3596199A1 (en) 2017-03-13 2020-01-22 DSM IP Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
CN110791439B (zh) * 2019-10-10 2022-04-19 天津科技大学 一株基因工程构建发酵生产苹果酸的重组黑曲霉菌株及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1195058C (zh) * 1999-02-22 2005-03-30 诺维信公司 草酰乙酸水解酶缺陷型真菌宿主细胞

Also Published As

Publication number Publication date
EP1157100B1 (en) 2006-01-11
CN1341149A (zh) 2002-03-20
WO2000050576A1 (en) 2000-08-31
JP2002536993A (ja) 2002-11-05
DE60025467D1 (de) 2006-04-06
EP1157100A1 (en) 2001-11-28
JP2011101651A (ja) 2011-05-26
DE60025467T2 (de) 2006-09-21
AU2658200A (en) 2000-09-14
JP4741082B2 (ja) 2011-08-03
ATE315638T1 (de) 2006-02-15
DK1157100T3 (da) 2006-05-29

Similar Documents

Publication Publication Date Title
CN1262639C (zh) 新的宿主细胞和生产蛋白质的方法
CN100347301C (zh) 无选择标志重组基因的菌株,得到这些菌株的方法及应用
CN1195058C (zh) 草酰乙酸水解酶缺陷型真菌宿主细胞
CN1253574C (zh) 来自米曲霉的areA基因和其中areA基因已被修饰的真菌
CN1940067A (zh) 用于在真菌细胞中表达基因的启动子
CN1260363C (zh) 由腈化合物生产酰胺的方法
CN100344765C (zh) 用于调节转录的dna序列
CN1192106C (zh) 分离突变体及克隆互补基因的新方法
CN1161461C (zh) 碱性磷酸酶在酵母中的表达
CN1622998A (zh) 丝状真菌来源的赖氨酰氧化酶
CN1852983A (zh) 蛋白质从酵母的分泌
CN1231579C (zh) trichodiene合成酶及其制备方法
CN1329667A (zh) 在制备多肽的方法中有效的真菌转录激活因子
CN1816627A (zh) 生产葡糖淀粉酶的方法及其用途
CN1160465C (zh) 其中areA、pepC和/或pepE基因已被灭活的真菌
CN1198939C (zh) 来自绿色木霉的纤维素酶cbh1基因的调控序列以及利用该序列的蛋白质或多肽的大量生产体系
CN1253575C (zh) 用共有翻译起始区序列制备多肽的方法
CN1592785A (zh) 酵母中来自Tritirachium album的重组蛋白酶K的表达
CN1268746C (zh) 用于在真菌细胞中生产多肽的方法
CN1301307A (zh) 在丝状真菌突变细胞中生产多肽的方法
CN1183248C (zh) 环状缩肽合成酶及其基因、以及环状缩肽的大规模生产系统
CN1969041A (zh) 用于生产多肽的信号肽
CN1152136C (zh) 具有5-氨基酮戊酸合酶活性的多肽和编码该多肽的核酸
CN1183255C (zh) 适合生产蛋白质的表达系统
CN1260832A (zh) 新ppgpp合成酶及用于改善感兴趣的蛋白产生的表达系统

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050330

Termination date: 20180218

CF01 Termination of patent right due to non-payment of annual fee