KR102670361B1 - 유전자 발현 조절을 위한 인위적인 게놈 조작 - Google Patents

유전자 발현 조절을 위한 인위적인 게놈 조작 Download PDF

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KR102670361B1
KR102670361B1 KR1020180114900A KR20180114900A KR102670361B1 KR 102670361 B1 KR102670361 B1 KR 102670361B1 KR 1020180114900 A KR1020180114900 A KR 1020180114900A KR 20180114900 A KR20180114900 A KR 20180114900A KR 102670361 B1 KR102670361 B1 KR 102670361B1
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gene
sequence
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nucleic acid
nucleotide sequence
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KR20190037145A (ko
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김석중
송동우
이재영
이정민
조규본
배희숙
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주식회사 툴젠
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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KR1020180114900A 2017-09-28 2018-09-27 유전자 발현 조절을 위한 인위적인 게놈 조작 Active KR102670361B1 (ko)

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US201762564478P 2017-09-28 2017-09-28
US62/564,478 2017-09-28
US201762565868P 2017-09-29 2017-09-29
US62/565,868 2017-09-29

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KR20190037145A KR20190037145A (ko) 2019-04-05
KR102670361B1 true KR102670361B1 (ko) 2024-05-29

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EP (1) EP3690047A4 (https=)
JP (2) JP2020536501A (https=)
KR (1) KR102670361B1 (https=)
CN (2) CN118581083A (https=)
AU (1) AU2018339164B2 (https=)
BR (1) BR112020006428A2 (https=)
RU (2) RU2767201C2 (https=)
SG (1) SG11202002130WA (https=)
WO (1) WO2019066490A2 (https=)

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CN110577969B (zh) * 2019-08-08 2022-07-22 复旦大学 CRISPR/Sa-SlugCas9基因编辑系统及其应用
CN110577970B (zh) * 2019-08-08 2022-11-18 复旦大学 CRISPR/Sa-SlutCas9基因编辑系统及其应用
CN110577972B (zh) * 2019-08-08 2022-10-11 复旦大学 CRISPR/Sa-ShaCas9基因编辑系统及其应用
EP4091635A4 (en) * 2020-01-14 2024-02-21 Toolgen Incorporated PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE AND USE THEREOF
AU2021390471A1 (en) * 2020-12-01 2023-06-29 Research Institute At Nationwide Children's Hospital Products and methods for inhibition of expression of peripheral myelin protein-22
US12516347B2 (en) 2021-02-02 2026-01-06 Limagrain Europe Linkage of a distal promoter to a gene of interest by gene editing to modify gene expression
CN114426982B (zh) * 2022-02-22 2024-03-22 上海交通大学 一种细胞代谢重编程的方法及其应用
WO2024053964A1 (ko) * 2022-09-06 2024-03-14 주식회사 툴젠 캄필로박터 제주니 유래 cas9의 가이드 rna 구조변화를 통한 유전자교정 향상 시스템
CN116536357A (zh) * 2023-04-17 2023-08-04 中国医学科学院输血研究所 构建CRISPR/Cas12a中sgRNA剪切活性筛选系统的方法
WO2025079278A1 (ja) * 2023-10-10 2025-04-17 国立大学法人 東京医科歯科大学 シャルコー・マリー・トゥース病の処置剤

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WO2014204728A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
WO2017053431A2 (en) 2015-09-21 2017-03-30 Arcturus Therapeutics, Inc. Allele selective gene editing and uses thereof

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CN105121648B (zh) * 2012-12-12 2021-05-07 布罗德研究所有限公司 用于序列操纵的系统、方法和优化的指导组合物的工程化
SI2986729T1 (sl) * 2013-04-16 2019-02-28 Regeneron Pharmaceuticals, Inc. Ciljana sprememba genoma podgane
US9388430B2 (en) * 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
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JP7416406B2 (ja) * 2016-12-08 2024-01-17 ケース ウェスタン リザーブ ユニバーシティ 機能的ミエリン産生を増進させるための方法および組成物

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WO2017053431A2 (en) 2015-09-21 2017-03-30 Arcturus Therapeutics, Inc. Allele selective gene editing and uses thereof

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CN118581083A (zh) 2024-09-03
JP2020536501A (ja) 2020-12-17
JP2022023144A (ja) 2022-02-07
BR112020006428A2 (pt) 2020-09-24
WO2019066490A3 (ko) 2019-06-27
EP3690047A4 (en) 2021-11-03
RU2767201C2 (ru) 2022-03-16
CN111527208B (zh) 2024-05-14
RU2022103641A (ru) 2022-03-18
EP3690047A2 (en) 2020-08-05
CA3077153A1 (en) 2019-04-04
RU2020114785A (ru) 2021-10-28
KR20190037145A (ko) 2019-04-05
CN111527208A (zh) 2020-08-11
AU2018339164B2 (en) 2022-06-16
RU2020114785A3 (https=) 2021-10-28
WO2019066490A2 (ko) 2019-04-04
SG11202002130WA (en) 2020-04-29
AU2018339164A1 (en) 2020-04-09
JP7440043B2 (ja) 2024-02-28

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