SG11202002130WA - Artificial genome manipulation for gene expression regulation - Google Patents
Artificial genome manipulation for gene expression regulationInfo
- Publication number
- SG11202002130WA SG11202002130WA SG11202002130WA SG11202002130WA SG11202002130WA SG 11202002130W A SG11202002130W A SG 11202002130WA SG 11202002130W A SG11202002130W A SG 11202002130WA SG 11202002130W A SG11202002130W A SG 11202002130WA SG 11202002130W A SG11202002130W A SG 11202002130WA
- Authority
- SG
- Singapore
- Prior art keywords
- gene expression
- expression regulation
- genome manipulation
- artificial genome
- artificial
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/34—Allele or polymorphism specific uses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762564478P | 2017-09-28 | 2017-09-28 | |
US201762565868P | 2017-09-29 | 2017-09-29 | |
PCT/KR2018/011424 WO2019066490A2 (en) | 2017-09-28 | 2018-09-27 | Artificial genome manipulation for gene expression regulation |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202002130WA true SG11202002130WA (en) | 2020-04-29 |
Family
ID=65902054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202002130WA SG11202002130WA (en) | 2017-09-28 | 2018-09-27 | Artificial genome manipulation for gene expression regulation |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP3690047A4 (en) |
JP (2) | JP2020536501A (en) |
KR (1) | KR20190037145A (en) |
CN (1) | CN111527208A (en) |
AU (1) | AU2018339164B2 (en) |
BR (1) | BR112020006428A2 (en) |
CA (1) | CA3077153A1 (en) |
RU (2) | RU2022103641A (en) |
SG (1) | SG11202002130WA (en) |
WO (1) | WO2019066490A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110577969B (en) * | 2019-08-08 | 2022-07-22 | 复旦大学 | CRISPR/Sa-SlugCas9 gene editing system and application thereof |
CN110577972B (en) * | 2019-08-08 | 2022-10-11 | 复旦大学 | CRISPR/Sa-ShaCas9 gene editing system and application thereof |
CN110577970B (en) * | 2019-08-08 | 2022-11-18 | 复旦大学 | CRISPR/Sa-SlutCas9 gene editing system and application thereof |
US20230053781A1 (en) * | 2020-01-14 | 2023-02-23 | Toolgen Incorporated | Pharmaceutical composition for preventing or treating alzheimer's and use thereof |
CN116917492A (en) * | 2020-12-01 | 2023-10-20 | 全国儿童医院研究所 | Products and methods for inhibiting expression of outer Zhou Suiqiao protein-22 |
WO2022167421A1 (en) * | 2021-02-02 | 2022-08-11 | Limagrain Europe | Linkage of a distal promoter to a gene of interest by gene editing to modify gene expression |
CN114426982B (en) * | 2022-02-22 | 2024-03-22 | 上海交通大学 | Method for reprogramming cell metabolism and application thereof |
WO2024053964A1 (en) * | 2022-09-06 | 2024-03-14 | 주식회사 툴젠 | System for improving gene editing through structural change of guide rna of cas9 derived from campylobacter jejuni |
CN116536357A (en) * | 2023-04-17 | 2023-08-04 | 中国医学科学院输血研究所 | Method for constructing sgRNA shearing activity screening system in CRISPR/Cas12a |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105441440B (en) * | 2012-10-23 | 2020-12-15 | 基因工具股份有限公司 | Composition for cleaving target DNA comprising guide RNA specific for target DNA and CAS protein-encoding nucleic acid or CAS protein, and use thereof |
CN113528577A (en) * | 2012-12-12 | 2021-10-22 | 布罗德研究所有限公司 | Engineering of systems, methods and optimized guide compositions for sequence manipulation |
LT3456831T (en) * | 2013-04-16 | 2021-09-10 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
US9322037B2 (en) * | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
WO2015048577A2 (en) * | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
BR112016013207A2 (en) * | 2013-12-12 | 2017-09-26 | Massachusetts Inst Technology | administration, use and therapeutic applications of crisp systems and compositions for hbv and viral disorders and diseases |
CA2996001A1 (en) * | 2015-08-25 | 2017-03-02 | Duke University | Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases |
CN108699542A (en) * | 2015-11-13 | 2018-10-23 | 阿维利诺美国实验室股份有限公司 | Method for treating corneal dystrophy |
EP3539980A4 (en) * | 2016-11-14 | 2020-10-07 | Toolgen Incorporated | Artificially engineered sc function control system |
EP4276187A3 (en) * | 2016-12-08 | 2024-01-17 | Case Western Reserve University | Methods and compositions for enhancing functional myelin production |
-
2018
- 2018-09-27 JP JP2020513755A patent/JP2020536501A/en active Pending
- 2018-09-27 CA CA3077153A patent/CA3077153A1/en active Pending
- 2018-09-27 SG SG11202002130WA patent/SG11202002130WA/en unknown
- 2018-09-27 AU AU2018339164A patent/AU2018339164B2/en active Active
- 2018-09-27 BR BR112020006428-9A patent/BR112020006428A2/en unknown
- 2018-09-27 WO PCT/KR2018/011424 patent/WO2019066490A2/en unknown
- 2018-09-27 EP EP18862957.0A patent/EP3690047A4/en active Pending
- 2018-09-27 CN CN201880076752.2A patent/CN111527208A/en active Pending
- 2018-09-27 RU RU2022103641A patent/RU2022103641A/en unknown
- 2018-09-27 KR KR1020180114900A patent/KR20190037145A/en active IP Right Grant
- 2018-09-27 RU RU2020114785A patent/RU2767201C2/en active
-
2021
- 2021-10-18 JP JP2021170086A patent/JP7440043B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
RU2020114785A3 (en) | 2021-10-28 |
AU2018339164A1 (en) | 2020-04-09 |
RU2022103641A (en) | 2022-03-18 |
CN111527208A (en) | 2020-08-11 |
EP3690047A4 (en) | 2021-11-03 |
JP7440043B2 (en) | 2024-02-28 |
KR20190037145A (en) | 2019-04-05 |
BR112020006428A2 (en) | 2020-09-24 |
RU2767201C2 (en) | 2022-03-16 |
WO2019066490A3 (en) | 2019-06-27 |
CA3077153A1 (en) | 2019-04-04 |
JP2020536501A (en) | 2020-12-17 |
WO2019066490A2 (en) | 2019-04-04 |
JP2022023144A (en) | 2022-02-07 |
RU2020114785A (en) | 2021-10-28 |
EP3690047A2 (en) | 2020-08-05 |
AU2018339164B2 (en) | 2022-06-16 |
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