CN1192696A - 用于充血性心力衰竭治疗的螺甾内酯与血管紧张素ⅱ拮抗药组合疗法 - Google Patents

用于充血性心力衰竭治疗的螺甾内酯与血管紧张素ⅱ拮抗药组合疗法 Download PDF

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Publication number
CN1192696A
CN1192696A CN96196086A CN96196086A CN1192696A CN 1192696 A CN1192696 A CN 1192696A CN 96196086 A CN96196086 A CN 96196086A CN 96196086 A CN96196086 A CN 96196086A CN 1192696 A CN1192696 A CN 1192696A
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CN
China
Prior art keywords
formula
angiotensin
group
receptor antagonist
disclosed
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN96196086A
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English (en)
Chinese (zh)
Inventor
T·E·马克劳兰
J·R·舒
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GD Searle LLC
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GD Searle LLC
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Publication date
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Publication of CN1192696A publication Critical patent/CN1192696A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN96196086A 1995-06-07 1996-06-05 用于充血性心力衰竭治疗的螺甾内酯与血管紧张素ⅱ拮抗药组合疗法 Pending CN1192696A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48608995A 1995-06-07 1995-06-07
US08/486,089 1995-06-07

Publications (1)

Publication Number Publication Date
CN1192696A true CN1192696A (zh) 1998-09-09

Family

ID=23930539

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96196086A Pending CN1192696A (zh) 1995-06-07 1996-06-05 用于充血性心力衰竭治疗的螺甾内酯与血管紧张素ⅱ拮抗药组合疗法

Country Status (16)

Country Link
US (1) US20040102423A1 (https=)
EP (1) EP0831911B1 (https=)
JP (1) JPH11509838A (https=)
KR (1) KR19990022723A (https=)
CN (1) CN1192696A (https=)
AT (1) ATE216261T1 (https=)
AU (1) AU6158096A (https=)
BR (1) BR9608505A (https=)
CA (1) CA2224222A1 (https=)
CZ (1) CZ291268B6 (https=)
DE (1) DE69620756T2 (https=)
DK (1) DK0831911T3 (https=)
ES (1) ES2175098T3 (https=)
IL (1) IL122246A (https=)
PT (1) PT831911E (https=)
WO (1) WO1996040258A2 (https=)

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CN1829511B (zh) * 2003-07-31 2011-08-17 贝林格尔·英格海姆国际有限公司 替米沙坦和氨氯地平或硝苯地平用于制备提高胰岛素敏感性药物组合物中的用途
CN102816126A (zh) * 2011-06-07 2012-12-12 中国药科大学 具有心血管活性的胺磺酰芳基取代的三氮唑类衍生物、其制备方法及用途

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EP2358720B1 (en) 2008-10-16 2016-03-02 The Regents of The University of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
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JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
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CN107899012A (zh) 2011-01-11 2018-04-13 戴麦里克斯生物科学有限公司 联合疗法
US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
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CA2846496C (en) 2011-09-02 2020-07-14 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829511B (zh) * 2003-07-31 2011-08-17 贝林格尔·英格海姆国际有限公司 替米沙坦和氨氯地平或硝苯地平用于制备提高胰岛素敏感性药物组合物中的用途
CN102816126A (zh) * 2011-06-07 2012-12-12 中国药科大学 具有心血管活性的胺磺酰芳基取代的三氮唑类衍生物、其制备方法及用途

Also Published As

Publication number Publication date
KR19990022723A (ko) 1999-03-25
CZ291268B6 (cs) 2003-01-15
AU6158096A (en) 1996-12-30
ES2175098T3 (es) 2002-11-16
US20040102423A1 (en) 2004-05-27
IL122246A (en) 2004-06-01
WO1996040258A3 (en) 1997-01-23
EP0831911B1 (en) 2002-04-17
CA2224222A1 (en) 1996-12-19
JPH11509838A (ja) 1999-08-31
DK0831911T3 (da) 2002-07-22
IL122246A0 (en) 1998-04-05
DE69620756T2 (de) 2002-11-14
CZ384897A3 (cs) 1998-05-13
PT831911E (pt) 2002-09-30
BR9608505A (pt) 1999-07-06
WO1996040258A2 (en) 1996-12-19
EP0831911A2 (en) 1998-04-01
DE69620756D1 (de) 2002-05-23
ATE216261T1 (de) 2002-05-15

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