AU2018339164B2 - Artificial genome manipulation for gene expression regulation - Google Patents

Artificial genome manipulation for gene expression regulation Download PDF

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AU2018339164B2
AU2018339164B2 AU2018339164A AU2018339164A AU2018339164B2 AU 2018339164 B2 AU2018339164 B2 AU 2018339164B2 AU 2018339164 A AU2018339164 A AU 2018339164A AU 2018339164 A AU2018339164 A AU 2018339164A AU 2018339164 B2 AU2018339164 B2 AU 2018339164B2
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sequence
gene
seq
domain
nucleic acid
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AU2018339164A1 (en
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Hee Sook Bae
Gyu Bon CHO
Seok Joong Kim
Jae Young Lee
Jung Min Lee
Dong Woo Song
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Toolgen Inc
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Toolgen Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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AU2018339164A 2017-09-28 2018-09-27 Artificial genome manipulation for gene expression regulation Active AU2018339164B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762564478P 2017-09-28 2017-09-28
US62/564,478 2017-09-28
US201762565868P 2017-09-29 2017-09-29
US62/565,868 2017-09-29
PCT/KR2018/011424 WO2019066490A2 (ko) 2017-09-28 2018-09-27 유전자 발현 조절을 위한 인위적인 게놈 조작

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AU2018339164A1 AU2018339164A1 (en) 2020-04-09
AU2018339164B2 true AU2018339164B2 (en) 2022-06-16

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EP (1) EP3690047A4 (https=)
JP (2) JP2020536501A (https=)
KR (1) KR102670361B1 (https=)
CN (2) CN111527208B (https=)
AU (1) AU2018339164B2 (https=)
BR (1) BR112020006428A2 (https=)
RU (2) RU2022103641A (https=)
SG (1) SG11202002130WA (https=)
WO (1) WO2019066490A2 (https=)

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CN110577972B (zh) * 2019-08-08 2022-10-11 复旦大学 CRISPR/Sa-ShaCas9基因编辑系统及其应用
CN110577970B (zh) * 2019-08-08 2022-11-18 复旦大学 CRISPR/Sa-SlutCas9基因编辑系统及其应用
CN110577969B (zh) * 2019-08-08 2022-07-22 复旦大学 CRISPR/Sa-SlugCas9基因编辑系统及其应用
KR102616080B1 (ko) * 2020-01-14 2023-12-21 주식회사 툴젠 알츠하이머 예방 또는 치료용 약학적 조성물 및 이의 용도
US20240318172A1 (en) * 2020-12-01 2024-09-26 Research Institute At Nationwide Children's Hospital Products and methods for inhibition of expression of peripheral myelin protein-22
WO2022167421A1 (en) * 2021-02-02 2022-08-11 Limagrain Europe Linkage of a distal promoter to a gene of interest by gene editing to modify gene expression
CN114426982B (zh) * 2022-02-22 2024-03-22 上海交通大学 一种细胞代谢重编程的方法及其应用
KR20240034661A (ko) * 2022-09-06 2024-03-14 주식회사 툴젠 캄필로박터 제주니 유래 Cas9의 가이드 RNA 구조변화를 통한 유전자교정 향상 시스템
CN116536357A (zh) * 2023-04-17 2023-08-04 中国医学科学院输血研究所 构建CRISPR/Cas12a中sgRNA剪切活性筛选系统的方法
WO2025079278A1 (ja) * 2023-10-10 2025-04-17 国立大学法人 東京医科歯科大学 シャルコー・マリー・トゥース病の処置剤

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DK3456831T3 (da) * 2013-04-16 2021-09-06 Regeneron Pharma Målrettet modifikation af rottegenom
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JP2020536501A (ja) 2020-12-17
RU2767201C2 (ru) 2022-03-16
AU2018339164A1 (en) 2020-04-09
JP2022023144A (ja) 2022-02-07
CN111527208A (zh) 2020-08-11
CN111527208B (zh) 2024-05-14
BR112020006428A2 (pt) 2020-09-24
EP3690047A2 (en) 2020-08-05
RU2022103641A (ru) 2022-03-18
KR20190037145A (ko) 2019-04-05
JP7440043B2 (ja) 2024-02-28
EP3690047A4 (en) 2021-11-03
WO2019066490A3 (ko) 2019-06-27
RU2020114785A (ru) 2021-10-28
SG11202002130WA (en) 2020-04-29
RU2020114785A3 (https=) 2021-10-28
CN118581083A (zh) 2024-09-03
CA3077153A1 (en) 2019-04-04
KR102670361B1 (ko) 2024-05-29
WO2019066490A2 (ko) 2019-04-04

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