RU2767201C2 - Искусственная модификация генома для регуляции экспрессии гена - Google Patents

Искусственная модификация генома для регуляции экспрессии гена Download PDF

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RU2767201C2
RU2767201C2 RU2020114785A RU2020114785A RU2767201C2 RU 2767201 C2 RU2767201 C2 RU 2767201C2 RU 2020114785 A RU2020114785 A RU 2020114785A RU 2020114785 A RU2020114785 A RU 2020114785A RU 2767201 C2 RU2767201 C2 RU 2767201C2
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seq
domain
sequence
sequences
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Сеок Дзоонг КИМ
Донг Воо СОНГ
Дзае Йоунг ЛИ
Дзунг Мин ЛИ
Гю Бон ЧО
Хи Сук Пэ
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Тулджен Инкорпорейтед
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RU2020114785A 2017-09-28 2018-09-27 Искусственная модификация генома для регуляции экспрессии гена RU2767201C2 (ru)

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US201762564478P 2017-09-28 2017-09-28
US62/564,478 2017-09-28
US201762565868P 2017-09-29 2017-09-29
US62/565,868 2017-09-29
PCT/KR2018/011424 WO2019066490A2 (ko) 2017-09-28 2018-09-27 유전자 발현 조절을 위한 인위적인 게놈 조작

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EP (1) EP3690047A4 (https=)
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CN (2) CN118581083A (https=)
AU (1) AU2018339164B2 (https=)
BR (1) BR112020006428A2 (https=)
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CN110577969B (zh) * 2019-08-08 2022-07-22 复旦大学 CRISPR/Sa-SlugCas9基因编辑系统及其应用
CN110577970B (zh) * 2019-08-08 2022-11-18 复旦大学 CRISPR/Sa-SlutCas9基因编辑系统及其应用
CN110577972B (zh) * 2019-08-08 2022-10-11 复旦大学 CRISPR/Sa-ShaCas9基因编辑系统及其应用
EP4091635A4 (en) * 2020-01-14 2024-02-21 Toolgen Incorporated PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE AND USE THEREOF
AU2021390471A1 (en) * 2020-12-01 2023-06-29 Research Institute At Nationwide Children's Hospital Products and methods for inhibition of expression of peripheral myelin protein-22
US12516347B2 (en) 2021-02-02 2026-01-06 Limagrain Europe Linkage of a distal promoter to a gene of interest by gene editing to modify gene expression
CN114426982B (zh) * 2022-02-22 2024-03-22 上海交通大学 一种细胞代谢重编程的方法及其应用
WO2024053964A1 (ko) * 2022-09-06 2024-03-14 주식회사 툴젠 캄필로박터 제주니 유래 cas9의 가이드 rna 구조변화를 통한 유전자교정 향상 시스템
CN116536357A (zh) * 2023-04-17 2023-08-04 中国医学科学院输血研究所 构建CRISPR/Cas12a中sgRNA剪切活性筛选系统的方法
WO2025079278A1 (ja) * 2023-10-10 2025-04-17 国立大学法人 東京医科歯科大学 シャルコー・マリー・トゥース病の処置剤

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WO2014093712A1 (en) * 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions for sequence manipulation
WO2015035162A2 (en) * 2013-09-06 2015-03-12 President And Fellows Of Harvard College Cas9 variants and uses thereof
WO2017035416A2 (en) * 2015-08-25 2017-03-02 Duke University Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
WO2017083852A1 (en) * 2015-11-13 2017-05-18 MOORE, Tara Methods for the treatment of corneal dystrophies
RU2015148637A (ru) * 2013-04-16 2017-05-22 Регенерон Фармасьютикалс, Инк. Направленная модификация генома крысы

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WO2014093712A1 (en) * 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions for sequence manipulation
RU2015148637A (ru) * 2013-04-16 2017-05-22 Регенерон Фармасьютикалс, Инк. Направленная модификация генома крысы
WO2015035162A2 (en) * 2013-09-06 2015-03-12 President And Fellows Of Harvard College Cas9 variants and uses thereof
WO2017035416A2 (en) * 2015-08-25 2017-03-02 Duke University Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
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JP2020536501A (ja) 2020-12-17
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BR112020006428A2 (pt) 2020-09-24
WO2019066490A3 (ko) 2019-06-27
EP3690047A4 (en) 2021-11-03
CN111527208B (zh) 2024-05-14
KR102670361B1 (ko) 2024-05-29
RU2022103641A (ru) 2022-03-18
EP3690047A2 (en) 2020-08-05
CA3077153A1 (en) 2019-04-04
RU2020114785A (ru) 2021-10-28
KR20190037145A (ko) 2019-04-05
CN111527208A (zh) 2020-08-11
AU2018339164B2 (en) 2022-06-16
RU2020114785A3 (https=) 2021-10-28
WO2019066490A2 (ko) 2019-04-04
SG11202002130WA (en) 2020-04-29
AU2018339164A1 (en) 2020-04-09
JP7440043B2 (ja) 2024-02-28

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