CN119454714A - 噁噻嗪样化合物、其制备方法和用途 - Google Patents

噁噻嗪样化合物、其制备方法和用途 Download PDF

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Publication number
CN119454714A
CN119454714A CN202310038641.5A CN202310038641A CN119454714A CN 119454714 A CN119454714 A CN 119454714A CN 202310038641 A CN202310038641 A CN 202310038641A CN 119454714 A CN119454714 A CN 119454714A
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Prior art keywords
cancer
compound
compounds
taurolidine
sodium
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CN202310038641.5A
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Chinese (zh)
Inventor
R·W·普弗曼
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Geistlich Pharma AG
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Geistlich Pharma AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/04—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
    • C07C303/12—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with thionylhalides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/18—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by reaction of sulfides with compounds having functional groups with formation of sulfo or halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/09—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
    • C07C309/10—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/12—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing esterified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78—Halides of sulfonic acids
    • C07C309/79—Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms
    • C07C309/82—Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms of a carbon skeleton substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/24—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
    • C07D291/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN202310038641.5A 2014-12-19 2015-12-17 噁噻嗪样化合物、其制备方法和用途 Pending CN119454714A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462094580P 2014-12-19 2014-12-19
US62/094,580 2014-12-19
CN201580072835.0A CN107257786B (zh) 2014-12-19 2015-12-17 制备噁噻嗪样化合物的方法
PCT/IB2015/059741 WO2016098054A1 (en) 2014-12-19 2015-12-17 Processes for preparing oxathiazin-like compounds

Related Parent Applications (1)

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CN201580072835.0A Division CN107257786B (zh) 2014-12-19 2015-12-17 制备噁噻嗪样化合物的方法

Publications (1)

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CN119454714A true CN119454714A (zh) 2025-02-18

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CN202310038641.5A Pending CN119454714A (zh) 2014-12-19 2015-12-17 噁噻嗪样化合物、其制备方法和用途
CN201580072835.0A Active CN107257786B (zh) 2014-12-19 2015-12-17 制备噁噻嗪样化合物的方法
CN201910974314.4A Pending CN110776479A (zh) 2014-12-19 2015-12-17 *噻嗪样化合物、其制备方法和用途

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CN201580072835.0A Active CN107257786B (zh) 2014-12-19 2015-12-17 制备噁噻嗪样化合物的方法
CN201910974314.4A Pending CN110776479A (zh) 2014-12-19 2015-12-17 *噻嗪样化合物、其制备方法和用途

Country Status (21)

Country Link
US (2) US10392355B2 (https=)
EP (2) EP4011871A3 (https=)
JP (4) JP6746605B2 (https=)
KR (1) KR102594322B1 (https=)
CN (3) CN119454714A (https=)
AU (2) AU2015365348B2 (https=)
CA (1) CA2971570A1 (https=)
CY (1) CY1125047T1 (https=)
DK (1) DK3233813T3 (https=)
ES (1) ES2907592T3 (https=)
HR (1) HRP20220313T1 (https=)
HU (1) HUE058257T2 (https=)
IL (1) IL252912B (https=)
LT (1) LT3233813T (https=)
MX (2) MX392353B (https=)
PL (1) PL3233813T3 (https=)
PT (1) PT3233813T (https=)
RS (1) RS62955B1 (https=)
SI (1) SI3233813T1 (https=)
SM (1) SMT202200091T1 (https=)
WO (1) WO2016098054A1 (https=)

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MX392353B (es) * 2014-12-19 2025-03-24 Geistlich Pharma Ag Procedimientos para preparar compuestos de tipo oxatiazina
US11591302B2 (en) * 2014-12-19 2023-02-28 Geistlich Pharm A Ag Processes for preparing oxathiazin-like compounds
BR112018070662A2 (pt) 2016-04-07 2019-02-05 Geistlich Pharma Ag processos para preparar compostos do tipo oxatiazina
EP3960172B1 (en) * 2017-02-27 2023-11-08 Seed Research Institute Co., Ltd. Antifungal composition
CN109602744A (zh) * 2018-12-13 2019-04-12 中国人民解放军总医院 荜茇酰胺在制备抗菌消炎药物中的应用
CA3140981A1 (en) * 2019-05-22 2020-11-26 Geistlich Pharma Ag Oxathiazin compounds for inhibiting gapdh
EP3972609B1 (en) 2019-05-22 2025-03-26 Geistlich Pharma AG Oxathiazin_dioxide for treating, preventing, inhibiting or reducing cytokine release
WO2020234829A1 (en) * 2019-05-22 2020-11-26 Geistlich Pharma Ag Methods and compositions for inhibiting gapdh
JP7752675B2 (ja) * 2020-07-06 2025-10-10 アカデミー オブ ミリタリー メディカル サイエンシズ ウイルスに対するタウロリジンの使用
CN111617086A (zh) * 2020-07-06 2020-09-04 长春迈灵生物工程有限公司 牛磺罗定在制备抗hpv病毒药物中的应用
CN111671758A (zh) * 2020-07-06 2020-09-18 长春迈灵生物工程有限公司 牛磺罗定在制备抗hiv病毒药物中的应用
KR20240004303A (ko) * 2021-04-29 2024-01-11 가이스틀리히 파마 아게 항균제 및 항암제
CN118724762A (zh) * 2024-06-24 2024-10-01 湖南增达生物科技有限公司 一种牛磺酸的制备新工艺
WO2026074499A1 (en) * 2024-10-03 2026-04-09 Geistlich Pharma Ag Methods and compositions for inhibiting c-myc

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DE1160443B (de) 1961-11-30 1964-01-02 Hoechst Ag Verfahren zur Herstellung von Tetrahydro-oxathiazin-dioxyden
GB1124285A (en) * 1964-10-06 1968-08-21 Geistlich Soehne Ag Novel perhydro-1,2,4-thiadiazine dioxides-(1,1), their preparation and compositionscontaining them
DE1234988B (de) 1964-11-28 1967-02-23 Bayer Ag Verfahren zur Herstellung von Copolymerisaten des Trioxans
DK167393B1 (da) * 1985-12-30 1993-10-25 Roussel Uclaf 1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf
GB8617482D0 (en) 1986-07-17 1986-08-28 Geistlich Soehne Ag Pharmaceutical composition
IT1296926B1 (it) 1997-12-05 1999-08-03 Zambon Spa Procedimento per la preparazione di composti ad attivita' antimicotica
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JP2008222659A (ja) * 2007-03-14 2008-09-25 Asahi Kasei Corp スルホンアミド化合物の製造方法
CN101679262A (zh) 2007-06-07 2010-03-24 安斯泰来制药株式会社 吡啶酮化合物
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US20120142676A1 (en) * 2010-08-18 2012-06-07 Gaik-Lean Chee Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules
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WO2013190355A1 (en) * 2012-06-18 2013-12-27 Geistlich Pharma Ag Oxathiazine derivatives as antibacterial and anticancer agents
MX392353B (es) * 2014-12-19 2025-03-24 Geistlich Pharma Ag Procedimientos para preparar compuestos de tipo oxatiazina

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MX392353B (es) 2025-03-24
PT3233813T (pt) 2022-03-14
CN107257786B (zh) 2019-12-24
KR102594322B1 (ko) 2023-10-26
AU2015365348B2 (en) 2019-11-28
HRP20220313T1 (hr) 2022-05-13
EP4011871A3 (en) 2022-08-24
ES2907592T3 (es) 2022-04-25
HUE058257T2 (hu) 2022-07-28
MX2019013194A (es) 2020-01-13
JP7030093B2 (ja) 2022-03-04
DK3233813T3 (da) 2022-03-07
SMT202200091T1 (it) 2022-03-21
EP3233813B1 (en) 2022-02-02
US20190389819A1 (en) 2019-12-26
EP4011871A2 (en) 2022-06-15
MX369462B (es) 2019-11-08
KR20170113546A (ko) 2017-10-12
BR112017013188A2 (pt) 2018-04-10
JP7449913B2 (ja) 2024-03-14
CN110776479A (zh) 2020-02-11
US10392355B2 (en) 2019-08-27
LT3233813T (lt) 2022-04-11
IL252912A0 (en) 2017-08-31
RS62955B1 (sr) 2022-03-31
MX2017008112A (es) 2018-02-09
JP2020040964A (ja) 2020-03-19
WO2016098054A1 (en) 2016-06-23
CA2971570A1 (en) 2016-06-23
JP6746605B2 (ja) 2020-08-26
IL252912B (en) 2020-01-30
AU2019261702A1 (en) 2019-11-28
NZ733723A (en) 2024-03-22
JP2022031717A (ja) 2022-02-22
US20180370932A1 (en) 2018-12-27
JP2024028794A (ja) 2024-03-05
JP2018502909A (ja) 2018-02-01
AU2019261702B2 (en) 2021-03-25
AU2015365348A1 (en) 2017-07-13
JP7688098B2 (ja) 2025-06-03
SI3233813T1 (sl) 2022-05-31
PL3233813T3 (pl) 2022-05-30
CN107257786A (zh) 2017-10-17
WO2016098054A9 (en) 2016-12-22
EP3233813A1 (en) 2017-10-25
US10968190B2 (en) 2021-04-06
CY1125047T1 (el) 2023-03-24

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