CN118206566A - 作为nrf2活化剂的羟基吡啶并氧氮杂环庚三烯 - Google Patents

作为nrf2活化剂的羟基吡啶并氧氮杂环庚三烯 Download PDF

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Publication number
CN118206566A
CN118206566A CN202410206971.5A CN202410206971A CN118206566A CN 118206566 A CN118206566 A CN 118206566A CN 202410206971 A CN202410206971 A CN 202410206971A CN 118206566 A CN118206566 A CN 118206566A
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methyl
dimethyl
compound
dihydropyrido
oxazepin
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Pending
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CN202410206971.5A
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Chinese (zh)
Inventor
M·埃尔班
M·P·格洛戈夫斯基
M·C·科廷
B·G·劳霍恩
J·M·马修斯
J·R·帕特森
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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Publication of CN118206566A publication Critical patent/CN118206566A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202410206971.5A 2019-02-15 2020-02-11 作为nrf2活化剂的羟基吡啶并氧氮杂环庚三烯 Pending CN118206566A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962806201P 2019-02-15 2019-02-15
US62/806,201 2019-02-15
US201962931877P 2019-11-07 2019-11-07
US62/931,877 2019-11-07
PCT/IB2020/051100 WO2020165776A1 (en) 2019-02-15 2020-02-11 Hydroxypyridoxazepines as nrf2 activators
CN202080014726.4A CN113474349B (zh) 2019-02-15 2020-02-11 作为nrf2活化剂的羟基吡啶并氧氮杂环庚三烯

Related Parent Applications (1)

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Publication Number Publication Date
CN118206566A true CN118206566A (zh) 2024-06-18

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CN202080014726.4A Active CN113474349B (zh) 2019-02-15 2020-02-11 作为nrf2活化剂的羟基吡啶并氧氮杂环庚三烯

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Country Status (18)

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US (3) US11945826B2 (enExample)
EP (1) EP3924356A1 (enExample)
JP (1) JP7602469B2 (enExample)
KR (1) KR20210126676A (enExample)
CN (2) CN118206566A (enExample)
AU (1) AU2020222080C1 (enExample)
BR (1) BR112021016042A2 (enExample)
CA (1) CA3129955A1 (enExample)
CL (1) CL2021002110A1 (enExample)
CO (1) CO2021010930A2 (enExample)
IL (2) IL285438B2 (enExample)
MA (1) MA54939A (enExample)
MX (1) MX2021009659A (enExample)
MY (1) MY209603A (enExample)
PH (1) PH12021551873A1 (enExample)
SG (1) SG11202108257TA (enExample)
TW (2) TWI880702B (enExample)
WO (1) WO2020165776A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3833662T (pt) 2018-08-20 2024-03-18 Janssen Pharmaceutica Nv Inibidores da interação proteína-proteína keap1-nrf2
PH12021551873A1 (en) * 2019-02-15 2022-05-23 Glaxosmithkline Ip Dev Ltd Hydroxypyridoxazepines as nrf2 activators
AR118050A1 (es) 2019-02-15 2021-09-15 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x
JP7524899B2 (ja) * 2019-05-31 2024-07-30 Ube株式会社 ベンゾトリアゾール誘導体
KR20240133727A (ko) 2022-01-07 2024-09-04 추가이 세이야쿠 가부시키가이샤 Nrf2 활성화 작용을 갖는 함질소 헤테로환 화합물
TW202404984A (zh) * 2022-04-28 2024-02-01 日商第一三共股份有限公司 苯并三唑化合物
TW202345792A (zh) 2022-04-28 2023-12-01 日商第一三共股份有限公司 苯并噻吩化合物
WO2024047248A1 (en) * 2022-09-02 2024-03-07 Institut National de la Santé et de la Recherche Médicale Use of nrf2 activators for the treatment of cerebral small vessel disease
AU2024314540A1 (en) 2023-06-19 2025-11-27 Chugai Seiyaku Kabushiki Kaisha Crystal of nitrogen-containing heterocyclic compound having nrf2 activation effect

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2094651A1 (en) * 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
AU2014369153B2 (en) * 2013-12-18 2017-09-21 Astex Therapeutics Limited Nrf2 regulators
EP3307729B1 (en) 2015-06-15 2020-09-02 GlaxoSmithKline Intellectual Property Development Limited Nrf2 regulators
RU2018101077A (ru) 2015-06-15 2019-07-15 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Регуляторы nrf2
PH12017502255B1 (en) * 2015-06-15 2022-07-22 Astex Therapeutics Ltd Nrf2 regulators
US10201531B2 (en) * 2015-08-12 2019-02-12 Mochida Pharmaceutical Co., Ltd. Indazolyl-oxo-isothiazole compounds
US10364256B2 (en) * 2015-10-06 2019-07-30 Glaxosmithkline Intellectual Property Development Limited Biaryl pyrazoles as NRF2 regulators
KR20190088404A (ko) * 2016-12-06 2019-07-26 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 3-(2,3-디히드로-1h-인덴-5-일)프로판산 유도체 및 nrf2 조절제로서의 그의 용도
JP2020500918A (ja) * 2016-12-12 2020-01-16 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited Nrf2レギュレーターとしてのn−アリールピラゾール
ES2901617T3 (es) * 2016-12-14 2022-03-23 Glaxosmithkline Ip Dev Ltd Bisarilamidas como reguladores de NRF2
WO2018109646A1 (en) 2016-12-15 2018-06-21 Glaxosmithkline Intellectual Property Development Limited Nrf2 compounds
PH12021551873A1 (en) * 2019-02-15 2022-05-23 Glaxosmithkline Ip Dev Ltd Hydroxypyridoxazepines as nrf2 activators

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Publication number Publication date
IL285438B1 (en) 2024-08-01
AU2020222080B2 (en) 2022-05-19
SG11202108257TA (en) 2021-08-30
TWI843806B (zh) 2024-06-01
CN113474349A (zh) 2021-10-01
MY209603A (en) 2025-07-24
JP7602469B2 (ja) 2024-12-18
CO2021010930A2 (es) 2021-09-09
CN113474349B (zh) 2024-03-01
IL285438A (en) 2021-09-30
IL285438B2 (en) 2024-12-01
JP2022520442A (ja) 2022-03-30
TW202440593A (zh) 2024-10-16
PH12021551873A1 (en) 2022-05-23
AU2020222080C1 (en) 2022-09-29
US20220204526A1 (en) 2022-06-30
CL2021002110A1 (es) 2022-02-11
WO2020165776A1 (en) 2020-08-20
US20250313573A1 (en) 2025-10-09
TW202045514A (zh) 2020-12-16
US11945826B2 (en) 2024-04-02
MX2021009659A (es) 2021-09-08
KR20210126676A (ko) 2021-10-20
MA54939A (fr) 2021-12-22
TWI880702B (zh) 2025-04-11
US20240352034A1 (en) 2024-10-24
IL313950A (en) 2024-08-01
BR112021016042A2 (pt) 2021-10-05
AU2020222080A1 (en) 2021-09-02
CA3129955A1 (en) 2020-08-20
EP3924356A1 (en) 2021-12-22

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