CN118591393A - 具有可水解的马来酰亚胺接头的抗体缀合化学降解诱导物及其方法 - Google Patents

具有可水解的马来酰亚胺接头的抗体缀合化学降解诱导物及其方法 Download PDF

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Publication number
CN118591393A
CN118591393A CN202380018416.3A CN202380018416A CN118591393A CN 118591393 A CN118591393 A CN 118591393A CN 202380018416 A CN202380018416 A CN 202380018416A CN 118591393 A CN118591393 A CN 118591393A
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China
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cide
hydrogen
alkyl
antibody
conjugate
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CN202380018416.3A
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English (en)
Chinese (zh)
Inventor
D·P·苏瑟林
D·张
S·A·贝克-道克瑞
P·S·德拉戈维奇
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202380018416.3A 2022-01-26 2023-01-25 具有可水解的马来酰亚胺接头的抗体缀合化学降解诱导物及其方法 Pending CN118591393A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263303447P 2022-01-26 2022-01-26
US63/303,447 2022-01-26
PCT/US2023/061216 WO2023147328A1 (en) 2022-01-26 2023-01-25 Antibody-conjugated chemical inducers of degradation with hydolysable maleimide linkers and methods thereof

Publications (1)

Publication Number Publication Date
CN118591393A true CN118591393A (zh) 2024-09-03

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ID=85477901

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CN202380018416.3A Pending CN118591393A (zh) 2022-01-26 2023-01-25 具有可水解的马来酰亚胺接头的抗体缀合化学降解诱导物及其方法

Country Status (7)

Country Link
US (1) US20250064968A1 (https=)
EP (1) EP4469090A1 (https=)
JP (1) JP2025506357A (https=)
CN (1) CN118591393A (https=)
AR (1) AR128330A1 (https=)
TW (1) TW202340146A (https=)
WO (1) WO2023147328A1 (https=)

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Publication number Publication date
TW202340146A (zh) 2023-10-16
JP2025506357A (ja) 2025-03-11
US20250064968A1 (en) 2025-02-27
EP4469090A1 (en) 2024-12-04
WO2023147328A1 (en) 2023-08-03
AR128330A1 (es) 2024-04-17

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