CN119241632A - 雷公藤红素的类似物 - Google Patents
雷公藤红素的类似物 Download PDFInfo
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- CN119241632A CN119241632A CN202411356905.2A CN202411356905A CN119241632A CN 119241632 A CN119241632 A CN 119241632A CN 202411356905 A CN202411356905 A CN 202411356905A CN 119241632 A CN119241632 A CN 119241632A
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 208000018316 severe headache Diseases 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 208000027765 speech disease Diseases 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
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- 239000008174 sterile solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 208000023516 stroke disease Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000003478 temporal lobe Anatomy 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 150000004897 thiazines Chemical class 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000006208 topical dosage form Substances 0.000 description 1
- 231100000440 toxicity profile Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
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- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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- 230000009278 visceral effect Effects 0.000 description 1
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- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Liquid Crystal (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Optical Filters (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245356P | 2015-10-23 | 2015-10-23 | |
| US62/245,356 | 2015-10-23 | ||
| PCT/US2016/058313 WO2017070615A1 (en) | 2015-10-23 | 2016-10-21 | Analogs of celastrol |
| CN201680076127.9A CN108601751A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680076127.9A Division CN108601751A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119241632A true CN119241632A (zh) | 2025-01-03 |
Family
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Family Applications (2)
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| CN202411356905.2A Pending CN119241632A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
| CN201680076127.9A Pending CN108601751A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680076127.9A Pending CN108601751A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10662218B2 (https=) |
| EP (1) | EP3364956A4 (https=) |
| JP (3) | JP7034078B2 (https=) |
| CN (2) | CN119241632A (https=) |
| AU (3) | AU2016342375B2 (https=) |
| BR (1) | BR112018008103A2 (https=) |
| MA (1) | MA45430A (https=) |
| WO (1) | WO2017070615A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7034078B2 (ja) * | 2015-10-23 | 2022-03-11 | イーアールエックス ファーマシューティカルズ インコーポレイテッド | セラストロールの類似体 |
| EP4610656A3 (en) | 2016-04-15 | 2025-11-19 | Beckman Coulter, Inc. | Photoactive macromolecules and uses thereof |
| AU2017285486B2 (en) * | 2016-06-15 | 2023-04-27 | Targa Biomedical | Reagents, compositions and methods for improving viability and function of cells, tissues and organs |
| JP2019523245A (ja) * | 2016-07-04 | 2019-08-22 | 厦▲門▼大学 | オーファン核内受容体Ｎｕｒ７７のリガンド及びその使用 |
| CN109705187B (zh) * | 2019-01-29 | 2021-08-20 | 石家庄学院 | 一种雷公藤红素衍生物及其制备方法与应用 |
| CN112094313B (zh) * | 2019-06-17 | 2023-07-04 | 中国科学院上海药物研究所 | 一类氨基取代的雷公藤红素衍生物以及其制备方法和用途 |
| CN112110977B (zh) * | 2019-06-21 | 2022-02-25 | 中国科学院上海药物研究所 | 一类雷公藤红素衍生物、其制备方法及用途 |
| AU2021207672A1 (en) | 2020-01-15 | 2022-07-14 | University Of Florida Research Foundation, Incorporated | Therapeutic agents and methods of treatment |
| CN111202737B (zh) * | 2020-03-20 | 2022-08-05 | 中国药科大学 | 雷公藤红素酰胺衍生物在制备治疗自身性免疫疾病药物的应用 |
| WO2022072094A2 (en) * | 2020-08-28 | 2022-04-07 | University Of Florida Research Foundation, Incorporated | Modulators of nuclear receptor subfamily 4 group a member 1 (nr4a1) and uses thereof |
| CN115677812B (zh) * | 2022-01-18 | 2023-12-15 | 聊城大学 | 一类雷公藤红素衍生物及其制备方法与应用 |
| WO2023249354A1 (ko) * | 2022-06-21 | 2023-12-28 | 서울대학교산학협력단 | 디메틸제일아스테럴을 포함하는 근육 감소로 인한 질환 예방 또는 치료용 약학 조성물 |
| WO2024015416A1 (en) * | 2022-07-15 | 2024-01-18 | Celloram Inc. | Celastrol derivatives |
| EP4618998A1 (en) * | 2022-11-17 | 2025-09-24 | ERX Pharmaceuticals Inc. | Celastrol salts, crystalline forms, and uses thereof |
| EP4618964A1 (en) * | 2022-11-17 | 2025-09-24 | ERX Pharmaceuticals Inc. | Compositions and methods for treatment of prader-willi syndrome |
| WO2025106760A1 (en) * | 2023-11-16 | 2025-05-22 | Erx Pharmaceuticals Corporation | Intranasal formulations of celastrol |
| CN119431489A (zh) * | 2024-11-13 | 2025-02-14 | 肇源县总医院 | 一种雷公藤红素衍生物及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| FR2875913A1 (fr) | 2004-09-29 | 2006-03-31 | Sea On Line Sa | Systeme d'alerte anti-collision installe a bord d'un vehicule marin et procede d'analyse anti-collision |
| ES2277568B1 (es) | 2005-12-30 | 2008-04-01 | Consejo Superior De Investigaciones Cientificas | Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias. |
| WO2007117466A2 (en) | 2006-03-31 | 2007-10-18 | Massachusetts Institute Of Technology | Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors |
| WO2008063513A2 (en) * | 2006-11-13 | 2008-05-29 | Trustees Of Columbia University In The City Of New York | Selective proteasome inhibitors for treating diabetes |
| WO2009026163A1 (en) | 2007-08-17 | 2009-02-26 | Burnham Institute For Medical Research | Compositions and methods for inhibiting growth and metastasis of melanoma |
| US8691977B2 (en) | 2010-08-23 | 2014-04-08 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| MX2014014188A (es) | 2012-05-25 | 2015-05-11 | Berg Llc | Metodos para tratar un sindrome metaboilico mediante la modulacion de la proteina de choque termico (hsp) 90-beta. |
| AU2013266252B2 (en) | 2012-05-25 | 2017-07-06 | Spm Oil & Gas Inc. | Evaluating systems associated with wellheads |
| RU2650646C2 (ru) * | 2012-09-27 | 2018-04-16 | Дзе Чилдрен'З Медикал Сентер Корпорейшн | Соединения, предназначенные для лечения ожирения, и способы их применения |
| CA3044998A1 (en) * | 2014-03-26 | 2015-10-01 | The Children's Medical Center Corporation | Celastrol and derivatives for the treatment of obesity |
| JP7034078B2 (ja) * | 2015-10-23 | 2022-03-11 | イーアールエックス ファーマシューティカルズ インコーポレイテッド | セラストロールの類似体 |
| EP3563343A4 (en) | 2017-01-02 | 2020-08-19 | Gauss Surgical, Inc. | SURGICAL ITEM FOLLOW-UP WITH DUAL ELEMENT IMAGING PREDICTION |
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2016
- 2016-10-21 JP JP2018541085A patent/JP7034078B2/ja active Active
- 2016-10-21 CN CN202411356905.2A patent/CN119241632A/zh active Pending
- 2016-10-21 AU AU2016342375A patent/AU2016342375B2/en active Active
- 2016-10-21 BR BR112018008103-5A patent/BR112018008103A2/pt not_active IP Right Cessation
- 2016-10-21 WO PCT/US2016/058313 patent/WO2017070615A1/en not_active Ceased
- 2016-10-21 EP EP16858395.3A patent/EP3364956A4/en active Pending
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- 2016-10-21 MA MA045430A patent/MA45430A/fr unknown
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2020
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2021
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2022
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2023
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2024
- 2024-03-07 AU AU2024201504A patent/AU2024201504A1/en not_active Abandoned
Also Published As
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| JP2022017473A (ja) | 2022-01-25 |
| EP3364956A4 (en) | 2019-05-01 |
| JP2023164877A (ja) | 2023-11-14 |
| US11753436B2 (en) | 2023-09-12 |
| AU2024201504A1 (en) | 2024-03-28 |
| AU2022204238A1 (en) | 2022-07-07 |
| JP2018531289A (ja) | 2018-10-25 |
| CN108601751A (zh) | 2018-09-28 |
| AU2016342375A1 (en) | 2018-05-17 |
| RU2018118633A (ru) | 2019-11-25 |
| US20240190911A1 (en) | 2024-06-13 |
| US20180362575A1 (en) | 2018-12-20 |
| CA3002924A1 (en) | 2017-04-27 |
| US10662218B2 (en) | 2020-05-26 |
| MA45430A (fr) | 2019-05-01 |
| AU2016342375B2 (en) | 2022-03-17 |
| US20210061851A1 (en) | 2021-03-04 |
| WO2017070615A1 (en) | 2017-04-27 |
| BR112018008103A2 (pt) | 2018-11-06 |
| EP3364956A1 (en) | 2018-08-29 |
| JP7034078B2 (ja) | 2022-03-11 |
| AU2022204238B2 (en) | 2023-12-14 |
| JP7339992B2 (ja) | 2023-09-06 |
| RU2018118633A3 (https=) | 2020-02-17 |
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