TW202340146A - 抗體結合的化學降解誘導物及其方法 - Google Patents

抗體結合的化學降解誘導物及其方法 Download PDF

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Publication number
TW202340146A
TW202340146A TW112103149A TW112103149A TW202340146A TW 202340146 A TW202340146 A TW 202340146A TW 112103149 A TW112103149 A TW 112103149A TW 112103149 A TW112103149 A TW 112103149A TW 202340146 A TW202340146 A TW 202340146A
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Taiwan
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hydrogen
compound
alkyl
cide
group
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TW112103149A
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English (en)
Chinese (zh)
Inventor
丹尼爾 P 索茲林
東路 張
多克雷 桑默 A 貝克
彼得 S 德瑞哥維克
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美商建南德克公司
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Publication of TW202340146A publication Critical patent/TW202340146A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW112103149A 2022-01-26 2023-01-30 抗體結合的化學降解誘導物及其方法 TW202340146A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263303447P 2022-01-26 2022-01-26
US63/303,447 2022-01-26

Publications (1)

Publication Number Publication Date
TW202340146A true TW202340146A (zh) 2023-10-16

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ID=85477901

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112103149A TW202340146A (zh) 2022-01-26 2023-01-30 抗體結合的化學降解誘導物及其方法

Country Status (7)

Country Link
US (1) US20250064968A1 (https=)
EP (1) EP4469090A1 (https=)
JP (1) JP2025506357A (https=)
CN (1) CN118591393A (https=)
AR (1) AR128330A1 (https=)
TW (1) TW202340146A (https=)
WO (1) WO2023147328A1 (https=)

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Also Published As

Publication number Publication date
JP2025506357A (ja) 2025-03-11
US20250064968A1 (en) 2025-02-27
EP4469090A1 (en) 2024-12-04
WO2023147328A1 (en) 2023-08-03
AR128330A1 (es) 2024-04-17
CN118591393A (zh) 2024-09-03

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