CN118581083A - 用于基因表达调节的人工基因组操纵 - Google Patents

用于基因表达调节的人工基因组操纵 Download PDF

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Publication number
CN118581083A
CN118581083A CN202410521102.1A CN202410521102A CN118581083A CN 118581083 A CN118581083 A CN 118581083A CN 202410521102 A CN202410521102 A CN 202410521102A CN 118581083 A CN118581083 A CN 118581083A
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sequence
gene
domain
seq
nucleic acid
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Chinese (zh)
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金奭中
宋东佑
李宰荣
李贞慜
曹圭本
裵希淑
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Toolgen Inc
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Toolgen Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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CN202410521102.1A 2017-09-28 2018-09-27 用于基因表达调节的人工基因组操纵 Pending CN118581083A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762564478P 2017-09-28 2017-09-28
US62/564,478 2017-09-28
US201762565868P 2017-09-29 2017-09-29
US62/565,868 2017-09-29
CN201880076752.2A CN111527208B (zh) 2017-09-28 2018-09-27 用于基因表达调节的人工基因组操纵
PCT/KR2018/011424 WO2019066490A2 (ko) 2017-09-28 2018-09-27 유전자 발현 조절을 위한 인위적인 게놈 조작

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CN118581083A true CN118581083A (zh) 2024-09-03

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CN201880076752.2A Active CN111527208B (zh) 2017-09-28 2018-09-27 用于基因表达调节的人工基因组操纵

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EP (1) EP3690047A4 (https=)
JP (2) JP2020536501A (https=)
KR (1) KR102670361B1 (https=)
CN (2) CN118581083A (https=)
AU (1) AU2018339164B2 (https=)
BR (1) BR112020006428A2 (https=)
RU (2) RU2767201C2 (https=)
SG (1) SG11202002130WA (https=)
WO (1) WO2019066490A2 (https=)

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CN110577969B (zh) * 2019-08-08 2022-07-22 复旦大学 CRISPR/Sa-SlugCas9基因编辑系统及其应用
CN110577970B (zh) * 2019-08-08 2022-11-18 复旦大学 CRISPR/Sa-SlutCas9基因编辑系统及其应用
CN110577972B (zh) * 2019-08-08 2022-10-11 复旦大学 CRISPR/Sa-ShaCas9基因编辑系统及其应用
EP4091635A4 (en) * 2020-01-14 2024-02-21 Toolgen Incorporated PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE AND USE THEREOF
AU2021390471A1 (en) * 2020-12-01 2023-06-29 Research Institute At Nationwide Children's Hospital Products and methods for inhibition of expression of peripheral myelin protein-22
US12516347B2 (en) 2021-02-02 2026-01-06 Limagrain Europe Linkage of a distal promoter to a gene of interest by gene editing to modify gene expression
CN114426982B (zh) * 2022-02-22 2024-03-22 上海交通大学 一种细胞代谢重编程的方法及其应用
WO2024053964A1 (ko) * 2022-09-06 2024-03-14 주식회사 툴젠 캄필로박터 제주니 유래 cas9의 가이드 rna 구조변화를 통한 유전자교정 향상 시스템
CN116536357A (zh) * 2023-04-17 2023-08-04 中国医学科学院输血研究所 构建CRISPR/Cas12a中sgRNA剪切活性筛选系统的方法
WO2025079278A1 (ja) * 2023-10-10 2025-04-17 国立大学法人 東京医科歯科大学 シャルコー・マリー・トゥース病の処置剤

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EP4357457B1 (en) * 2012-10-23 2024-10-16 Toolgen Incorporated Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
CN105121648B (zh) * 2012-12-12 2021-05-07 布罗德研究所有限公司 用于序列操纵的系统、方法和优化的指导组合物的工程化
SI2986729T1 (sl) * 2013-04-16 2019-02-28 Regeneron Pharmaceuticals, Inc. Ciljana sprememba genoma podgane
KR20160019553A (ko) 2013-06-17 2016-02-19 더 브로드 인스티튜트, 인코퍼레이티드 유사분열 후 세포의 질병 및 장애를 표적화하고 모델링하기 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
US9388430B2 (en) * 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
WO2015048577A2 (en) * 2013-09-27 2015-04-02 Editas Medicine, Inc. Crispr-related methods and compositions
BR112016013207A2 (pt) * 2013-12-12 2017-09-26 Massachusetts Inst Technology administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para o hbv e distúrbios e doenças virais
EP3341727B1 (en) * 2015-08-25 2022-08-10 Duke University Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
WO2017053431A2 (en) 2015-09-21 2017-03-30 Arcturus Therapeutics, Inc. Allele selective gene editing and uses thereof
ES2905558T3 (es) * 2015-11-13 2022-04-11 Avellino Lab Usa Inc Procedimientos para el tratamiento de las distrofias corneales
WO2018088694A2 (ko) * 2016-11-14 2018-05-17 주식회사 툴젠 인위적으로 조작된 sc 기능 조절 시스템
JP7416406B2 (ja) * 2016-12-08 2024-01-17 ケース ウェスタン リザーブ ユニバーシティ 機能的ミエリン産生を増進させるための方法および組成物

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JP2020536501A (ja) 2020-12-17
JP2022023144A (ja) 2022-02-07
BR112020006428A2 (pt) 2020-09-24
WO2019066490A3 (ko) 2019-06-27
EP3690047A4 (en) 2021-11-03
RU2767201C2 (ru) 2022-03-16
CN111527208B (zh) 2024-05-14
KR102670361B1 (ko) 2024-05-29
RU2022103641A (ru) 2022-03-18
EP3690047A2 (en) 2020-08-05
CA3077153A1 (en) 2019-04-04
RU2020114785A (ru) 2021-10-28
KR20190037145A (ko) 2019-04-05
CN111527208A (zh) 2020-08-11
AU2018339164B2 (en) 2022-06-16
RU2020114785A3 (https=) 2021-10-28
WO2019066490A2 (ko) 2019-04-04
SG11202002130WA (en) 2020-04-29
AU2018339164A1 (en) 2020-04-09
JP7440043B2 (ja) 2024-02-28

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