CA3129955A1 - Hydroxypyridoxazepines as nrf2 activators - Google Patents
Hydroxypyridoxazepines as nrf2 activators Download PDFInfo
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- CA3129955A1 CA3129955A1 CA3129955A CA3129955A CA3129955A1 CA 3129955 A1 CA3129955 A1 CA 3129955A1 CA 3129955 A CA3129955 A CA 3129955A CA 3129955 A CA3129955 A CA 3129955A CA 3129955 A1 CA3129955 A1 CA 3129955A1
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- Prior art keywords
- compound
- dihydropyrido
- benzo
- triazol
- oxazepin
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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- Transplantation (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| US201962806201P | 2019-02-15 | 2019-02-15 | |
| US62/806,201 | 2019-02-15 | ||
| US201962931877P | 2019-11-07 | 2019-11-07 | |
| US62/931,877 | 2019-11-07 | ||
| PCT/IB2020/051100 WO2020165776A1 (en) | 2019-02-15 | 2020-02-11 | Hydroxypyridoxazepines as nrf2 activators |
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| CA3129955A1 true CA3129955A1 (en) | 2020-08-20 |
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| CA3129955A Pending CA3129955A1 (en) | 2019-02-15 | 2020-02-11 | Hydroxypyridoxazepines as nrf2 activators |
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| JP (1) | JP7602469B2 (enExample) |
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| CA (1) | CA3129955A1 (enExample) |
| CL (1) | CL2021002110A1 (enExample) |
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| PH12021551873A1 (en) * | 2019-02-15 | 2022-05-23 | Glaxosmithkline Ip Dev Ltd | Hydroxypyridoxazepines as nrf2 activators |
| AR118050A1 (es) | 2019-02-15 | 2021-09-15 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x |
| JP7524899B2 (ja) * | 2019-05-31 | 2024-07-30 | Ｕｂｅ株式会社 | ベンゾトリアゾール誘導体 |
| KR20240133727A (ko) | 2022-01-07 | 2024-09-04 | 추가이 세이야쿠 가부시키가이샤 | Nrf2 활성화 작용을 갖는 함질소 헤테로환 화합물 |
| TW202404984A (zh) * | 2022-04-28 | 2024-02-01 | 日商第一三共股份有限公司 | 苯并三唑化合物 |
| TW202345792A (zh) | 2022-04-28 | 2023-12-01 | 日商第一三共股份有限公司 | 苯并噻吩化合物 |
| WO2024047248A1 (en) * | 2022-09-02 | 2024-03-07 | Institut National de la Santé et de la Recherche Médicale | Use of nrf2 activators for the treatment of cerebral small vessel disease |
| AU2024314540A1 (en) | 2023-06-19 | 2025-11-27 | Chugai Seiyaku Kabushiki Kaisha | Crystal of nitrogen-containing heterocyclic compound having nrf2 activation effect |
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| EP2094651A1 (en) * | 2006-11-17 | 2009-09-02 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| AU2014369153B2 (en) * | 2013-12-18 | 2017-09-21 | Astex Therapeutics Limited | Nrf2 regulators |
| EP3307729B1 (en) | 2015-06-15 | 2020-09-02 | GlaxoSmithKline Intellectual Property Development Limited | Nrf2 regulators |
| RU2018101077A (ru) | 2015-06-15 | 2019-07-15 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Регуляторы nrf2 |
| PH12017502255B1 (en) * | 2015-06-15 | 2022-07-22 | Astex Therapeutics Ltd | Nrf2 regulators |
| US10201531B2 (en) * | 2015-08-12 | 2019-02-12 | Mochida Pharmaceutical Co., Ltd. | Indazolyl-oxo-isothiazole compounds |
| US10364256B2 (en) * | 2015-10-06 | 2019-07-30 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as NRF2 regulators |
| KR20190088404A (ko) * | 2016-12-06 | 2019-07-26 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 3-(2,3-디히드로-1h-인덴-5-일)프로판산 유도체 및 nrf2 조절제로서의 그의 용도 |
| JP2020500918A (ja) * | 2016-12-12 | 2020-01-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２レギュレーターとしてのｎ−アリールピラゾール |
| ES2901617T3 (es) * | 2016-12-14 | 2022-03-23 | Glaxosmithkline Ip Dev Ltd | Bisarilamidas como reguladores de NRF2 |
| WO2018109646A1 (en) | 2016-12-15 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 compounds |
| PH12021551873A1 (en) * | 2019-02-15 | 2022-05-23 | Glaxosmithkline Ip Dev Ltd | Hydroxypyridoxazepines as nrf2 activators |
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2020
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| SG11202108257TA (en) | 2021-08-30 |
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| JP7602469B2 (ja) | 2024-12-18 |
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| IL285438B2 (en) | 2024-12-01 |
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| PH12021551873A1 (en) | 2022-05-23 |
| AU2020222080C1 (en) | 2022-09-29 |
| US20220204526A1 (en) | 2022-06-30 |
| CN118206566A (zh) | 2024-06-18 |
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| WO2020165776A1 (en) | 2020-08-20 |
| US20250313573A1 (en) | 2025-10-09 |
| TW202045514A (zh) | 2020-12-16 |
| US11945826B2 (en) | 2024-04-02 |
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| IL313950A (en) | 2024-08-01 |
| BR112021016042A2 (pt) | 2021-10-05 |
| AU2020222080A1 (en) | 2021-09-02 |
| EP3924356A1 (en) | 2021-12-22 |
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